Article
Medicine, General & Internal
David Hupin, Philip Sarajlic, Ashwin Venkateshvaran, Cecilia Friden, Birgitta Nordgren, Christina H. Opava, Ingrid E. Lundberg, Magnus Baeck
Summary: Chronic inflammation in patients with rheumatoid arthritis (RA) can lead to autonomic dysfunction, increasing the risk of cardiovascular diseases (CVD). Exercise has been shown to improve autonomic nervous system (ANS) activity, particularly the parasympathetic component, in RA patients, which can help reduce the risk of CVD. Factors such as blood pressure response, low BMI, and muscular strength are important predictors of changes in heart rate recovery (HRR) in RA patients undergoing physical activity programs.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Jianan Zhao, Lingxia Xu, Cen Chang, Ping Jiang, Kai Wei, Yiming Shi, Linshuai Xu, Yixin Zheng, Yu Shan, Yanqin Bian, Li Li, Shicheng Guo, Steven J. Schrodi, Rongsheng Wang, Dongyi He
Summary: This study found a significant hypermethylation of the promoter region of HTR2A, indicating its potential clinical diagnostic role in rheumatoid arthritis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Guangshuai Zhang, Guangyuan Sun, Haishan Guan, Mo Li, Yanhua Liu, Baocheng Tian, Zhonggui He, Qiang Fu
Summary: The study aimed to improve the therapeutic efficacy of naringenin by formulating it into nanocrystals, showing promising results in enhancing bioavailability, cellular uptake, and rheumatoid arthritis treatment.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Mislav Radic, Ivan Vlak, Marijana Vuckovic, Josipa Radic, Erim Besic, Tonko Vlak
Summary: The aim of this study was to evaluate various factors in patients with rheumatoid arthritis (RA) and examine their associations. The results showed that the patients had long disease duration and high disease activity.
Article
Rheumatology
Joshua F. Baker, Bryant R. England, Michael George, Grant Cannon, Brian Sauer, Alexis Ogdie, Bartlett C. Hamilton, Carlos Hunter, Michael J. Duryee, Geoffrey Thiele, Ted R. Mikuls
Summary: The study found that higher disease activity and elevated levels of cytokines/chemokines are associated with a higher risk of incident diabetes mellitus in patients with rheumatoid arthritis. Factors such as high DAS28-CRP, obese BMI, older age, and male sex were associated with increased risk for incident diabetes mellitus.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Juan He, Yu Li, Jian Chen, Qi Wu, Hongying Shan, Xiaocheng Wang, Miaomiao Zhang, Liping Nie, Qingwen Wang
Summary: Different subsets of CD8+ T cells are associated with clinical features and serological parameters in rheumatoid arthritis (RA). Naive CD8+ T cells are negatively correlated with disease activity, while CD8+ CD28-T cells and CD8+ CD27-T cells are positively correlated with disease activity. Activated CD8+ T cells and TCR gamma E+ CD8+ T cells may be involved in inflammation and lipid metabolism in RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Eleana Bolla, Nikolaos Tentolouris, Petros P. Sfikakis, Maria G. Tektonidou
Summary: This study aimed to evaluate the prevalence of Metabolic Syndrome (MetS) in antiphospholipid syndrome (APS) patients and its associations with cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. The results showed that MetS was present in approximately one-fourth of APS patients and was associated with arterial thrombosis, cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. This suggests that MetS plays an important role in cardiovascular risk stratification and management in APS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Krzysztof Grzechnik, Bozena Targonska-Stepniak
Summary: This study found that the presence of metabolic syndrome (MetS) was associated with higher disease activity in patients with rheumatoid arthritis (RA). There were also correlations between metabolic parameters and indices of RA activity.
Article
Rheumatology
Masahiro Tada, Yutaro Yamada, Koji Mandai, Yoshinari Matsumoto, Noriaki Hidaka
Summary: This study quantitatively measured the daily physical activity and steps of patients with rheumatoid arthritis (RA) using a wearable activity meter and examined their associations with patients' background characteristics. The study found that daily physical activity and steps were significantly decreased in RA patients with moderate and high disease activity.
CLINICAL RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jeneen Panezai, Ambereen Ghaffar, Mohammad Altamash, Mikael Aberg, Thomas E. Van Dyke, Anders Larsson, Per-Erik Engstrom
Summary: Periodontal disease enhances the expression of CVD-related biomarkers in RA patients through shared pathological clusters, concurrently enhancing metabolic and skeletal disease protein interactions, independent of autoimmune status.
Article
Rheumatology
Roswitha Dietzel, Sabine Wiegmann, Diana Borucki, Christian Detzer, Kim Nikola Zeiner, Desiree Schaumburg, Bjoern Buehring, Frank Buttgereit, Gabriele Armbrecht
Summary: In patients with rheumatoid arthritis (RA), chronic inflammation can lead to muscle depletion. The study found that sarcopenia is more common in RA patients and is associated with factors such as body weight, BMI, inflammation markers, and disease duration.
Article
Medicine, General & Internal
Xing Song, Yan-Hong Wang, Meng-Tao Li, Xin-Wang Duan, Hong-Bin Li, Xiao-Feng Zeng
Summary: The study on Chinese patients with RA showed high correlations and concordance among different DAIs, but significant discordance was also observed. The four DAIs are not interchangeable in clinical practice for assessing disease activity in RA patients.
CHINESE MEDICAL JOURNAL
(2021)
Article
Immunology
W. Watson Buchanan, Colin A. Kean, Walter F. Kean, K. D. Rainsford
Summary: It is difficult to determine the exact origin of Rheumatoid Arthritis, but there were clear descriptions in the 17th century. Augustin Jacob Landre-Beauvais is credited with the first clear description of the disease in his thesis. Sir Alfred Baring Garrod gave the disease its current name in 1859, which was later adapted by the Ministry of Health in Britain in 1922. Some forms of Juvenile Arthritis are related to adult Rheumatoid Arthritis, and if left untreated, it can lead to severe joint damage and systemic complications. The discovery of anti TNF-alpha agents in the 1990s and subsequent biologic agents have greatly improved the clinical outcome of Rheumatoid Arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Aikaterini Arida, Aigli-Ioanna Legaki, Evrydiki Kravvariti, Athanasios Protogerou, Petros P. Sfikakis, Antonios Chatzigeorgiou
Summary: The study reveals the significant role of the PCSK9/LDLR system in atherosclerosis related to rheumatoid arthritis, suggesting its potential use as a screening tool for disease progression in the future.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Immunology
Robin Caire, Estelle Audoux, Guillaume Courbon, Eva Michaud, Claudie Petit, Elisa Dalix, Marwa Chafchafi, Mireille Thomas, Arnaud Vanden-Bossche, Laurent Navarro, Marie-Therese Linossier, Sylvie Peyroche, Alain Guignandon, Laurence Vico, Stephane Paul, Hubert Marotte
Summary: The study indicates that YAP/TAZ play crucial roles in arthritis, and their transcriptional inhibition may be relevant for treating inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Orthopedics
Frank Timo Beil, Rolf D. Burghardt, Andre Strahl, Wolfgang Ruether, Andreas Niemeier
JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
(2017)
Article
Rheumatology
A. Strahl, O. Schneider, J. Frankenhauser-Mannuss, S. Knapstein, C. Hermann, B. Lembeck, H. -M. Lorenz, W. Ruether, J. Flechtenmacher
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2018)
Article
Education & Educational Research
Andre Strahl, Christian Gerlich, Georg W. Alpers, Katja Ehrmann, Jorg Gehrke, Annette Muller-Garnn, Heiner Vogel
BMC MEDICAL EDUCATION
(2018)
Article
Clinical Neurology
Lennart Viezens, Phillip Reer, Andre Strahl, Lukas Weiser, Malte Schroeder, Joerg Beyerlein, Christian Schaefer
WORLD NEUROSURGERY
(2018)
Article
Orthopedics
Maciej J. K. Simon, Andre Strahl, Haider Mussawy, Tim Rolvien, Robert F. Schumacher, Marcel Seller, Wolfgang Ruether
FOOT & ANKLE INTERNATIONAL
(2019)
Article
Orthopedics
Nicola Oehler, Julia Kristin Ruby, Andre Strahl, Rainer Maas, Wolfgang Ruether, Andreas Niemeier
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2020)
Article
Gastroenterology & Hepatology
Tobias Schmidt, Constantin Schmidt, Andre Strahl, Haider Mussawy, Tim Rolvien, Nico M. Jandl, Christian Casar, Ralf Oheim, Thorsten Schinke, Ansgar W. Lohse, Michael Amling, Christoph Schramm, Florian Barvencik
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Health Care Sciences & Services
Andre Strahl, Christian Gerlich, Georg W. Alpers, Joerg Gehrke, Annette Mueller-Garnn, Heiner Vogel
BMC HEALTH SERVICES RESEARCH
(2019)
Article
Surgery
Maciej J. K. Simon, Vivian E. Aartsen, Jennifer A. Coghlan, Andre Strahl, Simon N. Bell
Summary: The study showed that intra-articular injections of ACS in patients with GH-OA can improve pain and function, delaying the need for a shoulder replacement. Some patients demonstrated significant pain improvement and avoided shoulder replacement surgery at two-year follow-up.
ANZ JOURNAL OF SURGERY
(2021)
Article
Orthopedics
Moritz Muehlenfeld, Andre Strahl, Ulrich Bechler, Nico Maximilian Jandl, Jan Hubert, Tim Rolvien
Summary: This study evaluated 50 adults with secondary OA due to rheumatic diseases, finding distinct frequencies and risk factors of low BMD in THA and TKA patients. The findings suggest a potential value of DXA in the preoperative evaluation of bone status.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
M. M. Delsmann, A. Strahl, M. Muhlenfeld, N. M. Jandl, F. T. Beil, C. Ries, T. Rolvien
Summary: The study found a high prevalence of low bone mineral density in elderly patients with end-stage osteoarthritis scheduled for total hip arthroplasty. Routine DXA measurements should be considered in these patients to prevent undiagnosed and untreated osteoporosis, which could impact the success of osseointegration and other clinical outcomes.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Leon-Gordian Koepke, Annika Heuer, Martin Stangenberg, Marc Dreimann, Lutz Welker, Carsten Bokemeyer, Andre Strahl, Anne Marie Asemissen, Lennart Viezens
Summary: Our study demonstrates that cytological evaluation of spinal lesions suspected of malignancy can provide a quick and reliable diagnosis of the underlying disease in patients with new-onset malignant spinal lesions, facilitating appropriate treatment. Implementing this process as a routine clinical diagnostic can shorten the time to diagnosis and improve treatment outcomes for this vulnerable patient group.
Article
Infectious Diseases
Lara Krueger, Andre Strahl, Leon-Gordian Koepke, Bernd Fink, Frank Timo Beil, Jan Hubert
Summary: This study evaluated the use of intraoperative cell salvage (ICS) during reimplantation of hip arthroplasties. Positive intraoperative cultures were found in 13 cases, but no significant correlation was found between the detection of positive cultures and the occurrence of complications. The use of ICS during reimplantation was considered to be indicated in terms of patient blood management, but further studies are needed for septic revision arthroplasty.
Article
Critical Care Medicine
F. Von Rehlingen-Prinz, L. Eggeling, J. Dehoust, C. Huppke, A. Strahl, M. V. Neumann-Langen, R. Glaab, K. H. Frosch, M. Krause
Summary: This study retrospectively analyzed data from 229 patients with distal femur fractures and found that lateral locking plate osteosynthesis was the main treatment method. The complication rate was 14.4% and was associated with increased BMI, increased fracture displacement, and specific fracture types.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
