Journal
REVUE NEUROLOGIQUE
Volume 175, Issue 3, Pages 157-162Publisher
MASSON EDITEUR
DOI: 10.1016/j.neurol.2019.01.393
Keywords
7-Tesla MRI; Ultra-high field MRI; Malformation of cortical development; Focal cortical dysplasia; Polymicrogyria; Periventricular nodular heterotopia
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Funding
- Excellence Initiative of Aix-Marseille University - A*MIDEX [A*MIDEX-EI-13-07-130115-08.38-7T-AMISTART, A*MIDEX-EI-17-29-170228-09.43-Imetionic-7]
- 7T-AMI EQUIPEX project [ANR-11-EQPX-0001]
- France Life Imaging network [ANR-11-INBS-0006]
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Comparison studies between 7T and 1.5 or 3T magnetic resonance imaging (MRI) have demonstrated the added value of ultra-high field (UHF) MRI to better identify, delineate and characterize malformations of cortical development (MCD), and to disambiguate doubtful findings observed at lower field strengths. High resolution structural sequences such as magnetization prepared two rapid acquisition gradient echoes (MP2RAGE), fluid and white matter suppression MP2RAGE (FLAWS), and susceptibility-weighted imaging (SWI) appear to be key to the improvement of MCD diagnosis in clinical practice. 7T MRI offers not only images of high resolution and contrast but also provides many quantitative approaches capable of acting as more efficient probes of microstructure and ameliorating the categorization of MCDs. Post-processing of multiparametric ultra-high resolution and quantitative data may also be used to improve automated detection of MCD via machine learning. Therefore, 7T MRI can be considered as a useful tool in the presurgical evaluation of drug resistant partial epilepsies, particularly, but not exclusively, in cases of normal appearing conventional MRI. It also opens many perspectives in the fields of in vivo histology and computational anatomy. (C) 2019 Elsevier Masson SAS. All rights reserved.
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