Review
Oncology
Paula Casano-Sancho, Ana Carolina Izurieta-Pacheco
Summary: Recent advances in cancer treatment have led to improved survival, but also an increase in sequelae among survivors. Childhood cancer survivors are at high risk of developing endocrine complications. Lifelong monitoring of childhood cancer survivors at risk is crucial. New treatment approaches and technologies should be taken into consideration.
Article
Oncology
Deveny Vanrusselt, Charlotte Sleurs, Sofie Prikken, Koen Raymaekers, Sabine Verschueren, Jurgen Lemiere, Koen Luyckx, Anne Uyttebroeck
Summary: This study found that childhood cancer survivors often experience chronic fatigue, which negatively affects their quality of life and psychosocial functioning. The study also showed associations between fear of cancer recurrence, post-traumatic stress, and fatigue. Interventions to improve fatigue levels should focus on addressing cancer-related distress and enhancing resilience.
Article
Oncology
Rebecca H. Foster, Robert J. Hayashi, Mingjuan Wang, Wei Liu, Caroline Mohrmann, Rebecca M. Howell, Susan A. Smith, Todd M. Gibson, DeoKumar Srivastava, Daniel M. Green, Kevin C. Oeffinger, Wendy M. Leisenring, Leslie L. Robison, Gregory T. Armstrong, Kevin R. Krull, Kristina K. Hardy
Summary: Adolescent survivors of Wilms tumor were similar to siblings in terms of mental health concerns, but were more likely to require special education. Monitoring of psychosocial and academic problems through adolescence is warranted, especially among those treated with radiation to the abdomen plus chest or with cardiac conditions.
Article
Oncology
Fabiola Mueller, Linde M. Veen, Henrike Galenkamp, Heather S. L. Jim, Anja Lok, Pythia T. Nieuwkerk, Jeanine Suurmond, Hanneke W. M. van Laarhoven, Hans Knoop
Summary: Insight into emotional distress of cancer survivors from ethnic minority groups in Europe is limited. This study aims to compare distress levels between survivors from ethnic minorities and the majority population, explore the differences in distress associated with having cancer among ethnic groups, and examine sociocultural factors related to distress.
Review
Oncology
Jordan Gilleland Marchak, Salome Christen, Renee L. Mulder, Katja Baust, Johanna M. C. Blom, Tara M. Brinkman, Iris Elens, Erika Harju, Nina S. Kadan-Lottick, Joel W. T. Khor, Jurgen Lemiere, Christopher J. Recklitis, Claire E. Wakefield, Lori Wiener, Louis S. Constine, Melissa M. Hudson, Leontien C. M. Kremer, Roderick Skinner, Janine Vetsch, Jennifer L. Lee, Gisela Michel
Summary: The clinical practice guideline aims to harmonize international recommendations for mental health surveillance in survivors of childhood, adolescent, and young adult cancer. It strongly recommends mental health surveillance for all survivors of these cancers at every follow-up visit and prompt referral to mental health specialists when problems are identified.
Article
Public, Environmental & Occupational Health
Eric Adjei Boakye, Katherine M. Polednik, Teresa L. Deshields, Arun Sharma, Yamile Molina, Lidia Schapira, Justin M. Barnes, Nosayaba Osazuwa-Peters
Summary: This study examined emotional distress in cancer survivors diagnosed as adolescents or young adults compared to survivors diagnosed as middle/older adults and the general population without a history of cancer. The findings showed that emotional distress was more prevalent among young adult cancer survivors than middle/older adult survivors. However, there was no difference in emotional distress between young adult cancer survivors and the general population without cancer.
ANNALS OF EPIDEMIOLOGY
(2022)
Review
Oncology
Jesse Lemmen, Festus Njuguna, Sanne Verhulst, Terry A. Vik, Johannes C. F. Ket, Gertjan J. L. Kaspers, Saskia Mostert
Summary: The number of childhood cancer survivors in Africa is increasing, but there is a lack of knowledge about late effects. This scoping review analyzed literature on the late effects of childhood cancer survivors in Africa. Sixty-eight studies were included, originating from 10 African countries. Physical late effects were described in 53 studies, while psychosocial late effects were mentioned in 17 studies. It is important for more countries to report on this topic to effectively prevent, identify, and monitor late effects.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Oncology
Jodie Rosenberg, Phyllis N. Butow, Joanne M. Shaw
Summary: Breast cancer survivors are at risk of experiencing late effects years after treatment, which can significantly impact physical functioning. A study with 36 participants revealed a lack of awareness of late effect risks, leading to uncertainty and fear of cancer recurrence among survivors. Data also showed a gap between national guidelines recommending education on late effects and the actual awareness and management by survivors.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Margaret M. Lubas, Mariana Szklo-Coxe, Belinda N. Mandrell, Carrie R. Howell, Kirsten K. Ness, Deo Kumar Srivastava, Melissa M. Hudson, Leslie L. Robison, Kevin R. Krull, Tara M. Brinkman
Summary: In survivors of childhood cancer, there is discordance between self-reported sleep and actigraphy-assessed sleep. Factors such as fatigue and poor sleep quality may lead to increased measurement discrepancies, while memory impairment, depression, and poor sleep quality are also associated with measurement errors.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Yafeng Zhang, Zhe Li, Chunli Wang, Linqi Zhang, Shufang Guo, Jia Lin, Chongchen Zhou, Zhong Zhang, Shan Huo, Lihua Fan, Xin Ni
Summary: This study explores the differential association between sex and depression, as well as the potential mediating pathways. The results indicate a significant association between sex and depression, with boys being more likely to experience depression. Family resilience, self-perceived burden, and behavioral problems partially explain the sex difference, while the combined effect of family functioning, resilience, social support, self-perceived burden, and behavioral problems may explain the majority of this difference.
Review
Oncology
Eveline Daetwyler, Mario Bargetzi, Maria Otth, Katrin Scheinemann
Summary: This study included 15 out of 1731 identified studies, with most focusing on childhood cancer survivors (CCSs) diagnosed with acute lymphoblastic leukemia. The studies mainly investigated late effects of HD-MTX on the central nervous system, renal, and bone health. While adverse outcomes in neuropsychological testing were observed in exposed CCSs, no negative impacts on bone density or renal function were found.
Article
Oncology
K. Y. Ho, Katherine K. W. Lam, W. Xia, S. Y. Chiu, Godfrey C. F. Chan
Summary: This study provides information on the prevalence and severity of sleep disruption among Hong Kong Chinese childhood cancer survivors. It identifies factors influencing sleep disruption and highlights the importance of physical activity in reducing sleep disturbance.
Article
Oncology
Christina Signorelli, Claire E. Wakefield, Jordana K. McLoone, Karen A. Johnston, Ann C. Mertens, Michael Osborn, Richard J. Cohn, Frank Alvaro
Summary: This study investigates the overall health of long-term childhood cancer survivors in Australia and New Zealand, as well as their motivations for attending survivorship clinics. The results show that most survivors reported at least one cancer-related late effect, with fatigue and memory/learning difficulties being the most common. The main motivations for seeking care were to understand the long-term consequences of cancer and treatment, and to receive reassurance about their health. Factors such as age, time since diagnosis, and number of motivating factors were associated with engagement in survivorship care.
Review
Oncology
Edit Bardi, Renee L. Mulder, Elvira C. van Dalen, Neel S. Bhatt, Kathy A. Ruble, Jennifer Burgis, Sharon M. Castellino, Louis S. Constine, Caroline M. den Hoed, Daniel M. Green, Bart G. P. Koot, Gill Levitt, Laszlo Szonyi, W. Hamish Wallace, Roderick Skinner, Melissa M. Hudson, Leontien C. M. Kremer, Karen E. Effinger, Dorine Bresters
Summary: This study developed guidelines for the surveillance of treatment-induced chronic liver disease in survivors of childhood, adolescent and young adult cancer. It strongly recommends physical examination and liver enzyme measurement at entry into long-term follow-up for those potentially exposed to radiation therapy.
CANCER TREATMENT REVIEWS
(2021)
Article
Oncology
Bryan Dieffenbach, Qi Liu, Andrew J. Murphy, Deborah R. Stein, Natalie Wu, Arin L. Madenci, Wendy M. Leisenring, Nina S. Kadan-Lottick, Emily R. Christison-Lagay, Robert E. Goldsby, Rebecca M. Howell, Susan A. Smith, Kevin C. Oeffinger, Yutaka Yasui, Gregory T. Armstrong, Christopher B. Weldon, Eric J. Chow, Brent R. Weil
Summary: This study investigated the incidence of late-onset kidney failure among childhood cancer survivors and found that factors such as high kidney dose from radiotherapy, high-dose anthracycline, any ifosfamide chemotherapy, and nephrectomy were associated with an increased risk. Successfully managing modifiable risk factors like diabetes and hypertension could help reduce the risk of late-onset kidney failure. The association of late-onset kidney failure with anthracycline chemotherapy is a novel finding that requires further study.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Hematology
Lucie M. Turcotte, Jillian A. Whitton, Wendy M. Leisenring, Rebecca M. Howell, Joseph P. Neglia, Rachel Phelan, Kevin C. Oeffinger, Kirsten K. Ness, William G. Woods, E. Anders Kolb, Leslie L. Robison, Gregory T. Armstrong, Eric J. Chow
Summary: The five-year survival rate for childhood acute myeloid leukemia (AML) has increased due to advancements in treatment and supportive care. However, the long-term health outcomes of AML survivors remain unclear. This study examined the incidence of late mortality and chronic health conditions (CHC) among 5-year AML survivors diagnosed between 1970 and 1999. The results showed that hematopoietic cell transplantation (HCT) was associated with higher late mortality, but the incidence of CHC has decreased over time for all treatment groups.
Article
Oncology
F. Lennie Wong, Janie M. Lee, Wendy M. Leisenring, Joseph P. Neglia, Rebecca M. Howell, Susan A. Smith, Kevin C. Oeffinger, Chaya S. Moskowitz, Tara O. Henderson, Ann Mertens, Paul C. Nathan, Yutaka Yasui, Wendy Landier, Gregory T. Armstrong, Leslie L. Robison, Smita Bhatia
Summary: This study evaluated the outcomes and cost-effectiveness of breast cancer screening using mammography and breast magnetic resonance imaging (MRI) in female chest-irradiated childhood Hodgkin lymphoma survivors. The results showed that annual mammography screening at age 30-74 years is effective and cost-effective in this population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Paul C. Nathan, I-Chan Huang, Yan Chen, Tara O. Henderson, Elyse R. Park, Anne C. Kirchhoff, Leslie L. Robison, Kevin Krull, Wendy Leisenring, Gregory T. Armstrong, Rena M. Conti, Yutaka Yasui, K. Robin Yabroff
Summary: This study aimed to estimate the prevalence of financial hardship among adult survivors of childhood cancer compared with siblings and identify the correlates of hardship. The results showed that survivors were more likely to experience financial hardship compared to siblings.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Chiara Papini, Ameera A. Fayad, Mingjuan Wang, Fiona S. M. Schulte, I-Chan Huang, Yu-Ping Chang, Rebecca M. Howell, Deokumar Srivastava, Wendy M. Leisenring, Gregory T. Armstrong, Todd M. Gibson, Leslie L. Robison, Kevin C. Oeffinger, Kevin R. Krull, Tara M. Brinkman
Summary: Young adult survivors of childhood cancer have an increased risk of loneliness, which can lead to physical and mental health issues in the future.
Article
Oncology
Chiara Papini, Victoria W. Willard, Amar Gajjar, Thomas E. Merchant, Deokumar Srivastava, Gregory T. Armstrong, Melissa M. Hudson, Kevin R. Krull, Tara M. Brinkman
Summary: This study found that adult survivors of pediatric CNS tumors face challenges in social cognition and adjustment. The survivors showed severe social cognitive impairments, but reported few social adjustment problems. Impaired executive functioning and nonverbal reasoning were associated with worse social cognitive performance. Better social perception was linked to higher odds of attaining full-time employment and at least some college education.
Article
Oncology
Fang Fang Zhang, Melissa M. M. Hudson, Fan Chen, Zhongyu Li, I-Chan Huang, Nickhill Bhakta, Kirsten K. K. Ness, Tara M. M. Brinkman, James Klosky, Rohit P. P. Ojha, Jennifer Q. Q. Lanctot, Leslie L. L. Robison, Kevin R. R. Krull
Summary: Adult survivors of childhood cancer have poor adherence to nutrition guidelines and inadequate intake of certain vitamins and minerals. The use of dietary supplements is common among these survivors. However, it is associated with both inadequate and excessive nutrient intake, and positively impacts certain aspects of quality of life.
Article
Oncology
Caroline Hesko, Wei Liu, Deo K. K. Srivastava, Tara M. M. Brinkman, Lisa Diller, Todd M. M. Gibson, Kevin C. C. Oeffinger, Wendy M. M. Leisenring, Rebecca Howell, Gregory T. T. Armstrong, Kevin R. R. Krull, Tara O. O. Henderson
Summary: This study explores neurocognitive outcomes in survivors of neuroblastoma and finds that survivors have a higher risk of impairments in emotional regulation and task efficiency. Factors such as treatment exposures, era of diagnosis, and chronic conditions are associated with these impairments. The study highlights the importance of identifying and managing these factors to improve outcomes for neuroblastoma survivors.
Article
Oncology
Lindsay F. Schwartz, Rikeenkumar Dhaduk, Carrie R. Howell, Tara M. Brinkman, Matthew J. Ehrhardt, Angela Delaney, Deo Kumar Srivastava, Jennifer Q. Lanctot, Gregory T. Armstrong, Leslie L. Robison, Melissa M. Hudson, Kirsten K. Ness, Tara O. Henderson
Summary: This study aims to evaluate the associations between neighborhood characteristics and frailty in childhood cancer survivors. The study found that frail and pre-frail survivors were more likely to live in neighborhoods with decreased exercise opportunities, reduced healthy food access, and lower neighborhood socioeconomic status. These findings provide valuable information for interventions to mitigate frailty and improve health outcomes in survivors.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Adam J. Esbenshade, Lu Lu, Debra L. Friedman, Kevin C. Oeffinger, Gregory T. Armstrong, Kevin R. Krull, Joseph P. Neglia, Wendy M. Leisenring, Rebecca Howell, Robyn Partin, Amy Sketch, Leslie L. Robison, Kirsten K. Ness
Summary: Using a geriatric rating scale, researchers found that childhood cancer survivors accumulate diseases at a faster rate compared to their siblings and the general population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Chiara Papini, Sedigheh Mirzaei S., Mengqi Xing, Ingrid Tonning Olsson, Peter M. K. de Blank, Katharine R. Lange, Ralph Salloum, Deokumar Srivastava, Wendy M. Leisenring, Rebecca M. Howell, Kevin C. Oeffinger, Leslie L. Robison, Gregory T. Armstrong, Kevin R. Krull, Tara M. Brinkman
Summary: The associations between treatment changes and neurocognition, as well as the contribution of neurocognition and chronic health conditions to attainment of adult independence, remain unknown in childhood glioma survivors.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Clinical Neurology
Megan Clegg-Kraynok, Lauren Barnovsky, Eric S. Zhou
Summary: This study found that there is a problem with timely adherence to paper-based sleep diaries, which can result in biased event recall. The participants greatly over-reported their adherence, but only 37.1% of diary entries were completed within the instructed timeframe. This poses a challenge for researchers and clinicians utilizing sleep diaries in clinical trials and therapy for insomnia.
Article
Public, Environmental & Occupational Health
Eric S. Zhou, Anna Revette, Lee M. Ritterband, Traci N. Bethea, Lauren Delp, Patricia D. Simmons, Lynn Rosenberg
Summary: Insomnia disorder is highly prevalent among Black women. Cognitive-behavioral therapy for insomnia (CBT-I) is considered the optimal treatment, but very little efficacy research has been conducted in minority populations. Culturally tailoring intervention content may increase participant engagement and improve treatment outcomes.
TRANSLATIONAL BEHAVIORAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Alexis L. Michaud, Briana Bice, Eva Miklos, Katherine McCormick, Cheryl Medeiros-Nancarrow, Eric S. Zhou, Christopher J. Recklitis
Summary: Young adult cancer survivors often experience chronic insomnia, and traditional cognitive behavioral therapy for insomnia (CBTI) is not readily available to them. To address this issue, the Sleep Treatment Education Program for Young Adult Cancer Survivors (STEP-YA) was developed as a low-intensity educational intervention delivered virtually online. This phase 2 trial aims to evaluate the efficacy of STEP-YA in improving insomnia symptoms and mood in young adult cancer survivors, as well as the utility of individualized coaching in enhancing treatment effects.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Oncology
Eric S. Zhou, Ariana F. Valenzuela, Rebecca Robbins, Jessica M. Page, Kira Bona
Summary: This study aimed to understand the parent's experience in the sleep domain during maintenance therapy for pediatric ALL patients. The results showed that parents felt unprepared to manage sleep disruptions and had limited knowledge about the issue despite consistent provider communication. Clear messaging and behavioral intervention may help empower parents to support their child's sleep health during ALL treatment.
JOURNAL OF PEDIATRIC HEMATOLOGY-ONCOLOGY NURSING
(2023)