Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 142, Issue -, Pages 1-3Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2018.12.003
Keywords
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Funding
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Canada Research Chair in Brain Lipid Metabolism
- Canadian government
- Inra
- Inserm
- Ministry of Education and Research through INSA-Lyon
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The brain requires a constant supply of docosahexaenoic acid (DHA) from blood to maintain DHA levels within the brain. Several plasma pools have been proposed to supply the brain with DHA, including plasma lipoproteins, lysophosphatidylcholine and unesterified fatty acids. Here we briefly review the evidence for each plasma pool supplying the brain highlighting controversies and remaining questions. We conclude that circulating lysophosphatidylcholine has a higher brain/body partition coefficient than unesterified DHA while unesterified DHA entry into the brain is more rapid.
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