RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation

RIP kinases as modulators of inflammation and immunity

(2018) Sudan He et al.   NATURE IMMUNOLOGY

Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury

(2018) Zhengxin Ying et al.   MOLECULAR CELL

Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome

(2017) Yan Ren et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives?

(2015) Norman R. Saunders et al.   Frontiers in Neuroscience

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

(2014) S. B. Berger et al.   JOURNAL OF IMMUNOLOGY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Origin of monocytes and macrophages in a committed progenitor

(2013) Jan Hettinger et al.   NATURE IMMUNOLOGY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Signaling via the RIP2 Adaptor Protein in Central Nervous System-Infiltrating Dendritic Cells Promotes Inflammation and Autoimmunity

(2011) Patrick J. Shaw et al.   IMMUNITY

Antibody response in MOG35–55 induced EAE

(2011) Patrice H. Lalive et al.   JOURNAL OF NEUROIMMUNOLOGY

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Sciatic nerve injury induces functional pro-nociceptive chemokine receptors in bladder-associated primary afferent neurons in the rat

(2011) R. Foster et al.   NEUROSCIENCE

Blood–brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE

(2010) Jami Bennett et al.   JOURNAL OF NEUROIMMUNOLOGY

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

ImKTx88, a novel selective Kv1.3 channel blocker derived from the scorpion Isometrus maculates

(2010) Song Han et al.   TOXICON

Oligodendrocytes: biology and pathology

(2009) Monika Bradl et al.   ACTA NEUROPATHOLOGICA

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression

(2008) Takashi Matsushita et al.   JOURNAL OF CLINICAL INVESTIGATION