Novel site-specific PEGylated L-asparaginase

Asparagine bioavailability governs metastasis in a model of breast cancer

(2018) Simon R. V. Knott et al.   NATURE

Multistep purification of cytochrome c PEGylated forms using polymer-based aqueous biphasic systems

(2017) João H. P. M. Santos et al.   GREEN CHEMISTRY

7-Ketocholesterol overcomes drug resistance in chronic myeloid leukemia cell lines beyond MDR1 mechanism

(2017) Lívia Rosa Fernandes et al.   Journal of Proteomics

Integrated process for high conversion and high yield protein PEGylation

(2016) David Pfister et al.   BIOTECHNOLOGY AND BIOENGINEERING

Recombinant L-asparaginase 1 from Saccharomyces cerevisiae: an allosteric enzyme with antineoplastic activity

(2016) Iris Munhoz Costa et al.   Scientific Reports

Mass-Up: an all-in-one open software application for MALDI-TOF mass spectrometry knowledge discovery

(2015) H. López-Fernández et al.   BMC BIOINFORMATICS

Catalytic Role of the Substrate Defines Specificity of Therapeutic l -Asparaginase

(2015) Andriy Anishkin et al.   JOURNAL OF MOLECULAR BIOLOGY

A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics

(2014) L. T. van der Meer et al.   BLOOD

Preparation of pegylated lumbrokinase and an evaluation of its thrombolytic activity both in vitro and in vivo

(2013) Mingji Jin et al.   Acta Pharmaceutica Sinica B

Low expression of asparagine synthetase in lymphoid blasts precludes its role in sensitivity to L-asparaginase

(2012) Ivana Hermanova et al.   EXPERIMENTAL HEMATOLOGY

PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl4-induced fibrogenesis in mice

(2012) Adriana Mattos et al.   JOURNAL OF CONTROLLED RELEASE

Effect of PEGylation on Protein Hydrodynamics

(2012) Yatin R. Gokarn et al.   MOLECULAR PHARMACEUTICS

State of the art in PEGylation: The great versatility achieved after forty years of research

(2011) Gianfranco Pasut et al.   JOURNAL OF CONTROLLED RELEASE

Interaction mechanism of mono-PEGylated proteins in electrostatic interaction chromatography

(2010) Mitsuyo Abe et al.   Biotechnology Journal

PEGylation of therapeutic proteins

(2010) Simona Jevševar et al.   Biotechnology Journal

Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity

(2010) M. N. Offman et al.   BLOOD

Purification of PEGylated Protein Using Membrane Chromatography

(2010) Deqiang Yu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Delivery of Therapeutic Proteins

(2010) Dipak S. Pisal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Anti-cancer PEG-enzymes: 30 years old, but still a current approach

(2007) Gianfranco Pasut et al.   ADVANCED DRUG DELIVERY REVIEWS