Article
Immunology
Ehsan Gharib, Vanessa Veilleux, Luc H. Boudreau, Nicolas Pichaud, Gilles A. Robichaud
Summary: Inflammation and platelets promote cancer malignancy. Platelet-derived microparticles (PMPs) induce metabolic plasticity and disease progression in chronic lymphocytic leukemia (CLL). PMPs enhance CLL tumor growth and invasiveness through mitochondrial internalization and OXPHOS stimulation, as well as increase resistance to chemotherapy drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marta Brambilla, Maria Talmon, Paola Canzano, Luigia G. Fresu, Sandra Brunelleschi, Elena Tremoli, Marina Camera
Summary: This study evaluated the effects of microvesicles derived from platelets and monocytes on endothelial function, and found that platelet-derived microvesicles can impair endothelial function in the acute phase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Grzegorz Procyk, Dominika Klimczak-Tomaniak, Grazyna Sygitowicz, Mariusz Tomaniak
Summary: MicroRNAs play an important role in the regulation of gene expression in cardiovascular diseases (CVD), with miR-126 and miR-223 being of particular interest. Despite numerous studies, there is still no conclusive evidence on the clinical utility of miRNA expression levels. This review critically appraises the association between miRNA expression, cardiovascular risk, and on-treatment platelet reactivity, and provides insights on future developments in the field.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ivan A. Muravlev, Anatoly B. Dobrovolsky, Olga A. Antonova, Svetlana G. Khaspekova, Amina K. Alieva, Dmitry V. Pevzner, Alexey V. Mazurov
Summary: Activated platelets play a role in blood coagulation by exposing phosphatidylserine (PS). Antiplatelet drugs have been found to have inhibitory effects on platelet impact in clot formation and PS exposure.
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Article
Environmental Sciences
Pietro Minuz, Luca De Toni, Stefano Dall'Acqua, Andrea Di Nisio, Iva Sabovic, Marco Castelli, Alessandra Meneguzzi, Carlo Foresta
Summary: The experimental results demonstrate that exposure to C6O4 increases platelet response to agonists, potentially leading to an elevated risk of cardiovascular events. Acetylsalicylic acid (ASA) can partially inhibit this effect, indicating a possible prophylactic use.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Physiology
Pamela Czajka, Alex Fitas, Daniel Jakubik, Ceren Eyileten, Aleksandra Gasecka, Zofia Wicik, Jolanta M. Siller-Matula, Krzysztof J. Filipiak, Marek Postula
Summary: MiRNAs play a crucial role in regulating platelet reactivity, serving as diagnostic and prognostic markers for platelet activity, as well as novel targets for cardiovascular disease therapy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Teresa L. Krammer, Stephan Zeibig, Waltraud C. Schrottmaier, Anita Pirabe, Silvia Goebel, Andreas B. Diendorfer, Hans-Peter Holthoff, Alice Assinger, Matthias Hackl
Summary: This study provides comprehensive evidence that activated platelets release miRNAs, resulting in measurable changes in circulatory miRNA levels, making them promising biomarker candidates for platelet activation.
Article
Biochemistry & Molecular Biology
Rosa Suades, Teresa Padro, Gemma Vilahur, Lina Badimon
Summary: Platelets play essential roles in thrombosis, inflammation, and angiogenesis. Stimulation by thrombin triggers the release of pEVs from platelets, which are rich in procoagulant and proadhesive proteins. Differential proteomic analysis revealed significant changes in protein composition between pEVs from activated platelets and non-activated platelets.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Kerstin Jurk, Korbinian F. Rothenaicher, Kathrin Gross, Heidi Rossmann, Gerhard Weisser, Irene Schmidtmann, Thomas Muenzel, Christine Espinola-Klein
Summary: Combination therapy with ASA and low-dose rivaroxaban has inhibitory effect on CD36-sensitive platelet thrombin formation, reducing major adverse cardiac and limb events in PAD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Matteo Sibilano, Valentina Tullio, Gaspare Adorno, Isabella Savini, Valeria Gasperi, Maria Valeria Catani
Summary: Platelets release microvesicles that modulate cell growth and dissemination in breast cancer. Enriched miR-126 in these microvesicles can suppress cell proliferation and invasion by targeting AKT2. High miR-126 and low AKT2 levels are associated with favorable prognosis in breast cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Diana Schrick, Tihamer Molnar, Margit Tokes-Fuzesi, Abigel Molnar, Erzsebet Ezer
Summary: This study aimed to explore the relationship between circulating microparticles and responsiveness to antiplatelet therapy. The results showed that the number of circulating microparticles was higher in post-stroke patients and correlated with platelet aggregation. Additionally, platelet-derived microparticles showed positive correlations with neutrophils. These findings contribute to monitoring the response to antiplatelet therapy in post-stroke patients and provide potential therapeutic targets for the future.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Cardiac & Cardiovascular Systems
Lukas Konecny, Marcel Hrubsa, Jana Karlickova, Alejandro Carazo, Lenka Javorska, Katerina Matousova, Lenka Kujovska Krcmova, Vladimir Blaha, Milan Blaha, Premysl Mladenka
Summary: This study analyzed the impact of different therapies on platelet aggregation in patients with familial hypercholesterolemia (FH) and found that treatment with PCSK9ab can reduce platelet reactivity in these patients. Rating: 8 points
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Cell Biology
Pooja Yadav, Abhishek R. Panigrahi, Samir K. Beura, Sunil K. Singh
Summary: Platelet-derived microvesicles (PMVs) are an important component of microvesicles in circulation and have been associated with various pathophysiological complications. Recent research shows that PMVs carry significant cargo that can influence cellular functions by affecting calcium oscillations in target cells. This study aimed to investigate the impact of PMVs on platelet calcium mobilization. It found that PMVs increase platelet intracellular calcium levels in a dose-dependent manner by utilizing intracellular storage and extracellular space.
CELL BIOLOGY INTERNATIONAL
(2023)
Review
Oncology
Yan Pan, Yingjian Wang, Yanzhong Wang, Shoufang Xu, Feiyu Jiang, Yetao Han, Mengsi Hu, Zhiwei Liu
Summary: Platelet-derived microvesicles (PMVs) play a crucial role in cancer by interacting with cancer cells and nontransformed cells in the tumor microenvironment, transferring platelet-derived contents, and influencing the response of target cells.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Wojciech Ambrosius, Slawomir Michalak, Wojciech Kozubski, Alicja Kalinowska
Summary: MOG-associated disease (MOGAD) is a rare inflammatory disorder of the central nervous system with various phenotypes, most commonly presenting as optic neuritis and ADEM. Diagnosis relies on detecting serum antibodies and MRI imaging, while treatment includes acute immunotherapy and immunosuppressive therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Marta Kowalska, Michal Prendecki, Thomas Piekut, Wojciech Kozubski, Jolanta Dorszewska
Summary: Migraine is a common neurological disease divided into two main types: with aura and without aura. Research shows that the activation of the trigeminovascular system and release of neuropeptides play crucial roles in headache pathogenesis. Cortical spreading depression, responsible for aura, stems from aberrant interactions between neurons and glia, particularly studied in FHM models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Adam Stepien, Wojciech Kozubski, Jacek J. Rozniecki, Izabela Domitrz
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2021)
Article
Pharmacology & Pharmacy
Joanna Wzorek, Radoslaw Bednarek, Cezary Watala, Magdalena Boncler
Summary: The study found that PSB 0777 and cangrelor interact with human serum albumin with moderate affinity, but do not share the same binding site on the protein. This suggests that concurrent administration of these two antiplatelet compounds will not affect their antiplatelet activity due to competition-induced changes in drug binding to HSA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dawid Polak, Marcin Talar, Nina Wolska, Dagmara W. Wojkowska, Kamil Karolczak, Karol Kramkowski, Tomasz A. Bonda, Cezary Watala, Tomasz Przygodzki
Summary: The A(2A) agonist HE-NECA in low doses in combination with inhibitors of P2Y(12) improved anti-thrombotic properties and was effective with chronic administration. Additionally, HE-NECA has hypotensive effects but does not significantly affect blood-brain barrier permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Wojciech Kozubski, Kevin Ong, Wioletta Waleszczyk, Matthew Zabel, Jolanta Dorszewska
Summary: This article discusses the importance of neural plasticity in neurodegenerative diseases, explores the main causes and symptoms of dementia, highlights the challenges in diagnosis and treatment of neurodegenerative diseases, and looks forward to potential breakthroughs in the future.
Article
Neurosciences
Ewelina Synowiec, Paulina Wigner, Natalia Cichon, Cezary Watala, Piotr Czarny, Joanna Saluk-Bijak, Elzbieta Miller, Tomasz Sliwinski, Ewa Zielinska-Nowak, Michal Bijak
Summary: The study identified specific genetic variants in SOD2, GPX4, NOS1, and NOS2 genes that are associated with an increased risk of stroke in the Polish population.
Article
Clinical Neurology
Michalina Jasiak-Zatonska, Slawomir Michalak, Krystyna Osztynowicz, Wojciech Kozubski, Alicja Kalinowska-Lyszczarz
Summary: The aim of this study was to evaluate the serum profile of anti-aquaporin antibodies, measure levels of cell-cell adhesion molecules as potential markers of blood-brain barrier permeability, and assess their relationship in NMOsd and MS patients. The results indicated a different profile of BBB disruption between MS and NMOsd patients, with AQP1-Ab identified as a promising indicator possibly associated with astrocytopathy.
NEUROLOGIA I NEUROCHIRURGIA POLSKA
(2022)
Article
Neurosciences
Karol Lubarski, Anna Mania, Slawomir Michalak, Krystyna Osztynowicz, Katarzyna Mazur-Melewska, Magdalena Figlerowicz
Summary: Neurological autoimmune diseases have diverse origins and pathogeneses. This study aimed to evaluate the relationship between autoantibodies, symptoms, demographic characteristics, and infection history, and found associations between specific antibodies and certain symptoms.
Article
Biochemistry & Molecular Biology
Natalia Misan, Slawomir Michalak, Katarzyna Kapska, Krystyna Osztynowicz, Mariola Ropacka-Lesiak
Summary: The study assessed the damage to the endothelial tight junctions in pregnancy complicated by fetal growth restriction and circulatory centralization, and found that it is associated with the destabilization of the fetal blood-brain barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Natalia Misan, Slawomir Michalak, Katarzyna Kapska, Krystyna Osztynowicz, Mariola Ropacka-Lesiak, Katarzyna Kawka-Paciorkowska
Summary: The aim of this study was to investigate the effects of early-onset and late-onset fetal growth restriction (FGR) on blood-brain barrier integrity and the association between blood-brain barrier breakdown and neurological disorders in FGR newborns. ELISA was used to evaluate the expression of serum tight junction (TJ) proteins and placental TJ proteins. Significant differences in serum OCLN concentrations were observed in pregnancies complicated by early-onset FGR, specifically in relation to intraventricular hemorrhage (IVH) in newborns. However, there were no significant differences in other protein concentrations between groups. NME1 was found to be a potential biomarker for predicting fetal circulatory centralization and extremely low birth weight in early-onset FGR pregnancies, while zo-1 concentration may have prognostic value for moderate neonatal acidosis in late-onset FGR pregnancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Natalia Misan, Slawomir Michalak, Piotr Rzymski, Barbara Poniedzialek, Katarzyna Kapska, Krystyna Osztynowicz, Mariola Ropacka-Lesiak
Summary: This study found that FGR is associated with damage to endothelial tight junctions, blood-brain barrier destabilization, and the appearance of neuronal injury proteins in maternal blood. Serum NME1 levels and placental CLN4 expression may serve as predictive markers of neurological complications in FGR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Karol Lubarski, Anna Mania, Slawomir Michalak, Krystyna Osztynowicz, Katarzyna Mazur-Melewska, Magdalena Figlerowicz
Summary: This study aimed to evaluate serum and cerebrospinal fluid autoantibodies in children with neurological disorders and compare the clinical and laboratory findings between different groups. Autoantibodies were found in 165 children, with the most common ones being anti-neuroendothelium and anti-N-Methyl-D-Aspartate receptor antibodies. These antibodies were more frequently found in children with autoimmunity and increased the risk of autoimmune diseases. The study proposed a model for diagnosing autoimmune diseases and showed the influence of age, living place, and medical history on the final diagnosis.
Article
Oncology
Mikolaj Piotr Zaborowski, Patrycja Stefens-Stawna, Krystyna Osztynowicz, Tomasz Piorunek, Halina Batura-Gabryel, Agnieszka Dyzmann-Sroka, Wojciech Kozubski, Ewa Nowak-Markwitz, Slawomir Michalak
Summary: The cytotoxic response measured in peripheral blood by GrB in PBMC is impaired both in the course of malignancy and PNS. Levels of GrB in PBMC were higher if onconeural antibodies were detected. Tracking reactive immune responses, such as GrB in PBMC may have diagnostic and monitoring value in malignancy and PNS.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Cell Biology
Jolanta Dorszewska, Marta Kowalska, Michal Prendecki, Thomas Piekut, Joanna Kozlowska, Wojciech Kozubski
Summary: Parkinson's disease (PD) is the second most common cause of neurodegeneration, with oxidative stress leading to dopaminergic neuron degeneration. Mutations in genes such as SNCA, PRKN, PINK1, DJ1, and LRRK2 are associated with disrupted oxidoreductive homeostasis in PD. Treatment options for PD include optimizing dopaminergic therapy and introducing advanced therapies such as deep brain stimulation, with genetic factors playing a role in response to treatment.
NEURAL REGENERATION RESEARCH
(2021)