Journal
PHYTOMEDICINE
Volume 55, Issue -, Pages 125-136Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2018.07.001
Keywords
Bioactive phytochemicals; Anticancer phytotherapeutics; Chemoprevention; Phenylpropanoids; Isoprenoids; Alkaloids
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Background: The plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. Purpose: In this view, epithelial-mesenchymal transition (EMT) represents a novel and major target in anticancer therapy. Therefore, this narrative review aims to provide an updated overview on the bioactive phytochemicals with anti-EMT activity. Conclusion: Among the plant products reviewed, phenylpropanoids were the most investigated at preclinical phase, thus exhibiting a promising potential as anticancer drugs, though an evidence-based clinical efficacy is still lacking.
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