Article
Green & Sustainable Science & Technology
Ahmet Can, Ahmet Kazankaya, Erdal Orman, Muttalip Gundogdu, Sezai Ercisli, Ravish Choudhary, Rohini Karunakaran
Summary: This study analyzed 55 wild-grown mulberry landraces in the Van Lake basin, belonging to Morus alba, Morus rubra, and Morus nigra species, to determine their fruit characteristics. The research found that chlorogenic acid and rutin were the predominant compounds in all mulberry landraces. Malic acid was identified as the dominant organic acid among genotypes. These findings suggest that these mulberry landraces could be valuable for breeding purposes and may have potential health benefits due to their rich bioactive compounds.
Article
Nutrition & Dietetics
Tae Sik Sung, Seung-Bum Ryoo, Chang-Hyun Lee, Seon-Min Choi, Joo-Won Nam, Hyun-Bok Kim, Ji Young Lee, Jung-Dae Lim, Kyu Joo Park, Hyun-Tai Lee
Summary: The fruit of Morus alba L. (MAF) has been used as a food worldwide and in traditional medicine in East Asia for thousands of years. This study found that MAF has prokinetic activity and can enhance gastrointestinal motor function in mice and human intestines. It increased both myogenic and neurogenic contractions, resulting in accelerated intestinal transit rate (ITR). These findings suggest that MAF has potential as a new prokinetic agent.
Review
Pharmacology & Pharmacy
Gaber El-Saber Batiha, Ali Esmail Al-Snafi, Mahdi M. M. Thuwaini, John Oluwafemi Teibo, Hazem M. M. Shaheen, Ayomide Peter Akomolafe, Titilade Kehinde Ayandeyi Teibo, Hayder M. M. Al-kuraishy, Ali I. I. Al-Garbeeb, Athanasios Alexiou, Marios Papadakis
Summary: Morus alba, a fast-growing shrub or tree, has various medicinal uses. The plant parts have been used to treat nerve disorders, as analgesics, antibacterials, and many more. The plant contains a wide range of chemical components and has shown various pharmacological effects, including antimicrobial, anti-inflammatory, and antioxidant properties.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Yahui Xuan, Bi Ma, Dong Li, Yu Tian, Qiwei Zeng, Ningjia He
Summary: This study analyzed the genome of wild mulberry species M. notabilis, revealing the chromosomal synteny and restructuring process between wild and cultivated mulberry. The activity of the centromere was found to be crucial for stable chromosome inheritance. Long terminal repeat retrotransposons were identified as the major driver of mulberry genome divergence and evolution after divergence.
HORTICULTURE RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Nurdaulet Zhumabayev, Kairat Zhakipbekov, Narbek Zhumabayev, Ubaidilla Datkhayev, Saken Tulemissov
Summary: The study of the composition of white mulberry fruits is important for the pharmaceutical industry due to its high medicinal value. This research identified the composition of white mulberry fruits in Kazakhstan for the first time, including alkaloids, flavonoids, vitamins, macro- and microelements, and amino acids. The findings demonstrate the potential use of white mulberry fruits in medicine, pharmacology, and the food industry.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Jun-Yu Zhu, Han-Zhuang Weng, Di-Kai Tang, Jin-Chen Long, Zhuo-Ya Tang, Ye Chen, Sheng Yin, Gui-Hua Tang
Summary: Three new prenylated dihydroflavones, moralbaflavones A-C (1-3), were isolated from the root barks of Morus alba L., along with four known compounds (4a/4b, 5, and 6). The structures and absolute configurations of these compounds were determined through HRMS, NMR, and ECD analysis. Moralbaflavone C (3) exhibited significant neuroprotective activity, surpassing the positive control edaravone, when screened at a concentration of 10 μM in sodium nitroprusside-induced rat pheochromocytoma PC-12 cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Agronomy
Ali Khadivi, Akram-Sadat Hosseini, Amineh Naderi
Summary: This study investigated the phenotypic variation of black mulberry, white mulberry, and M. alba var. nigra, and selected promising accessions based on fruit quality. Fruit weight showed positive correlations with other traits, and cluster analysis divided the accessions into two main groups.
GENETIC RESOURCES AND CROP EVOLUTION
(2023)
Article
Pharmacology & Pharmacy
Sheng-li Pei, Fang Kan, Chun-jiang Yue
Summary: The study showed that Morus alba extract has significant antihypertensive effects in renovascular hypertensive rats, possibly through inhibiting endothelin-converting enzyme and exerting antioxidant activity. Additionally, it significantly improved renal function in the rats.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shoma Hirokawa, Nagao Kobayashi, Soji Shimizu
Summary: The study elaborates inherently chiral subporphyrins by forming a fused pyran ring at the periphery, showing that the chiroptical properties can be controlled by peripheral substitution and meso-aryl substituents. The circular dichroism (CD) properties of chiral subporphyrins are largely affected by the peripheral substituents and the dihedral angles between the meso-aryl substituents and the subporphyrin core.
Article
Physics, Multidisciplinary
Dongsheng Song, Rafal E. Dunin-Borkowski
Summary: This study presents a method for three-dimensional magnetic measurement at atomic scale using EMCD technology, which allows for obtaining signals related to magnetization in three Cartesian directions by using a subangstrom convergent electron beam in STEM. Atomic resolution EMCD signals from all three directions can be separately acquired by moving the detector, and signal enhancement can be achieved by using a defocused electron beam.
PHYSICAL REVIEW LETTERS
(2021)
Article
Optics
Joohoon Kim, Wonjoong Kim, Dong Kyo Oh, Hyunjung Kang, Hongyoon Kim, Trevon Badloe, Seokwoo Kim, Chanwoong Park, Hojung Choi, Heon Lee, Junsuk Rho
Summary: This paper introduces a single-step printable platform for UV metasurfaces, which solves the problems of scarcity in low-loss UV materials and manufacturing limitations of high cost and low throughput. A UV-curable resin dispersed with zirconium dioxide (ZrO2) nanoparticles is developed as a printable material, which has a high refractive index and low extinction coefficient in the UV range. By utilizing nanoimprint lithography, UV metasurfaces can be fabricated in a single step. Experimental results demonstrate the feasibility of this method in fabricating UV metaholograms with vivid and clear holographic images. The proposed method enables repeat and rapid manufacturing of UV metasurfaces, bringing them closer to real-life applications.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Zhaohui Zong, Heng Zhang, Aiyou Hao, Pengyao Xing
Summary: This study reveals that intramolecular chirality transfer behaviors in ferrocene-conjugated amino acids depend on the substituent groups, influencing multiple intramolecular interactions and molecular geometry. The research also demonstrates that intramolecular weak forces have an impact on molecular geometry and contribute to diverse Cotton effects. This work provides evidence for the ignored intramolecular factors in self-assembled systems and paves the way for the fabrication of functional chiroptical systems.
DALTON TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Jagruti Chauhan, Riddhi P. Mathukiya, Satya P. Singh, Sangeeta D. Gohel
Summary: The Nocardiopsis alba strain OM-5 exhibited maximum protease production in submerged culture and the purified protease showed high activity and stability at high temperatures and salinity levels. The protease displayed significant adaptability to various environmental factors, suggesting its potential for industrial applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Optics
Xianglai Liao, Lili Gui, Ang Gao, Zhenming Yu, Kun Xu
Summary: Recently, deep reinforcement learning has gained attention in the field of metasurface design. However, the time-consuming numerical simulation has limited its adoption. In this study, a deep learning-based virtual environment proximal policy optimization method was applied to design chiral plasmonic metasurfaces with flexible targets. The well-trained agent exhibited excellent performance in designing chiral metasurfaces with optimal circular dichroism values at various target wavelengths, and the training process was remarkably fast. This approach has the potential for efficient and intelligent design of nanophotonic devices.
Article
Chemistry, Multidisciplinary
Natalie Fehn, Melanie Strauss, Christian Jandl, Markus Drees, Ueli Heiz, Klaus Koehler, Aras Kartouzian
Summary: In this work, the transfer of chirality between a chiral metal-organic catalyst and a substrate was investigated through induced circular dichroism (ICD) studies on [Pd(Me)(2)(BINAP)]. The catalyst was successfully synthesized and characterized using single-crystal X-ray diffraction and CD spectroscopy, in addition to density functional theory calculations. It was demonstrated that BINAP not only acted as a steric guide during catalysis, but also influenced the electronic properties of the Pd center through ICD.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Applied
Fang-Yu Yuan, Xiao-Ling Wang, Shu-Qi Wang, Tao Shen, Dong-Mei Ren, Hong-Xiang Lou, Xiao-Ning Wang
Summary: This study isolated two new triterpenoids, 3β-hydroxytirucall-7,25-dien-24-one (1) and 3β-acetoxytirucall-7,23,25-triene (2), along with one new sesquiterpenoid, alloaromadendrane-12α,14β-dioic acid (3), from the vines and leaves of Chonemorpha megacalyx Pierre. The structures of these compounds were determined based on extensive spectroscopic data.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yu-Lin You, Fei-Fei Li, Ning Wang, Shu-Qi Wang
Summary: DOSY is a powerful tool for investigating mixtures, but similar diffusion coefficients of components can limit resolution. This study used matrix-assisted DOSY to explore diffusion resolution in complex mixtures and found that using SDS micelles as the matrix can improve resolution. Increasing SDS concentration can also enhance resolution of DOSY spectrum.
Article
Chemistry, Analytical
Yanli Zhang, Weiliang Cui, Xianghong Liu, Ning Wang, Wenru Kong, Junyu Sui, Huifen Li, Shuqi Wang
Summary: This study developed a HPLC-MS/MS method to quantify seven bioactive constituents from Danshen in rat plasma, showing that wine-processing significantly impacted certain components in Danshen.
Article
Chemistry, Medicinal
Qingying Liu, Hao Zheng, Xiaoning Wang, Lu Zhou, Shuqi Wang, Tao Shen, Dongmei Ren
Summary: Caged-polyprenylated xanthonoids, mainly found in Genus Garcinia, are a rare class of natural products. Phytochemical studies on Garcinia oligantha led to the discovery of new compounds with potential anti-cancer effects, particularly in inducing apoptosis in human lung cancer cells.
Article
Plant Sciences
Huaran Zhang, Xuejia Zhang, Yun Huang, Jie Yuan, Xiaoyi Wei, Jianhua Ju
Summary: In this study, three new actinopyrone derivatives were isolated from a deep-sea hydrothermal vent bacterium. The structures and absolute configurations of these compounds were determined using various analytical techniques. One of the compounds exhibited notable cytotoxicity against human cancer cells, suggesting its potential as an antitumor agent.
JOURNAL OF NATURAL PRODUCTS
(2022)
Review
Medicine, General & Internal
Feifei Li, Shuqi Wang, Youlong Yao, Xueming Sun, Xiaoyan Wang, Ning Wang, Yulin You, Yanli Zhang
Summary: This study systematically evaluated the knowledge structure, development trend, and research hotspot of MCTs research field by analyzing publications from 2010 to 2020. The results showed that high expression of MCTs induced by oxidative stress and glycolysis, regulation of metabolism in tumor microenvironment, prognostic markers of cancer, and targeted inhibitors are the top research frontiers topics. The study provides valuable insights for new researchers in understanding the MCTs related field and guiding follow-up research direction.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Xinyan Zhang, Wenru Kong, Shuqi Wang
Summary: Researchers developed a highly reliable and reproducible method for the expression and purification of CAV1, demonstrating a caveolae-like membrane curvature in artificial lipid membranes. Solid-state nuclear magnetic resonance (ssNMR) structural characterization revealed that CAV1 is primarily alpha-helical in structure, with its scaffolding domain adopting an alpha-helical structure.
Article
Chemistry, Medicinal
Huaran Zhang, Yingying Chen, Yanqing Li, Yongxiang Song, Junying Ma, Jianhua Ju
Summary: The study on Streptomyces sp. SCSIO ZS0520 revealed new secondary metabolites and conducted bioinformatic analysis to lay foundations for solving remaining biosynthetic issues.
Article
Chemistry, Organic
Huaran Zhang, Chunyan Zhang, Qinglian Li, Junying Ma, Jianhua Ju
Summary: Continuous mining of the Streptomyces olivaceus SCSIO T05 genome led to the discovery of new lipopeptides and the verification of their corresponding biosynthetic gene cluster.
Article
Biochemistry & Molecular Biology
Hao Zheng, Qingying Liu, Shuqi Wang, Xiaoqing Liu, Mengjiao Ma, Tao Shen, Xiaoning Wang, Dongmei Ren
Summary: This study described the anti-cancer effects of Epimedokoreanin B (EKB) and its underlying mechanism in non-small cell lung cancer cells. EKB inhibited cell proliferation and migration and induced cell death, showing features of apoptotic cell death and endoplasmic reticulum stress.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Analytical
Zhi-Fan Wang, Wen-Ru Kong, Ning Wang, Yu-Lin You, Jian-Feng Wang, Shu-Qi Wang
Summary: This study investigated the mechanism of 5-FU chemosensitization induced by the combination of RVA and traditional chemotherapeutic drug in CRC using LC-MS based metabolomics. The results showed that RVA may enhance the sensitivity of 5-FU by influencing lipid and cell energy metabolism, and exert anti-tumor activity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Analytical
Fei-Fei Li, Yan-Li Zhang, Dong-Xiao Guo, Chang-Jun Zhao, Yun-Feng Yao, Yong-Qiang Lin, Shu-Qi Wang
Summary: This study demonstrated the sensitization effects of Curcuma longa L. on 5-FU resistant colorectal cancer cells and established a method to identify potential sensitization agents and predict their action mechanisms before obtaining the agents. The results indicated that curcumin, demethoxycurcumin, and bisdemethoxycurcumin were responsible for the effects, and two possible mechanisms, reversal of drug resistance and disruption in lactate excretion, were suggested. The compounds significantly enhanced the sensitivity of the cancer cells to 5-FU treatment, which was supported by the downregulation of drug resistance-related transporters and lactate membrane transporter.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Mengjiao Ma, Xiaoyi Luan, Hao Zheng, Xiaoning Wang, Shuqi Wang, Tao Shen, Dongmei Ren
Summary: The mulberry tree, cultivated in China for thousands of years, contains a compound called mulberry Diels-Alder-type adducts (MDAAs) that have unique structures and diverse bioactivities. Kuwanon M (KWM) is an MDAA isolated from the root bark of Morus alba, and this study shows that it has inhibitory effects on human lung cancer cells by inducing apoptosis and paraptosis through the mitochondrial and ER stress pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Yulin You, Dongxiao Guo, Weiliang Cui, Zhifan Wang, Chunguo Yang, Yongqiang Lin, Shuqi Wang
Summary: The MA DOSY technology was applied to analyze a flavonoid mixture, and the effects of various factors on the resolution of the DOSY spectrum were investigated. The optimized method was successfully used for the qualitative analysis of a total flavonoid mixture, confirming the practical value of this method for analyzing flavonoid mixtures.
Article
Oncology
Xiaoqing Liu, Shuqi Wang, Hao Zheng, Qingying Liu, Tao Shen, Xiaoning Wang, Dongmei Ren
Summary: Methuosis is a novel type of non-apoptotic cell death characterized by cytoplasmic vacuolization. This study demonstrated that EKC, a prenylated flavonoid from Epimedium koreanum, induces methuosis-like cell death in lung cancer cells and synergizes with conventional chemotherapy drugs. The regulation of Rac1 and Arf6 appears to be at least partially involved in EKC-induced methuosis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Plant Sciences
Yi Zhu, Junlin Wang, Lu Tang, Yuxin Shang, Weiyi Zhao, Wei Zhang, Ping Hai, Yongbiao Zheng, Wenbo Li, Yanfang Su
Summary: One new iridoid glucoside and two new lignan glycosides, along with three known compounds, were isolated from the whole plants of Lancea tibetica. The structures were determined by spectroscopic methods and X-ray crystallographic analysis. One of the new iridoid glucosides and the known compounds exhibited moderate antioxidant activity.
PHYTOCHEMISTRY LETTERS
(2024)
Article
Plant Sciences
Yi Deng, Minghua Chen, Junming Yi, Yuguo Zheng
Summary: This study successfully designed and synthesized a series of quinazolinone derivatives containing purine molecules, and found that some compounds exhibited strong antiviral activity against tobacco mosaic virus. The findings have important implications for further development of antiviral drugs.
PHYTOCHEMISTRY LETTERS
(2024)
