Journal
PEDIATRIC DERMATOLOGY
Volume 36, Issue 3, Pages 342-345Publisher
WILEY
DOI: 10.1111/pde.13778
Keywords
infliximab; mycoplasma pneumoniae; Stevens-Johnson syndrome; toxic epidermal necrolysis; toxic epidermal necrolysis; alpha inhibitor
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Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-alpha inhibitors has been described in adults. We present a case of a 7-year-old boy with infection-associated TEN, diagnosed by typical clinical and histopathological features, most likely caused by Mycoplasma pneumoniae. Treatment with a single dose of infliximab 5 mg/kg intravenously on day 5 after the onset of symptoms was followed by cessation of all blister formation over 3 days and complete resolution within a week. Sequelae were mild, consisting of postinflammatory hyperpigmentation and dry eyes.
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