Article
Pediatrics
Cal Robinson, Erin Hessey, Sophia Nunes, Marc Dorais, Rahul Chanchlani, Jacques Lacroix, Philippe Jouvet, Veronique Phan, Michael Zappitelli
Summary: This study found that nephrology follow-up after pediatric AKI was uncommon, but nearly all survivors received follow-up from non-nephrologist physicians within one year post discharge. This suggests that knowledge translation strategies for AKI follow-up should be targeted at non-nephrology healthcare providers.
PEDIATRIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Shinhyeung Kwak, Jeong Yeon Kim, Heeyeon Cho
Summary: This retrospective study conducted at Samsung Medical Center in Seoul, South Korea, aimed to investigate the prevalence and risk factors of vancomycin-induced nephrotoxicity in non-ICU pediatric patients. The study found that a longer hospital stay, concomitant use of piperacillin-tazobactam, and a serum trough level of vancomycin above 24.35 mu g/mL were independently associated with VIN. The study suggests that measuring serum trough level of vancomycin can help clinicians prevent VIN in pediatric patients.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Marco Fiorentino, Francesca Bagagli, Annamaria Deleonardis, Alessandra Stasi, Rossana Franzin, Francesca Conserva, Barbara Infante, Giovanni Stallone, Paola Pontrelli, Loreto Gesualdo
Summary: Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD). Kidney transplant recipients (KTRs) are at a higher risk of ICU admission, mainly in the late post-transplant period. Urosepsis and bloodstream infections are the main reasons for ICU admissions, and side effects of immunosuppressive treatment should also be accounted for. AKI incidence is common in KTRs during ICU stay, and in-hospital mortality can be high. The present review aims to explore the impact of AKI on outcomes in KTRs and provide insights into its diagnosis, management, and immunosuppression modulation.
Article
Critical Care Medicine
Celeste G. Dixon, Sameer Thadani, Julie C. Fitzgerald, Ayse Akcan-Arikan, Nadir Yehya
Summary: This study aimed to explore the association between acute kidney injury (AKI) and poor outcomes in pediatric patients with acute respiratory distress syndrome (ARDS), and found that fluid overload (FO), creatinine, and urine output were related to the occurrence of AKI in a temporal manner. A retrospective cohort study revealed that AKI was associated with increased mortality and decreased ventilator-free days (VFDs), regardless of the timing of onset. A group of patients with "Cryptic AKI" was identified by adjusting creatinine levels, and their outcomes were similar to those who met AKI criteria by traditional means. Increases in FO, FO-adjusted creatinine, and ANGPT2 occurred prior to meeting conventional AKI criteria, providing important insights for clinical practice.
CRITICAL CARE MEDICINE
(2023)
Article
Pediatrics
Avichai Weissbach, Eytan Kaplan, Gili Kadmon, Yulia Gendler, Elhanan Nahum, Barak Meidan, Shirley Friedman, Efraim Sadot, Itay Ayalon
Summary: This retrospective observational study aimed to investigate the prevalence, severity, nature, and significance of acute kidney injury (AKI) among children admitted to the pediatric intensive care unit (PICU) with toxic shock syndrome (TSS). The study included 41 children diagnosed with TSS from 2009-2022 and found that 59% of them had AKI, indicating a complex course of illness.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Pediatrics
Rupesh Raina, Ronith Chakraborty, Isabelle Mawby, Nirav Agarwal, Sidharth Sethi, Michael Forbes
Summary: Research on AKI in pediatric COVID-19 patients shows a high incidence and mortality rate of AKI in children and adolescents. The study also found a high incidence of multisystem inflammatory syndrome in children (MIS-C) among COVID-19 patients.
PEDIATRIC NEPHROLOGY
(2021)
Article
Multidisciplinary Sciences
Alexander C. Reisinger, Tobias Niedrist, Florian Posch, Stefan Hatzl, Gerald Hackl, Juergen Prattes, Gernot Schilcher, Anna-Maria Meissl, Reinhard B. Raggam, Markus Herrmann, Philipp Eller
Summary: Soluble urokinase plasminogen activator receptor (suPAR) levels at ICU admission are associated with ICU and 28-day mortality, as well as SOFA score, coagulation and inflammation markers, and AKI-3 occurrence. suPAR may offer additional value for risk stratification, especially in ICU patients with moderate organ dysfunction.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Shubhi Kaushik, Sindy Villacres, Ruth Eisenberg, Shivanand S. Medar
Summary: This study showed that 64% of children with ARDS develop AKI, with varying degrees of severity. The occurrence and recovery of AKI are associated with multiple factors, including oxygenation index and medication requirements. Patients with AKI had a significantly longer duration of hospital stay, but no significant impact on ICU stay, MV duration, and mortality was observed.
JOURNAL OF INTENSIVE CARE MEDICINE
(2021)
Article
Geriatrics & Gerontology
Amjad Bani Hani, Mahmoud Abu Abeeleh, Sondos Al-Najjar, Abdulla Alzibdeh, Shahd Mansour, Isam Bsisu, Nour Awamleh, Randa Farah
Summary: This study investigated the incidence, risk factors, and outcomes of acute kidney injury (AKI) in patients aged 80 years or older in a surgical intensive care unit (SICU). The study found that the incidence of AKI was 32.7%, and it was significantly associated with the use of beta blockers, mechanical ventilation, and inotropes. Further research is needed to assess the incidence of AKI in this population and identify preventive measures and strategies.
Article
Pediatrics
Chih-Ching Chang, Yi-Chen Lin, Tzu-Chun Chen, Jainn-Jim Lin, Shao-Hsuan Hsia, Oi-Wa Chan, En-Pei Lee
Summary: Based on a study of 102 children receiving HFNC therapy, we found that HFNC therapy could be initiated as the first-line therapy for various etiologies of acute respiratory distress with hypoxia in a pediatric intensive care unit and for all age groups.
FRONTIERS IN PEDIATRICS
(2021)
Review
Respiratory System
Jason A. Clayton, Katherine N. Slain, Steven L. Shein, Ira M. Cheifetz
Summary: The use of high flow nasal cannula (HFNC) in pediatric intensive care units (PICUs) has become widespread, but there is a lack of studies evaluating its safety and efficacy. This scoping review examines the application and mechanisms of HFNC in critically ill children. Current research is limited to small observational studies, and there is a need for more robust studies to evaluate patient-centered outcomes.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2022)
Article
Urology & Nephrology
Dongliang Yang, Jian Kang, Yuanhao Li, Chao Wen, Suosuo Yang, Yanbo Ren, Hui Wang, Yuling Li
Summary: A simple model was developed to predict the occurrence of acute respiratory distress syndrome (ARDS) in patients with acute pancreatitis (AP) and acute kidney injury (AKI). The model can aid clinicians in identifying high-risk patients and optimizing therapeutic strategies.
Article
Medicine, General & Internal
Kevin Pilarczyk, Katharina Huenges, Burkhard Bewig, Lorenz Balke, Jochen Cremer, Assad Haneya, Bernd Panholzer
Summary: AKI is a common complication in adult patients receiving ECMO support, with two-thirds of patients experiencing moderate to severe AKI and increased morbidity and long-term mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Respiratory System
Shuxing Wei, Yongsheng Zhang, Hongmeng Dong, Ying Chen, Xiya Wang, Xiaomei Zhu, Guang Zhang, Shubin Guo
Summary: Machine learning techniques, particularly XGBoost, are reliable in predicting acute kidney injury (AKI) in acute respiratory distress syndrome (ARDS) patients. The compact model with fewer variables maintains excellent predictive ability, providing valuable guidance in identifying AKI in ARDS for improved patient outcomes.
BMC PULMONARY MEDICINE
(2023)
Article
Microbiology
Fabrizio Fabrizi, Carlo M. Alfieri, Paolo Molinari, Francesco Tamborini, Marianna Tangredi, Anna Sikharulidze, Francesco Blasi, Anna Fracanzani, Walter Monzani, Flora Peyvandi, Giuseppe Castellano
Summary: The study reveals that acute kidney injury (AKI) is a common complication among SARS-CoV-2-positive patients who undergo hospitalization. The occurrence of AKI is related to the severity of COVID-19 and factors such as elevated levels of ferritin, IL-6, and azotemia at admission.
Article
Health Care Sciences & Services
Markita Suttle, Mark W. Hall, Murray M. Pollack, Robert A. Berg, Patrick S. McQuillen, Peter M. Mourani, Anil Sapru, Joseph A. Carcillo, Emily Startup, Richard Holubkov, J. Michael Dean, Daniel A. Notterman, Kathleen L. Meert
Summary: Mental health symptoms show improvement among parents during the first 13 months after their child's death, but persist for some. Black parents and families with sudden unexpected death of a child may be at higher risk for poor adjustment during bereavement.
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE
(2022)
Article
Critical Care Medicine
Michelle J. Lim, Matt S. Zinter, Lucia Chen, Kayley Man Yee Wong, Anoopindar Bhalla, Kinisha Gala, Mona Guglielmo, Mustafa Alkhouli, Leanna L. Huard, Mark R. Hanudel, Sitaram Vangala, Andreas Schwingshackl, Michael Matthay, Anil Sapru
Summary: This study investigates the relationship between plasma soluble receptor for advanced glycation end products (sRAGE) and primary pulmonary dysfunction, extrapulmonary organ dysfunction, and mortality in pediatric acute respiratory distress syndrome (ARDS) patients. The results show that sRAGE is associated with extrapulmonary organ dysfunction and markers of inflammation in ARDS patients, and is also related to mortality in children with indirect lung injury.
CRITICAL CARE MEDICINE
(2022)
Article
Health Care Sciences & Services
Markita Suttle, Mark W. Hall, Murray M. Pollack, Robert A. Berg, Patrick S. McQuillen, Peter M. Mourani, Anil Sapru, Joseph A. Carcillo, Emily Startup, Richard Holubkov, Daniel A. Notterman, Gillian Colville, Kathleen L. Meert
Summary: In the first 13 months after a child's death in the PICU, parents bereaved perceive a moderate level of post-traumatic growth, with wide variability. Education level and complicated grief symptoms may influence how parents perceive post-traumatic growth.
JOURNAL OF PALLIATIVE MEDICINE
(2022)
Article
Medicine, General & Internal
Robert M. Sutton, Heather A. Wolfe, Ron W. Reeder, Tageldin Ahmed, Robert Bishop, Matthew Bochkoris, Candice Burns, J. Wesley Diddle, Myke Federman, Richard Fernandez, Deborah Franzon, Aisha H. Frazier, Stuart H. Friess, Kathryn Graham, David Hehir, Christopher M. Horvat, Leanna L. Huard, William P. Landis, Tensing Maa, Arushi Manga, Ryan W. Morgan, Vinay M. Nadkarni, Maryam Y. Naim, Chella A. Palmer, Carleen Schneiter, Matthew P. Sharron, Ashley Siems, Neeraj Srivastava, Sarah Tabbutt, Bradley Tilford, Shirley Viteri, Robert A. Berg, Michael J. Bell, Joseph A. Carcillo, Todd C. Carpenter, J. Michael Dean, Ericka L. Fink, Mark Hall, Patrick S. McQuillen, Kathleen L. Meert, Peter M. Mourani, Daniel Notterman, Murray M. Pollack, Anil Sapru, David Wessel, Andrew R. Yates, Athena F. Zuppa
Summary: A bundled intervention of cardiopulmonary resuscitation training and physiologically focused structured debriefing did not significantly improve patient survival with favorable neurologic outcome in pediatric patients who experienced cardiac arrest in the ICU compared to usual care.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Critical Care Medicine
Andrew R. Yates, John T. Berger, Ron W. Reeder, Russell Banks, Peter M. Mourani, Robert A. Berg, Joseph A. Carcillo, Todd Carpenter, Mark W. Hall, Kathleen L. Meert, Patrick S. McQuillen, Murray M. Pollack, Anil Sapru, Daniel A. Notterman, Richard Holubkov, J. Michael Dean, David L. Wessel
Summary: This study characterizes the use of inhaled nitric oxide (iNO) in pediatric cardiac patients and investigates the relationship between patient characteristics before iNO initiation and outcomes following cardiac surgery. The study found that pediatric patients who received iNO treatment for cardiac indications had a high mortality rate and significant morbidity. Right ventricular dysfunction was associated with mortality and the need for ventilator support, while pulmonary hypertension was not associated with these outcomes.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Aline B. Maddux, Jerry J. Zimmerman, Russell K. Banks, Ron W. Reeder, Kathleen L. Meert, Angela S. Czaja, Robert A. Berg, Anil Sapru, Joseph A. Carcillo, Christopher J. L. Newth, Michael W. Quasney, Peter M. Mourani
Summary: This study evaluated postdischarge health resource use in pediatric survivors of septic shock and identified factors associated with health resource use. The study found that children with septic shock have high-resource needs after discharge, and the factors associated with resource use vary based on patients' preexisting conditions.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Cell Biology
Matt S. Zinter, A. Birgitta Versluys, Caroline A. Lindemans, Madeline Y. Mayday, Gustavo Reyes, Sara Sunshine, Marilynn Chan, Elizabeth K. Fiorino, Maria Cancio, Sabine Prevaes, Marina Sirota, Michael A. Matthay, Sandhya Kharbanda, Christopher C. Dvorak, Jaap J. Boelens, Joseph L. DeRisi
Summary: This study reveals the association between the metatranscriptomes of bronchoalveolar lavage (BAL) and pretransplant lung function in pediatric allogeneic hematopoietic cell transplantation (HCT). Abnormal pulmonary function and dysregulated microbial composition and gene expression in BAL are associated with post-HCT mortality. These findings highlight the potential importance of microbiome depletion and epithelial gene expression in the development of pre-HCT lung dysfunction.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Chionye Ossai, Steven Bedrick, Benjamin Orwoll
Summary: More and more parents are using online physician rating sites to choose pediatricians, but little research has examined the influence of social media on parents' choices. This study analyzed threads on the Reddit platform and found that factors influencing parents' choice of a pediatrician include pediatrician-specific factors, office-related factors, parent/patient factors, and social factors. Online peer support communities can be an important source of information for parents when searching for a pediatrician. Pediatric practices should focus on meeting parents' information needs and easing the search process.
JOURNAL OF CONSUMER HEALTH ON THE INTERNET
(2022)
Article
Computer Science, Information Systems
Sky Corby, Joan S. Ash, Keaton Whittaker, Vishnu Mohan, Nicholas Solberg, James Becton, Robby Bergstrom, Benjamin Orwoll, Christopher Hoekstra, Jeffrey A. Gold
Summary: This paper describes the development of core knowledge, skills, and attitudes (KSAs) for medical scribes. The research team used a mixed qualitative methods approach to identify and refine 90 descriptions of scribe-related KSAs. The results generated three lists of KSAs that can be incorporated into scribe training programs.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Letter
Critical Care Medicine
Matt S. Zinter, Daniela Markovic, Lisa A. Asaro, Vinay M. Nadkarni, Patrick S. McQuillen, Pratik Sinha, Michael A. Matthay, Marc G. Jeschke, Michael S. D. Agus, Anil Sapru
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Pediatrics
Amy L. Holley, Trevor A. Hall, Ben Orwoll, Anna C. Wilson, Eleanor A. J. Battison, Denae Clohessy, Cydni N. Williams
Summary: This study investigated the prevalence and factors associated with opioid prescriptions at discharge in pediatric intensive care units (PICUs). The results showed that 23.7% of children received an opioid prescription at discharge. Older age and surgical admission type were consistent predictors of receiving an opioid prescription.
Article
Respiratory System
Nadir Yehya, Matt S. Zinter, Jill M. Thompson, Michelle J. Lim, Mark R. Hanudel, Mustafa F. Alkhouli, Hector Wong, Matthew N. Alder, Daniel J. Mckeone, E. Scott Halstead, Pratik Sinha, Anil Sapru
Summary: Latent class analysis identified two subphenotypes of pediatric ARDS characterized by differential elevation of biomarkers reflecting inflammation and endotheliopathy in two separate cohorts. These subphenotypes showed significant differences in clinical characteristics and outcomes, with the hyperinflammatory subtype associated with greater illness severity, more sepsis, and higher mortality rates. There was overlap with adult subphenotypes, suggesting potential utility for prognostic and predictive enrichment in future pediatric ARDS trials.
Article
Respiratory System
Michael A. Smith, Doantrang Dinh, Ngoc P. Ly, Shan L. Ward, Meghan E. McGarry, Matt S. Zinter
Summary: In recent years, there has been an increase in the number of pediatric patients receiving intensive care management for asthma in the United States, despite lower overall hospitalization rates. The study shows that there has been a shift in the use of mechanical ventilation for pediatric asthma, with a decrease in intubation and an increase in noninvasive ventilation. This change in practice may be partially related to a younger patient cohort.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Critical Care Medicine
Mary K. Dahmer, Guangyu Yang, Min Zhang, Michael W. Quasney, Anil Sapru, Heidi M. Weeks, Pratik Sinha, Martha A. Q. Curley, Kevin L. Delucchi, Carolyn S. Calfee, Heidi Flori
Summary: This study used latent class analysis to identify phenotypes in children with ARDS and found two distinct phenotypes, with worse outcomes observed in children with the hyperinflammatory phenotype.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Critical Care Medicine
Anoopindar K. Bhalla, Margaret J. Klein, Vicent Modesto Alapont, Guillaume Emeriaud, Martin C. J. Kneyber, Alberto Medina, Pablo Cruces, Franco Diaz, Muneyuki Takeuchi, Aline B. Maddux, Peter M. Mourani, Cristina Camilo, Benjamin R. White, Nadir Yehya, John Pappachan, Matteo Di Nardo, Steven Shein, Christopher Newth, Robinder Khemani
Summary: The study demonstrates that higher mechanical power is associated with fewer ventilator-free days in children with pediatric acute respiratory distress syndrome (PARDS), especially in children under 2 years old.