Article
Oncology
Yinghui Hong, Mingliang Ye, Fan Wang, Jun Fang, Chun Wang, Jie Luo, Jialiang Liu, Jing Liu, Lan Liu, Qiu Zhao, Ying Chang
Summary: This study reveals that miR-21-3p promotes migration and invasion of HCC cells and upregulates YAP1 expression by directly inhibiting SMAD7, highlighting a major epigenetic mechanism in HCC pathogenesis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zhenzhao Luo, Yue Fan, Xianchang Liu, Shuiyi Liu, Xiaoyu Kong, Zhonghuan Ding, Ying Li, Liqing Wei
Summary: MiR-188-3p and miR-133b exert a suppressive effect on hepatocellular carcinoma proliferation, invasion, and migration through downregulation of NDRG1.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Hongyuan Chen, Meng Kong, Ying Chen, Yugang Jiang, Mingxin Wen, Xinke Zhang
Summary: The study revealed that low expression of miR-203 was significantly associated with tumor recurrence and poor survival in patients with early-stage HCC, suggesting its potential as a novel predictor and molecular target for HCC therapy.
Article
Oncology
Xuesong Deng, Jun Cheng, Naiyang Zhan, Jianwei Chen, Yongqiang Zhan, Yong Ni, Caixian Liao
Summary: This study found that TONSL-AS1 expression is downregulated in hepatocellular carcinoma tissues, associated with lower survival rates. There is an interaction between miR-135a and TONSL-AS1, where overexpression of miR-135a decreases TONSL-AS1 expression. Overexpression of TONSL-AS1 inhibits HCC cell proliferation, while overexpression of miR-135a promotes cell proliferation.
Article
Cell Biology
Hui Hu, Wei Huang, Hong Zhang, Jianye Li, Qiong Zhang, Ya-Ru Miao, Fei-Fei Hu, Lu Gan, Zhenhong Su, Xiangliang Yang, An-Yuan Guo
Summary: The miR-9-5p/FOXO1/CPEB3 feed-forward loop was identified and found to play a critical role in the progression of hepatocellular carcinoma (HCC). This regulatory module could potentially serve as a new therapeutic target for HCC treatment.
Article
Oncology
Yuan Chen, Hao Xu, Hao Tang, Hongyuan Li, Chi Zhang, Shengjie Jin, Dousheng Bai
Summary: This study found that miR-9-5p can predict vascular invasion and prognosis in hepatocellular carcinoma (HCC) patients. Experimental results showed that downregulation of miR-9-5p inhibits migration, invasion, and angiogenesis of HCC cells. MiR-9-5p is an independent risk factor for HCC, and the nomogram based on miR-9-5p has a good predictive value for HCC survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiaobin Chi, Yi Jiang, Yongbiao Chen, Lizhi Lv, Jianwei Chen, Fang Yang, Xiaojin Zhang, Fan Pan, Qiucheng Cai
Summary: High expression of miR-652-3p in HCC is associated with clinical severity, and elevated levels may lead to poorer prognosis.
Article
Oncology
Shuangshuang Li, Jiajia Shao, Guohua Lou, Chao Wu, Yanning Liu, Min Zheng
Summary: The study uncovered the role of EIF4G2 in HCC development through ERK pathway activation. It was also found that EIF4G2 could be negatively regulated by the tumor suppressor miR-144. Investigations suggested that EIF4G2 might be a promising therapeutic target in HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Guanlin Zhou, Yijun Zeng, Yingmin Luo, Sheng Guo, Longyuan Bao, Qiong Zhang
Summary: miR-93-5p shows potential as a biomarker for early detection of HBV-related HCC. Urine miR-93-5p can also be used to predict the prognosis of patients with HBV-related HCC.
Review
Oncology
Tian-Run Lv, Hai-Jie Hu, Parbatraj Regmi, Fei Liu, Fu-Yu Li
Summary: Sarcomatoid hepatocellular carcinoma (SHCC) is a rare subtype of primary liver malignancies. Compared to conventional hepatocellular carcinoma (HCC), SHCC has worse prognosis and exhibits more aggressive behavior.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Jianting Long, Baoxian Liu, Zhijia Yao, Huiwen Weng, Heping Li, Chunlin Jiang, Shi Fang
Summary: miR-500a-3p may serve as a biomarker for hepatocellular carcinoma, with diagnostic and prognostic significance.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Cell Biology
Tianxiang Chen, Runkun Liu, Yongshen Niu, Huanye Mo, Hao Wang, Ye Lu, Liang Wang, Liankang Sun, Yufeng Wang, Kangsheng Tu, Qingguang Liu
Summary: This study identified a novel lncRNA, KDM4A-AS1, which is highly expressed in HCC tissues and plays a crucial role in promoting tumor growth and metastasis by competitively binding miR-411-5p, thereby activating the AKT pathway. Additionally, KDM4A-AS1 was found to be regulated by hypoxia-inducible factor 1 alpha (HIF-1 alpha) through the KPNA2/AKT signaling pathway, providing a potential prognostic and therapeutic target for HCC.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Shuying Chen, Yinqi Mao, Wei Chen, Chenbin Liu, Han Wu, Jingjun Zhang, Shenghao Wang, Chengpan Wang, Yong Lin, Yuan Lv
Summary: This study found that serum exosomal miR-34a is significantly down-regulated in patients with hepatocellular carcinoma (HCC), and it may serve as a novel non-invasive biomarker for the diagnosis and prognosis of HCC.
Article
Biochemistry & Molecular Biology
Michael A. Lopez, Ying Si, Xianzhen Hu, Valentyna Williams, Fuad Qushair, Jackson Carlyle, Lyndsy Alesce, Michael Conklin, Shawn Gilbert, Marcas M. Bamman, Matthew S. Alexander, Peter H. King
Summary: Duchenne muscular dystrophy (DMD) is characterized by muscle instability, wasting, and fibrosis. This study found an aberrant upregulation of a signaling pathway and a decrease in specific microRNAs in DMD patient muscle cells. Inhibition of this pathway promoted muscle cell differentiation and suppressed inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Liguo Zhang, Ping Zhang, Tonggang Liu, Dongmei Li, Xianxian Liu
Summary: circ_0006404 is overexpressed in hepatocellular carcinoma (HCC) and promotes HCC cell growth, cycle, and migration. It functions by regulating the expression of miR-624. These findings suggest that circ_0006404 may serve as a new biomarker for HCC.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)