Journal
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
Volume 36, Issue 4, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppsc.201800420
Keywords
antibacterial; fluorescent; GHK-Cu; self-assembly; wound healing
Funding
- National Natural Science Foundation of China [31771577, 31700700]
- China Postdoctoral Science Foundation [2018M631197, 2017M623232]
- Natural Science Basic Research Plan in Shaanxi Province of China [2018JM3027]
- Fundamental Research Funds for the Central Universities [3102017OQD047, 3102017OQD049, 31020180QD063]
- National Undergraduate Training Programs for Innovation and Entrepreneurship [201810699343]
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GHK-Cu is demonstrated with the abilities to improve wound healing, accelerate anti-inflammatory activity, and repair DNA damage. However, the instability of the GHK-Cu in biological fluids is always a big challenge for its long-term and efficient function at the target site. Therefore, the self-assembled GHK-Cu nanoparticles (GHK-Cu NPs) are investigated in this work to solve the instability issue. The crystalline nanostructure within the GHK-Cu nanoparticles offers them visible and near-infrared fluorescent properties. With the excellent self-assembly performance, the antibacterial properties of GHK-Cu NPs are demonstrated using E. coli and S. aureus. The L929 dermal fibroblast cells are utilized to prove the good biocompatibility and enhanced wound healing applications of GHK-Cu NPs. This study could pave the way for the design and elaboration of a new class of fluorescent peptides with various biological functions in biomedical applications.
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