Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 23, Issue 5, Pages 825-835Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.8b00374
Keywords
aerobic oxidation; iron catalysis; 4-OH-TEMPO; aldehydes; ketones
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Funding
- National Basic Research Program of China [2015CB856600]
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An aerobic oxidation reaction of alcohols toward aldehydes or ketones using catalytic amounts of Fe(NO3)(3)center dot 9H(2)O, 4-OH-TEMPO, and NaCl has been developed. Compared with the former catalytic system with TEMPO developed in this group, the new protocol using 4-OH-TEMPO, which is much cheaper on an industrial scale, accomplished the transformation with a higher selectivity, especially for aliphatic alcohols toward aldehydes. alpha,beta-Unsaturated alkynals or alkynones can be efficiently synthesized from propargyl alcohols, which has been much less studied in the literature.
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