Journal
ORGANIC LETTERS
Volume 21, Issue 4, Pages 926-930Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03892
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21602105]
- National Key R&D Program of China [2017YFA0204704]
- Natural Science Foundation of Jiangsu Province [BK20171460]
Ask authors/readers for more resources
A novel strategy for the construction of 2,2-diacyl spirocyclohexanones 3 has been demonstrated on the basis of an NHC-catalyzed [3C + 3C] annulation of potassium 2-oxo-3-enoates with 2-ethylidene 1,3-indandiones. Furthermore, enantioenriched 3 was obtained in good to excellent yields with good enantioselectivities when chiral N-heterocyclic carbene (NHC) was employed. Notably, ring opening of the resulting 2,2-diacyl spirocyclohexanones 3 with hydrazine led to the formation of phthalazinones in good to excellent yields.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available