Article
Gastroenterology & Hepatology
Ashish Chauhan, Ramesh Kumar, Sanchit Sharma, Mousumi Mahanta, Sudheer K. Vayuuru, Baibaswata Nayak, Sonu Kumar, Shalimar
Summary: Intestinal flora plays a critical role in immunity against HBV. FMT may be a potential immunomodulatory therapy in CHB patients. The study showed FMT could be effective in viral suppression and HBeAg clearance in HBeAg-positive CHB patients.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Microbiology
Divya Gopinath, Rohit Kunnath Menon, Chong Chun Wie, Moinak Banerjee, Swagatika Panda, Deviprasad Mandal, Paresh Kumar Behera, Susanta Roychoudhury, Supriya Kheur, Michael George Botelho, Newell W. Johnson
Summary: Oral leukoplakia and oral cancer patients have considerable overlap in the bacteriome of whole mouth fluid, while a clearer separation exists with healthy controls. This suggests a potential role of oral bacteria in early stages of oral carcinogenesis.
JOURNAL OF ORAL MICROBIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Suhana Chattopadhyay, Leena Malayil, Emmanuel F. Mongodin, Amy R. Sapkota
Summary: Research indicates a wide range of bacterial and fungal microbiomes present in tobacco products, with some known human pathogens and others as potential opportunistic pathogens. Future studies should focus on the viability of these microorganisms and their potential transfer to the respiratory tract of users, potentially impacting their health.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Immunology
Pilar Cornejo Ulloa, Bastiaan P. Krom, Monique H. van der Veen
Summary: Sex steroid hormones can affect both oral microbiota and host cells, potentially leading to oral health problems. Current research mainly focuses on the impact of hormonal changes on oral microorganisms, while broader studies have suggested new hypotheses about the effects of SSH.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maria Contaldo, Alberta Lucchese, Antonio Romano, Fedora Della Vella, Dario Di Stasio, Rosario Serpico, Massimo Petruzzi
Summary: Studies have shown differences in oral microbiota composition between individuals with DS, healthy subjects, and those with other intellectual disabilities. However, data on the mycobiome and virobiome of DS are limited, indicating further research is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Amy Newman, Emma Picot, Sian Davies, Sally Hilton, Isabelle A. Carre, Gary D. Bending
Summary: Aberrant function of plant circadian clock can lead to altered rhythmicity of rhizosphere bacteria and fungi, resulting in changes in the composition of rhizosphere microbiome with potential consequences for plant health.
Article
Environmental Sciences
Yangquanwei Zhong, Jin Liu, Xiaoyu Jia, Zhuangsheng Tang, Zhouping Shangguan, Ruiwu Wang, Weiming Yan
Summary: This study investigates the responses of soil microbial communities in drylands to environmental stress factors. The results show that bacterial and fungal diversity and community similarity have different sensitivities to environmental stress, with mean annual precipitation being the most important factor. Dominant subcommunities of bacteria and fungi are more sensitive to stress than non-dominant subcommunities. Additionally, certain bacterial and fungal taxa are found to be sensitive to environmental stress and are correlated with carbon and nitrogen cycling-related genes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Oncology
Giacomo Pietrobon, Marta Tagliabue, Luigi Marco Stringa, Rita De Berardinis, Francesco Chu, Jacopo Zocchi, Elena Carlotto, Susanna Chiocca, Mohssen Ansarin
Summary: The role of oral microbiota in oral cavity leukoplakia is significant, potentially serving as a marker for the progression from leukoplakia to oral squamous cell carcinoma. However, the reviewed studies have limitations, and more longitudinal studies are needed to address these biases.
Article
Allergy
Ariangela J. Kozik, Lesa A. Begley, Njira Lugogo, Alan Baptist, John Erb-Downward, Kristopher Opron, Yvonne J. Huang
Summary: This study compared the relationship between airway microbiota and immune markers in obese and nonobese individuals with and without mild-moderate asthma. The results showed that obesity itself is associated with an altered sputum microbiome, and there are distinct differences in the airway microbiota and immune marker relationships in obese asthma. These differences may affect the mechanisms and outcomes of obese asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Shuli Yang, Guangrong Zhang, Zaimei Yuan, Shichun He, Rongjiao Wang, Jieyi Zheng, Huaming Mao, Jianmin Chai, Dongwang Wu
Summary: In this study, the bacterial and fungal communities in the rumen of pastured yaks of different ages were analyzed using full-length sequencing. The results showed that the rumen microflora of Zhongdian yaks changed gradually from 5 to 180 days after birth and tended to stabilize at 2 years of age. The rumen of adult yaks was the most suitable for the growth and reproduction of most bacteria. At 90 days of age, the yak rumen was the most suitable for the growth and reproduction of most fungi, and 90 days of age could be a cut-off point for the distribution of fungal communities. The study provided insights into the dynamic changes of dominant microflora with yak growth.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Pratima Kumari, Priyanka Debta, Anshuman Dixit
Summary: Oral cancer is a critical health issue, with the majority of new cases occurring in Asia. Various factors, such as genetics and lifestyle, are closely associated with its occurrence and progression. Early signs of oral cancer include oral lesions, genetic mutations, and viral infections. Lesions with dysplastic features have a high risk of malignancy, and OPMDs have a high prevalence in South Asian countries. Early detection, prevention, and treatment of OPMDs are crucial.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Hua Zha, Qian Li, Kevin Chang, Jiafeng Xia, Shengjie Li, Ruiqi Tang, Lanjuan Li
Summary: Multiple probiotics have protective effects against different types of liver injury, and intestinal microbes may be associated with the immune improvement effect of probiotics in the treated cohorts. The composition of bacterial and fungal microbiome differs in rats with different cytokine profiles. Certain microbes are associated with specific cytokine profiles and have a significant influence on the immunity improvement effect of probiotics. These identified intestinal microbes could potentially serve as microbial biomarkers for assessing the immune status of probiotics-treated cohorts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Grzegorz Janusz, Andrzej Mazur, Anna Pawlik, Dorota Kolodynska, Bogdan Jaroszewicz, Anna Marzec-Grzadziel, Piotr Koper
Summary: Deadwood plays a crucial role in forest ecology, and the degradation and carbon assimilation of deadwood are carried out by fungi and bacteria. This study investigated the abundance and distribution of microbial taxa in dead spruce logs and the soil below over a 50-year period. The results showed differences in microbial diversity and relative abundance between the samples from 1974 and 2014, with certain taxa being more predominant in each time period.
Article
Soil Science
Shawn P. Brown, Matthew Brogden, Christina Cortes, Avery E. Tucker, Allison Rick VandeVoort, Bruce A. Snyder
Summary: This study used the millipede Cherokia georgiana georgiana as a model and metabarcoding approach to investigate the impacts of millipedes on soil microbial communities with varying nitrogen levels. The research found that millipedes strongly alter soil communities, but nitrogen levels did not impact millipede gut communities. Additionally, the study provided evidence that millipede gut communities are mainly derived from soils rather than leaf litter.
SOIL BIOLOGY & BIOCHEMISTRY
(2021)
Article
Oncology
Jia Zhang, Yangting He, Lu Xia, Jing Yi, Zhen Wang, Yingying Zhao, Xuemei Song, Jia Li, Hongli Liu, Xinjun Liang, Shaofa Nie, Li Liu
Summary: This study identified microbial diagnostic models that can distinguish colorectal tumor patients from healthy controls, expanding the potential biomarkers for colorectal tumors. The study also identified gene pathways regulated by aberrant gut bacteria and revealed potential interactions of gut bacteria with viruses in colorectal tumors, contributing to our understanding of dysbiosis in colorectal carcinogenesis.
Review
Dentistry, Oral Surgery & Medicine
Francesca Bravi, Yuan-Chin Amy Lee, Mia Hashibe, Paolo Boffetta, David I. Conway, Monica Ferraroni, Carlo La Vecchia, Valeria Edefonti
Summary: The INHANCE consortium's research findings have revealed the association of head and neck cancer with smoking, alcohol consumption, and occupational exposure, as well as the benefits of good oral health, hormonal factors, and fruit and vegetable consumption in reducing the incidence of head and neck cancer. The studies also provide insights into the survival rates and recurrence rates of head and neck cancer.
Review
Pediatrics
Khalid Elmaghrawy, Seamus Hussey, Gary P. Moran
Summary: The oral microbiome may play an important role in the development of gastrointestinal diseases, including Crohn's disease and ulcerative colitis. Bacteria and yeasts from the oral cavity may translocate to the gut, triggering inflammation, and dysbiosis of the oral microbiome could potentially serve as a biomarker for GI health.
FRONTIERS IN PEDIATRICS
(2021)
Article
Public, Environmental & Occupational Health
David Conway, Jan Hovanec, Wolfgang Ahrens, Alastair Ross, Ivana Holcatova, Pagona Lagiou, Diego Serraino, Cristina Canova, Lorenzo Richiardi, Claire Healy, Kristina Kjaerheim, Gary J. Macfarlane, Peter Thomson, Antonio Agudo, Ariana Znaor, Paul Brennan, Daniele Luce, Gwenn Menvielle, Isabelle Stucker, Simone Benhamou, Heribert Ramroth, Paolo Boffetta, Marta Vilensky, Leticia Fernandez, Maria Paula Curado, Ana Menezes, Alexander Daudt, Rosalina Koifman, Victor Wunsch-Filho, Amy Lee Yuan-Chin, Mia Hashibe, Thomas Behrens, Alex D. McMahon
Summary: Low occupational socioeconomic prestige, position, and manual work are associated with head and neck cancer risk, which is only partially explained by smoking, alcohol, and occupational exposures. Perceptual occupational psychosocial status (SIOPS) appears to be the strongest socioeconomic factor relative to socioeconomic position and manual/non-manual work in relation to head and neck cancer risk.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2021)
Article
Spectroscopy
Hugh J. Byrne, Isha Behl, Genecy Calado, Ola Ibrahim, Mary Toner, Sheila Galvin, Claire M. Healy, Stephen Flint, Fiona M. Lyng
Summary: Vibrational spectroscopy, whether based on infrared absorption or Raman scattering, has increasingly attracted attention for biomedical applications. Proof of concept explorations have shown potential for diagnosis of oral potentially malignant disorders and cancer. Raman microspectroscopy is being widely applied for analysis of histological, cytological, and saliva samples, with future prospects for routine in vivo screening.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemical Research Methods
Damien Traynor, Isha Behl, Declan O'Dea, Franck Bonnier, Siobhan Nicholson, Finbar O'Connell, Aoife Maguire, Stephen Flint, Sheila Galvin, Claire M. Healy, Cara M. Martin, John J. O'Leary, Alison Malkin, Hugh J. Byrne, Fiona M. Lyng
Summary: The protocol presented in this study outlines the use of Raman spectroscopy for cancer cytopathology diagnosis, covering detailed instructions for sample preparation, data acquisition, preprocessing, and analysis.
Article
Spectroscopy
Isha Behl, Genecy Calado, Anika Vishwakarma, Damien Traynor, Stephen Flint, Sheila Galvin, Claire M. Healy, Marina Leite Pimentel, Alison Malkin, Hugh J. Byrne, Fiona M. Lyng
Summary: Raman microspectroscopy has demonstrated potential for oral cancer diagnosis by effectively distinguishing healthy donors from patients with oral mucosal dysplastic lesions. Models based on cytopathological and histopathological assessment can help differentiate low and high grade dysplasia, potentially reducing the need for multiple biopsies.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Multidisciplinary Sciences
Aida Ferreiro-Iglesias, James D. McKay, Nicole Brenner, Shama Virani, Corina Lesseur, Valerie Gaborieau, Andy R. Ness, Rayjean J. Hung, Geoffrey Liu, Brenda Diergaarde, Andrew F. Olshan, Neil Hayes, Mark C. Weissler, Lea Schroeder, Noemi Bender, Michael Pawlita, Steve Thomas, Miranda Pring, Tom Dudding, Beatriz Kanterewicz, Robert Ferris, Sera Thomas, Yonathan Brhane, Virginia Diez-Obrero, Maja Milojevic, Karl Smith-Byrne, Daniela Mariosa, Mattias J. Johansson, Rolando Herrero, Stefania Boccia, Gabriella Cadoni, Martin Lacko, Ivana Holcatova, Wolfgang Ahrens, Pagona Lagiou, Areti Lagiou, Jerry Polesel, Lorenzo Simonato, Franco Merletti, Claire M. Healy, Bo T. Hansen, Mari Nygard, David I. Conway, Sylvia Wright, Tatiana V. Macfarlane, Max Robinson, Laia Alemany, Antonio Agudo, Ariana Znaor, Christopher I. Amos, Tim Waterboer, Paul Brennan
Summary: This study identifies specific genetic susceptibility loci for oropharyngeal cancer, particularly in the HLA region, which are associated with HPV status. The protective role of HLA variants against HPV infection is highlighted, suggesting their potential implications in vaccine development for HPV(+)OPC prevention.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Wanjun Qi, Maikel Acosta-Zaldivar, Peter R. Flanagan, Ning-Ning Liu, Niketa Jani, Jose F. Fierro, Maria T. Andres, Gary P. Moran, Julia R. Kohler
Summary: This study investigates the role of the N-terminal HEAT repeats of the Tor1 protein in Candida albicans, showing that loss of these repeats affects stress responses and growth acceleration in certain conditions. Cells lacking this region display impaired stress responses but tolerance to other stressors, along with difficulties in utilizing favorable nutritional conditions.
Article
Gastroenterology & Hepatology
Khalid Elmaghrawy, Paddy Fleming, Kirsten Fitzgerald, Sarah Cooper, Anna Dominik, Seamus Hussey, Gary P. Moran
Summary: This study examined the oral microbiome in pediatric inflammatory bowel disease (IBD) and identified differences in microbiome composition between IBD patients and healthy controls. The dysbiosis in the oral microbiome was associated with disease severity and was resolved following successful treatment. A predictive model of IBD was developed using machine learning methods. The findings suggest the potential diagnostic value of the oral microbiome in pediatric IBD.
JOURNAL OF CROHNS & COLITIS
(2022)
Letter
Oncology
Ciara Mulvihill, Kirsten Fitzgerald, Esther O'Regan, Claire M. Healy, Timothy Ronan Leahy
Article
Dentistry, Oral Surgery & Medicine
Lewis Winning, Gary Moran, Mary McClory, Ikhlas El Karim, Fionnuala T. Lundy, Christopher C. Patterson, Dermot Linden, Kathy M. Cullen, Frank Kee, Gerard J. Linden
Summary: This study investigated the association between subgingival microbial diversity and reduced respiratory function. A group of dentate men aged 58-72 in Northern Ireland underwent a periodontal examination and subgingival plaque sampling. The results showed that an increase in MDI was associated with a decrease in % predicted FEV1 after adjusting for confounders.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Toxicology
Gary P. Moran, Lina Zgaga, Blanaid Daly, Mairead Harding, Therese Montgomery
Summary: Fluoride is added to drinking water to prevent tooth decay, but the potential effects on neurodevelopment and endocrine dysfunction require further research. However, there is a lack of studies examining the effects of fluoridated water on the human microbiome. Animal studies suggest that fluoride exposure can disrupt the normal microbiome, but further investigation is needed for its significance in humans living in areas with fluoridated water. The use of fluoride-containing oral hygiene products may have beneficial effects on the oral microbiome regarding caries prevention.
TOXICOLOGY LETTERS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Sheila Galvin, Gary P. Moran, Claire M. Healy
Summary: The tongue and floor of the mouth are high-risk sites for oral squamous cell carcinoma (OSCC), while smoking is its most significant risk factor. Recently, questions have been raised about the role of the oral microbiome in OSCC due to evidence showing that the microbiome of OSCC differs from that of healthy mucosa. However, the impact of oral site and smoking on oral microbial communities and their role in OSCC and precursor lesions has not been considered.
FRONTIERS IN ORAL HEALTH
(2023)
Article
Microbiology
Sheila Galvin, Sviatlana Anishchuk, Claire M. Healy, Gary P. Moran
Summary: This study investigates the bacterial colonisation patterns of healthy mucosa in adults and finds that smoking, tooth loss, plaque levels, and oral hygiene practices affect mucosal colonisation. The frequency of tooth brushing has a greater impact on mucosal community structure than plaque levels. Tooth loss is associated with a reduction in mucosal biodiversity.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Mackenzie O'Connor, Grant Harrison, Declan Lenahan, Gary P. Moran
Summary: Human saliva contains natural antimicrobial enzymes. This study compared the antimicrobial activity of a dentifrice containing a salivary enzyme complex (SEC) with xylitol to a standard 0.12% chlorhexidine (CHX) dentifrice. The SEC-xylitol dentifrice showed significant reduction in bacterial viability and greater antimicrobial activity compared to CHX. The combination of SEC and xylitol generated a highly effective antimicrobial dentifrice with potential for routine use and management of gingivitis and periodontal disease.
LETTERS IN APPLIED MICROBIOLOGY
(2023)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
