Article
Radiology, Nuclear Medicine & Medical Imaging
Myles T. Taffel, Robert D. Petrocelli, Danielle Rigau, Nicola Schieda, Sumaya Al-Rasheed, Benjamin W. Carney, Ryan Chung, Michael L. Yao, Michael A. Blake, Khaled M. Elsayes, Mohamed Badawy, Sergio Klimkowski, Erick M. Remer, Adam Wetzel, Amit Pandya, Elaine M. Caoili, Michael T. Corwin
Summary: The presence of heterogeneous microscopic fat in adrenal nodules on chemical-shift MRI indicates a high likelihood of benignancy, particularly in patients without prior cancer. Additional imaging evaluation is not required for adrenal nodules with heterogeneous microscopic fat in the absence of prior cancer.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Oncology
Binhao Zhang, Huangqi Zhang, Xin Li, Shengze Jin, Jiawen Yang, Wenting Pan, Xue Dong, Jin Chen, Wenbin Ji
Summary: An unenhanced CT-based radiomics model was developed to effectively differentiate adrenal lipid-poor adenomas. The diagnostic power of conventional unenhanced CT imaging features may be underestimated and further exploration is warranted.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Jean Pierre Bayley, Birke Bausch, Jeroen C. Jansen, Erik F. Hensen, Karin van der Tuin, Eleonora P. M. Corssmit, Peter Devilee, Hartmut P. H. Neumann
Summary: This study investigates the genotype-phenotype associations of SDHB gene variants and finds that truncating variants are associated with a higher risk of developing both PPGL and malignancy compared to missense variants. These findings further support the previously established associations between truncating variants and PPGL, and suggest that the two variant types differ in their impact on complex II function.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Endocrinology & Metabolism
Zhijiang Han, Mengwei Wu, Peiying Wei, Hanlin Zhu, Xiaohan Zhang, Zhongxiang Ding, Ming Zhang
Summary: AV(mean), AV(min), and CTH are important parameters for differentiating adrenal adenoma from non-adenoma. Even for adenomas with AV(mean) > 10 HU, AV(min) and CTH still have high diagnostic efficiency.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Peng, Guanglei Tang, Mengya Sun, Shuang Yu, Yanglei Cheng, Yu Wang, Weiwei Deng, Yanbing Li, Jian Guan
Summary: This study assessed the feasibility of using spectral CT-derived extracellular volume (ECV) to differentiate aldosterone-producing nodules (APN) from nonfunctioning adrenal nodules (NFN). The results showed that the ECV fraction can effectively differentiate APN from NFN.
EUROPEAN RADIOLOGY
(2023)
Review
Urology & Nephrology
Marissa Maas, Nima Nassiri, Sumeet Bhanvadia, John D. Carmichael, Vinay Duddalwar, Siamak Daneshmand
Summary: Guidelines for the diagnosis and treatment of adrenal incidentalomas vary among specialties, particularly in terms of reimaging, repeat hormone testing, and management of tumors characterized as benign or malignant. Consensus on initial evaluation exists, but discrepancies arise in follow-up recommendations. Recommendations range from avoiding repeat imaging and hormone testing to frequent monitoring over several years. Best practices may lie in finding common ground among divergent guidelines.
JOURNAL OF UROLOGY
(2021)
Review
Endocrinology & Metabolism
Byung Kwan Park, Masashi Fujimori, Shu-Huei Shen, Uei Pua
Summary: The article introduces the first version of ACTA guidelines for adrenal tumor ablation, highlighting thermal ablation as a good alternative treatment for patients who are unable to undergo adrenalectomy.
ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Pharmacology & Pharmacy
Shilpi Singh, Waseem Raza, Shahnaz Parveen, Abha Meena, Suaib Luqman
Summary: miRNAs, as non-coding nucleotide sequences, play a crucial role in cancer development, with evidence suggesting that their deregulation is associated with tumorigenesis. Flavonoids are known to modulate miRNAs expression, potentially serving as chemopreventive agents by targeting miRNAs involved in cancer progression. While extensively studied in pre-clinical settings, more research is needed to explore the clinical implications of flavonoids in targeting miRNAs for cancer prevention and treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shengze Jin, Huangqi Zhang, Wenting Pan, Jiawen Yang, Binhao Zhang, Xue Dong, Xin Li, Xiuli Wu, Wenbin Ji
Summary: The relative enhancement ratio parameter has better diagnostic performance in differentiating lipid-poor adrenal adenomas from non-adenomas, particularly in differentiating them from hypoenhancing non-adenomas.
ABDOMINAL RADIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Valentina Angerilli, Francesca Galuppini, Gianluca Businello, Luca Dal Santo, Edoardo Savarino, Stefano Realdon, Vincenza Guzzardo, Lorenzo Nicole, Vanni Lazzarin, Sara Lonardi, Fotios Loupakis, Matteo Fassan
Summary: The introduction of precision therapies targeting specific gene mutations in neoplasms is revolutionizing oncology, but resistance mechanisms developed by tumors pose challenges to the effectiveness of these drugs over time. Identifying indicators for monitoring and overcoming drug resistance is crucial. MicroRNAs, as stable molecules easily detectable in tissues and biofluids, are ideal biomarkers for identifying patients with resistance to targeted therapies.
Article
Medicine, General & Internal
Juan Yao, Wen He, Huifang Chen, Yu Qi
Summary: This study aims to evaluate the nursing effect of continuous nursing intervention based on Internet Plus on patients with severe adrenal tumors. A total of 128 patients were divided into the observation group (received routine care) and the control group (received continuous care based on Internet Plus). The observation group showed significantly shorter recovery times, longer postoperative sleep time, lower visual analog scale scores, and improved psychological well-being and quality of life compared to the control group. Nursing intervention based on Internet Plus continuous mode can promote physical recovery, reduce psychological pressure, and improve the quality of life for severe adrenal tumor patients.
Article
Medicine, General & Internal
Barbara Gardella, Andrea Gritti, Annachiara Licia Scatigno, Anna Maria Clelia Gallotti, Francesca Perotti, Mattia Dominoni
Summary: Adrenal crisis in pregnant women is rare but can lead to serious maternal and fetal complications. Prompt diagnosis and treatment by a multidisciplinary team are crucial. This report discusses a case of adrenal crisis in a young pregnant woman with tuberculosis, cocaine abuse, and massive hemorrhage, and reviews the literature on the management of adrenal crisis and adrenal insufficiency in pregnancy.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Benjamin V. Stone, Jacob E. Tallman, Kelvin A. Moses
Summary: The study found that treatment of adrenocortical carcinoma at an academic center is associated with improved overall survival compared to community programs. Academic centers had more aggressive surgical treatment practices, and the survival benefit persisted even after controlling for treatment modality in multivariable analysis.
JOURNAL OF UROLOGY
(2021)
Review
Oncology
Rina Masadah, Syahrul Rauf, Muhammad Yogi Pratama, Claudio Tiribelli, Devis Pascut
Summary: miRNAs play a fundamental role in the drug and radioresistance of cervical cancer, with evidence suggesting their potential application in clinical settings. Understanding the mechanisms by which miRNAs affect resistance and exploring new combined therapies could improve outcomes for cervical cancer patients.
Article
Oncology
Wenjiao Tang, Juan Xu, Caigang Xu
Summary: Multiple myeloma (MM) is a common but incurable hematological malignancy. The bone marrow microenvironment plays a crucial role in MM, and noncoding RNAs are emerging as important regulators of intercellular communication within the microenvironment. This review summarizes recent advances in the regulatory mechanisms of noncoding RNAs in MM and discusses their therapeutic potential.
Article
Surgery
Stephan B. Dreyer, Sarah Rae, Kirsty Bisset, Rosie Upstill-Goddard, Georgios Gemenetzis, Amber L. Johns, Euan J. Dickson, Anubhav Mittal, Anthony Gill, Fraser T. Duthie, Antonio Pea, Rita Lawlor, Aldo Scarpa, Roberto Salvia, Alessandra Pulvirenti, Alessandro J. Zerbi, Federica V. Marchesi, Colin S. McKay, Andrew K. Biankin, Jaswinder B. Samra, David K. Chang, Nigel Jamieson
Summary: The aim of this study was to evaluate the performance of molecular subtypes in traditional staging criteria for pancreatic ductal adenocarcinoma (PDAC). The results showed that TNM staging criteria and margin status only have prognostic value in tumors with classical pancreatic subtype. Patients with squamous subtype tumors have a poor outcome regardless of favorable traditional pathological staging, and margin status has no impact on survival in squamous subtype.
Article
Surgery
Elise A. J. de Savornin Lohman, T. J. J. de Bitter, G. Hannink, M. F. T. Wietsma, E. Vink-Borger, I. D. Nagtegaal, T. J. Hugh, A. J. Gill, N. Bhimani, M. Seyed Ahadi, R. S. van der Post, Philip R. de Reuver
Summary: The study aimed to develop and validate a clinical prediction model for overall survival in patients with nonmetastatic, resected gallbladder cancer (GBC). Data from a Dutch cohort was used for development and an Australian cohort for external validation. The proposed model demonstrated superior discriminatory capacity compared to the AJCC staging system and can be a useful tool for physicians and patients.
Article
Pathology
Kwan Yee Tsui, Fiona Maclean, Denis Moir, Alison Cheah, Fiona Bonar, Joel Tabot, Anthony J. Gill, A. Cristina Vargas
Summary: This study aimed to determine the expression of FOS and FOSB in epithelioid hemangiomas and compare it with other vascular lesions. The results showed a high expression rate of FOSB, and the use of both antibodies increased the detection rate of epithelioid hemangiomas.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Letter
Pathology
C. Mitchell, V. Malalasekera, A. J. Gill, J. H. A. Vissers, S. J. Luen, S. M. Grimmond, J. Lewin
Article
Surgery
Hiro Masuda, Krishna Kotecha, Tamara Gall, Anthony J. Gill, Anubhav Mittal, Jaswinder S. Samra
Summary: This study examines the experience of a surgeon in Australia during the transition to robotic distal pancreatectomy. The results show that robotic distal pancreatectomy is feasible and safe in a traditionally low-volume country like Australia.
ANZ JOURNAL OF SURGERY
(2023)
Correction
Multidisciplinary Sciences
Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Jeremiah A. Wala, Ofer Shapira, Grace Tiao, Henrik Hornshoj, Julian M. Hess, Randi Istrup Juul, Ziao Lin, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andres Lanzos, Carl Herrmann, Yosef E. Maruvka, Ciyue Shen, Samirkumar B. Amin, Pratiti Bandopadhayay, Johanna Bertl, Keith A. Boroevich, John Busanovich, Joana Carlevaro-Fita, Dimple Chakravarty, Calvin Wing Yiu Chan, David Craft, Priyanka Dhingra, Klev Diamanti, Nuno A. Fonseca, Abel Gonzalez-Perez, Qianyun Guo, Mark P. Hamilton, Nicholas J. Haradhvala, Chen Hong, Keren Isaev, Todd A. Johnson, Malene Juul, Andre Kahles, Abdullah Kahraman, Youngwook Kim, Jan Komorowski, Kiran Kumar, Sushant Kumar, Donghoon Lee, Kjong-Van Lehmann, Yilong Li, Eric Minwei Liu, Lucas Lochovsky, Keunchil Park, Oriol Pich, Nicola D. Roberts, Gordon Saksena, Steven E. Schumacher, Nikos Sidiropoulos, Lina Sieverling, Nasa Sinnott-Armstrong, Chip Stewart, David Tamborero, Jose M. C. Tubio, Husen M. Umer, Liis Uuskuela-Reimand, Claes Wadelius, Lina Wadi, Xiaotong Yao, Cheng-Zhong Zhang, Jing Zhang, James E. Haber, Asger Hobolth, Marcin Imielinski, Manolis Kellis, Michael S. Lawrence, Christian von Mering, Hidewaki Nakagawa, Benjamin J. Raphael, Mark A. Rubin, Chris Sander, Lincoln D. Stein, Joshua M. Stuart, Tatsuhiko Tsunoda, David A. Wheeler, Rory Johnson, Jueri Reimand, Mark Gerstein, Ekta Khurana, Peter J. Campbell, Nuria Lopez-Bigas, Joachim Weischenfeldt, Rameen Beroukhim, Inigo Martincorena, Jakob Skou Pedersen, Gad Getz
Article
Pathology
Yagiz Aksoy, Angela Chou, Mahiar Mahjoub, Amy Sheen, Loretta Sioson, Mahsa S. Ahadi, Anthony J. Gill, Talia L. Fuchs
Summary: Recent advances in the management of Diffuse Pleural Mesothelioma (DPM) have increased interest in prognostication and risk stratification. Predictive modelling using deep learning algorithms is regarded as the gold standard in prognostication. We developed and validated a prognostic nomogram for DPM, which incorporates well-established prognostic markers and demonstrates excellent predictive capability.
Article
Otorhinolaryngology
Leba Michael Sarkis, Rory Clifton-Bligh, David Veivers, Anthony James Gill
Summary: This study aimed to estimate the prevalence of succinate dehydrogenase (SDH) deficiency in patients with carotid body paragangliomas. Out of 64 identified cases, 43 (67%) were found to be SDH-deficient. These findings suggest that genetic testing and counseling should be offered to all patients with carotid body paragangliomas.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Endocrinology & Metabolism
Nicholas Kesby, Robert Mechera, Talia Fuchs, Alexander Papachristos, Matti Gild, Venessa Tsang, Roderick Clifton-Bligh, Bruce Robinson, Mark Sywak, Stan Sidhu, Angela Chou, Anthony J. Gill, Anthony Glover
Summary: This study reports the outcomes of surgically managed sporadic micro-MTC and identifies factors associated with recurrence and disease-specific survival. Most sporadic micro-MTCs are incidentally detected and generally have good outcomes. Personalized management can be achieved by considering grade, lymph node metastasis, and postoperative calcitonin levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Sarah Maloney, Nick Pavlakis, Malinda Itchins, Jennifer Arena, Anubhav Mittal, Amanda Hudson, Emily Colvin, Sumit Sahni, Connie Diakos, David Chan, Anthony J. Gill, Jaswinder Samra, Stephen J. Clarke
Summary: Pancreatic cancer has low survival rates, and there are currently no available biomarkers to predict chemotherapy response or prognosis. However, studies have shown that higher neutrophil-to-lymphocyte ratios are associated with worse prognosis. Our study found that patients with a neutrophil-to-lymphocyte ratio >5 at diagnosis had shorter median overall survival compared to those with ratios <= 5. Additionally, a higher platelet-to-lymphocyte ratio was weakly correlated with increased residual tumor in patients receiving neoadjuvant chemotherapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Ian Brown, Andrew P. Zammit, Mark Bettington, Caroline Cooper, Anthony J. Gill, Agoston Agoston, Robert Odze
Summary: Most malignant colorectal polyps with adverse histological features do not have lymph node metastases at the time of resection, so there is a need for better refinement of histological risk factors. This study found that larger tumor size, vascular invasion, and poor tumor differentiation were associated with a higher risk for metastasis. A predictive model including factors such as vascular invasion, tumor budding, tumor width and depth, and peritumoral desmoplasia showed excellent performance in predicting metastatic disease.
Letter
Endocrinology & Metabolism
Nicholas Kesby, Robert Mechera, Talia Fuchs, Alexander Papachristos, Matti Gild, Venessa Tsang, Roderick Clifton-Bligh, Bruce Robinson, Mark Sywak, Stan Sidhu, Angela Chou, Anthony J. Gill, Anthony Glover
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Oncology
Sooin Byeon, Taymin du Toit-Thompson, Josef Gillson, Anthony J. Gill, Jaswinder S. Samra, Anubhav Mittal, Sumit Sahni
Summary: Background: Pancreatic ductal adenocarcinoma is one of the deadliest malignancies in the world, and its mortality rate is predicted to be the second-highest cause of cancer-related deaths by 2030. Methods: This review focuses on the use of single-cell RNA sequencing and other single-cell analysis technologies to uncover the heterogeneity of pancreatic ductal adenocarcinoma in different cellular subpopulations. Results and Conclusion: The application of single-cell RNA sequencing has revealed associations between disease progression and heterogeneity in the pancreatic tumor microenvironment, which could have implications for future treatment strategies.
Article
Oncology
Sumit Sahni, Christopher Nahm, Mahsa S. S. Ahadi, Loretta Sioson, Sooin Byeon, Angela Chou, Sarah Maloney, Elizabeth Moon, Nick Pavlakis, Anthony J. J. Gill, Jaswinder Samra, Anubhav Mittal
Summary: This study aimed to identify key differences in gene expression profile in tumors from chemoresponsive and chemoresistant patients. The results showed a distinct gene expression profile between good- and poor-chemotherapy responders, and a biomarker panel was selected with high diagnostic ability for good-responding PDAC patients.
Article
Oncology
Jessica L. Chitty, Michelle Yam, Lara Perryman, Amelia L. Parker, Joanna N. Skhinas, Yordanos F. I. Setargew, Ellie T. Y. Mok, Emmi Tran, Rhiannon D. Grant, Sharissa L. Latham, Brooke A. Pereira, Shona C. Ritchie, Kendelle J. Murphy, Michael Trpceski, Alison D. Findlay, Pauline Melenec, Elysse C. Filipe, Audrey Nadalini, Sipiththa Velayuthar, Gretel Major, Kaitlin Wyllie, Michael Papanicolaou, Shivanjali Ratnaseelan, Phoebe A. Phillips, George Sharbeen, Janet Youkhana, Alice Russo, Antonia Blackwell, Jordan F. Hastings, Morghan C. Lucas, Cecilia R. Chambers, Daniel A. Reed, Janett Stoehr, Claire Vennin, Ruth Pidsley, Anaiis Zaratzian, Andrew M. Da Silva, Michael Tayao, Brett Charlton, David Herrmann, Max Nobis, Susan J. Clark, Andrew V. Biankin, Amber L. Johns, David R. Croucher, Adnan Nagrial, Anthony J. Gill, Sean M. Grimmond, Amber L. Johns, Anthony J. Gill, Lorraine A. Chantrill, Paul Timpson, Angela Chou, Marina Pajic, Tanya Dwarte, David Herrmann, Claire Vennin, Thomas R. Cox, Brooke A. Pereira, Shona C. Ritchie, Daniel A. Reed, Cecilia R. Chambers, Xanthe L. Metcalf, Max Nobis, Gloria Jeong, Lara Kenyon, Nicola Waddell, John V. Pearson, Ann-Marie Patch, Katia Nones, Felicity Newell, Pamela Mukhopadhyay, Venkateswar Addala, Stephen Kazakoff, Oliver Holmes, Conrad Leonard, Scott Wood, Sean M. Grimmond, Oliver Hofmann, Jaswinder S. Samra, Nick Pavlakis, Jennifer Arena, Hilda A. High, Ray Asghari, Neil D. Merrett, Amitabha Das, Peter H. Cosman, Kasim Ismail, Alina Stoita, David Williams, Allan Spigellman, Duncan Mcleo, Judy Kirk, James G. Kench, Peter Grimison, Charbel Sandroussi, Annabel Goodwin, R. Scott Mead, Katherine Tucker, Lesley Andrews, Michael Texler, Cindy Forrest, Mo Ballal, David Fletcher, Maria Beilin, Kynan Feeney, Krishna Epari, Sanjay Mukhedkar, Nikolajs Zeps, Nan Q. Nguyen, Andrew R. Ruszkiewicz, Chris Worthley, John Chen, Mark E. Brooke-Smith, Virginia Papangelis, Andrew D. Clouston, Andrew P. Barbour, Thomas J. O'Rourke, Jonathan W. Fawcett, Kellee Slater, Michael Hatzifotis, Peter Hodgkinson, Mehrdad Nikfarjam, James R. Eshleman, Ralph H. Hruban, Christopher L. Wolfgang, Aldo Scarpa, Rita T. Lawlor, Vincenzo Corbo, Claudio Bassi, Andrew V. Biankin, Nigel B. Jamieson, David K. Chang, Stephan B. Dreyer, Paul Timpson, Thomas R. Cox, Marina Pajic, Anthony J. Gill, Jaswinder S. Samra, Brooke A. Pereira, David Herrmann, Amber L. Johns, Gloria Jeong, Shona C. Ritchie, Daniel A. Reed, Cecilia R. Chambers, Janett Stoehr, Morghan C. Lucas, Joanna N. Skhinas, Lea Abdulkhalek, Max Nobis, Tatjana Schmitz, Victoria Lee, Xanthe L. Metcalf, Sean M. Grimmond, Kym Pham Stewart, Mehreen Arshi, Angela M. Steinmann, Lara Kenyon, Marina Pajic, Paul Timpson, Wolfgang Jarolimek, Thomas R. Cox
Summary: The pan-lysyl oxidase inhibitor PXS-5505 reduces chemotherapy-induced desmoplasia and stiffness, improving chemotherapy response and survival in pancreatic cancer models.