mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma

Activation of SREBP1-mediated lipogenesis by the Epstein-Barr Virus-encoded LMP1 promotes cell proliferation and progression of nasopharyngeal carcinoma

(2018) Angela Kwok-Fung Lo et al.   JOURNAL OF PATHOLOGY

Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma

(2018) Weitao Lin et al.   Nature Communications

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

Epstein–Barr virus infection and nasopharyngeal carcinoma

(2017) Sai Wah Tsao et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma

(2017) Xianyue Ren et al.   Nature Communications

Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

(2017) Yvonne Y Li et al.   Nature Communications

LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma

(2017) Ting-Ting Cai et al.   PLoS Pathogens

Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer

(2017) Peter W Stacpoole   JNCI-Journal of the National Cancer Institute

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming

(2016) Young Chan Chae et al.   CANCER CELL

Nasopharyngeal carcinoma

(2016) Melvin L K Chua et al.   LANCET

Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity

(2016) D Zhang et al.   ONCOGENE

Metabolic stress is a barrier to Epstein–Barr virus-mediated B-cell immortalization

(2016) Karyn McFadden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

mTORC2 is a tyrosine kinase

(2015) Xuemin Wang et al.   CELL RESEARCH

Significance of NF-κB activation in immortalization of nasopharyngeal epithelial cells

(2015) Dan Dan Zhu et al.   INTERNATIONAL JOURNAL OF CANCER

Activation of the FGFR1 signalling pathway by the Epstein-Barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells

(2015) Angela Kwok-Fung Lo et al.   JOURNAL OF PATHOLOGY

Metabolic reprogramming: a hallmark of viral oncogenesis

(2015) P Lévy et al.   ONCOGENE

The motility-proliferation-metabolism interplay during metastatic invasion

(2015) Inbal Hecht et al.   Scientific Reports

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

The Role of Snail in EMT and Tumorigenesis

(2014) Yifan Wang et al.   CURRENT CANCER DRUG TARGETS

The role of Epstein-Barr virus in epithelial malignancies

(2014) Sai-Wah Tsao et al.   JOURNAL OF PATHOLOGY

LMP1 Promotes Expression of Insulin-Like Growth Factor 1 (IGF1) To Selectively Activate IGF1 Receptor and Drive Cell Proliferation

(2014) Kathryn Tworkoski et al.   JOURNAL OF VIROLOGY

Targeting Epstein–Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy

(2014) L Xiao et al.   ONCOGENE

Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition

(2014) A. Hamabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells

(2012) C. M. Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epstein-Barr Virus-Encoded LMP1 Interacts with FGD4 to Activate Cdc42 and Thereby Promote Migration of Nasopharyngeal Carcinoma Cells

(2012) Hao-Ping Liu et al.   PLoS Pathogens

Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial–mesenchymal transition in metastatic nasopharyngeal carcinoma

(2011) T Horikawa et al.   BRITISH JOURNAL OF CANCER

IKK  and NF- B Transcription Govern Lymphoma Cell Survival through AKT-Induced Plasma Membrane Trafficking of GLUT1

(2011) T. G. Sommermann et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Epstein-Barr virus infection in immortalized nasopharyngeal epithelial cells: Regulation of infection and phenotypic characterization

(2010) Chi Man Tsang et al.   INTERNATIONAL JOURNAL OF CANCER

Epstein-Barr Virus Latent Membrane Protein-1 Effects on Junctional Plakoglobin and Induction of a Cadherin Switch

(2009) K. H.Y Shair et al.   CANCER RESEARCH