Journal
OCULAR SURFACE
Volume 17, Issue 2, Pages 186-197Publisher
ELSEVIER
DOI: 10.1016/j.jtos.2019.01.008
Keywords
Autophagy; Cornea; Stroma; Corneal fibrosis; Keratoconus; Angiogenesis; Autophagy dysregulation; Atg
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Funding
- University of Missouri Ruth M. Kraeuchi Missouri Endowed Chair Ophthalmology Fund (RRM)
- NIH/NEI [R01EY017294]
- Veterans Health Affairs Merit [1I01BX00357]
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Autophagy is a well-conserved self-eating mechanism of cell survival during periods of nutrient deprivation, stress and injury. Autophagy is implicated in many pathophysiological conditions across all organ systems. The cornea is an avascular transparent tissue that is prone to damage by trauma, injury and infection. Following insult, the cornea undergoes a complex wound healing process, which is regulated by multiple factors including autophagy. The involvement of autophagy in keratoconus and HSV-1 infection has been demonstrated, underlining the importance of this mechanism in corneal disorders. However, the role of autophagy in corneal wound repair, fibrosis and angiogenesis is still unclear. Recently, we characterized the expression of autophagy-related genes in cornea and are studying their role in the modulation of corneal conditions including fibrosis and dystrophies. Preliminary results presented within this review article support further investigation of the dynamic modulation of autophagy-related genes in corneal health and disease. This article provides an overview of how autophagy modulates corneal function.
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