Article
Nutrition & Dietetics
Malia S. Q. Murphy, Katherine A. Muldoon, Hauna Sheyholislami, Nathalie Behan, Yvonne Lamers, Natalie Rybak, Ruth Rennicks White, Alysha L. J. Harvey, Laura M. Gaudet, Graeme N. Smith, Mark C. Walker, Shi Wu Wen, Amanda J. MacFarlane
Summary: The study found that high-dose folic acid supplementation in early pregnancy can increase maternal serum folate concentrations but does not increase red blood cell folate concentrations, suggesting tissue saturation. Higher UMFA concentrations in women receiving high-dose folic acid supplements suggest that these doses may be supraphysiological, but there is no evidence of altered 1-carbon metabolism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Nutrition & Dietetics
Nayomi Perera, Victoria L. Rudland, David Simmons, Sarah A. L. Price
Summary: Folate supplementation is important for preventing neural tube defects in the periconceptual period. Some countries have mandatory folic acid fortification in food. Low-dose folic acid (0.4 mg/day) is recommended for all women, and high-dose folic acid (5 mg/day) is recommended for women with pre-existing diabetes in some guidelines.
Article
Obstetrics & Gynecology
Daniel J. Corsi, Laura M. Gaudet, Darine El-Chaar, Ruth Rennicks White, Natalie Rybak, Alysha Harvey, Katerine Muldoon, Shi Wu Wen, Mark Walker
Summary: The study aimed to determine the efficacy of high-dose folic acid for the prevention of preeclampsia in twin pregnancies, but the results showed that high-dose folic acid supplementation was not significantly associated with a reduced risk of preeclampsia. This may provide insights into the etiology of preeclampsia, despite the lack of a confirmed elevated risk.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Food Science & Technology
Hanxiao Chen, Lang Qin, Rui Gao, Xiaolei Jin, Kemin Cheng, Sirui Zhang, Xiao Hu, Wenming Xu, Hongjing Wang
Summary: In this study, a systematic review and meta-analysis were conducted to investigate the impact of maternal folic acid supplementation on postnatal neurodevelopmental outcomes. The findings suggest that prenatal folic acid supplementation has positive effects on offspring's neurodevelopment, including improved intellectual development and reduced risk of autism traits, ADHD, behavioral, and language problems. However, excessive folic acid supplementation may not improve offspring's brain development and may even have negative impacts on neurodevelopmental outcomes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Pediatrics
Fushuang Yang, Jinpu Zhu, Zhongtian Wang, Lei Wang, Tianhui Tan, Liping Sun
Summary: This systematic review and meta-analysis found a significant association between maternal folic acid supplementation during pregnancy and the risk of childhood asthma. Folic acid supplementation during different stages of pregnancy (first trimester, third trimester, and entire pregnancy) was significantly correlated with asthma risk. Additionally, the dose-response analysis revealed a nonlinear relationship between maternal folic acid intake during pregnancy and the risk of childhood asthma.
FRONTIERS IN PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Fanny Petermann-Rocha, Desiree Valera-Gran, Daniel Prieto-Botella, Dries S. Martens, Sandra Gonzalez-Palacios, Isolina Riano-Galan, Mario Murcia, Amaia Irizar, Jordi Julvez, Loreto Santa-Marina, Adonina Tardon, Jordi Sunyer, Jesus Vioque, Tim Nawrot, Eva-Maria Navarrete-Munoz
Summary: This study found that the use of high-dose folic acid supplements during pregnancy may be associated with shorter telomere length in children at age four, particularly in boys.
Review
Nutrition & Dietetics
Omid Asbaghi, Damoon Ashtary-Larky, Reza Bagheri, Seyedeh Parisa Moosavian, Behzad Nazarian, Reza Afrisham, Mahnaz Rezaei Kelishadi, Alexei Wong, Frederic Dutheil, Katsuhiko Suzuki, Amirmansour Alavi Naeini
Summary: This study found that folic acid supplementation may improve inflammation by reducing serum concentrations of CRP, but had no significant effects on IL-6 and TNF-alpha. Dose-response analysis showed a significant relationship between higher doses of folic acid supplementation and lower CRP concentrations. Future RCTs with larger sample sizes and more diverse populations are needed to confirm and expand these findings.
Article
Medicine, General & Internal
Emmanuelle Mathieu d'Argent, Celia Ravel, Alexandra Rousseau, Karine Morcel, Nathalie Massin, Julie Sussfeld, Tabassome Simon, Jean-Marie Antoine, Jacqueline Mandelbaume, Emile Darai, Kamila Kolanska
Summary: High-dose folic acid supplementation in men with male infertility undergoing IVF-ICSI has been shown to increase the biochemical pregnancy rate, reduce DNA fragmentation, and potentially improve the clinical pregnancy rate. Despite no observed changes in sperm characteristics, folic acid supplementation appears to have a positive impact on IVF-ICSI outcomes for male infertility patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Xingyue Yang, Wenyan Sun, Qian Wu, Hongyan Lin, Zhixing Lu, Xin Shen, Yongqi Chen, Yan Zhou, Li Huang, Feng Wu, Fei Liu, Dandan Chu
Summary: The use of folic acid during early pregnancy can protect against birth defects, but excess folic acid has been shown to have gender-specific neurodevelopmental toxicity. This study found that female offspring exposed to excess folic acid exhibited increased anxiety, impaired exploratory behavior, motor coordination, and spatial memory. Gene expression analysis revealed specific changes in the brain transcriptome of the female offspring. Certain genes showed apparent gender specificity in response to excess folic acid.
Article
Clinical Neurology
Zhen Yang, Sisi Hu, Wei Tong, Zhihao Xu, Xiaoliu Huang, Weiye Wang
Summary: This study investigated the relationship between sleep duration, quality, and risk of gestational diabetes mellitus (GDM), as well as the impact of folic acid (FA) supplementation on this relationship. The results showed that both short and long sleep durations were associated with increased risk of GDM. Poor sleep quality also increased the risk. However, adequate FA supplementation was found to mitigate the increased risk of GDM associated with short sleep duration.
SLEEP AND BREATHING
(2023)
Article
Agriculture, Dairy & Animal Science
Abdelrahman A. Kilany, Abdel-Halim A. El-Darawany, Akram A. El-Tarabany, Khaled M. Al-Marakby
Summary: The research found that oral folic acid supplementation can improve progesterone levels, blood metabolites, and biochemical indices in heat-stressed Holstein cows, which helps maintain normal reproductive capabilities.
Article
Food Science & Technology
Berin Doru, Nele Hockamp, Erika Sievers, Philipp Huelk, Thomas Luecke, Mathilde Kersting
Summary: Supplementation of certain micronutrients during pregnancy and lactation, particularly folic acid and iodine, is recommended in Germany. A nationwide study found that the majority of mothers did not adhere to these recommendations, with only a small percentage following them for both folic acid and iodine.
FOOD SCIENCE & NUTRITION
(2023)
Article
Nutrition & Dietetics
Kazi Istiaque Sanin, Mahbubul Alam Shaun, Razia Sultana Rita, Md. Khaledul Hasan, Mansura Khanam, Md. Ahshanul Haque
Summary: This study analyzed data from the 2017-2018 Bangladesh Demographic and Health Survey and found that full compliance to iron-folic acid supplementation (IFAS) is still sub-optimal in Bangladesh. Precise context-specific intervention strategies need to be developed and implemented to improve the level of full compliance.
Review
Biochemistry & Molecular Biology
Ilona Jaszczuk, Izabela Winkler, Dorota Koczkodaj, Maciej Skrzypczak, Agata Filip
Summary: This review article analyzes the role of C19MC miRNA in the development of pre-eclampsia and summarizes the current research data. The results indicate that C19MC miRNAs are significantly upregulated in placental tissue of pre-eclampsia patients and can be detected in high levels in the blood. Among them, miR-525-5p shows low expression in the plasma of the first trimester. By identifying these miRNAs, it may be possible to predict the development of pre-eclampsia before the onset of clinical symptoms, thereby avoiding serious complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Jiang Xiaomang, Wei Yanling
Summary: This study supplemented pregnant women with vitamin D3 to observe its effect on the risk of pre-eclampsia. The results showed a significant increase in vitamin D levels in the high-dose group, a lower relative risk reduction rate, and a significantly lower incidence of pre-eclampsia.
JOURNAL OF PERINATAL MEDICINE
(2021)
