☆ 4.6 Article

Pre-existing malignancies in renal transplant candidates-time to reconsider waiting times

NEPHROLOGY DIALYSIS TRANSPLANTATION (2019)

Journal

NEPHROLOGY DIALYSIS TRANSPLANTATION

Volume 34, Issue 8, Pages 1292-1300

Publisher

OXFORD UNIV PRESS

DOI: 10.1093/ndt/gfz026

Keywords

malignancy; pretransplant evaluation; transplantation; waiting list; waiting time

Categories

Transplantation Urology & Nephrology

Funding

ERA-EDTA

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

Current proposals for waiting times for a renal transplant after malignant disease may not be appropriate. New data on malignancies in end-stage renal disease and recent diagnostic and therapeutic options should lead us to reconsider our current practice.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Critical Care Medicine

Incorporating Effects of Time Accrued on the Waiting List into Lung Transplantation Survival Models

Jarrod E. Dalton, Paul R. Gunsalus, Carli J. Lehr, Johnie Rose, Belinda L. Udeh, Maryam Valapour

Summary: The current U.S. lung transplant mortality risk models do not consider the disease progression of patients over time. This study investigated the impact of accrued waitlist time on mortality in lung transplant candidates and recipients beyond clinical deterioration and proposed a new framework for conceptualizing mortality risk in end-stage lung disease.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)

Add to Collection

Review Oncology

Role of Pretransplant Treatments for Patients with Hepatocellular Carcinoma Waiting for Liver Transplantation

Kohei Ogawa, Yasutsugu Takada

Summary: Hepatocellular carcinoma (HCC) is a common cancer in men and a leading cause of cancer death. Liver transplantation (LT) is a treatment option for HCC patients. Locoregional therapy, such as transarterial chemoembolization and radiofrequency ablation, has been used as a pretreatment before LT. In Western countries, locoregional therapy is used to bridge until transplantation or for downstaging. Recent reports have clarified the effects of bridging and downstaging locoregional therapy before LT.

CANCERS (2022)

Add to Collection

Article Microbiology

COVID-19-Importance for Patients on the Waiting List and after Kidney Transplantation-A Single Center Evaluation in 2020-2021

Simone C. Boedecker, Pascal Klimpke, Daniel Kraus, Stefan Runkel, Peter R. Galle, Martina Koch, Julia Weinmann-Menke

Summary: Dialysis patients and kidney transplant recipients are at high risk for SARS-CoV-2 infection, but immunocompromised patients can still develop antibodies. In Germany, patients on the waiting list experienced mild symptoms, while transplanted patients needed hospitalization but recovered quickly.

PATHOGENS (2021)

Add to Collection

Review Surgery

Pretransplant solid organ malignancy and organ transplant candidacy: A consensus expert opinion statement

David P. Al-Adra, Laura Hammel, John Roberts, E. Steve Woodle, Deborah Levine, Didier Mandelbrot, Elizabeth Verna, Jayme Locke, Jonathan D'Cunha, Maryjane Farr, Deirdre Sawinski, Piyush K. Agarwal, Jennifer Plichta, Sandhya Pruthi, Deborah Farr, Richard Carvajal, John Walker, Fiona Zwald, Thomas Habermann, Morie Gertz, Philip Bierman, Don S. Dizon, Carrie Langstraat, Talal Al-Qaoud, Scott Eggener, John P. Richgels, George J. Chang, Cristina Geltzeiler, Gonzalo Sapisochin, Rocco Ricciardi, Alexander S. Krupnick, Cassie Kennedy, Nisha Mohindra, David P. Foley, Kymberly D. Watt

Summary: This article discusses the evaluation of solid organ transplantation for patients with a history of malignancy, emphasizing the need to balance the benefits of transplantation and the risk of tumor recurrence. It also points out that previous guidelines do not fully consider current staging, disease biology, and advances in cancer treatments.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Add to Collection

Article Medicine, General & Internal

Tumor Recurrence and Graft Survival in Renal Transplant Recipients with a History of Pretransplant Malignancy: A Matched Pair Analysis

Felix Becker, Anne-Sophie Mehdorn, Vasilios Getsopulos, Katharina Schuette-Nuetgen, Stefan Reuter, Barbara Suwelack, Andreas Pascher, Jens G. Brockmann, Ralf Bahde

Summary: The study found that renal transplant recipients with a history of pretransplant malignancy (PTM) have inferior graft survival rates, highlighting the need for enhanced monitoring of these recipients and heightened vigilance for cancer recurrence.

JOURNAL OF CLINICAL MEDICINE (2021)

Add to Collection

Article Urology & Nephrology

Waiting Time for Second Kidney Transplantation and Mortality

Alexander Kainz, Michael Kammer, Roman Reindl-Schwaighofer, Susanne Strohmaier, Vojtch Petr, Ondrej Viklicky, Daniel Abramowicz, Marcel Naik, Gert Mayer, Rainer Oberbauer

Summary: The study results indicate that second kidney transplantation is associated with longer survival time compared to remaining on the waiting list after 10 years of follow-up. However, this survival difference diminishes with longer waiting times after the loss of the first graft.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Impact of Pretransplant Malignancy on Heart Transplantation Outcomes: Contemporary United Network for Organ Sharing Analysis Amidst Evolving Cancer Therapies

Jaya Batra, Ersilia M. DeFilippis, Stephanie Golob, Kevin Clerkin, Veli K. Topkara, Marlena Habal, Susan Restaino, Jan Griffin, Sun Hi Lee, Farhana Latif, Maryjane A. Farr, Gabriel Sayer, Jayant Raikelkar, Nir Uriel

Summary: The prevalence of pretransplant malignancy in heart transplant recipients has nearly tripled over the past 20 years. Patients with hematologic pretransplant malignancy are at increased risk of early mortality after heart transplantation. Patients with pretransplant malignancy are also more likely to develop posttransplant malignancies.

CIRCULATION-HEART FAILURE (2022)

Add to Collection

Article Urology & Nephrology

Patient Preferences for Waiting Time and Kidney Quality

Sanjay Mehrotra, Juan Marcos Gonzalez, Karolina Schantz, Jui-Chen Yang, John J. Friedewald, Richard Knight

Summary: Understanding patient preferences regarding accepting marginal-quality kidneys could help increase the transplantation of currently discarded kidneys, particularly for older patients with lower functional status.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

Add to Collection

Article Urology & Nephrology

Frailty among chronic kidney disease patients on the kidney transplant waiting list: the sex-frailty paradox

Maria Jose Perez-Saez, Carlos E. Arias-Cabrales, Vanesa Davalos-Yerovi, Dolores Redondo, Anna Faura, Maria Vera, Anna Bach, Guillermo Pedreira, Ernestina Junyent, Marta Crespo, Ester Marco, Leocadio Rodriguez-Manas, Julio Pascual

Summary: Frailty is more common in women with advanced CKD compared to men, with differences in frailty criteria distribution and phenotype between sexes. This suggests the need for specific and individualized interventions to improve their status before transplantation.

CLINICAL KIDNEY JOURNAL (2022)

Add to Collection

Article Mathematics

Dynamic Surgical Waiting List Methodology: A Networking Approach

Fabian Silva-Aravena, Jenny Morales

Summary: The supply of medical care has decreased due to the COVID-19 crisis in Chile and the world. In Chile, there is a critical outlook in both medical and surgical care, with 1.7 million people waiting for care and surgery wait times increasing to an average of 525 days. This paper proposes a methodology using machine learning to predict the prioritization of patients on surgical waiting lists at a high complexity hospital in Chile, aiming to optimize the process and reduce wait times. The proposed prioritization strategy shows potential for significant savings in medical hours and a decrease in the risk of waiting patients.

MATHEMATICS (2022)

Add to Collection

Article Public, Environmental & Occupational Health

Waiting for kidney transplantation from deceased donors: Experiences and support needs during the waiting time -A qualitative study

Kristina Nilsson, Mats Westas, Gerhard Andersson, Peter Johansson, Johan Lundgren

Summary: This study explores and describes the experiences of patients waiting for kidney transplantation and the support they receive during the waiting period. The findings highlight the challenges faced by patients during the waiting period, including lack of understanding of the transplantation process and unrealistic expectations of post-transplantation life. The study emphasizes the need for continuous education and support to help patients manage the waiting time.

PATIENT EDUCATION AND COUNSELING (2022)

Add to Collection

Article Nutrition & Dietetics

Bioelectrical impedance vector analysis in patients on the waiting list for liver transplant: Associated factors and prognostic effects

Barbara Chaves Santos, Livia Garcia Ferreira, Helem Sena Ribeiro, Maria Isabel Toulson Davisson Correia, Agnaldo Soares Lima, Francisco Guilherme Cancela E Penna, Lucilene Rezende Anastacio

Summary: This study aimed to assess patients on the waiting list for liver transplant using bioelectrical impedance vector analysis (BIVA) and determine the association between vector placement on the graph and clinical outcomes. The study found that patients with vectors placed in quadrant 4 (Q4) had a worse prognosis.

NUTRITION (2022)

Add to Collection

Article Medicine, General & Internal

Prognostic Significance of the N-Terminal Pro-B-Type Natriuretic Peptide in Lung Transplant Candidates on the Waiting List

Shimon Izhakian, Assaf Frajman, Lev Freidkin, Osnat Shtraichman, Dror Rosengarten, Barak Pertzov, Yaron D. Barac, Mordechai Reuven Kramer

Summary: This study investigated the prognostic significance of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in lung transplant candidates. The results showed that NT-proBNP levels were associated with age, lung function, and pulmonary artery pressure, and higher levels were associated with increased mortality among the candidates.

DIAGNOSTICS (2022)

Add to Collection

Article Engineering, Aerospace

A Simulated Annealing Algorithm with Tabu List for the Multi-Satellite Downlink Schedule Problem Considering Waiting Time

Yan Liu, Shengyu Zhang, Haiying Hu

Summary: In this study, a method is proposed to solve the multi-satellite and multi-ground station downlink task scheduling problem. By using a two-stage scheduling strategy and simulated annealing algorithm, the efficiency of task selection and the waiting time can be improved. Simulation analysis validates the practical value of this method.

AEROSPACE (2022)

Add to Collection

Article Medicine, General & Internal

Trends in Cost Attributable to Kidney Transplantation Evaluation and Waiting List Management in the United States, 2012-2017

Xingxing S. Cheng, Jialin Han, Jennifer L. Braggs-Gresham, Philip J. Held, Stephan Busque, John P. Roberts, Jane C. Tan, John D. Scandling, Glenn M. Chertow, Avi Dor

Summary: This study aims to describe the temporal trends in Organ Acquisition Cost Center (OACC) costs per kidney transplantation and identify the factors associated with cost. The study found that OACC costs increased by 4% per year from 2012 to 2017 and were not solely attributable to the cost of organ procurement. Expanding the waiting list is likely to contribute to further increases in OACC costs and substantially increase Medicare liability.

JAMA NETWORK OPEN (2022)

Add to Collection

Article Urology & Nephrology

What matters to you?: The relevance of patient priorities in dialysis care for assessment and clinical practice

Judith Tommel, Andrea W. M. Evers, Henk W. van Hamersvelt, Rien Jordens, Sandra van Dijk, Luuk B. Hilbrands, Marc M. H. Hermans, Daan A. M. J. Hollander, Jos J. van de Kerkhof, Marc A. G. J. ten Dam, Henriet van Middendorp

Summary: The study aimed to identify dialysis patients' most prominent problems and calculate disease-specific norms for questionnaires measuring these problems. Results showed that fatigue was the most prominent problem, and patient priorities and functioning domains differed based on patient characteristics.

SEMINARS IN DIALYSIS (2023)

Add to Collection

Article Immunology

Antibody and T-Cell Responses 6 Months After Coronavirus Disease 2019 Messenger RNA-1273 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant

Jan Stephan F. Sanders, A. Lianne Messchendorp, Rory D. de Vries, Carla C. Baan, Debbie van Baarle, Rob van Binnendijk, Dimitri A. Diavatopoulos, Daryl Geers, Katharina S. Schmitz, Corine H. GeurtsvanKessel, Gerco den Hartog, Marcia M. L. Kho, Marion P. G. Koopmans, Renate G. van der Molen, Ester B. M. Remmerswaal, Nynke Rots, Ron T. Gansevoort, Frederike J. Bemelman, Luuk B. Hilbrands, Marlies E. J. Reinders

Summary: The immune response to COVID-19 vaccination is inferior in kidney transplant recipients and to a lesser extent in patients on dialysis or with chronic kidney disease. The antibody levels and T-cell responses significantly decrease after 6 months of vaccination, and neutralization of the Omicron variant is barely detectable.

CLINICAL INFECTIOUS DISEASES (2023)

Add to Collection

Article Infectious Diseases

Alternative strategies to increase the immunogenicity of COVID-19 vaccines in kidney transplant recipients not responding to two or three doses of an mRNA vaccine (RECOVAC): a randomised clinical trial

Marcia M. L. Kho, A. Lianne Messchendorp, Sophie C. Froelke, Celine Imhof, Vera J. C. H. Koomen, S. Reshwan K. Malahe, Priya Vart, Daryl Geers, Rory D. de Vries, Corine H. Geurtsvan Kessel, Carla C. Baan, Renate G. van der Molen, Dimitri A. Diavatopoulos, Ester B. M. Remmerswaal, Debbie van Baarle, Rob van Binnendijk, Gerco den Hartog, Aiko P. J. de Vries, Ron T. Gansevoort, Frederike J. Bemelman, Marlies E. J. Reinders, Jan-Stephan F. Sanders, Luuk B. Hilbrands

Summary: This study aimed to compare three alternative strategies for improving the COVID-19 vaccine response in kidney transplant recipients: double vaccine dose, heterologous vaccination, and temporary discontinuation of mycophenolate mofetil or mycophenolic acid. The results showed that repeated vaccination increased SARS-CoV-2-specific antibodies in kidney transplant recipients, but higher dose, heterologous vaccine, or discontinuation of immunosuppressants did not further enhance the response.

LANCET INFECTIOUS DISEASES (2023)

Add to Collection

Editorial Material Medicine, General & Internal

Six pills less: no benefit for bicarbonate supplementation in renal allograft recipients

Klemens Budde, Fabian Halleck

LANCET (2023)

Add to Collection

Article Transplantation

A single centre in-depth analysis of death with a functioning kidney graft and reasons for overall graft failure

Manuel Mayrdorfer, Lutz Liefeldt, Bilgin Osmanodja, Marcel G. Naik, Danilo Schmidt, Wiebke Duettmann, Charlotte Hammett, Eva Schrezenmeier, Frank Friedersdorff, Kaiyin Wu, Fabian Halleck, Klemens Budde

Summary: This study analyzed 1477 adult kidney transplants and found that cardiovascular disease, malignancy, and infections were the most common causes of death. The study also discovered that there were many shared causes between death with a functioning graft and death-censored graft failure.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2023)

Add to Collection

Review Transplantation

The 3-Step Model of informed consent for living kidney donation: a proposal on behalf of the DESCaRTES Working Group of the European Renal Association

Alessandra Agnese Grossi, Mehmet Sukru Sever, Rachel Hellemans, Christophe Mariat, Marta Crespo, Bruno Watschinger, Licia Peruzzi, Erol Demir, Arzu Velioglu, Ilaria Gandolfini, Gabriel C. Oniscu, Luuk Hilbrands, Geir Mjoen

Summary: Living donation challenges the ethical principle of non-maleficence as it involves exposing healthy individuals to risks for the sake of others. A proposed 3-S Model for standardized informed consent (IC) in living kidney donation emphasizes the importance of safety, education, and equitable decision-making. This model provides guidance for nephrologists and transplant clinicians concerning timing, content, communication of risks, and assessment of understanding prior to donation.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2023)

Add to Collection

Review Pediatrics

Rejection markers in kidney transplantation: do new technologies help children?

Licia Peruzzi, Silvia Deaglio

Summary: Recent insights have revealed that the process of allorecognition and graft rejection in transplantation involves multiple pathways of both adaptive and innate immune response. Traditional markers for transplant monitoring, such as serum creatinine, proteinuria, and drug blood levels, are widely used due to their affordability and availability. Donor-specific antibodies, the most common immunological biomarkers, are included in routine post-transplant monitoring but have some reproducibility issues. New omic technologies have led to the identification of novel biomarkers, including urinary chemokines and cell-free DNA of donor origin, which show promise but are currently expensive. Transcriptomics, metabolomics, proteomics, and the study of extracellular vesicles also have the potential for early identification of rejection in a cost-effective manner. These new biomarkers are expected to integrate with traditional tools for improved rejection detection and timely intervention.

PEDIATRIC NEPHROLOGY (2023)

Add to Collection

Review Urology & Nephrology

Strategies to prevent SARS-CoV-2 transmission in hemodialysis centres across Europe-lessons for the future

Marlies Noordzij, Bjorn Meijers, Ron T. Gansevoort, Adrian Covic, Raphael Duivenvoorden, Luuk B. Hilbrands, Marc H. Hemmelder, Kitty J. Jager, Geir Mjoen, Ionut Nistor, Ekaterina Parshina, Giuseppina Pessolano, Serhan Tuglular, Priya Vart, Luca Zanoli, Casper F. M. Franssen, ERACODA collaborators

Summary: This study analyzed the infection prevention and control strategies implemented by dialysis centers in Europe during the first wave of the COVID-19 pandemic. The results showed that most centers implemented measures such as fever screening, hand disinfection, and mask-wearing to prevent the spread of the virus. There were variations between centers and national guidelines in terms of recommended distances between dialysis chairs and isolation practices.

CLINICAL KIDNEY JOURNAL (2023)

Add to Collection

Article Multidisciplinary Sciences

When performance is not enough-A multidisciplinary view on clinical decision support

Roland Roller, Aljoscha Burchardt, David Samhammer, Simon Ronicke, Wiebke Duettmann, Sven Schmeier, Sebastian Moeller, Peter Dabrock, Klemens Budde, Manuel Mayrdorfer, Bilgin Osmanodja

Summary: This article discusses the application of machine learning models in healthcare and presents a multidisciplinary view of medical decision support systems. It covers information technology, medical, and ethical aspects and provides insights into implementing and evaluating these systems in a clinical setting.

PLOS ONE (2023)

Add to Collection

Article Pharmacology & Pharmacy

Immunosuppressant drugs and quality-of-life outcomes in kidney transplant recipients: An international cohort study (EU-TRAIN)

Francois R. Girardin, Anna Nicolet, Oriol Bestard, Carmen Lefaucheur, Klemens Budde, Fabian Halleck, Sophie Brouard, Magali Giral, Pierre-Antoine Gourraud, Beatrice Horcholle, Jean Villard, Joachim Marti, Alexandre Loupy

Summary: This multi-center cohort study investigated the quality of life (QoL) of kidney transplant recipients during the first year after transplantation. Using EQ-5D and VAS data as measures, the study found that patients who maintained standard-of-care therapy had better QoL compared to those who switched therapies. These findings provide important insights for assessing the QoL of kidney transplant recipients.

FRONTIERS IN PHARMACOLOGY (2023)

Add to Collection

Article Medicine, General & Internal

Pregnancy after Kidney Transplantation-Impact of Functional Renal Reserve, Slope of eGFR before Pregnancy, and Intensity of Immunosuppression on Kidney Function and Maternal Health

Rebecca Kaatz, Elisabetta Latartara, Friederike Bachmann, Nils Lachmann, Nadine Koch, Bianca Zukunft, Kaiyin Wu, Danilo Schmidt, Fabian Halleck, Peter Nickel, Kai-Uwe Eckardt, Klemens Budde, Stefan Verlohren, Mira Choi

Summary: Women of childbearing age who have undergone kidney transplantation experience increased fertility, but are at risk for complications such as preeclampsia, preterm delivery, and allograft dysfunction. A retrospective study was conducted on 40 women who had post-transplant pregnancies between 2003 and 2019. The study found that the pregnancies had good outcomes for both the mothers and the transplanted kidneys, although there were declines in kidney function. Adverse pregnancy events, such as preeclampsia with severe end-organ dysfunction, were associated with impaired hyperfiltration during pregnancy and a decline in renal function. The frequency of de novo donor-specific antibodies did not increase after delivery.

JOURNAL OF CLINICAL MEDICINE (2023)

Add to Collection

Article Transplantation

Predictors of graft failure after first detection of de novo donor-specific HLA antibodies in kidney transplant recipients

Covadonga Lopez del Moral, Kaiyin Wu, Marcel Naik, Bilgin Osmanodja, Aylin Akifova, Nils Lachmann, Diana Stauch, Sabine Hergovits, Mira Choi, Friederike Bachmann, Fabian Halleck, Eva Schrezenmeier, Danilo Schmidt, Klemens Budde

Summary: This study found that renal function, proteinuria, and rejection are strongly associated with graft failure in patients with dnDSAs and may serve as surrogate endpoints.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2023)

Add to Collection

Article Immunology

Expanded Hemodialysis ameliorates uremia-induced impairment of vasculoprotective KLF2 and concomitant proinflammatory priming of endothelial cells through an ERK/AP1/cFOS-dependent mechanism

Hongfan Zhao, Dashan Wu, Michael Adu Gyamfi, Pinchao Wang, Christian Luecht, Anna Maria Pfefferkorn, Muhammad Imtiaz Ashraf, Julian Kamhieh-Milz, Janusz Witowski, Duska Dragun, Klemens Budde, Ralf Schindler, Daniel Zickler, Guido Moll, Rusan Catar

Summary: Expanded hemodialysis therapy with improved molecular cut-off dialyzers has beneficial effects in reducing uremia-associated chronic systemic microinflammation, which is a driver of endothelial dysfunction and cardiovascular disease in hemodialysis patients. The transcription factor KLF2 and its associated molecular signaling pathways are identified as key targets and regulators in uremia-induced endothelial microinflammation.

FRONTIERS IN IMMUNOLOGY (2023)

Add to Collection

Article Surgery

Can We Predict Graft Intolerance Syndrome After Kidney Transplant Failure? External Validation of a Previously Developed Model

Kim Bunthof, Khalid Saboerali, Jacqueline Van De Wetering, Azam Nurmohamed, Frederike Bemelman, Arjan Van Zuilen, Jan Van Den Brand, Marije Baas, Luuk Hilbrands

Summary: This study aimed to validate a previously established prediction model for graft intolerance syndrome in an independent cohort. The validation cohort consisted of patients with late kidney graft failure between 2008 and 2018. The original model, which included donor age, graft survival, and number of acute rejections, performed poorly in the validation cohort. However, after retraining the model using recipient age at graft failure instead of donor age, it showed moderate performance in both the development and validation cohorts.

TRANSPLANT INTERNATIONAL (2023)

Add to Collection

Article Urology & Nephrology

Sustained employment, work disability and work functioning in CKD patients: a cross-sectional survey study

Manna A. Alma, Sijrike F. van der Mei, Sandra Brouwer, Luuk B. Hilbrands, Paul J. M. van der Boog, Herma Uiterwijk, Femke Waanders, Maaike Hengst, Ron T. Gansevoort, Annemieke Visser

Summary: Kidney failure negatively impacts employment opportunities. Employed patients with chronic kidney disease face difficulties in work functioning, requiring adjustments or work disability benefits. Pre-emptive transplantation and good physical health contribute to sustained employment.

JOURNAL OF NEPHROLOGY (2023)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.