Article
Clinical Neurology
Florian Pernin, Julia Xiao Xuan Luo, Qiao-Ling Cui, Manon Blain, Milton G. F. Fernandes, Moein Yaqubi, Myriam Srour, Jeff Hall, Roy Dudley, Helene Jamann, Catherine Larochelle, Stephanie E. J. Zandee, Alexandre Prat, Jo Anne Stratton, Timothy E. Kennedy, Jack P. Antel
Summary: The early lesions of multiple sclerosis involve the degeneration of myelinating processes of oligodendrocytes, while the cell bodies of these cells are relatively preserved. As the disease progresses, there is loss of oligodendrocytes. The injury mediators that contribute to this process include metabolic stress, pro-inflammatory mediators, and excitotoxins. It is important to understand the specific effects of these mediators on human oligodendrocytes in order to develop effective neuroprotective therapies for multiple sclerosis.
Review
Cell Biology
Hayder M. Al-kuraishy, Majid S. Jabir, Ali I. Al-Gareeb, Hebatallah M. Saad, Gaber El-Saber Batiha, Daniel J. Klionsky
Summary: This study explores the protective and harmful effects of autophagy in the pathogenesis of multiple sclerosis (MS). Autophagy can prevent the progression of MS by reducing oxidative stress and inflammatory disorders, but over-activated autophagy can worsen the neuropathology of MS. Additionally, autophagy can modulate cell proliferation and affect demyelination and remyelination. Overall, autophagy plays a significant role in the pathogenesis of MS.
Article
Biochemistry & Molecular Biology
Jacopo Angelini, Davide Marangon, Stefano Raffaele, Davide Lecca, Maria P. Abbracchio
Summary: The study identified a significant increase of GPR17-expressing cells in multiple sclerosis (MS) patients, mainly accumulating in the normal appearing white matter (NAWM) with moderate inflammation. Additionally, two distinct subpopulations of GPR17-expressing oligodendroglial cells were found in the white matter of healthy controls and MS patients, characterized by different morphologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Nadjet Gacem, Brahim Nait-Oumesmar
Summary: Myelination by oligodendrocytes is crucial for central nervous system development and function, with multiple sclerosis being a common neurodegenerative disease characterized by inflammation and demyelination. Current treatments for MS target the immune component of the disease, but there is ongoing research on pharmacological compounds that could enhance remyelination.
Article
Medicine, Research & Experimental
Laura Ghezzi, Bryan Bollman, Luca De Feo, Laura Piccio, Bruce D. Trapp, Robert E. Schmidt, Anne H. Cross
Summary: Multiple sclerosis (MS) is a CNS demyelinating disease that often leads to unsuccessful remyelination and neuronal/axonal damage. While oligodendroglial cells are responsible for myelin production, remyelination by Schwann cells (SchC) has been observed in spinal cord demyelination. This study investigated the extent of SchC remyelination in the brain and spinal cords of autopsied MS specimens.
LABORATORY INVESTIGATION
(2023)
Review
Cell Biology
Viktoria Gudi, Pawel Grieb, Ralf A. Linker, Thomas Skripuletz
Summary: Multiple sclerosis is a chronic inflammatory disease of the central nervous system, resulting in demyelination and functional disability. CDP-choline, a compound with regenerative properties, has been shown to improve myelin regeneration in animal models of multiple sclerosis. However, its effects in human patients have not been studied yet.
NEURAL REGENERATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Xinda Zhao, Claire Jacob
Summary: All licensed medications for multiple sclerosis (MS) target the immune system, but most drug candidates in human clinical trials have modest or no effects on disease amelioration and remyelination enhancement. Remyelination is a complex process involving multiple cell types, and the interplay between them may differ in humans and rodent models. Successful remyelination requires the regulation of each cell type in a highly organized spatio-temporal manner, making it challenging for drug candidates targeting a single pathway or cell population. Therefore, considering the effects on all CNS cell populations and the optimal time of administration is crucial when exploring new drug candidates for MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Vasiliki Pantazou, Thomas Roux, Vanessa Oliveira Moreira, Catherine Lubetzki, Anne Desmazieres
Summary: Multiple sclerosis is a complex inflammatory disease of the central nervous system characterized by neurodegeneration and demyelination. Understanding the mechanisms of remyelination is crucial for promoting neuroprotection and limiting disease progression. The interaction between neurons and the oligodendroglial lineage plays a significant role in potential therapeutic strategies for supporting remyelination and neuroprotection in MS.
Article
Biochemistry & Molecular Biology
Roya Rahmat-Zaie, Javad Amini, Mohammad Haddadi, Cordian Beyer, Nima Sanadgol, Adib Zendedel
Summary: By analyzing gene expression data, we identified a common neuroinflammatory pathway in animal models of multiple sclerosis (MS) and identified several important candidate genes. These findings are helpful in evaluating the clinical efficacy of pharmacological interventions and designing targeted therapies.
Article
Biochemistry & Molecular Biology
Cristina Agliardi, Franca Rosa Guerini, Milena Zanzottera, Elisabetta Bolognesi, Silvia Picciolini, Domenico Caputo, Marco Rovaris, Maria Barbara Pasanisi, Mario Clerici
Summary: Approximately 15% of MS patients develop primary progressive form of disease, which is difficult to diagnose and treat. Brain-derived EVs and their protein cargoes could potentially serve as biomarkers for MS. The study found that MBP concentration in ODEVs was significantly increased in MS patients and correlated with disease severity. A minimally invasive blood test measuring MBP concentration in ODEVs could be a promising tool for MS diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Claudia Guerriero, Giulia Puliatti, Tamara Di Marino, Ada Maria Tata
Summary: DMF has anti-inflammatory and antioxidant effects, and can promote the differentiation of oligodendrocytes into mature cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Sumita Mehta, Anshul Grover, Nalini Mittal, Pratibha Nanda, Ritu Khatuja, Azra Naseem
Summary: This study assessed the knowledge, attitude, and practices of women regarding menstrual hygiene and found that reusable sanitary pads are an effective and environmentally friendly alternative to disposable napkins.
JOURNAL OF PUBLIC HEALTH
(2022)
Editorial Material
Medicine, General & Internal
Carolyn V. Gould, J. Erin Staples, Claire Y. -H. Huang, Aaron C. Brault, Randall J. Nett
Summary: "Revisiting the need for human West Nile virus vaccines is crucial. Since its detection in the United States in 1999, WNV has emerged as the leading cause of domestic arthropod-borne diseases."
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Karolina Salwierak-Glosna, Pawel Piatek, Malgorzata Domowicz, Mariola Swiderek-Matysiak
Summary: Multiple sclerosis (MS) is an autoimmune neurological disorder. Experimental therapies using mesenchymal stem cells (MSCs) have shown promising immunomodulatory potential. In this study, we investigated the effect of cerebrospinal fluid (CSF) obtained from MS patients on the secretory activity of Wharton's jelly-derived MSCs (WJ-MSCs), and further explored the interactions between WJ-MSCs and human oligodendroglia cell line (OLs). Our results demonstrate the diverse immunomodulatory properties of WJ-MSCs and how these effects can be influenced by the transplantation milieu.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Pauline E. M. van Schaik, Inge S. Zuhorn, Wia Baron
Summary: Multiple sclerosis is a neuroinflammatory and neurodegenerative disease with unknown etiology that can be characterized by demyelinated lesions. Remyelination is essential for axonal survival and functional recovery, but fibronectin inhibits this process. The blood-brain barrier poses a challenge for delivering therapeutic interventions to the lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
