An efficient, step-economical strategy for the design of functional metalloproteins

Determining the structural and energetic basis of allostery in a de novo designed metalloprotein assembly

(2018) Lewis A. Churchfield et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolving artificial metalloenzymes via random mutagenesis

(2018) Hao Yang et al.   Nature Chemistry

Targeting Metalloenzymes for Therapeutic Intervention

(2018) Allie Y. Chen et al.   CHEMICAL REVIEWS

Non-heme High-Spin {FeNO}6–8 Complexes: One Ligand Platform Can Do It All

(2018) Amy L. Speelman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Importance of Scaffold Flexibility/Rigidity in the Design and Directed Evolution of Artificial Metallo-β-lactamases

(2017) Woon Ju Song et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peroxide Activation Regulated by Hydrogen Bonds within Artificial Cu Proteins

(2017) Samuel I. Mann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human calprotectin affects the redox speciation of iron

(2017) Toshiki G. Nakashige et al.   Metallomics

Enhancing Mn(II)-Binding and Manganese Peroxidase Activity in a Designed Cytochrome c Peroxidase through Fine-Tuning Secondary-Sphere Interactions

(2016) Parisa Hosseinzadeh et al.   BIOCHEMISTRY

De Novo Design of an Allosteric Metalloprotein Assembly with Strained Disulfide Bonds

(2016) Lewis A. Churchfield et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Abiological catalysis by artificial haem proteins containing noble metals in place of iron

(2016) Hanna M. Key et al.   NATURE

Directed evolution of artificial metalloenzymes for in vivo metathesis

(2016) Markus Jeschek et al.   NATURE

Structure of the Sulfoxide Synthase EgtB from the Ergothioneine Biosynthetic Pathway

(2015) Kristina V. Goncharenko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Crystal Structure of an Integral Membrane Fatty Acid α-Hydroxylase

(2015) Guangyu Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experimental Correlation of Substrate Position with Reaction Outcome in the Aliphatic Halogenase, SyrB2

(2015) Ryan J. Martinie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Designing Hydrolytic Zinc Metalloenzymes

(2014) Melissa L. Zastrow et al.   BIOCHEMISTRY

Protein Design: Toward Functional Metalloenzymes

(2014) Fangting Yu et al.   CHEMICAL REVIEWS

Short peptides self-assemble to produce catalytic amyloids

(2014) Caroline M. Rufo et al.   Nature Chemistry

A designed supramolecular protein assembly with in vivo enzymatic activity

(2014) Woon Ju Song et al.   SCIENCE

Protein disulfide engineering

(2013) Alan A. Dombkowski et al.   FEBS LETTERS

High-Affinity Manganese Coordination by Human Calprotectin Is Calcium-Dependent and Requires the Histidine-Rich Site Formed at the Dimer Interface

(2013) Joshua A. Hayden et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Artificial Metalloenzymes by Creation of a Novel Active Site at the Protein Dimer Interface

(2012) Jeffrey Bos et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering oxidoreductases: maquette proteins designed from scratch

(2012) Bruce R. Lichtenstein et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Catalysis by a De Novo Zinc-Mediated Protein Interface: Implications for Natural Enzyme Evolution and Rational Enzyme Engineering

(2012) Bryan S. Der et al.   BIOCHEMISTRY

Azurin as a Protein Scaffold for a Low-coordinate Nonheme Iron Site with a Small-molecule Binding Pocket

(2012) Matthew P. McLaughlin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metallation and mismetallation of iron and manganese proteins in vitro and in vivo: the class I ribonucleotide reductases as a case study

(2012) Joseph A. Cotruvo et al.   Metallomics

Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins

(2012) Amanda J. Reig et al.   Nature Chemistry

Biotinylated Rh(III) Complexes in Engineered Streptavidin for Accelerated Asymmetric C-H Activation

(2012) T. K. Hyster et al.   SCIENCE

Crystal structure of oxygen-evolving photosystem II at a resolution of 1.9 Å

(2011) Yasufumi Umena et al.   NATURE

Hydrolytic catalysis and structural stabilization in a designed metalloprotein

(2011) Melissa L. Zastrow et al.   Nature Chemistry

Metal-Directed Protein Self-Assembly

(2010) Eric N. Salgado et al.   ACCOUNTS OF CHEMICAL RESEARCH

Crystal Structures of Apo and Metal-Bound Forms of the UreE Protein fromHelicobacter pylori: Role of Multiple Metal Binding Sites,

(2010) Rong Shi et al.   BIOCHEMISTRY

Evolution of Metal Selectivity in Templated Protein Interfaces

(2010) Jeffrey D. Brodin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystallographic snapshots of the reaction of aromatic C–H with O2 catalysed by a protein-bound iron complex

(2010) Christine Cavazza et al.   Nature Chemistry

Trapping and spectroscopic characterization of an FeIII-superoxo intermediate from a nonheme mononuclear iron-containing enzyme

(2010) M. M. Mbughuni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational design of a structural and functional nitric oxide reductase

(2009) Natasha Yeung et al.   NATURE

Design and engineering of an O2 transport protein

(2009) Ronald L. Koder et al.   NATURE

Design of functional metalloproteins

(2009) Yi Lu et al.   NATURE

Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis

(2008) José M. Matés et al.   ARCHIVES OF TOXICOLOGY

Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

(2008) Brian D. Corbin et al.   SCIENCE

Function-Oriented Synthesis, Step Economy, and Drug Design

(2007) Paul A. Wender et al.   ACCOUNTS OF CHEMICAL RESEARCH