Journal
MOLECULES
Volume 24, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/molecules24061028
Keywords
Isaria fumosorosea; flavonoids; microbial transformation; methylglycosylation
Funding
- Agricultural Science and Technology Innovation Program [CAAS-ASTIP-2017-ICS]
- Special Fund for Agroscientific Research in the Public Interest of China [201503135]
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Glycosylation is an efficient strategy to modulate the solubility, stability, bioavailability and bioactivity of drug-like natural products. Biological methods, such as whole-cell biocatalyst, promise a simple but highly effective approach to glycosylate biologically active small molecules with remarkable regio- and stereo-selectivity. Herein, we use the entomopathogenic filamentous fungus Isaria fumosorosea ACCC 37814 to biotransform a panel of phenolic natural products, including flavonoids and anthraquinone, into their glycosides. Six new flavonoid (4-O-methyl)glucopyranosides are obtained and structurally characterized using high resolution mass and nuclear magnetic resonance spectroscopic techniques. These compounds further expand the structural diversity of flavonoid glycosides and may be used in biological study.
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