Novel Therapeutics for Epstein–Barr Virus

Defective Epstein–Barr virus in chronic active infection and haematological malignancy

(2019) Yusuke Okuno et al.   Nature Microbiology

Post-Transplantation Lymphoproliferative Disorders in Adults

(2018) Daan Dierickx et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact of antiviral prophylaxis in adults Epstein-Barr Virus-seronegative kidney recipients on early and late post-transplantation lymphoproliferative disorder onset: a retrospective cohort study

(2018) Simon Ville et al.   TRANSPLANT INTERNATIONAL

EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers

(2018) Joanna Wilson et al.   Cancers

Antiviral Therapies for Herpesviruses: Current Agents and New Directions

(2018) Claudette L. Poole et al.   CLINICAL THERAPEUTICS

In vitro toxicity and efficacy of verdinexor, an exportin 1 inhibitor, on opportunistic viruses affecting immunocompromised individuals

(2018) Douglas G. Widman et al.   PLoS One

A standardized approach to the evaluation of antivirals against DNA viruses: Polyomaviruses and lymphotropic herpesviruses

(2018) Kathy A. Keith et al.   ANTIVIRAL RESEARCH

Chronic active Epstein-Barr virus infection of T-cell type, systemic form in an African migrant: case report and review of the literature on diagnostics standards and therapeutic options

(2018) Maxi Wass et al.   BMC CANCER

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial of Oral Brincidofovir for Cytomegalovirus Prophylaxis in Allogeneic Hematopoietic Cell Transplantation

(2018) Francisco M. Marty et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Everolimus delayed and suppressed cytomegalovirus DNA synthesis, spread of the infection, and alleviated cytomegalovirus infection

(2018) Long Tan et al.   ANTIVIRAL RESEARCH

Epstein-Barr virus lytic cycle involvement in diffuse large B cell lymphoma

(2017) Melina Cohen et al.   HEMATOLOGICAL ONCOLOGY

Valganciclovir for the Suppression of Epstein-Barr Virus Replication

(2017) Jessica E Yager et al.   JOURNAL OF INFECTIOUS DISEASES

Viral load of EBV DNAemia is a predictor of EBV-related post-transplant lymphoproliferative disorders in pediatric renal transplant recipients

(2017) Elisa Colombini et al.   PEDIATRIC NEPHROLOGY

No effect of treatment with intravenous ganciclovir on Epstein-Barr virus viremia demonstrated after pediatric liver transplantation

(2017) Anniken B. Østensen et al.   PEDIATRIC TRANSPLANTATION

Chronic Active Epstein–Barr Virus Disease

(2017) Hiroshi Kimura et al.   Frontiers in Immunology

Computational analysis of EBNA1 “druggability” suggests novel insights for Epstein-Barr virus inhibitor design

(2016) Eleonora Gianti et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

(2016) Ferdy R. van Diemen et al.   PLoS Pathogens

Post-transplant lymphoproliferative disorders

(2016) Vikas R. Dharnidharka et al.   Nature Reviews Disease Primers

Insights into the mechanism of action of cidofovir and other acyclic nucleoside phosphonates against polyoma- and papillomaviruses and non-viral induced neoplasia

(2015) G. Andrei et al.   ANTIVIRAL RESEARCH

Post-transplant lymphoproliferative disorders: From epidemiology to pathogenesis-driven treatment

(2015) Maria Raffaella Petrara et al.   CANCER LETTERS

Antiherpesvirus Activities of Two Novel 4′-Thiothymidine Derivatives, KAY-2-41 and KAH-39-149, Are Dependent on Viral and Cellular Thymidine Kinases

(2014) Natacha Coen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Spectrum of Activity and Mechanisms of Resistance of Various Nucleoside Derivatives against Gammaherpesviruses

(2014) Natacha Coen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiviral activity of topoisomerase II catalytic inhibitors against Epstein–Barr virus

(2014) Ting Wu et al.   ANTIVIRAL RESEARCH

Small molecule inhibition of Epstein–Barr virus nuclear antigen-1 DNA binding activity interferes with replication and persistence of the viral genome

(2014) Eun Kyung Lee et al.   ANTIVIRAL RESEARCH

Cytomegalovirus

(2014) Paul Griffiths et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Valganciclovir suppressed Epstein Barr virus reactivation during immunosuppression with alemtuzumab

(2014) Harinder Gill et al.   JOURNAL OF CLINICAL VIROLOGY

Human Cytomegalovirus UL97 Phosphorylates the Viral Nuclear Egress Complex

(2014) Mayuri Sharma et al.   JOURNAL OF VIROLOGY

Activation and Repression of Epstein-Barr Virus and Kaposi's Sarcoma-Associated Herpesvirus Lytic Cycles by Short- and Medium-Chain Fatty Acids

(2014) Kelly L. Gorres et al.   JOURNAL OF VIROLOGY

Inhibition of Epstein-Barr Virus Lytic Cycle by an Ethyl Acetate Subfraction Separated from Polygonum cuspidatum Root and Its Major Component, Emodin

(2014) Ching-Yi Yiu et al.   MOLECULES

Gammaherpesviruses and Lymphoproliferative Disorders

(2013) Ethel Cesarman   Annual Review of Pathology-Mechanisms of Disease

Synthesis and Antiviral Activities of Methylenecyclopropane Analogs with 6-Alkoxy and 6-Alkylthio Substitutions That Exhibit Broad-Spectrum Antiviral Activity against Human Herpesviruses

(2013) Mark N. Prichard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cytomegalovirus UL97 Kinase Catalytic Domain Mutations That Confer Multidrug Resistance

(2013) Sunwen Chou et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiviral activity of angelicin against gammaherpesviruses

(2013) Hye-Jeong Cho et al.   ANTIVIRAL RESEARCH

Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-κB and MAPKs signal pathways

(2013) Depeng Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Potential Antiviral Lignans from the Roots of Saururus chinensis with Activity against Epstein–Barr Virus Lytic Replication

(2013) Hui Cui et al.   JOURNAL OF NATURAL PRODUCTS

Maribavir Inhibits Epstein-Barr Virus Transcription through the EBV Protein Kinase

(2013) C. B. Whitehurst et al.   JOURNAL OF VIROLOGY

Evaluation of Novel Acyclic Nucleoside Phosphonates against Human and Animal Gammaherpesviruses Revealed an Altered Metabolism of Cyclic Prodrugs upon Epstein-Barr Virus Reactivation in P3HR-1 Cells

(2013) N. Coen et al.   JOURNAL OF VIROLOGY

Activity and Mechanism of Action of HDVD, a Novel Pyrimidine Nucleoside Derivative with High Levels of Selectivity and Potency against Gammaherpesviruses

(2013) N. Coen et al.   JOURNAL OF VIROLOGY

Switching of EBV cycles between latent and lytic states

(2013) Takayuki Murata et al.   REVIEWS IN MEDICAL VIROLOGY

Potential of protein kinase inhibitors for treating herpesvirus-associated disease

(2013) Renfeng Li et al.   TRENDS IN MICROBIOLOGY

Efficacy and Safety of Maribavir Dosed at 100 mg Orally Twice Daily for the Prevention of Cytomegalovirus Disease in Liver Transplant Recipients: A Randomized, Double-Blind, Multicenter Controlled Trial

(2012) D. J. Winston et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir

(2012) Chengwei Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

(-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBV-positive cells

(2012) S. Liu et al.   CARCINOGENESIS

Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding

(2012) Mayur M. Uttekar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activation of lytic cycle of Epstein-Barr virus by suberoylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinoma

(2012) K.F. Hui et al.   INTERNATIONAL JOURNAL OF CANCER

Everolimus is associated with a reduced incidence of cytomegalovirus infection followingde novocardiac transplantation

(2012) J. Kobashigawa et al.   Transplant Infectious Disease

(Val-)Ganciclovir prophylaxis reduces Epstein-Barr virus primary infection in pediatric renal transplantation

(2012) Britta Höcker et al.   TRANSPLANT INTERNATIONAL

Potent Antiviral Activity of Topoisomerase I and II Inhibitors against Kaposi's Sarcoma-Associated Herpesvirus

(2011) Lorenzo González-Molleda et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cyclopropavir Susceptibility of Cytomegalovirus DNA Polymerase Mutants Selected after Antiviral Drug Exposure

(2011) Sunwen Chou et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cyclopropavir Inhibits the Normal Function of the Human Cytomegalovirus UL97 Kinase

(2011) Scott H. James et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients

(2011) Ethel Cesarman   CANCER LETTERS

Inhibition of the Epstein-Barr virus lytic cycle by protoapigenone

(2011) C.-P. Tung et al.   JOURNAL OF GENERAL VIROLOGY

Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial

(2011) Francisco M Marty et al.   LANCET INFECTIOUS DISEASES

Stage of Action of Naturally Occurring Andrographolides and Their Semisynthetic Analogues against Herpes Simplex Virus Type 1in Vitro

(2011) Chantana Aromdee et al.   PLANTA MEDICA

Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility

(2010) Sunwen Chou et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Viral Response to Chemotherapy in Endemic Burkitt Lymphoma

(2010) W. Tang et al.   CLINICAL CANCER RESEARCH

Antiviral Drug Resistance of Human Cytomegalovirus

(2010) N. S. Lurain et al.   CLINICAL MICROBIOLOGY REVIEWS

Anti-Influenza Drug Discovery: Structure−Activity Relationship and Mechanistic Insight into Novel Angelicin Derivatives

(2010) Jiann-Yih Yeh et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Epstein-Barr Virus (EBV)-Encoded Protein Kinase, EBV-PK, but Not the Thymidine Kinase (EBV-TK), Is Required for Ganciclovir and Acyclovir Inhibition of Lytic Viral Production

(2010) Q. Meng et al.   JOURNAL OF VIROLOGY

A New Model of Epstein-Barr Virus Infection Reveals an Important Role for Early Lytic Viral Protein Expression in the Development of Lymphomas

(2010) S.-D. Ma et al.   JOURNAL OF VIROLOGY

Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: Current state of the art

(2009) Karl Y. Hostetler   ANTIVIRAL RESEARCH

Lignan, sesquilignans and dilignans, novel HIV-1 protease and cytopathic effect inhibitors purified from the rhizomes of Saururus chinensis

(2009) JiSuk Lee et al.   ANTIVIRAL RESEARCH

Inhibition of the Epstein–Barr virus lytic cycle by moronic acid

(2009) Fang-Rong Chang et al.   ANTIVIRAL RESEARCH

How I treat EBV lymphoproliferation

(2009) H. E. Heslop   BLOOD

Topoisomerase I and RecQL1 Function in Epstein-Barr Virus Lytic Reactivation

(2009) P. Wang et al.   JOURNAL OF VIROLOGY

Maribavir Inhibits Epstein-Barr Virus Transcription in Addition to Viral DNA Replication

(2009) F.-Z. Wang et al.   JOURNAL OF VIROLOGY

Chronic Fatigue Syndrome After Infectious Mononucleosis in Adolescents

(2009) B. Z. Katz et al.   PEDIATRICS

Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir

(2009) Mark N. Prichard   REVIEWS IN MEDICAL VIROLOGY

Lower incidence of cytomegalovirus infection with everolimus versus mycophenolate mofetil inde novocardiac transplant recipients: a randomized, multicenter study

(2009) M. Viganò et al.   Transplant Infectious Disease

Efficient production of infectious viruses requires enzymatic activity of Epstein-Barr virus protein kinase

(2009) Takayuki Murata et al.   VIROLOGY

Inhibition of the Epstein–Barr Virus Lytic Cycle by Andrographolide

(2008) Tsuey-Pin Lin et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Treatment of locally recurrent epstein–barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir

(2008) Tomokazu Yoshizaki et al.   JOURNAL OF MEDICAL VIROLOGY

Histone Hyperacetylation Occurs on Promoters of Lytic Cycle Regulatory Genes in Epstein-Barr Virus-Infected Cell Lines Which Are Refractory to Disruption of Latency by Histone Deacetylase Inhibitors

(2008) J. K. Countryman et al.   JOURNAL OF VIROLOGY

High levels of Epstein–Barr virus DNA in latently infected gastric adenocarcinoma

(2008) Julie L Ryan et al.   LABORATORY INVESTIGATION

Efficacy and safety of valganciclovir in liver-transplanted children infected with Epstein-Barr virus

(2008) Loreto Hierro et al.   LIVER TRANSPLANTATION

Bortezomib-induced enzyme-targeted radiation therapy in herpesvirus-associated tumors

(2008) De-Xue Fu et al.   NATURE MEDICINE

Cardiovascular Effects of Lignans Isolated from Saururus chinensis

(2008) Kwang-Seok Oh et al.   PLANTA MEDICA

Cytomegalovirus UL97 mutations in the era of ganciclovir and maribavir

(2008) Sunwen Chou   REVIEWS IN MEDICAL VIROLOGY