Article
Biochemistry & Molecular Biology
Xue-Feng Bao, Pei-Hong Cao, Jin Zeng, Luo-Min Xiao, Zhi-Hui Luo, Jian Zou, Chuan-Xi Wang, Zhong-Xiang Zhao, Zheng-Qun Zhou, Hui Zhi, Hao Gao
Summary: Eleven unknown and three known pterocarpans were isolated and identified from Huang-qi, a traditional Chinese medicine. Among them, nine rare apiosyl-containing pterocarpan glycosides were discovered. These compounds exhibited hypoglycemic and antioxidant activities.
Article
Plant Sciences
Yanan Xu, Weifeng Wu, Yi Chen, Tingting Zhang, Keling Tu, Yun Hao, Hailu Cao, Xuehui Dong, Qun Sun
Summary: The non-destructive and highly accurate discrimination of Astragalus membranaceus var. mongholicus, A. membranaceus, and similar seeds using hyperspectral imaging was achieved, providing support for standardization in the Astragalus production industry.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Yinli Bi, Zike Xue
Summary: The influence of dark septate endophytic (DSE) on the antioxidant activity of Astragalus membranaceus var. mongholicus under heat stress was investigated. DSE inoculation significantly decreased the malondialdehyde (MDA) content during the initial three days of heat stress. The activities of superoxide dismutase (SOD) and peroxidase (POD) of A. membranaceus leaves were significantly enhanced by DSE inoculation under heat stress, with SOD activities being 63-81% higher than in other treatments. The glutathione (GSH) and putrescine (Put) contents accumulated significantly on the third day under heat stress with DSE inoculation.
PHYSIOLOGIA PLANTARUM
(2023)
Article
Plant Sciences
Zhi-Hui Luo, Jin Zeng, Hai-Yang Yu, Hui-Yun Huang, Xue-Feng Bao, Sheng-Ying Qin, Guo-Dong Chen, Zheng-Qun Zhou, Hui Zhi, Xin-Sheng Yao, Hao Gao
Summary: Twenty new malabaricane triterpenoids have been isolated from the roots of Astragalus membranaceus var. mongholicus and their structures have been determined. These compounds show significant inhibitory activity on migration and proliferation, and are reported in the genus Astragalus for the first time.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Applied
Tong Zhao, Liuwei Zhao, Miao Wang, Suzhen Qi, Xiaofeng Xue, Liming Wu, Qiangqiang Li
Summary: This study identified calycosin and formononetin as reliable chemical markers for MH-Am authentication, and determined their contents in MH-Am, other honeys and P-Am through a targeted quantitative analysis. Free radical scavenging assays showed that calycosin directly contributed to the antioxidative activity of MH-Am.
Article
Agriculture, Multidisciplinary
Haifeng Sun, Xinyu Zuo, Qingqing Zhang, Jianping Gao, Guoyin Kai
Summary: This study investigated the effects of adding (E)-2-hexenal and 2,3-butanediol into the medium on bioactive metabolites in Astragalus membranaceus var. mongholicus adventitious root cultures. The results showed that the combination of 2,3-butanediol and (E)-2-hexenal promoted the accumulation of astragaloside IV, while their individual application delayed it. The production of CG and ononin was not significantly affected, but their accumulation patterns were changed. This finding provides important insights into the production of bioactive products in herbal plants.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Yadong Wang, Chao Wang, Yuanhao Wang, Qing Hu, Fenghuan Wang
Summary: A new isoflavan glucoside, astramemside A, along with six known compounds, were isolated from the roots of Astragalus membranaceus var. mongholicus. Compound 1 exhibited moderate inhibition on nitric oxide production induced by lipopolysaccharide in RAW264.7 cells.
RECORDS OF NATURAL PRODUCTS
(2022)
Article
Soil Science
Bingzhen Li, Qianqian Zhang, Yinghui Chen, Youla Su, Shuying Sun, Guilin Chen
Summary: Crop rotation with Avena sativa L significantly promoted the growth of A. mongholicus and improved soil quality by increasing organic matter, total nitrogen, total phosphorus, and available potassium contents. It also enhanced the diversity of bacterial communities in the rhizosphere of A. mongholicus and increased the abundance of beneficial bacteria like Clostridia, Rubrobacterales, and Micromonosporales. Additionally, the composition of rhizosphere bacterial community varied with different sampling times and crop rotation practices, indicating the effectiveness of crop rotation in alleviating continuous cropping obstacles for A. mongholicus.
APPLIED SOIL ECOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hai-dan Zou, Yan Liu, Zhen-Peng Zhang, Jia-Tong Wu, Jing Wang, Juan Pan, Wei Guan, Hai-xue Kuang, Bing-you Yang
Summary: In this study, a phytochemical investigation of Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao ethanol extract led to the identification of seven new triterpenoid saponins, astralanosaponins F-L, along with fifteen known compounds. The structures of these compounds were determined through 1D-NMR and 2D-NMR spectroscopy and compared with similar compounds reported previously. The absolute configuration of sugar was determined using GC-MS. The inhibitory effects of these compounds on high glucose-induced SV40 MES 13 cells were evaluated using the CCK-8 assay, and compound 19 showed significant inhibition with an IC50 value of 12.2 + 1.29 mM. Compounds 5 and 9 also displayed moderate inhibitory effects with IC50 values below 30 mM. The possible structure-activity relationships were preliminarily summarized.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Acoustics
Yue Meng, Xiaoyu Sui, Xu Pan, Xinyi Zhang, Huimin Sui, Tao Xu, Honglian Zhang, Tingting Liu, Jicheng Liu, Pengling Ge
Summary: In this study, a green and high-density natural deep eutectic solvent was used for the extraction and purification of Astragalus polysaccharides under ultrasound-assisted conditions. By selecting the best solvent and optimizing the extraction process, the recovery of polysaccharides was significantly increased, simplifying the purification process and reducing impurities.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Plant Sciences
Guowei Gong, Huiru Yu, Yuzhong Zheng, Baohui Qi, Huan He, Tianpeng Yin, Tina T. X. Dong, Karl W. K. Tsim
Summary: Astragaloside IV enhances the expression of heme recycling proteins through the Nrf2/ARE signaling pathway, promoting heme iron recycling during erythrophagocytosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhili Sheng, Yueming Jiang, Junmei Liu, Bao Yang
Summary: Astragalus membranaceus is a valuable medicinal plant species widely distributed in Asia with its root being the main medicinal tissue rich in methoxylated flavonoids. The chemical composition and antioxidant activity of the plant can be influenced by its origin, as shown through UHPLC-MS/MS analysis of extracts from four different origins. The study identified key compounds that can differentiate A. membranaceus from different regions and found that extracts from Inner Mongolia exhibited the highest antioxidant activity.
Article
Plant Sciences
Y. Cui, M. Jiang, K. -C. Yu, D. -Z. Ma, J. -H. LI, K. -Y. Zhang, J. -C. Liu, H. LI
Summary: This study compared the gene expression patterns of two different varieties of radix astragali, and found that they have many homologous genes but differ in different metabolic pathways. By analyzing these genes, valuable information for further development and utilization of these two species of astragalus can be obtained.
BIOLOGIA PLANTARUM
(2023)
Article
Agricultural Engineering
Haifeng Sun, Hong Gao, Chunfen Zhang, Qiufen Cao
Summary: The study revealed that GLVs could promote the production of CG in Astragalus membranaceus var. mongholicus adventitious roots, with hexanol as an effective elicitor that could inhibit the biosynthesis of CG scaffolds in the short term but upregulate CG biosynthesis genes in the long term.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Agriculture, Multidisciplinary
Xiaojie Li, Yingtong Mu, Xiaoming Zhang, Junjie Wang
Summary: This study aims to provide a standard phenological scale for Astragalus cultivated in temperate conditions, improving agricultural production and scientific communication.
ANNALS OF APPLIED BIOLOGY
(2023)