Article
Medicine, Research & Experimental
Nan Jin, Bhumsuk Keam, Janice Cho, Michelle J. Lee, Hye Ryun Kim, Hayarpi Torosyan, Natalia Jura, Patrick Ks Ng, Gordon B. Mills, Hua Li, Yan Zeng, Zohar Barbash, Gabi Tarcic, Hyunseok Kang, Julie E. Bauman, Mi-Ok Kim, Nathan K. VanLandingham, Danielle L. Swaney, Nevan J. Krogan, Daniel E. Johnson, Jennifer R. Grandis
Summary: This study identified activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma, suggesting that patients with these mutations may benefit from treatment with PI3K alpha inhibitors such as alpelisib. Characterization of these mutations' functional impact is crucial for personalized treatment strategies in HNSCC patients.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
Teresa Magnes, Sandro Wagner, Dominik Kiem, Lukas Weiss, Gabriel Rinnerthaler, Richard Greil, Thomas Melchardt
Summary: Head and neck squamous cell carcinoma is a heterogeneous disease arising from the mucosa of the upper aerodigestive tract, with only about one third of patients responding to checkpoint inhibitors. HPV status and combined positive score are the main biomarkers used in clinical practice, while other factors like tumor mutational burden and immune microenvironment show promise but require validation in prospective trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sindhu Nair, James A. Bonner, Markus Bredel
Summary: EGFR is overexpressed in head and neck squamous cell carcinoma and anti-EGFR strategies have shown some clinical benefit but often lead to resistance. Mutations in various domains of the EGFR gene can impact drug binding, radiation response, and overall survival in HNSCC patients. Understanding the EGFR mutational landscape and its effects on treatment resistance can help stratify patients for targeted therapies and maximize therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Minsu Kwon, Gi-Hoon Nam, Hanul Jung, Seong A. Kim, Seohyun Kim, Yeonju Choi, Yoon Se Lee, Hyo Jung Cho, In-San Kim
Summary: The study showed that statins can enhance the anticancer effects of cisplatin, activate antigen-presenting cells, and increase tumor-specific CD8(+) T cells, thus potentiating the efficacy of immunotherapy in HNSCC. The combination of statins with anti-PD-1 antibody further led to tumor eradication and improved survival in tumor-bearing mice. This suggests a potential repurposing of statins as an adjuvant immunotherapeutic option for HNSCC.
Review
Dentistry, Oral Surgery & Medicine
Fruzsina Kiss, Krisztina Pohoczky, Aniko Gorbe, Fanni Dembrovszky, Szabolcs Kiss, Peter Hegyi, Lajos Szako, Lilla Toth, Eva Somogyine Ezer, Eszter Szalai, Zsuzsanna Helyes
Summary: This meta-analysis found that the addition of EGFR inhibitors to standard chemotherapy significantly decreased mortality and disease progression in patients with head and neck squamous cell carcinoma (HNSCC), but also increased the risk of skin rashes.
Review
Immunology
Huanhuan Wang, Qin Zhao, Yuyu Zhang, Qihe Zhang, Zhuangzhuang Zheng, Shiyu Liu, Zijing Liu, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Head and neck cancer, primarily head and neck squamous cell carcinoma, is commonly treated with surgery, radiotherapy, chemotherapy, and immunotherapy. Immunotherapy, particularly for HPV-positive patients, has shown promising results possibly due to higher immune cell infiltration and differential expression of immune checkpoints in tumors. Personalized immunotherapy trials are also being conducted in HPV-positive patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Elena Muraro, Giuseppe Fanetti, Valentina Lupato, Vittorio Giacomarra, Agostino Steffan, Carlo Gobitti, Emanuela Vaccher, Giovanni Franchin
Summary: Cetuximab in combination with radiotherapy is limited to locally advanced HNSCC patients unfit for cisplatin. Reliable biomarkers for cetuximab efficacy in this cancer setting are lacking. Adverse events like skin rash are associated with efficacy, while acquired resistance is linked to microenvironment plasticity.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Albiruni R. Abdul Razak, Hung-Ming Wang, Jang-Yang Chang, Myung-Ju Ahn, Pamela Munster, George Blumenschein Jr, Benjamin Solomon, Darren Wan-Teck Lim, Ruey-Long Hong, David Pfister, Nabil F. Saba, Se-Hoon Lee, Carla van Herpen, Cornelia Quadt, Douglas Bootle, Lars Blumenstein, David Demanse, Jean-Pierre Delord
Summary: The combination of alpelisib and cetuximab showed moderate activity in cetuximab-resistant patients with head and neck squamous cell carcinoma, but did not demonstrate a progression-free survival benefit in cetuximab-naive patients.
Review
Oncology
Santiago Cabezas-Camarero, Pedro Perez-Segura
Summary: Immune-checkpoint inhibitors have shown to be effective in the treatment of squamous cell carcinoma of the head and neck. Recent neoadjuvant IO studies have demonstrated the safety and feasibility of using these inhibitors in combination or as a single agent. There is promising evidence of efficacy in terms of pathologic response, but there are still debates on evaluation methods and biomarker criteria. The future perspective of neoadjuvant IO in squamous cell carcinoma of the head and neck will be discussed.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Oncology
Jennifer M. Johnson, Ioannis A. Vathiotis, Larry A. Harshyne, Ayesha Ali, Voichita Bar Ad, Rita Axelrod, Emily Lorber, Joseph Curry, David M. Cognetti, Adam J. Luginbuhl, Madalina Tuluc, Scott Keith, My G. Mahoney, Athanassios Argiris
Summary: This is a phase I study on the combination treatment of nivolumab and ipilimumab for squamous cell carcinoma of the head and neck. The results show that this treatment has sufficient clinical activity to support further development. Early changes in circulating biomarkers can predict treatment outcomes as well as in-field soft tissue ulceration.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Eddy S. Yang, Eric Deutsch, Altan Mehmet, Jerome Fayette, Yungan Tao, Lisle Nabell, Sharon A. Spencer, Xuejing A. Wang, Elizabeth A. Spoljoric, Wei Zhang, Scott M. Hynes, Rodney L. Decker, Aimee K. Bence Lin, William N. William
Summary: This study aimed to investigate the feasibility of combining prexasertib with cisplatin-radiotherapy or cetuximab-radiotherapy in treating HNSCC, and concluded that prexasertib could be safely combined with cetuximab-radiotherapy, although a safe dose for cisplatin-radiotherapy was not established.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Immunology
K. Devaraja, Sadhna Aggarwal, Manisha Singh
Summary: Therapeutic vaccination is a promising approach for head and neck squamous cell carcinomas (HNSCC), which tend to exhibit unfavorable responses to existing treatments. Inducing antigen-specific cytotoxicity and countering the immunosuppressive tumor microenvironment have shown encouraging results in HNSCC immunotherapy.
Article
Oncology
Matthew H. Taylor, Courtney B. Betts, Lauren Maloney, Eric Nadler, Alain Algazi, Michael J. Guarino, John Nemunaitis, Antonio Jimeno, Priti Patel, Veerendra Munugalavadla, Lin Tao, Douglas Adkins, Jerome H. Goldschmidt, Ezra E. W. Cohen, Lisa M. Coussens
Summary: This study evaluated the efficacy and safety of pembrolizumab and acalabrutinib combination therapy in recurrent or metastatic HNSCC. The results showed a higher incidence of adverse events with combination therapy and lack of clinical efficacy. Immune subset analysis suggested additive effects of the combination, but the associated toxicity limited its feasibility.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Wassapol Wongpanuwich, Somchai Yodsanga, Risa Chaisuparat, Panomwat Amornphimoltham
Summary: This study found that PD-L1 and HTN1 play a role in the progression of HNSCC. The expression of PD-L1 correlated with that of HTN3.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Xia Li, Qigen Fang, Wei Du, Xu Zhang, Liyuan Dai, Yongming Qiao
Summary: The addition of sintilimab to induction chemotherapy in locally advanced head and neck squamous cell carcinoma patients resulted in a significantly higher objective response rate and longer progression-free survival compared to chemotherapy alone. However, there was no significant difference in overall survival between the two groups. The incidence of grade 3 or higher acute toxicity was similar in both groups.
Article
Biology
Bing He, Jian Shi, Xinwen Wang, Hui Jiang, Hao-Jie Zhu
Article
Clinical Neurology
Molly E. Heft Neal, Nicole L. Michmerhuizen, Mark E. P. Prince, Kevin J. Kovatch, John Henry J. Owen, Jingyi Zhai, Hui Jiang, Erin L. McKean, J. Chad Brenner
Summary: This study developed a high-throughput drug screening method using chordoma models to identify new combination therapies for chordoma. Several combination therapies, including PI3K inhibitors with other drugs, were identified as having potential therapeutic efficacy. ALK, PDGFR, VEGFR, aurora kinase, and BCL-2 were identified as important targets. T (brachyury) inhibition reduced cell viability, but did not show additional benefit with PI3K pathway inhibition in this model.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2022)
Article
Oncology
Molly E. Heft Neal, Andrew C. Birkeland, Apurva D. Bhangale, Jingyi Zhai, Aditi Kulkarni, Susan K. Foltin, Brittany M. Jewell, Megan L. Ludwig, Lisa Pinatti, Hui Jiang, Jonathan B. McHugh, Lawence Marentette, Erin L. McKean, J. Chad Brenner
Summary: This study evaluated the survival outcomes of 46 SNUC patients and identified tobacco use as the only significant predictor of survival. Additionally, it confirmed previously published findings on IDH and SMARC family mutations and discovered novel recurrent aberrations in the JAK/STAT and PI3K pathways. The study also validated a novel PGAP3-SRPK1 gene fusion and showed its negative association with EGFR, E2F, and MYC signaling.
Article
Statistics & Probability
Yunzhang Zhu, Xiaotong Shen, Hui Jiang, Wing Hung Wong
Summary: This article proposes a collaborative-learning framework for multilabel classification to exploit label dependence and improve prediction accuracy. A new classifier is designed based on a loss function and Bayes rule, along with weighted random forest and stacking scheme to enhance supervised learning performance. Decomposing the multilabel classification into independent learning tasks reduces computational complexity.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Oncology
M. E. Heft Neal, E. Gensterblum-Miller, A. D. Bhangale, A. Kulkarni, J. Zhai, J. Smith, C. Brummel, S. K. Foltin, D. Thomas, H. Jiang, J. B. McHugh, J. C. Brenner
Summary: This study conducted full characterization of five independent HCCC cases, revealing insulin-like growth factor alterations and identifying a 354 gene signature that can differentiate HCCC from MEC. The study also discovered elevated expression of ATF1 binding motif-enriched genes in HCCC, supporting a transcriptional pathogenic mechanism related to EWSR1-ATF1 fusion. Furthermore, analysis showed elevated levels of IGF1R, SGK1, SGK3, and CXCR4 protein in HCCC cases, potentially providing actionable alterations for clinical care.
Article
Mathematics, Interdisciplinary Applications
Wenbo Wu, Jeremy M. G. Taylor, Andrew F. Brouwer, Lingfeng Luo, Jian Kang, Hui Jiang, Kevin He
Summary: This study proposes a method to address the challenges encountered in estimating time-varying coefficients. Existing methods cannot handle large-scale data and binary predictors with near-zero variance, while this method can solve these problems. Simulation studies and applications to real-world data demonstrate improved estimation accuracy and significantly reduced time and memory costs with this approach.
LIFETIME DATA ANALYSIS
(2022)
Article
Genetics & Heredity
Yang Shi, Ji-Hyun Lee, Huining Kang, Hui Jiang
Summary: The study focuses on the unique features of single-cell gene expression data and proposes a two-part mixed model for modeling the data. The approach shows improved power for detecting differentially expressed genes in single-cell high-throughput gene expression data when compared to existing methods.
Article
Oncology
Jacqueline E. Mann, Megan L. Ludwig, Aditi Kulkarni, Erin B. Scheftz, Isabel R. Murray, Jingyi Zhai, Elizabeth Gensterblum-Miller, Hui Jiang, J. Chad Brenner
Summary: The study reveals the important role of Toll-like Receptor 2 (TLR2) in driving PDL1 expression, which may contribute to immune evasion in head and neck squamous cell carcinoma (HNSCC). Therefore, a detailed understanding of the complex mechanisms regulating PDL1 in HNSCC cells is necessary.
Article
Biology
Lam Tran, Kevin He, Di Wang, Hui Jiang
Summary: This article introduces a new method of weighted data integration, which uses external data to minimize the leave-one-out cross validation error of local data, in order to improve the accuracy of parameter estimation and model prediction. Through simulations and real-world examples, it is demonstrated that this method can significantly reduce estimation error and prediction error.
Article
Otorhinolaryngology
Nicole L. Michmerhuizen, Megan L. Ludwig, Andrew C. Birkeland, Sai Nimmagadda, Jingyi Zhai, Jiayu Wang, Brittany M. Jewell, Dylan Genouw, Lindsay Remer, Daniel Kim, Susan K. Foltin, Apurva Bhangale, Aditi Kulkarni, Carol R. Bradford, Paul L. Swiecicki, Thomas E. Carey, Hui Jiang, J. Chad Brenner
Summary: This study identified novel synergistic combinations of EGFR inhibitors with other advanced inhibitors through a high throughput drug screen, showing promising cell activity in resistant models.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Acoustics
Xiaoli Wu, Xiaoqing Meng, Tse-Shao Chang, Shuo Feng, Miki Lee, Sangeeta Jaiswal, Eun-Young K. Choi, Lam Tran, Hui Jiang, Thomas D. Wang
Summary: The study optimized the peptide sequence using a structural model, identified a peptide specific to CD44, and demonstrated its potential for in vivo imaging of HCC, providing a new approach for early cancer detection and surgery.
Article
Biochemistry & Molecular Biology
Atsunori Kaneshige, Longchuan Bai, Mi Wang, Donna McEachern, Jennifer L. Meagher, Renqi Xu, Yu Wang, Wei Jiang, Hoda Metwally, Paul D. Kirchhoff, Lijie Zhao, Hui Jiang, Meilin Wang, Bo Wen, Duxin Sun, Jeanne A. Stuckey, Shaomeng Wang
Summary: AK-2292 is a potent and selective small-molecule degrader of both STAT5A and STAT5B isoforms. It selectively inhibits STAT5 activity and induces degradation of STAT5A/B proteins without affecting other STAT proteins and numerous non-STAT proteins. AK-2292 effectively induces STAT5 depletion in both normal tissues and CML xenograft tissues, leading to tumor regression in CML xenograft mouse models. It is not only a powerful research tool to study STAT5 biology and therapeutic potential, but also a promising lead compound for STAT5-targeted therapy development.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Biochemical Research Methods
Lucy Her, Jian Shi, Xinwen Wang, Bing He, Logan S. S. Smith, Hui Jiang, Hao-Jie Zhu
Summary: This study utilized a recently developed allele-specific protein expression (ASPE) assay to identify cis-acting regulatory variants of the CES1 gene. It found two significant associations between regulatory variants and CES1 protein expression and activity. ASPE demonstrated improved statistical power compared to conventional gene expression-based approaches.
Article
Mathematical & Computational Biology
Jingyi Zhai, Hui Jiang
Summary: This paper proposes a novel two-sample testing procedure using a combination of g-modeling density estimation and the two-sample Kolmogorov-Smirnov test to address the challenge of non-identically distributed observed data associated with unobserved parameters. Efficient bootstrap algorithms are also proposed to estimate the statistical significance of such tests. The utility of the proposed approach is demonstrated through two biostatistical applications.
STATISTICS IN MEDICINE
(2023)
Article
Obstetrics & Gynecology
Allie Sakowicz, Chloe N. Matovina, Sidney K. Imeroni, Maya Daiter, Olivia Barry, William A. Grobman, Emily S. Miller
Summary: The COVID-19 pandemic resulted in decreased postpartum care service utilization, including postpartum depression screening and long-acting reversible contraception initiation.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)