Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 63, Issue 7, Pages -Publisher
WILEY
DOI: 10.1002/mnfr.201800967
Keywords
alkylresorcinols; glucose tolerance; insulin; low-glycemic diet; obesity
Categories
Funding
- Nestle
- NIH [T32 DK007319]
- NIH Research Resources [UL1RR024989]
Ask authors/readers for more resources
Introduction The effect of whole-grain (WG) versus refined-grain (RG) diets on glucose-stimulated insulin secretion (GSIS) and beta-cell function is unclear. Methods In a double-blind crossover randomized controlled trial, 13 prediabetic adults (37.2 +/- 1.8 y, BMI: 33.6 +/- 1.4 kg m(-2), 2 h glucose: 146.9 +/- 11.6 mg dL(-1)) are provided isocaloric-matched WG and RG diets for 8-weeks each, with an 8-10 week washout between diets. Glucose, insulin, and C-peptide are studied over 240 min following a 75 g OGTT. Incretins (GLP-1 and GIP), PYY, and total ghrelin are assessed at 0, 30, and 60 min. Mixed-meal diets for carbohydrate (54%), fat (28%), and protein (18%) contain either WG (50 g/1000 kcal) or equivalent RG. Results Both diets induce fat loss (approximate to 2 kg). While neither diet impacts early phase GSIS, the WG diet increases total GSIS (iAUC of C-peptide(0-240)/Glc(0-240), p = 0.02) and beta-cell function (disposition index; GSIS x insulin sensitivity, p = 0.02). GIP and PYY are unaltered by either diet, but GLP-1 is higher at 30 min following RG versus WG (p = 0.04). Ghrelin levels are higher at 60 min of the OGTT following both interventions (p = 0.01). Conclusion A WG-rich diet increases beta-cell function independent of gut hormones in adults with prediabetes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available