Article
Physiology
Justine M. Abais-Battad, Fatima L. Saravia, Hayley Lund, John Henry Dasinger, Daniel J. Fehrenbach, Ammar J. Alsheikh, Jeylan Zemaj, John R. Kirby, David L. Mattson
Summary: This study demonstrates that dietary modulation directly contributes to the development of salt-sensitive hypertension and renal injury in Dahl salt-sensitive rats through changes in the gut microbiota.
Article
Agriculture, Multidisciplinary
Xiaoyuan Wang, Yueyue Liu, Yu Wang, Xinyue Dong, Youhua Wang, Xingbin Yang, Honglei Tian, Ting Li
Summary: This study explored the salutary effects and mechanisms of coriander on high-fructose and high-salt diet-induced hypertension in rats. The results showed that coriander effectively attenuated the elevation of blood pressure, increased vasodilator factors, decreased sodium retention and serum uric acid level, and improved glucolipid profiles. Correlation analysis revealed the association between gut microbiota composition and relevant factors. LC-MS/MS analysis identified various flavonoids in coriander. Overall, coriander may ameliorate hypertension by mitigating abnormal changes in vascular function, sodium absorption, glucolipid homeostasis, and gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Yueyuan Liao, Chao Chu, Yu Yan, Dan Wang, Qiong Ma, Ke Gao, Yue Sun, Jiawen Hu, Wenling Zheng, Jianjun Mu
Summary: This study found that a high salt diet increases serum levels of H3K4me1 and Set7 in salt-sensitive individuals, but not in salt-resistant individuals.
FRONTIERS IN NUTRITION
(2022)
Review
Peripheral Vascular Disease
David L. Mattson, John Henry Dasinger, Justine M. Abais-Battad
Summary: Salt-sensitive hypertension in patients with high blood pressure is associated with higher morbidity, mortality, and renal damage compared to those with normal blood pressure or salt-resistant hypertension. Dietary components other than salt play a role in modulating hypertension, and immunity and inflammation are key factors that amplify the development of salt-sensitive hypertension.
Article
Multidisciplinary Sciences
Goher Kerem, Xiangfang Yu, Aynur Ismayi, Bin Teng, Anjaneyulu Udduttula, Chang Liu, Zhongjia Yu, Dilbar Tohty, Jian V. Zhang, Pei-Gen Ren
Summary: Obesity is a global concern due to the increased risk of diseases, and it has been found that a high salt diet can alter the gut microbiota. This study investigated the changes in Small Intestinal Microbiota (SIM) in obesity-T2DM mice and found that high salt intake reduced body weight to some extent and led to the development of T2DM. High-throughput sequencing analysis revealed an increase in the F/B ratio and a decrease in beneficial bacteria in the high salt-high fat diet group. Additionally, Halorubrum luteum was observed in the small intestine for the first time.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Zan Song, Lin Liu, Yanyi Xu, Ruofan Cao, Xianyong Lan, Chuanying Pan, Shengxiang Zhang, Haiyu Zhao
Summary: Chronic caffeine-induced sleep restriction affects the diversity and composition of the gut microbiota in mice and substantially alters the metabolic profiles of the gut microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Fusheng Xu, Ruimin Chen, Chengcheng Zhang, Hao Wang, Zhijie Ding, Leilei Yu, Fengwei Tian, Wei Chen, Yongping Zhou, Qixiao Zhai
Summary: Cholecystectomy has significant effects on the gut microbiota and is associated with specific dietary patterns.
Article
Biochemistry & Molecular Biology
Ya-nan Ou-Yang, Meng-di Yuan, Zheng-mao Yang, Zhuo Min, Yue-xin Jin, Zhong-min Tian
Summary: Salt-induced renal metabolism dysfunction is a significant mechanism of salt-sensitive hypertension. This study aimed to investigate the extra-renal mechanism involving hepatic metabolism and gut microbiota, and the potential protective effects of curcumin. The results showed that a high-salt diet led to alterations in hepatic metabolic pathways and changes in gut microbial composition, which were associated with metabolic disorders. The dysfunction in hepatic metabolism was correlated with enhanced lipopolysaccharide (LPS) biosynthesis and apoptosis in gut microbes. Curcumin administration alleviated the salt-induced metabolic dysfunctions and protected against salt-sensitive hypertension.
Article
Microbiology
Annefleur M. Koopen, Eduardo L. Almeida, Ilias Attaye, Julia J. Witjes, Elena Rampanelli, Soumia Majait, Marleen Kemper, Johannes H. M. Levels, Alinda W. M. Schimmel, Hilde Herrema, Torsten P. M. Scheithauer, Werner Frei, Lars Dragsted, Bolette Hartmann, Jens J. Holst, Paul W. O'Toole, Albert K. Groen, Max Nieuwdorp
Summary: Recent study investigated the potential synergistic effects of combining a Mediterranean diet with lean donor fecal microbiota transplantation (FMT) in metabolic syndrome subjects. The results showed no significant synergistic effects on insulin sensitivity, although the Mediterranean diet led to reductions in body weight, HOMA-IR, and lipid levels. Further trials are needed to explore the combination of other microbial interventions and diets in metabolic syndrome.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kristine Sto, Jorgen Valeur, Thor Ueland, Gunn Helen Malmstrom, Vigdis Bjerkeli, Marius Troseid, Johannes R. R. Hov, Kristian Holm, Beate Vestad, Bente Halvorsen, Mona Skjelland, Karolina R. R. Skagen
Summary: This study aimed to investigate the association between fecal butyric acid, carotid atherosclerosis, and risk factors for ischemic stroke. The results showed that patients with severe carotid atherosclerosis had higher levels of fecal butyric acid, but similar plasma levels. Gut barrier damage in patients might contribute to the higher fecal butyric acid level.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Rongrong Zhou, Dan He, Haichao Zhang, Jing Xie, Shuihan Zhang, Xuefei Tian, Hongliang Zeng, Yuhui Qin, Luqi Huang
Summary: This study aimed to explore the insulin-sensitizing and anti-diabetic effects of ginsenoside Rb1 and its underlying mechanisms. Using a diabetes model, the study found that ginsenoside Rb1 reduces blood glucose and insulin levels, and improves gut microbiota dysbiosis and fecal metabolites. Antibiotic intervention showed that ginsenoside Rb1 fails to improve high-fat diet-induced diabetes.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Rong Tan, Huiwei Dong, Zhengshan Chen, Min Jin, Jing Yin, Haibei Li, Danyang Shi, Yifan Shao, Huaran Wang, Tianjiao Chen, Dong Yang, Junwen Li
Summary: Unhealthy dietary habits are associated with increased incidence of chronic diseases, with high-fat and high-fructose diets leading to reduced defecation volume, increased levels of pro-inflammatory cytokines and IgG in serum, inflammatory cell infiltration in intestinal tissue, changes in microbial composition, alterations in microbial metabolites, and potential causes of constipation and inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Antonio Francavilla, Giulio Ferrero, Barbara Pardini, Sonia Tarallo, Laura Zanatto, Gian Paolo Caviglia, Sabina Sieri, Sara Grioni, Giulia Francescato, Francesco Stalla, Cristina Guiotto, Lucia Crocella, Marco Astegiano, Mauro Bruno, Pier Luigi Calvo, Paolo Vineis, Davide Giuseppe Ribaldone, Alessio Naccarati
Summary: Current treatment for celiac disease is adhering to a gluten-free diet, but its long-term molecular effects are still unknown. This study explored fecal small non-coding RNAs and gut microbiome profiles in celiac disease subjects and found altered miRNA and microbial profiles in treated celiac disease subjects.
Article
Biochemistry & Molecular Biology
Pengfei Yang, Luxin Zhou, Meng Chen, Li Zeng, Yanan Ouyang, Xuewei Zheng, Xiangbo Chen, Zhe Yang, Zhongmin Tian
Summary: The study found that AO supplementation prevented high-salt diet-induced hypertension in SS rats by restoring the metabolic balance of the kidneys. Therefore, AO has the potential to become a functional food additive to improve salt-sensitive hypertension.
Article
Peripheral Vascular Disease
Jonnelle M. Edwards, Shaunak Roy, Sarah L. Galla, Jeremy C. Tomcho, Nicole R. Bearss, Emily W. Waigi, Blair Mell, Xi Cheng, Piu Saha, Matam Vijay-Kumar, Cameron G. McCarthy, Bina Joe, Camilla F. Wenceslau
Summary: Cell death has been a characteristic phenotype of organ damage in hypertension, while leaky gut has recently been revealed as a novel hypertensive phenotype. Both mitochondria and bacteria produce NFPs, which activate FPR-1 to contribute to hypertension pathophysiology.