Article
Plant Sciences
Jung-Eun Lee, Young-Whan Choi, Dong-Soon Im
Summary: The aim of this study was to identify an active phytochemical from Schisandra chinensis and evaluate its effects on AD-like symptoms. The results showed that alpha-cubebenoate, an active phytochemical in Schisandra chinensis, significantly improved AD-like symptoms by reducing skin hypertrophy and mast cell accumulation, as well as decreasing pro-inflammatory chemokine and cytokine levels. This study provides evidence for the therapeutic efficacy of alpha-cubebenoate in the treatment of AD symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Yi Zhang, Wenxia Du, Defen Zhu, Meiling Li, Lu Qu, Gaoxiong Rao, Yuping Lin, Xiaoyun Tong, Yun Sun, Feng Huang
Summary: Vasicine has therapeutic potential for atopic dermatitis (AD) by inhibiting mast cell infiltration and regulating immune responses to improve the severity of AD-like lesions.
CLINICAL IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuling Wang, Zeyan Tang, Xueping Guo, Yuqi Zhao, Shujing Ren, Zhenhai Zhang, Huixia Lv
Summary: In this study, cyclodextrin was grafted onto hyaluronic acid to form a topical delivery carrier for the treatment of atopic dermatitis. The results showed that the carrier could penetrate into the skin quickly and remain stable. In vitro penetration test demonstrated improved drug retention in the stratum corneum and dermis. The carrier was found to interact with corneum lipids, promoting drug penetration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Integrative & Complementary Medicine
Zeng Zhi-wen, Huang Jin-quan, Chen Yong, Yu Xiao, Zhu Wei, Zhang Dong-shu
Summary: This study evaluated the therapeutic effects of acupoint autohemotherapy on atopic dermatitis in mice and its regulation of Th1/Th2 immune responses. The results showed that acupoint autohemotherapy can significantly alleviate symptoms, decrease serum IgE levels, and regulate the Th1/Th2 shift by increasing the expression of related transcription factors.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Medicine, Research & Experimental
Songwen Ren, You Gao, Luanjin Wang, Ce Qiu, Lingtao Yang, Li Li, Yueyue Xiao, Nengming Xiao, Lixin Liao, Zhenghong Zuo, Chunyan Yang, Chengyong He
Summary: The study demonstrated that Sacran could alleviate symptoms in AD mice, reduce skin inflammation induced by DNCB, potentially through inhibiting Th2 cell activation and decreasing IgE release.
Article
Immunology
Lu Yu, Qishan Xu, Ping Wang, Jialiang Luo, Zhuojun Zheng, Jia Zhou, Liyun Zhang, Ledong Sun, Daming Zuo
Summary: Atopic dermatitis (AD) is a severe inflammatory skin disease, and this study found that intestinal microbiome disorders and changes in the immune microenvironment are associated with AD. The researchers demonstrated that oral administration of a natural dietary lignan called secoisolariciresinol-diglycoside (SDG) significantly reduced serum IgE levels, limited skin inflammation, and decreased Th2 immune responses in AD mice. Furthermore, the study showed that the bacterial metabolite enterolactone (ENL), which is derived from SDG, suppressed IL-4 production via the JAK-STAT6 signaling pathway. These findings suggest that SDG and ENL may have potential as therapeutic candidates for AD treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Allergy
Daphne S. Bakker, Marlies de Graaf, Stefan Nierkens, Eveline M. Delemarre, Edward Knol, Femke van Wijk, Marjolein S. de Bruin-Weller, Julia Drylewicz, Judith L. Thijs
Summary: This study identified four distinct patient clusters based on serum biomarker profiles in pediatric atopic dermatitis (AD) patients, and compared them with clusters found in adult AD patients. These findings highlight the importance of studying AD in children and provide a basis for exploring different treatment approaches.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Pan Huang, Fan Hu, Zhi-Bo Yang, Yi Pan, Rong Zhou, Yi-Ning Yan, Hai-Zhen Wang, Chang Wang
Summary: This study investigated the pharmacological effects of matrine on atopic dermatitis (AD) and its underlying mechanism. Matrine was found to alleviate AD symptoms and decrease the expression of heat shock protein 90 (Hsp90). It also inhibited the secretion of inflammatory cytokines by repressing the Hsp90/NF-kappa B signaling axis, thereby regulating the Th1/Th2 inflammatory response and providing a potential candidate for AD treatment.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Dermatology
Yue Zhang, Hanyi Zhang, Boyue Jiang, Xiaoliang Tong, Siyu Yan, Jianyun Lu
Summary: Atopic dermatitis is a chronic inflammatory skin disease involving skin barrier dysfunction and immune imbalance. Neuropeptides, secreted by nerve endings, may play roles in AD by promoting vasodilation, plasma extravasation, chemotaxis of inflammatory cells, and mediating pruritus. Neuropeptides could be novel potential targets in the treatment of AD.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Tropical Medicine
Fardin Khajepour, Mohammad Zangouyee, Arezu Khosravimashizi, Ali Afgar, Vahideh Abdollahi, Shahriar Dabiri, Reza Nosratabadi
Summary: Caraway has been found to possess anti-inflammatory and antioxidant effects in mice with atopic dermatitis, reducing the severity of dermatitis, regulating cytokines and antioxidant parameters to improve the disease symptoms.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Thi Van Nguyen, Chun Hua Piao, Yan Jing Fan, Zhen Nan Yu, So-Young Lee, Chang Ho Song, Hee Soon Shin, Ok Hee Chai
Summary: This study investigated the effects of Artemisia gmelinii extracts (AGE) on an ovalbumin-induced CARAS mouse model. The results demonstrated that AGE could alleviate symptoms, regulate immune response, and inhibit mast cell degranulation, suggesting its potential as a therapeutic agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Remo Poto, Isabella Quinti, Gianni Marone, Maurizio Taglialatela, Amato de Paulis, Vincenzo Casolaro, Gilda Varricchi
Summary: Release of proinflammatory mediators and cytokines from basophils and mast cells mediated by IgE is a key event in allergic disorders. The presence and functional activity of anti-IgE autoantibodies in atopic dermatitis (AD) are largely unknown. This study evaluated the ability of IgG anti-IgE from patients with AD to induce in vitro IgE-dependent activation of basophils and mast cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Axel P. Villani, Ana B. Pavel, Jianni Wu, Marie Fernandes, Catherine Maari, Etienne Saint-Cyr Proulx, Carolyn Jack, Jacob Glickman, Seulah Choi, Helen He, Benjamin Ungar, Yeriel Estrada, Naoya Kameyama, Ning Zhang, Juana Gonzales, Jean-Claude Tardif, James G. Krueger, Robert Bissonnette, Emma Guttman-Yassky
Summary: The study found significant correlations between vascular inflammation and Th2-related products in the skin and blood of AD patients, as well as atherosclerosis-related markers modulated by dupilumab. Circulating levels of endothelial microparticles were significantly higher in severe AD patients and tended to correlate with vascular inflammation.
Review
Allergy
Daphne Bakker, Marjolein de Bruin-Weller, Julia Drylewicz, Femke van Wijk, Judith Thijs
Summary: Atopic dermatitis (AD) is a complex and heterogeneous inflammatory skin disease. The development of targeted therapies for AD has prompted the need for patient stratification using immunologic biomarkers. This review examines the use of different biomarkers to classify AD patients based on immunologic profiles and predictive biomarkers, aiming to achieve personalized and endotype-specific management.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Georgia Pappa, Dimitrios Sgouros, Konstantinos Theodoropoulos, Antonios Kanelleas, Evangelia Bozi, Stamatios Gregoriou, Konstantinos Krasagakis, Alexander C. Katoulis
Summary: Atopic dermatitis is a complex inflammatory skin disease with multiple underlying factors. Recent studies have highlighted the important roles of interleukins-4 and -13 in the pathogenesis of atopic dermatitis. Novel therapeutic approaches targeting Th2 cytokines and their pathways offer potential for optimizing the treatment of atopic dermatitis.
JOURNAL OF CLINICAL MEDICINE
(2022)