p53-targeted lincRNA-p21 acts as a tumor suppressor by inhibiting JAK2/STAT3 signaling pathways in head and neck squamous cell carcinoma

Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma

(2018) Hailong Ma et al.   BRITISH JOURNAL OF CANCER

STAT3/HOTAIR Signaling Axis Regulates HNSCC Growth in an EZH2-dependent Manner

(2018) Shanshan Sun et al.   CLINICAL CANCER RESEARCH

Cell division cycle 7 is a potential therapeutic target in oral squamous cell carcinoma and is regulated by E2F1

(2018) Shufang Jin et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments

(2018) Benjamin Solomon et al.   SEMINARS IN CANCER BIOLOGY

FXR1 Is an IL-19-Responsive RNA-Binding Protein that Destabilizes Pro-inflammatory Transcripts in Vascular Smooth Muscle Cells

(2018) Allison B. Herman et al.   Cell Reports

Loss of GAS5 tumour suppressor lncRNA: an independent molecular cancer biomarker for short-term relapse and progression in bladder cancer patients

(2018) Margaritis Avgeris et al.   BRITISH JOURNAL OF CANCER

Interferon-alpha promotes immunosuppression through IFNAR1/STAT1 signalling in head and neck squamous cell carcinoma

(2018) Hailong Ma et al.   BRITISH JOURNAL OF CANCER

LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumorigenesis by promoting cell-cycle progression

(2018) Ru Wang et al.   Molecular Cancer

Stathmin is overexpressed and regulated by mutant p53 in oral squamous cell carcinoma

(2017) Hai-long Ma et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

LincRNa-p21: function and mechanism in cancer

(2017) Shaoyun Chen et al.   MEDICAL ONCOLOGY

Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others

(2017) Kanaga Sabapathy et al.   Nature Reviews Clinical Oncology

Long intragenic non-coding RNA lincRNA-p21 suppresses development of human prostate cancer

(2016) Xiaohai Wang et al.   CELL PROLIFERATION

lincRNA-p21 inhibits invasion and metastasis of hepatocellular carcinoma through Notch signaling-induced epithelial-mesenchymal transition

(2016) Meng Jia et al.   HEPATOLOGY RESEARCH

Overexpression of lncRNA H19/miR-675 promotes tumorigenesis in head and neck squamous cell carcinoma

(2016) Guo-fang Guan et al.   International Journal of Medical Sciences

LincRNA-p21 Impacts Prognosis in Resected Non–Small Cell Lung Cancer Patients through Angiogenesis Regulation

(2016) Joan J. Castellano et al.   Journal of Thoracic Oncology

H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer

(2016) Masahisa Ohtsuka et al.   EBioMedicine

LincRNA-p21 predicts favorable clinical outcome and impairs tumorigenesis in diffuse large B cell lymphoma patients treated with R-CHOP chemotherapy

(2015) Wei Peng et al.   CLINICAL AND EXPERIMENTAL MEDICINE

XL413, a cell division cycle 7 kinase inhibitor enhanced the anti-fibrotic effect of pirfenidone on TGF-β1-stimulated C3H10T1/2 cells via Smad2/4

(2015) Shu-fang Jin et al.   EXPERIMENTAL CELL RESEARCH

lincRNA-p21 inhibits hepatic stellate cell activation and liver fibrogenesis via p21

(2015) Jianjian Zheng et al.   FEBS Journal

Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling

(2015) Wei-Ming Fu et al.   JOURNAL OF HEPATOLOGY

p53-dependent non-coding RNA networks in chronic lymphocytic leukemia

(2015) C J Blume et al.   LEUKEMIA

HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer

(2015) Andrew E. Teschendorff et al.   Genome Medicine

The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis

(2015) Qing Chang et al.   NEOPLASIA

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters

(2014) Xichen Bao et al.   CELL RESEARCH

LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity

(2014) Gengze Wu et al.   CIRCULATION

c-Myc-induced, long, noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer

(2014) Er-Bao Zhang et al.   MEDICAL ONCOLOGY

Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

(2014) Ge Zhou et al.   MOLECULAR CELL

LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint

(2014) Nadya Dimitrova et al.   MOLECULAR CELL

Association of p21 with NF-YA suppresses the expression of Polo-like kinase 1 and prevents mitotic death in response to DNA damage

(2014) Y-C Lin et al.   Cell Death & Disease

Clinical Significance of Long Intergenic Noncoding RNA-p21 in Colorectal Cancer

(2013) Haiyan Zhai et al.   Clinical Colorectal Cancer

Reciprocal Regulation of HIF-1α and LincRNA-p21 Modulates the Warburg Effect

(2013) Fan Yang et al.   MOLECULAR CELL

Long non-coding RNAs: new players in cell differentiation and development

(2013) Alessandro Fatica et al.   NATURE REVIEWS GENETICS

LncRNA loc285194 is a p53-regulated tumor suppressor

(2013) Qian Liu et al.   NUCLEIC ACIDS RESEARCH

The molecular pathogenesis of head and neck squamous cell carcinoma

(2012) S. Michael Rothenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

LincRNA-p21 Suppresses Target mRNA Translation

(2012) Je-Hyun Yoon et al.   MOLECULAR CELL

RNAscope

(2011) Fay Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL