Article
Immunology
Qimin Zhou, Ouyang Yuan, Hongtu Cui, Tao Hu, Gary Guishan Xiao, Jiao Wei, Honglei Zhang, Chengjun Wu
Summary: HPV infection is identified as a significant carcinogen for head and neck squamous cell carcinomas, altering the tumor microenvironment. Through RNA sequencing analysis, genes associated with HNSCC development and patient survival were identified, regulated negatively by DNA methylation and correlated with the tumor microenvironment and immune infiltration in HNSCC.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Yu-Hsuan Lin, Yi-Fang Yang, Yow-Ling Shiue
Summary: In head and neck squamous cell carcinoma, FCGBP expression level is lower in cancer tissues, and a high FCGBP level is significantly associated with better overall- and disease-specific-survivals. Low FCGBP levels correlated to a higher tumor protein p53 (TP53) mutation rate, and FCGBP may regulate the tumor microenvironment through affecting immune and inflammatory responses.
Review
Medicine, General & Internal
Kamila Romanowska, Agnieszka Sobecka, Agnieszka A. Rawluszko-Wieczorek, Wiktoria M. Suchorska, Wojciech Golusinski
Summary: Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with molecular pathogenesis involving cell cycle disorders, intercellular signaling, proliferation, squamous cell differentiation, and apoptosis. In addition to genetic mutations, epigenetic alterations such as DNA methylation and histone modifications play a key role in promoting cancer formation and progression, making them potential biomarkers and therapeutic targets for HNSCC.
Article
Oncology
Linhui Yang, Zhiwei Chen, Yunliang Liu, Xiaoyan Wang, Jing Li, Qing Ye
Summary: This study investigates the potential molecular biological roles of immune ferroptosis genes in head and neck squamous cell carcinoma (HNSC) and establishes 12 immune-ferroptosis-related mRNA (IFRM) signatures for predicting clinical outcomes and treatment responses. The characteristic-based risk scores derived from the IFRM signatures show better predictive accuracy than traditional clinicopathological features. The study also reveals significant differences in the expression of certain immune cells and genes between high- and low-risk groups, as well as higher proportion of high-risk mutations in the former. Furthermore, the high-risk group demonstrates increased sensitivity to specific chemotherapy drugs.
Article
Oncology
Julia Schnoell, Alexandra Scheiflinger, Sega Al-Gboore, Lorenz Kadletz-Wanke, Lukas Kenner, Gregor Heiduschka, Bernhard J. Jank
Summary: PSMD14 is commonly expressed in HNSCC patients and associated with advanced stages. High expression of PSMD14 mRNA is associated with a worse outcome, but this may be due to the association of PSMD14 with poor prognosticators.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Teresa Magnes, Sandro Wagner, Dominik Kiem, Lukas Weiss, Gabriel Rinnerthaler, Richard Greil, Thomas Melchardt
Summary: Head and neck squamous cell carcinoma is a heterogeneous disease arising from the mucosa of the upper aerodigestive tract, with only about one third of patients responding to checkpoint inhibitors. HPV status and combined positive score are the main biomarkers used in clinical practice, while other factors like tumor mutational burden and immune microenvironment show promise but require validation in prospective trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Baoling Liu, Quanping Su, Jianhua Ma, Cheng Chen, Lijuan Wang, Fengyuan Che, Xueyuan Heng
Summary: The study established an eight-gene signature for predicting prognosis in patients with head and neck squamous cell carcinoma (HNSCC). The signature was shown to be independent and effective in prognostic evaluation, facilitating personalized treatment for HNSCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yaoting Zhang, Dongsheng Gu
Summary: This study found that pretreatment serum CRP level is associated with prognosis in patients with head and neck squamous cell carcinoma. Patients with high CRP level had worse survival outcomes, and CRP level is correlated with N1-3 stage and prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Cheng Lin, Yuebing Chen, Jianji Pan, Qiongjiao Lu, Pengjie Ji, Shuiqin Lin, Chunfeng Liu, Shaojun Lin, Meifang Li, Jingfeng Zong
Summary: This study aimed to construct a risk model based on therapeutic response-related genes (TRRGs) to predict therapy response and prognosis in TRRGs-defined subgroups of head and neck squamous cell carcinoma (HNSCC). By analyzing data from TCGA and GEO databases, differentially expressed TRRGs significantly associated with survival were identified, and a signature and prognostic nomogram based on TRRGs were established. The results showed that the model could effectively predict therapy response and overall survival in HNSCC patients.
Article
Cell Biology
Chao Huang, Yun Liang, Yi Dong, Li Huang, Anlei Li, Ran Du, Hao Huang
Summary: This study establishes a novel prognostic model for head and neck squamous cell carcinoma (HNSCC) based on six matrisome genes. The high-risk group has worse prognosis and higher enrichment of pathways associated with cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Health Care Sciences & Services
Wenmei Jiang, Yudong Li, Ruiyu Li, Wenkuan Chen, Ming Song, Quan Zhang, Shuwei Chen
Summary: This study aimed to investigate the clinical significance of FOXD1 in head and neck squamous cell carcinoma (HNSCC). The results showed that FOXD1 expression was closely associated with postoperative recurrence and patients with high FOXD1 expression had poorer prognoses. Multivariate analysis revealed that FOXD1 was an independent prognostic factor for overall survival and disease-free survival in HNSCC patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Genetics & Heredity
Longzhu Zhao, Jiusi Liang, Wen Zhong, Caixia Han, Dongzhe Liu, Xiuhui Chen
Summary: This study found that BGN is highly expressed in Head and neck squamous cell carcinoma (HNSC) and is associated with poor clinical outcome. BGN may serve as a potential prognostic biomarker for patients survival in HNSC.
Article
Biochemistry & Molecular Biology
Cristina Stefania Dumitru, Amalia Raluca Ceausu, Nela Pusa Gaje, Cristian Silviu Suciu, Marius Raica
Summary: This study demonstrates the importance of double immunolabeling in assessing lymphangiogenesis and tumor proliferation in correlation with histopathological grades in HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Wanzun Lin, Yanyan Xu, Jing Gao, Haojiong Zhang, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Summary: The study identifies B7-H3 as a novel biomarker for head and neck squamous cell carcinoma (HNSCC), predicting prognosis and response to immunotherapy; high expression of B7-H3 is associated with poor prognosis, immunotherapy resistance, and contributes to an immunosuppressive microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hasan Baysal, Vasiliki Siozopoulou, Hannah Zaryouh, Christophe Hermans, Ho Wa Lau, Hilde Lambrechts, Erik Fransen, Ines De Pauw, Julie Jacobs, Marc Peeters, Patrick Pauwels, Jan Baptist Vermorken, Evelien Smits, Filip Lardon, Jorrit De Waele, An Wouters
Summary: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors with a poor prognosis. This study explored the immune signature and the interaction between HNSCC and the immune system. The results identified potential therapeutic targets and prognostic factors for HNSCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Thana Patimarattananan, Arkom Nongnuch, Poompis Pattaranutaporn, Nattawut Unwanatham, Chuleeporn Jiarpinitnun, Nuttapong Ngamphaiboon
Summary: An incidence of 34% cisplatin-induced acute kidney injury was reported in locally advanced head and neck squamous cell carcinoma patients. One third of patients who underwent cisplatin-based chemoradiotherapy developed acute kidney disease (AKD), with eGFR not recovering to baseline even after 1 year. Factors associated with AKD included ECOG status 0 and hypertension.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Cardiac & Cardiovascular Systems
Pongprueth Rujirachun, Apichaya Junyavoraluk, Manop Pithukpakorn, Bhoom Suktitipat, Arjbordin Winijkul
Summary: Andersen-Tawil syndrome (ATS) is a rare disorder characterized by ventricular arrhythmia, dysmorphic features, and periodic paralysis. Treatment of arrhythmia during pregnancy in ATS patients is challenging, but a combination of beta-blocker and flecainide may be effective. Two ATS patients successfully underwent vaginal birth, suggesting potential benefits of combined therapy for managing arrhythmia during pregnancy.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2021)
Article
Pediatrics
Thipwimol Tim-Aroon, Khunton Wichajarn, Kamornwan Katanyuwong, Pranoot Tanpaiboon, Nithiwat Vatanavicharn, Kullasate Sakpichaisakul, Arthaporn Kongkrapan, Jakris Eu-ahsunthornwattana, Supranee Thongpradit, Kanya Moolsuwan, Nusara Satproedprai, Surakameth Mahasirimongkol, Tassanee Lerksuthirat, Bhoom Suktitipat, Natini Jinawath, Duangrurdee Wattanasirichaigoon
Summary: Sandhoff disease (SD) is an autosomal recessive lysosomal storage disorder caused by deficiency of beta -hexosaminidase B (HEX-B) due to pathogenic variant of human HEXB gene. This study identified potential common variant in HEXB in Thai patients with infantile onset SD and provided data that can aid in rapid molecular confirmation of the disease.
Review
Health Care Sciences & Services
Manit Saeteaw, Phitjira Sanguanboonyaphong, Jukapun Yoodee, Kaitlyn Craft, Ratree Sawangjit, Nuttapong Ngamphaiboon, Prapimporn Chattranukulchai Shantavasinkul, Suphat Subongkot, Nathorn Chaiyakunapruk
Summary: The study found that several pharmacological interventions have the potential to offer benefits in the treatment of cachexia, especially high-dose megestrol acetate and short-term use corticosteroids. However, high-quality comparative studies are needed to compare safety and efficacy for better management of cachexia.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2021)
Article
Oncology
Lalida Arsa, Teerada Siripoon, Narumol Trachu, Sasithorn Foyhirun, Duangjai Pangpunyakulchai, Suda Sanpapant, Natini Jinawath, Poompis Pattaranutaporn, Artit Jinawath, Nuttapong Ngamphaiboon
Summary: The prevalence of HPV infection and p16 expression is lower in Thai patients with HNSCC compared to Western countries. p16 is a significant prognostic factor for OS in both HPV-associated oropharyngeal squamous cell carcinoma and non-OPSCC. Detection of HPV should be performed regardless of p16 expression in order to assess the association with HNSCC.
Article
Hematology
Fei Yang, Nicola Long, Tauangtham Anekpuritanang, Daniel Bottomly, Jonathan C. Savage, Tiffany Lee, Jose Solis-Ruiz, Uma Borate, Beth Wilmot, Cristina Tognon, Allison M. Bock, Daniel A. Pollyea, Saikripa Radhakrishnan, Srinidhi Radhakrishnan, Prapti Patel, Robert H. Collins, Srinivas Tantravahi, Michael W. Deininger, Guang Fan, Brian Druker, Ujwal Shinde, Jeffrey W. Tyner, Richard D. Press, Shannon McWeeney, Anupriya Agarwal
Summary: Inherited predisposition to myeloid malignancies is more common than previously appreciated. Through whole-exome sequencing analysis on 391 adult patients, it was found that pathogenic/likely pathogenic germline variants were identified in 13.6% of acute myeloid leukemia (AML) patients in 34 genes. This highlights the need for a comprehensive understanding of the predisposition potential of many germline variants.
Article
Integrative & Complementary Medicine
Jiraporn Jantaravinid, Sukhum Jiamton, Chatchawan Srisawat, Bhoom Suktitipat, Napatara Tirawanchai
Summary: A randomized clinical trial showed that Clinacanthus nutans Lindua (C. nutans) had a different therapeutic effect and molecular mechanism compared with podophyllin in treating condyloma acuminata (CA). C. nutans demonstrated efficacy in reducing CA lesions and inhibiting HPV infection through the activation of immune response, suggesting it as a potential alternative treatment for CA.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Tauangtham Anekpuritanang, Maythad Uataya, Apichaya Claimon, Natthawadee Laokulrath, Warut Pongsapich, Paveena Pithuksurachai
Summary: The study found that papillary thyroid carcinomas with BRAF(V)(600E) mutation were more likely to be negative for NIS expression. Both BRAF(V)(600E) mutation and NIS expression cannot be used as predictors for radioiodine sensitivity.
ONCOTARGETS AND THERAPY
(2021)
Review
Genetics & Heredity
Pongtawat Lertwilaiwittaya, Bhoom Suktitipat, Phongphak Khongthon, Warut Pongsapich, Chanin Limwongse, Manop Pithukpakorn
Summary: This report describes Thai siblings with an ultra-rare form of osteopetrosis. Molecular diagnosis identified a novel mutation in TNFSF11 (RANKL) in both siblings, leading to a milder phenotype compared to previously published cases.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Letter
Hematology
Tauangtham Anekpuritanang, Matthew M. Klairmont, Joel Gradowski, Kohei Hagiwara, Nathanael G. Bailey, Pranil Chandra, Yiwei Liu, Heather L. Mulder, John Easton, Jinghui Zhang, Michael G. Martin, Anna B. Owczarczyk, Jennifer B. Dunlap, Guang Fan, Richard D. Press, Philipp W. Raess
Article
Biochemistry & Molecular Biology
Jarichad Toosaranont, Sukanya Ruschadaariyachat, Jantarika Kumar Arora, Varodom Charoensawan, Bhoom Suktitipat, Thomas N. Palmer, Sue Fletcher, Steve D. Wilton, Chalermchai Mitrpant, Warasinee Mujchariyakul
Summary: This study explores the restoration of SMN expression in fibroblasts from a type I SMA patient using antisense oligonucleotides. The induction of hnRNPA1b is found to enhance SMN protein expression, but not at a clinically relevant level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Sophida Suta, Apinya Surawit, Pichanun Mongkolsucharitkul, Bonggochpass Pinsawas, Thamonwan Manosan, Suphawan Ophakas, Tanyaporn Pongkunakorn, Sureeporn Pumeiam, Kitti Sranacharoenpong, Sawannee Sutheeworapong, Patcha Poungsombat, Sakda Khoomrung, Pravit Akarasereenont, Iyarit Thaipisuttikul, Bhoom Suktitipat, Korapat Mayurasakorn
Summary: The study found that providing additional eggs to primary school children can improve growth, gut microbiota, and nutritional biomarkers without adverse effects on blood lipoproteins.
Article
Otorhinolaryngology
Prachya Maneeprasopchoke, Cheerasook Chongkolwatana, Warut Pongsapich, Ayaka J. Iwata, Dipti Kamani, Gregory W. Randolph
Summary: This study evaluated the clinical value of intraoperative nerve monitoring in thyroidectomies by comparing procedure times for surgeries performed with and without IONM. The results showed that IONM reduced the time needed for recurrent laryngeal nerve identification, providing reassurance to surgeons and not significantly impacting setup and total operative times.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2021)
Article
Surgery
Warut Pongsapich, Cheerasook Chongkolwatana, Hataikarn Chuetnok, Narin Ratanaprasert
Summary: Transoral robotic surgery (TORS) is a novel approach for treating head and neck tumors, with favorable postoperative outcomes. Despite challenges, cost-effective utilization and proper training can help shorten the learning curve for operative staff.
JOURNAL OF ROBOTIC SURGERY
(2021)
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.