Journal
MICRO & NANO LETTERS
Volume 14, Issue 8, Pages 852-855Publisher
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/mnl.2018.5806
Keywords
laser sintering; tissue engineering; porous materials; elastic moduli; bone; elongation; biomedical materials; cellular biophysics; biological tissues; elasticity; polymer blends; selective laser sintering; tissue engineering; porous polycaprolactone scaffolds; critical processing parameters; experiment mechanical property assessment; PCL-alginate-polyacrylamide scaffold; cell seeding; in vitro culture; cell viability; SLS technique; skeletal tissue repair; elastic modulus
Funding
- National Natural Science Foundation of China [61603002]
- 973 Project [2014CB931804]
- 111 Projects [B07033]
- NSFC-CAS Joint Fund [U1332130]
- Key Research and Development Program of Anhui [1704a0902051]
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In this work, porous polycaprolactone (PCL) scaffolds were designed and fabricated using selective laser sintering (SLS). The critical processing parameters of the SLS for PCL were optimised. This work post-processed these PCL scaffolds to produce PCL/alginate/polyacrylamide (PAAm) scaffolds to improve their performance. The experiment mechanical property assessment showed that the sample's average elastic modulus increases from 6.99 MPa (PCL) to 12.67 MPa (PCL/alginate/PAAm), and the elongation at break of samples increases from 59% (PCL) to 112.9% (PCL/alginate/PAAm). Cell seeding and in vitro culture showed that cell viability remained above 94% over 5 days. Thus, the current study suggests that a promising strategy for the improvement of the characteristics of PCL/alginate/PAAm scaffolds and advances the potential application of SLS technique towards skeletal tissue repair.
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