Article
Nanoscience & Nanotechnology
Monica G. Simoes, Georg Urstoeger, Robert Schennach, Ulrich Hirn
Summary: Adhesion occurs at nanoscale contact between surfaces, which can be evaluated using FRET spectroscopy/microscopy within a range of 1-10 nm. Increased pressure during film pressing leads to higher NSC and adhesion force/energy. FRET microscopy enables visualization of local variations in molecular contact.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Qian Meng, Junxiong Yao, Mengyu Chen, Yajie Dong, Xinyi Liu, Shuyang Zhao, Rui Qiao, Cuibing Bai, Changqing Qu, Hui Miao
Summary: In this study, a novel near-infrared fluorescence sensor DBHM was developed for the detection of ascorbic acid (AA) involving Cu2+. The DBHM + Cu2+ sensor exhibited high sensitivity with a detection limit of 2.37 μM. A dual-mode sensing platform (fluorescence and smartphone app) was utilized for qualitative and quantitative detection of AA in beverages, fruits, and Vitamin C tablets. Furthermore, the sensor demonstrated low toxicity and excellent bioimaging in various living organisms.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Nyema M. Harmon, Xueting Huang, Chia-Hung Christine Hsiao, Andrew J. Wiemer, David F. Wiemer
Summary: Cell-cleavable protecting groups combined with fluorescent groups can be an effective strategy for constructing biological probes to address issues such as stability, solubility, and cellular uptake. A novel synthesis method was utilized to successfully create a phosphonate compound containing a FRET pair, which can deliver payloads to intracellular receptors. This study demonstrates the potential of bioactivatable phosphonates with FRET pairs in developing probes for monitoring cellular uptake of otherwise charged payloads.
BIOORGANIC CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Shuya Liu, Xiaoling Liu, Yanjun Gong, Qiongzheng Hu, Li Yu
Summary: In the field of fluorescence-based gas sensing, it is challenging to distinguish molecules with similar chemical properties and slight structural differences. In this study, coassemblies of energy-donor molecule 1 and energy-acceptor molecule 2 with different molar ratios were fabricated. These materials selectively differentiate methanol and ethanol by regulating the distance of exciton migration and can also detect methanol from the mixture vapors of methanol and ethanol.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Ashton N. Bartley, Sadie F. Depeter, Ronald K. Castellano
Summary: This article reports the preparation and photophysical investigation of the first molecular multi-FRET system from the benzotrifuranone (BTF) scaffold. The target molecule was synthesized using a step-conservative approach, incorporating three optically complementary chromophores. The study demonstrates high energy transfer efficiency and significant pseudo-Stokes shift in the fluorescence emission of the target. The design has potential applications in material science and life sciences.
Article
Chemistry, Analytical
Ning Li, Feng Zhang, Wenying Sun, Lili Zhang, Xingguang Su
Summary: In this study, a sensitive fluorescence biosensor based on fluorescence resonance energy transfer (FRET) between MoS2 quantum dots (MQDs) and CoOOH nanoflakes was developed for the assay of ascorbic acid oxidase (AAO). Under optimal experimental conditions, the developed fluorescence method exhibited good linear ranges and low detection limits for AAO detection. The proposed biosensor showed high sensitivity and selectivity, and was successfully applied for AAO determination in human serum samples.
Review
Chemistry, Multidisciplinary
Bin Fang, Yu Shen, Bo Peng, Hua Bai, Limin Wang, Jiaxin Zhang, Wenbo Hu, Li Fu, Wei Zhang, Lin Li, Wei Huang
Summary: This article summarizes the advances of small-molecule quenchers used in FRET-based probes, and provides suggestions for the rational design and selection of fluorophore-quencher FRET pairs that are compatible with challenging analytical applications in various biological systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Nutrition & Dietetics
Anitra C. Carr, Jens Lykkesfeldt
Summary: The study examines the relationship between vitamin C dose and concentration, specifically in relation to age and smoking status. It found that while vitamin C intake was similar across age groups, older individuals had significantly lower circulating vitamin C concentrations. This effect was more pronounced in non-smokers and suggests that older individuals may be more sensitive to low vitamin C intake, possibly due to the effects of long-term smoking and increased chronic disease prevalence.
Article
Chemistry, Analytical
P. Venugopalan, N. Vidya
Summary: In this study, a completely greener method was used to convert a natural precursor into high-valued nano-scale material using microwave-assisted conversion. The fluorescent carbon dots prepared, known as long pepper derived carbon dots (LPCDs), were thoroughly characterized and found to exhibit excitation dependent emission behavior. The LPCDs were successfully employed as a fluorescent sensing probe for detecting Sudan I with good selectivity and sensitivity.
Article
Chemistry, Physical
Abdullah O. Hamza, Ali Al-Dulaimi, Jean-Sebastien G. Bouillard, Ali M. Adawi
Summary: The development of a long-range and efficient FRET process is crucial for optoelectronic and sensing technologies. Researchers experimentally demonstrate long-range and high-efficiency FRET using a plasmonic nanogap. This study provides a strategy to develop novel optoelectronic devices and long-range FRET imaging and sensing systems.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Biochemistry & Molecular Biology
Lydia Olejko, Anushree Dutta, Kosar Shahsavar, Ilko Bald
Summary: In this study, specific G-quadruplex structures formed by reversed human telomeric DNA in the presence of different cations were analyzed using circular dichroism spectroscopy and Forster resonance energy transfer. The results provide important insights into the formation of G-quadruplexes in different environments and the rational design of G-quadruplex-based applications in sensing and nanotechnology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biophysics
Ganapathi Bharathi, Fangrui Lin, Liwei Liu, Tymish Y. Ohulchanskyy, Rui Hu, Junle Qu
Summary: Ovarian cancer is a deadly disease threatening women's health, and late diagnosis is a major reason for related deaths. Using HE4 as a biomarker can improve the accuracy of ovarian cancer diagnosis. Developing an all-graphene quantum dot FRET probe allows for ratiometric detection of the HE4 ovarian cancer biomarker.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Louise Idalgo Vasques, Cristina Wohlke Vendruscolo, Gislaine Ricci Leonardi
Summary: The topical application of vitamin C and its derivatives in skincare is essential, but there is still a lack of scientific data regarding their efficacy, especially in vivo. Studies on the stability, safety, adverse reactions, and efficacy with standardized parameters and a relevant number of subjects are necessary for better understanding their effects.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Marcelo Villagran, Jorge Ferreira, Miquel Martorell, Lorena Mardones
Summary: Vitamin C plays a significant role in cancer prevention and treatment, with studies showing its potential benefits in preventing pulmonary and breast cancer, as well as its synergistic effects with pancreatic cancer drugs. However, a Mendelian randomized study did not find an association between vitamin C and cancer prevention. Ongoing research is needed to further explore the therapeutic role of vitamin C in cancer through new phase II and III clinical trials.
Article
Nutrition & Dietetics
Nayef Chahin, Miheret S. Yitayew, Alicia Richards, Brielle Forsthoffer, Jie Xu, Karen D. Hendricks-Munoz
Summary: Little is known about the nutritional needs of premature infants <37 weeks gestation. This study investigated the relationship between infant characteristics, maternal health, and plasma ascorbic acid (AscA) levels in premature infants during postnatal development. The results suggest that prenatal and postnatal factors influence the initial AscA levels, potentially impacting organ health and disease risk. Dietary targets may need to be adjusted for this population.