Article
Chemistry, Applied
Xiangsheng Zhao, Dan Liu, Xinquan Yang, Lei Zhang, Meihua Yang
Summary: An UPLC-MS/MS method was developed for the detection of Alternaria mycotoxins in edible and medicinal herbs. The method showed satisfactory extraction with lower matrix effect. It was successfully applied to analyze 260 samples, revealing a high incidence of contamination by multiple mycotoxins. Alternariol mono methylether was the predominant mycotoxin. The results obtained from this study will contribute to better risk assessments and future regulation.
Article
Plant Sciences
Xinrui Wang, Jingze Zhang, Lifei Luo, Xinbo Song, Ping Wang, Dailin Liu
Summary: In this study, a rapid and sensitive UPLC-MS/MS analytical method was developed and applied to 24 major bioactive components in normal and ARDS rats after the oral administration of XFBD granules. This will serve to form the basis for further studies on the pharmacokinetic-pharmacodynamic correlation of XFBD granules.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Qiang You, Dan Li, Haiyan Ding, Hongping Chen, Yuan Hu, Youping Liu
Summary: Polymethoxyflavones (PMFs) are a subgroup of flavonoids with various health benefits. The number and position of hydroxy and methoxy groups play an important role in modulating the pharmacokinetics and metabolites of PMFs, with hydroxy-containing PMFs generally more cytotoxic than those without hydroxy groups.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Environmental Sciences
Thamires Martins, Claudia Schinke, Sonia C. N. Queiroz, Patricia A. de C. Braga, Fabio S. P. Silva, Itamar S. Melo, Felix G. R. Reyes
Summary: The fungus Acremonium camptosporum associated with the marine sponge Aplysina fulva was found to produce antibacterial secondary metabolites. Analysis of mass spectra data revealed the presence of cytotoxic compounds, indicating a close association between the sponge and the fungus with its compounds.
Article
Pharmacology & Pharmacy
Baorui Cao, Zhiying Wang, Jiayi Zhang, Jialei Fu, Zhongwen Zhang, Jinxin Du, Tingting Deng, Jingxiang Pang, Meina Yang, Jinxiang Han
Summary: The quality evaluation system for Chinese herbs, especially fresh ones, is imperfect. This study aims to correlate the biophoton characteristics with the quality states of fresh Chinese herbs and find characteristic parameters for quality assessment. The results show that the counts per second (CPS) and initial intensity (I-0) of biophotons have better correlations with the quality states, making them potential parameters for assessing fresh Chinese herbs' quality.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Agricultural Engineering
Safa M. Shams Eldin, Eman Shawky, Shaimaa M. Sallam, Nefertiti El-Nikhely, Samah M. El Sohafy
Summary: This study utilized a metabolomic approach to investigate the chemical constituents in the roots and herbs of three Echinacea species and identified immunomodulatory biomarkers. The roots of E. angustifolia were separate from the other samples due to specific secondary metabolites. While the roots of Echinacea species exhibited similar immunomodulatory responses, the herbs were less efficient as immunomodulators.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Medicine, Research & Experimental
Kaihui Zhang, Meiqi Wang, Yufeng Yao, Tao Huang, Fangle Liu, Chenchen Zhu, Chaozhan Lin
Summary: A novel UPLC-MS method has been developed for the simultaneous determination of seven major bioactive components in Xiaoyan Lidan Formula in rat plasma. The method showed significant differences in pharmacokinetic properties of the analytes between cholestatic and control groups, providing valuable information for understanding the mechanism of XYLDF and its clinical applications.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemical Research Methods
Hongda Sheng, Yufei Li, Wei Liu, Yingchao Wang, Shufang Wang, Zhixue Zhan, Zhicheng Lai, Bin Guan, Shifa Qiang, Jing Qian, Yi Wang
Summary: This study identified the bioactive ingredients of Babaodan (BBD), a traditional Chinese medicine, using UPLC-QTOF-MS and mass spectrometry molecular networking analysis. Network pharmacology analysis was then performed to predict the potential targets and pathways regulated by BBD. Several compounds were found to have anti-inflammatory effects, validating their use in BBD. This research provides a scientific basis for the clinical application of BBD in inflammation-related diseases.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Plant Sciences
Tong-Tong Jin, Feng-Jie Liu, Yan Jiang, Long Wang, Xu Lu, Ping Li, Hui-Jun Li
Summary: The new strategy of molecular-network-guided discovery can efficiently differentiate the chemical differences in medicinal herbs with close genetic relationship and identify species-specific markers. These markers can be used for quality and safety control in medicinal herb industry.
Article
Plant Sciences
Gaurav Kumar, Sanjay Kumar Dey, Suman Kundu
Summary: Medicinal plants contain bioactive phytochemicals that can positively influence cardiovascular health, potentially offering anti-hypertensive and cardio-protective effects. However, some herbs may also have adverse effects, highlighting the importance of cautious evaluation when considering the use of medicinal plants in cardiovascular biology.
Article
Environmental Sciences
Jing Dai, Linyuan Zhang, Jianfeng Xu, Fangda Peng, Zhijun Wu, Longlong Fu, Ying Guo, Bing Chang, Wenhong Lu, Chunguang Ding
Summary: We developed a method to detect four endocrine-disrupting chemicals (parabens) and two metabolites in human seminal plasma. The study analyzed 144 seminal plasma samples from Chinese males and found that parabens and their metabolites are widely distributed in the male reproductive system. The study also provided the first measurement of paraben metabolite levels in human seminal plasma.
Review
Biochemistry & Molecular Biology
Bingyu Sun, Yongqiang Liu, Danhua He, Jinke Li, Jiawei Wang, Wulin Wen, Ming Hong
Summary: Current chemotherapy agents have severe cytotoxicity to normal cells, resulting in decreased quality of life. Traditional Chinese medicine ingredients have shown potential to sensitize tumor cells to TRAIL-induced apoptosis, offering new insights for cancer treatment.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Biochemistry & Molecular Biology
Dalia M. Rasheed, Ayat M. Emad, Sherifa F. Ali, Sameh S. Ali, Mohamed A. Farag, Meselhy R. Meselhy, Essam A. Sattar
Summary: The study evaluated the hydroxyl radical scavenging capacity of aqueous dill shoot extract and identified fraction 4 as having the highest radical scavenging activity. Metabolite profiling revealed 87 metabolites, with 64 compounds identified in the most active fraction. Additionally, the dill shoot extract demonstrated hepatoprotective effects against acetaminophen-induced liver damage in rats.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Jing Huang, Ruixing Chen, Jie Zhou, Qing Zhang, Cun Xue, Yueting Li, Lin Zheng, Yong Huang, Qun Wang, Yi Chen, Zipeng Gong
Summary: The pharmacokinetic effects of five active ingredients in Inula cappa extract were investigated in normal and inflammatory cells. The results showed that these ingredients exhibited nonlinear pharmacokinetic characteristics, with faster uptake and increased AUC and C-max values in inflammatory cells compared to normal cells. The pharmacokinetic profile was dose-dependent and changed in the inflammatory state.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Jia Zhang, Liwei Xu, Xinxin Xu, Xiaoling Wu, Hua Kuang, Chuanlai Xu
Summary: Mycotoxin pollution in cereal poses a great threat to food security and human health. This study systematically assessed the migration and transformation of sterigmatocystin (STG) mycotoxin during contaminated rice wine processing. The findings of this study provide new insights into the migration and transformation mechanism of STG during rice wine processing and shed light on the potential impact of STG on the metabolic profile of rice wine composition.