Article
Chemistry, Multidisciplinary
Qian-Zhi Ni, Bing Zhu, Yan Ji, Qian-Wen Zheng, Xin Liang, Ning Ma, Hao Jiang, Feng-Kun Zhang, Yu-Rong Shang, Yi-Kang Wang, Sheng Xu, Er-Bin Zhang, Yan-Mei Yuan, Tian-Wei Chen, Fen-Fen Yin, Hui-Jun Cao, Jing-Yi Huang, Ji Xia, Xu-Fen Ding, Xiao-Song Qiu, Kai Ding, Chao Song, Wen-Tao Zhou, Meng Wu, Kang Wang, Rui Lui, Qiu Lin, Wei Chen, Zhi-Gang Li, Shu-Qun Cheng, Xiao-Fan Wang, Dong Xie, Jing-Jing Li
Summary: This study reveals that PPDPF functions as an important regulator of SOS1 and promotes tumor development in pancreatic ductal adenocarcinoma (PDAC) through the PPDPF-SOS1 axis. This finding provides a potential therapeutic target for PDAC.
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Haiyuan Li, Lei Gao, Xiaojuan Kang, Xueyan Wang, Yang Yu, Yaqing Zhang, Hao Chen
Summary: This study explored the expression and function of 40S ribosomal protein S24 (RPS24) in hepatocellular carcinoma (HCC). Results showed that RPS24 was elevated in HCC samples and related to poor prognosis. Furthermore, RPS24 overexpression or promoter methylation correlated with unfavorable prognosis in HCC patients. High expression of RPS24 was associated with DNA replication, cell cycle, immune infiltration, and immunotherapy response. Experimental validation demonstrated that silencing of RPS24 suppressed HCC cell growth and tumor proliferation. Therefore, RPS24 may serve as a potential adverse biomarker for HCC prognosis, acting through cell proliferation facilitation and the formation of an immunosuppressive microenvironment, and targeting RPS24 could be a promising therapeutic option for HCC management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yanjing Zhu, Ruiqi Huang, Zhourui Wu, Simin Song, Liming Cheng, Rongrong Zhu
Summary: The differentiation of neural stem cells into neurons is crucial for potential cell-based therapeutic strategies for CNS diseases. Using deep learning, researchers have developed a reliable model for predicting NSCs fate, demonstrating high precision in identifying differentiated cell types early in culture and applicability across various inducers.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Tianlong Ding, Yang Yu, Lei Gao, Lin Xiang, Bo Xu, Baohong Gu, Hao Chen
Summary: ADAM17 is upregulated in hepatocellular carcinoma (HCC) and plays a crucial role in HCC development and immune evasion. Pathways involved include epithelial-mesenchymal transition, inflammatory response, Hedgehog, and KRAS signaling. ADAM17 is positively correlated with immune cell infiltration and immune checkpoint expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eugene Kopantzev, Liya Kondratyeva, Marina Kopantseva, Kirill Kashkin, Dmitry Gnatenko, Elizaveta Grigorieva, Irina Alekseenko, Dina Safina, Igor Chernov
Summary: SOX9 is upregulated in pancreatic ductal adenocarcinoma and plays a crucial role in tumor phenotypes and development. Downregulating the expression of SOX9 in pancreatic cancer cells leads to cell-line-specific changes in protein markers and affects cell proliferation and apoptosis.
Article
Medicine, Research & Experimental
Liping Sun, Shuguang Liu, Xiaopai Wang, Xuefeng Zheng, Ya Chen, Hong Shen
Summary: The study demonstrated that eIF6 expression was significantly increased in HCC and correlated with its pathological progression. eIF6 served as a new diagnostic biomarker and an independent risk factor for OS in HCC patients. Functional studies showed that deletion of eIF6 exhibited tumor-suppressor activity in HCC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Jiasheng Lei, Shuoshuo Ma, Wanliang Sun, Dongdong Wang, Zheng Lu, Dengyong Zhang
Summary: In this study, the researchers found that H2AFY is highly expressed in liver cancer cells and tissues. H2AFY promotes the proliferation and clone formation of liver cancer cells, but has no significant effects on cell migration and invasion. The study suggests that H2AFY could be a potential target for liver cancer therapy.
Article
Pharmacology & Pharmacy
Wenqian Qi, Qian Zhang
Summary: This study revealed the differentiation evolution and functional landscape of epithelial cells in hepatocellular carcinoma (HCC), and established a 3-gene risk model closely related to clinical features and drug sensitivity prediction.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Zhipeng Du, Zhongchao Zhang, Xu Han, Huaping Xie, Wei Yan, Dean Tian, Mei Liu, Caijun Rao
Summary: This study reveals the upregulation of SFXN4 in hepatocellular carcinoma (HCC) and its correlation with poor prognosis. SFXN4 is associated with oxidative phosphorylation, metabolic pathways, and several cancer-related pathways. It is regulated by multiple transcription factors and miRNAs. Knockdown of SFXN4 inhibits HCC proliferation, migration, and invasion in vitro, and suppresses tumor growth in vivo.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Oncology
Lin Cai, Yu Du, Kai Song, Peng Peng, Fei Han
Summary: The study found that transmembrane protein 88 (TMEM88) is negatively correlated with the progression of hepatocellular carcinoma (HCC), and higher levels of TMEM88 can predict better survival rates in HCC patients. In cell and animal models, overexpression of TMEM88 inhibits the growth of HCC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Manal Alfwuaires, Hany Elsawy, Azza Sedky
Summary: This study suggests that ACN can inhibit the activation of STAT3 and suppress the expression of genes associated with HCC, making it a promising therapeutic compound for the treatment of HCC and other cancers.
Article
Oncology
Ning Zhang, Cailing Lu, Jiao Mo, Xinhang Wang, Simi Liao, Ningjing Liang, Mei Feng, Tingting Tang, Yijie Wu, Yunqing Li, Chunhua Lan, Chengying Chen, Qianqian Shi, Lancheng Wei, Zhijian Zheng, Yu Lei, Zhiming Zhang, Shen Tang, Xiyi Li
Summary: This study evaluated the expression pattern and clinical significance of LCMT1 in HCC and found that LCMT1 was upregulated in HCC tissues and correlated with a poor prognosis. Further studies revealed that LCMT1 silencing inhibited the proliferation of HCC cells and its effect was partially dependent on PP2A. These findings provide new insights into HCC therapy and potential therapeutic targets.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Jianxin Tang, Jing Liu, Jinjun Li, Ziming Liang, Kaining Zeng, Haibo Li, Zhenlin Zhao, Li Zhou, Nan Jiang
Summary: The study found that SKA3 is highly expressed in liver cancer and is associated with clinical pathological characteristics and patient survival. GSEA analysis showed that SKA3 is correlated with proliferation-related gene set signaling pathways. Knockdown of SKA3 inhibited proliferation, cell cycle arrest, and tumorigenesis in liver cancer cells.
Article
Biochemistry & Molecular Biology
Tingting Zou, Yang Wang, Ling Dong, Tiantian Che, Huakan Zhao, Xiaohua Yan, Zhenghong Lin
Summary: This study reveals that the interaction between ubiquitin-specific peptidase 27 (USP27) and histone methyltransferase SETD3 promotes tumor cell growth and is positively correlated in hepatocellular carcinoma (HCC) tissues. Higher expression of USP27 and SETD3 predicts a worse survival in HCC patients.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
