Article
Endocrinology & Metabolism
Wei-Wei Chang, Li-Ying Wen, Liu Zhang, Xin Tong, Yue-Long Jin, Gui-Mei Chen
Summary: This study investigated the relationship between the miR-146a rs2910164 polymorphism and the genetic susceptibility of T2DM in the Chinese Han population and conducted a meta-analysis. The results showed that the miR-146a rs2910164 polymorphism was associated with the risk of T2DM in certain age and BMI subgroups, but no significant association was found in the overall meta-analysis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Qinxue Bao, Rui Li, Chengfeng Wang, Shan Wang, Minli Cheng, Chunhua Pu, Lei Zou, Chao Liu
Summary: This meta-analysis suggests that miR-146a rs2910164 may be associated with lower susceptibility to coronary heart disease. This association is particularly significant in the Chinese population.
Article
Biochemistry & Molecular Biology
Chrysostomos Avgeros, Aikaterini Patsatsi, Dimitrios Dimitriadis, Andigoni Malousi, Triantafyllia Koletsa, Despoina Papathemeli, Antonia Syrnioti, Paraskevi Avgerou, Elizabeth Lazaridou, Georgios Tzimagiorgis, Elisavet Georgiou
Summary: This study evaluates the plasma levels of miR-146a and miR-155 in Mycosis Fungoides (MF) patients and investigates their association with SNPs of their genes. The results show that the plasma levels of miR-146a and miR-155 are significantly higher in MF patients compared to controls, especially in early and advanced stages. miR-155 levels are significantly higher in patients with skin tumors or erythroderma. The presence of specific SNPs is associated with the expression of miRs and potentially with disease susceptibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Chao Liu, Wenhui Gao, Yijun Shi, Lu Lv, Weifeng Tang
Summary: This study investigated the relationship between miRNA rs2910164, rs11614913, and rs3746444 polymorphisms and the susceptibility to esophageal squamous cell cancer (ESCC) in the Chinese Han nationality. The results suggest that the rs3746444 GG genotype is associated with an increased risk of ESCC, while rs11614913 and rs2910164 polymorphisms are not associated with ESCC.
Article
Ophthalmology
Jiankang Shan, Pengyi Zhou, Zhenzhen Liu, Kaifeng Zheng, Xuemin Jin, Liping Du
Summary: The meta-analysis shows that the miRNA-146a gene polymorphism rs2910164 G allele increases susceptibility to Behcet's disease, especially in Caucasians.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Medicine, Research & Experimental
Xiang-Rui Qiao, Tao Zheng, Yifei Xie, Xinyi Yao, Zuyi Yuan, Yue Wu, Dong Zhou, Tao Chen
Summary: Polymorphisms in miR-146a and miR-34b are associated with the development and prognosis of ACS. The rs2910164 variant of miR-146a is closely related to ACS risk and may activate the NF-kappa B inflammatory pathway through oxidized miR-146a mispairing with IKBA 3'UTR.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jiakai Jiang, Sheng Zhang, Weifeng Tang, Zhiyuan Qiu
Summary: The miR-146a rs2910164 C/G polymorphism is not associated with the susceptibility of CRC, and further research is needed to confirm these results.
BIOSCIENCE REPORTS
(2021)
Review
Genetics & Heredity
Fuqiang Liu, Shengping Wang, Zhi Luo
Summary: The rs2910164 polymorphism in the miRNA-146a gene is significantly associated with atherogenic dyslipidemia, affecting increased TG, TC, and LDL-C levels as well as decreased HDL-C levels; whereas the rs3746444 polymorphism in the miRNA-499a gene is only correlated with decreased TG levels.
FRONTIERS IN GENETICS
(2021)
Article
Ophthalmology
Eloisa Toscan Massignam, Cristine Dieter, Felipe Mateus Pellenz, Tais Silveira Assmann, Daisy Crispim
Summary: The A allele of miR-126 rs4636297 miRSNP may be associated with protection against DR in a Southern Brazilian population, while miR-146a rs2910164 miRSNP is not associated with DR.
ACTA OPHTHALMOLOGICA
(2021)
Review
Allergy
Young Ho Lee, Gwan Gyu Song
Summary: This study aimed to determine if miR-146a and miR-499 polymorphisms are associated with susceptibility to SLE. The results showed that the miR-146a rs2431697 C allele is associated with SLE and has a protective effect. However, the miR-146a rs2910164 is not associated with susceptibility to SLE.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Ehsan Zare Mehrjardi, Masoud Dehghan Tezerjani, Fahimeh Shemshad Ghad, Seyed Morteza Seifati
Summary: This study aims to assess the role of miR-146a polymorphism in cardiovascular disease. Through gene typing and computational analysis, it was found that the genotype frequency of miR-146a (rs2910164) showed no significant difference between cardiovascular disease patients and controls. Computational analysis suggested that different miR-146a variants may lead to different RNA folding arrangements and protein binding sites.
Article
Oncology
Silvia Jimenez-Morales, Juan Carlos Nunez-Enriquez, Jazmin Cruz-Islas, Vilma Carolina Bekker-Mendez, Elva Jimenez-Hernandez, Aurora Medina-Sanson, Irma Olarte-Carrillo, Adolfo Martinez-Tovar, Janet Flores-Lujano, Julian Ramirez-Bello, Maria Luisa Perez-Saldivar, Jorge Alfonso Martin-Trejo, Hector Perez-Lorenzana, Raquel Amador-Sanchez, Felix Gustavo Mora-Rios, Jose Gabriel Penaloza-Gonzalez, David Aldebaran Duarte-Rodriguez, Jose Refugio Torres-Nava, Juan Eduardo Flores-Bautista, Rosa Martha Espinosa-Elizondo, Pedro Francisco Roman-Zepeda, Luz Victoria Flores-Villegas, Edna Liliana Tamez-Gomez, Victor Hugo Lopez-Garcia, Jose Ramon Lara-Ramos, Juana Esther Gonzalez-Ulivarri, Sofia Irene Martinez-Silva, Gilberto Espinoza-Anrubio, Carolina Almeida-Hernandez, Rosario Ramirez-Colorado, Luis Hernandez-Mora, Luis Ramiro Garcia-Lopez, Gabriela Adriana Cruz-Ojeda, Arturo Emilio Godoy-Esquivel, Iris Contreras-Hernandez, Abraham Medina-Hernandez, Maria Guadalupe Lopez-Caballero, Norma Angelica Hernandez-Pineda, Jorge Granados-Kraulles, Maria Adriana Rodriguez-Vazquez, Delfino Torres-Valle, Carlos Cortes-Reyes, Francisco Medrano-Lopez, Jessica Arleet Perez-Gomez, Annel Martinez-Rios, Antonio Aguilar-De-los-Santos, Berenice Serafin-Diaz, Maria de Lourdes Gutierrez-Rivera, Laura Elizabeth Merino-Pasaye, Gilberto Vargas-Alarcon, Minerva Mata-Rocha, Omar Alejandro Sepulveda-Robles, Haydee Rosas-Vargas, Alfredo Hidalgo-Miranda, Juan Manuel Mejia-Arangure
Summary: The study found that the SNP in the miR-499a gene (rs3746444) showed significant differences between ALL patients and the control group, with the GG genotype posing a higher risk for ALL, especially in males. There was also a gender-dependent association between SNPs in the miR-146a and miR-196a-2 genes and susceptibility to ALL in Mexican children.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Olfat G. Shaker, Omayma O. Abdelaleem, Nermeen A. Fouad, Naglaa A. Ahmed, Hoda A. Hussein, Enas G. Ibrahem, Abdelrahmaan A. Mohamed, Othman M. Ahmed, Doaa Y. Ali
Summary: This study found that miR-146a (rs2910164) and miR-155 (rs767649) gene polymorphisms are closely related to the development of BD in the Egyptian population and also influence disease severity.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Genetics & Heredity
Barbara Leal, Claudia Carvalho, Ana Marta Ferreira, Miguel Nogueira, Sandra Bras, Berta M. Silva, Manuela Selores, Paulo P. Costa, Tiago Torres
Summary: The study focused on the importance of miR-146a in patients with moderate-to-severe psoriasis and the impact of rs57095329 and rs2910164 polymorphisms in a psoriatic Portuguese population. The results showed upregulated miR-146a levels in psoriasis patients, particularly in those with active disease, with no correlation to genetic variations. This study, being the largest with a homogeneous psoriasis population, could contribute to a better understanding of psoriasis pathogenesis and potential treatment avenues.
MOLECULAR DIAGNOSIS & THERAPY
(2021)
Article
Immunology
Asmaa Kamal, Fatema T. Elgengehy, Zahraa Elawady, Nahla A. Fawzy, Ola El Sisi
Summary: The study found that the gene variants miR-146a rs2910164 and UTS2 rs228648 are significantly associated with the development and clinical modulation of Behcet's disease (BD) in Egyptian patients.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
