Article
Nutrition & Dietetics
Zhengyuan Wang, Xin Xu, Yangzong Deji, Shanxi Gao, Chunxiang Wu, Qi Song, Zehuan Shi, Xuesong Xiang, Jiajie Zang, Jin Su
Summary: Gut microbial dysbiosis affects sarcopenia development. This case-control study examined gut microbiota composition in elderly Chinese women with sarcopenia. Information from 50 cases and 50 controls was collected. Grip strength, body weight, body mass index, skeletal muscle mass, energy intake, and protein intake were lower in cases than in controls. Gut microbiota metagenomic sequencing revealed significant differences in the abundance of Bacteroides and Prevotella. Linear discriminant analysis identified distinct microbial taxa enriched in the case and control groups, including Prevotella copri and Bifidobacterium longum. Elderly women with sarcopenia showed significantly different gut microbiota compositions compared to healthy controls.
Article
Medicine, General & Internal
Anastasia Markaki, Periklis Kyriazis, Eleftheria-Kleio Dermitzaki, Sevasti Maragou, Emmanuel Psylinakis, Aspasia Spyridaki, Helen Drosataki, Dimitra Lygerou, Maria G. Grammatikopoulou, Ioannis Petrakis, Kostas Stylianou
Summary: Handgrip strength (HGS) is considered as an important determinant of muscle function in chronic kidney disease (CKD) stage 5D patients, with lower predialysis serum sodium (sNa) levels associated with reduced HGS. However, lower sNa levels seem to be more of a marker of underlying unfavorable conditions, rather than a causal determinant of reduced HGS. Further investigation is needed to determine whether optimizing sNa levels can improve patient muscle performance.
FRONTIERS IN MEDICINE
(2021)
Review
Nutrition & Dietetics
Santo Colosimo, Simona Bertoli, Francesca Saffioti
Summary: This article explores the importance of nutritional status in the prognosis of advanced chronic liver disease (ACLD), focusing on the role of frailty and muscle wasting, as well as the use of branched-chain amino acids (BCAAs) in managing liver disease.
Article
Urology & Nephrology
Madeleine Elder, Avalon Moonen, Sjorjina Crowther, Jasna Aleksova, Jacqueline Center, Grahame J. Elder
Summary: This study assessed the influence of sarcopenia on mortality in elderly haemodialysis patients. The results showed that sarcopenia is highly prevalent in this population but is not an independent predictor of mortality. Instead, a lower mean arterial pressure and higher total comorbidity score better predicted mortality.
Article
Multidisciplinary Sciences
Kenta Yamamoto, Yoji Ishizu, Takashi Honda, Takanori Ito, Norihiro Imai, Masanao Nakamura, Hiroki Kawashima, Yasuyuki Kitaura, Masatoshi Ishigami, Mitsuhiro Fujishiro
Summary: This study found a correlation between sarcopenia and the microbiome in patients with chronic liver disease. The microbiome in patients with low skeletal muscle mass showed differences compared to the normal muscle mass group, with a potential decrease in amino acid synthesis. This finding is important for the recovery of patients with liver disease.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yuki Kinoshita, Koji Tamai, Makoto Oka, Hasibullah Habibi, Hidetomi Terai, Masatoshi Hoshino, Hiromitsu Toyoda, Akinobu Suzuki, Shinji Takahashi, Hiroaki Nakamura
Summary: Old age and spinal surgery are significant risk factors for postoperative hyponatremia, especially in elderly patients. Symptoms such as vomiting, nausea, headache, and disturbances in consciousness are more common in elderly patients with postoperative hyponatremia.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Che Wang, Xinru Guo, Xieguanxuan Xu, Shuang Liang, Wenling Wang, Fanglei Zhu, Siyang Wang, Jie Wu, Li Zhang, Xuefeng Sun, Xiangmei Chen, Guangyan Cai
Summary: This study aimed to determine frailty-associated factors in elderly CKD I-IV patients and early identify and intervene in frailty of elderly CKD patients. The results showed that sarcopenia was independently associated with an increased risk for frailty in elderly CKD I-IV patients. Patients with sarcopenia, advanced age, high CKD stage, high waist-hip ratio, and low serum albumin level should be assessed for frailty.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Health Care Sciences & Services
Do-Youn Lee, Sunghoon Shin
Summary: This study investigated the association between chronic kidney disease (CKD) and dynapenia in Korean elderly individuals. The results showed a significant association between CKD and dynapenia, especially in women. The prevalence of dynapenia also increased significantly with the stage of CKD.
Article
Medicine, General & Internal
N. Rahman, A. K. Pannu, R. Yadav, S. Sethi, A. Saroch, M. Garg, D. Kumar, A. Bhalla
Summary: Significant differences in clinical, CSF, and radiological characteristics exist between elderly and young TBM patients, with the survival rate remaining dismal in the elderly.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2022)
Review
Clinical Neurology
Jintao Chen, Xinyi Wang, Zherong Xu
Summary: Chronic pain is significantly associated with an increased risk of sarcopenia in older adults, particularly in low-income countries, according to a systematic review and meta-analysis.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Clinical Neurology
Myung Woo Park, Sang Jun Park, Sun Gun Chung
Summary: This study examined the relationship between loss of skeletal muscle mass, lumbar lordosis, and chronic low back pain (CLBP). The results showed that the lumbar lordosis of the CLBP group was significantly lower than that of the control group, and the skeletal muscle mass index was also decreased in the CLBP group. There was a positive correlation between the skeletal muscle mass index and lumbar lordotic angle.
Article
Nutrition & Dietetics
M. L. Sanchez-Tocino, S. Mas-Fontao, C. Gracia-Iguacel, M. Pereira, I. Gonzalez-Ibarguren, A. Ortiz, M. D. Arenas, E. Gonzalez Parra
Summary: This study aimed to develop a sarcopenia index based on malnutrition parameters for screening muscle wasting in elderly hemodialysis patients. The results showed that the combination of loss of strength, loss of muscle mass, and low physical performance correlated with malnutrition. Regression equations were developed to predict the severity of sarcopenia, and easily accessible anthropometric and nutritional parameters were used for screening.
Article
Cell Biology
Chung-Huang Tsai, Pei-Ju Huang, I. T. Lee, Chien-Min Chen, Min Huan Wu
Summary: This study investigates the relationship between diabetes and sarcopenia, focusing on the molecular mechanism of endothelin-1 (ET-1). The results show that ET-1 is positively correlated with HbA1c, creatinine levels, and duration of disease in diabetes patients. ET-1 induces inflammation in muscle cells and decreases energy metabolism in fat, contributing to the development of myopathy. Furthermore, ET-1 suppresses the expression of miR-let-7g-5p in myocytes and adipocytes. Overall, this study reveals a new mechanism of chronic inflammation triggered by ET-1 in patients with hyperglycemia.
Article
Geriatrics & Gerontology
Huang-Chun Liu, Der-Sheng Han, Chih-Chin Hsu, Jong-Shyan Wang
Summary: This study suggests that circulating myo-miRNA (c-miR-486) and inflammation-related miRNA (c-miR-146a) may serve as superior biomarkers for age-related sarcopenia compared to inflammatory peroxide and cytokines in plasma.
Article
Oncology
Yun-Zhou Xiao, Xiao-Ting Wen, Ying-Ying Ying, Xiao-Yan Zhang, Lu-Yao Li, Zhong-Chu Wang, Miao-Guang Su, Xiang-Wu Zheng, Shou-Liang Miao
Summary: This study aimed to evaluate the association between total abdominal muscle area (TAMA), total psoas area (TPA), psoas muscle density (PMD), and short-term postoperative complications in elderly patients with rectal cancer. The results showed that preoperative assessment of psoas muscle density on CT can be a simple and practical method for identifying elderly patients with rectal cancer at risk for severe postoperative complications.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)