Article
Materials Science, Composites
Qingfeng Tian, Chunhua Zhang, Yuan Tang, Yalan Liu, Liyong Niu, Tao Ding, Xiaohong Li, Zhijun Zhang
Summary: By adjusting the modifier dosage, nano-silica with enhanced compatibility and dispersibility in rubber matrix were successfully prepared, leading to improved mechanical properties and abrasion resistance of the composite materials.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zifan Zhao, Jing Zhang, Zaibo Yang, Qin Zhao
Summary: Biodegradability is a crucial property of implantable bone biomaterials, influencing their bioactivity and osteogenic effect. This study found that beta-tricalcium phosphate (beta-TCP) induced more foreign body giant cells (FBGC) formation, accompanied by higher levels of TNF alpha, IFN gamma, and T-cells, compared to hydroxyapatite (HA), resulting in improved biodegradability. T-cell depletion experiments confirmed that T-cell-mediated immune responses play a decisive role in FBGC formation and promote bioceramic biodegradation. This study reveals the biological mechanism of in vivo biodegradation of implantable bone tissue engineering materials and provides a theoretical basis for optimizing implantable material properties.
Article
Pharmacology & Pharmacy
Mila Kovacevic, Ilija German Ilic, Katarina Bolko Seljak, Alenka Zvonar Pobirk
Summary: Mesoporous carriers are suitable for solidifying self-microemulsifying drug delivery systems (SMEDDS) to improve the solubility of poorly water-soluble drugs. Wet granulation methods were used to prepare SMEDDS granules with suitable flow properties and high SMEDDS content. HS granulation produced SMEDDS loaded granules with superior flow characteristics.
Review
Engineering, Chemical
R. Hazlett, C. Schmidmeier, J. A. O'Mahony
Summary: Challenges encountered in handling high-protein dairy powders are often due to poor flowability caused by increased cohesive forces between particles. Traditional agglomeration and novel approaches such as dry-and wet-coating and roller compaction can be used to improve powder flowability.
Article
Engineering, Environmental
Hossein Baniasadi, Sami Lipponen, Max Asplund, Jukka Seppala
Summary: Blending polymers with a high concentration of bio-based fillers can reduce dependency on petroleum-based feedstocks and decrease the carbon footprint. In this study, n-octadecyl isocyanate (ODI) molecules were grafted onto lignin particles to make them compatible with a copolyamide matrix. Different concentrations of the surface-modified particles were blended with a low-melting point copolyimide, resulting in improved mechanical properties of the biocomposites. The findings suggest that these newly developed biocomposites with a green content of up to 80% are attractive alternatives to petroleum-based plastics.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Mehdi Shams, Mohammad Karimi, Vafa Jahangir, Milad Mohammadian, Ali Salimi
Summary: Nanofibrous polyethersulfone (PESf) scaffolds modified with fluorapatite nanoparticles (FAn) showed improved hydrophilicity, roughness, porosity, and biodegradation. The inclusion of FAn led to enhanced viability, growth, proliferation, and differentiation of human bone marrow mesenchymal stem cells (hBMMSCs). The surface topography and release of bioactive ions contributed to the positive effects on cell-surface interactions, biocalcification, and osteogenesis.
SURFACES AND INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Jiacheng Cai, Kai Yang, Hao Xu, Jun Tan, Zhifa Wang, Lujun Lin, Tingting Zhang, Li Liu, Xiao Li
Summary: This study incorporated baicalin (BC) onto commonly used modified titanium surfaces, and found that BC-coated titanium surfaces showed satisfactory biocompatibility and promoted osteoblastic differentiation. Among them, TNTs with BC coating exhibited optimal incorporation and osteoinduction, suggesting their great potential for application in implant dentistry.
JOURNAL OF MATERIALS RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Shen Hu, Junru Liu, Guanghua Ye, Xinggui Zhou, Marc-Olivier Coppens, Weikang Yuan
Summary: A generalizable strategy has been developed to quantify the effect of surface barriers on zeolite catalysis using isomerization of n-pentane as a model system. Surface modification by SiO2 deposition was found to reduce surface barriers, improve diffusion, and increase catalytic activity of Pt/Beta catalyst. These results demonstrate that reducing surface barriers can effectively enhance zeolite catalyst performance affected by transport limitations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Xue Jiang, Fei Han, Mingshu Cui, Wei Zhang, Yuwen Wang, Ziyue Xi, Lu Xu
Summary: In this study, alanine-modified chiral mesoporous silica (CMS) with highly ordered structure and good biocompatibility was successfully synthesized. The alanine-modified CMS demonstrated chiral-selective delivery of an achiral drug, leading to improved oral bioavailability. This research lays the foundation for the rational design of chiral nano-drug delivery systems and promotes the application of CMSs in medicine.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Elisa Bindini, Tanja Luedtke, Dorleta Otaegui, Marco Moeller, Ryma Haddad, Cedric Boissiere, Sergio E. Moya
Summary: Surface engineering of metal-organic frameworks with a mesoporous silica coating can enhance mechanical properties and allow for decoration with organic or biological molecules. However, destabilization of the core during deposition of the silica shell may occur, but can be controlled by adjusting silicate concentration to preserve the MOF integrity. The resulting core-shell nanoparticles demonstrate a compact structure with no gap between the MOF core and the silica shell, showcasing potential for designing new hierarchical materials.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Materials Science, Multidisciplinary
Chun-Sheng Shao, Liang-Jian Chen, Rui-Min Tang, Bo Zhang, Jiang-Jie Tang, Wei-Na Ma
Summary: The combination of biphasic calcium phosphate (BCP) with osteomimetic porous micro-structure obtained via freeze casting is believed to achieve excellent bone regeneration, while the effects of different ratios of HA and beta-TCP on the degradation and biological performance of the BCP scaffolds need to be studied. The BCP scaffolds with varying HA/beta-TCP ratios demonstrated similar microstructure, mechanical performance, and protein absorption capacity, with the HA70/beta-TCP30 ratio showing optimal degradation rate. The in vitro and in vivo experiments confirmed the biocompatibility and bone regeneration capacity of the porous osteomimetic BCP scaffold with a 30:70 HA/beta-TCP ratio.
Article
Biotechnology & Applied Microbiology
Julia Sala-Jarque, Elisa Garcia-Lara, Paula Carreras-Dominguez, Chunfang Zhou, Neus Rabaneda-Lombarte, Carme Sola, Jose M. Vidal-Taboada, Adam Feiler, Ninnie Abrahamsson, Elena N. Kozlova, Josep Saura
Summary: This study analyzed the responses of two types of brain cells, astrocytes and microglia, to mesoporous silica particles (MSPs), and found that MSPs can be effectively internalized into microglial cells without affecting cell viability or morphology, but significantly increase extracellular levels of proinflammatory mediators when used in combination with lipopolysaccharide. These results suggest that MSPs could be a novel tool for specific drug delivery to microglial cells.
Article
Materials Science, Ceramics
Eva Krakor, Sven Saniternik, Isabel Gessner, Robert Frohnhoven, Michael Wilhelm, Marco Drexelius, Nurgul Tosun, Ines Neundorf, Sanjay Mathur
Summary: Intensive and overuse of antibiotics have led to a rise in antibiotic resistance globally, creating a demand for alternative treatments. Metal ions like copper, silver, and zinc have been used to inhibit microorganism growth for centuries. This study focuses on the synthesis of metal and oxide nanoparticles immobilized on hollow mesoporous silica capsules (HMSCs) for efficient antimicrobial effects against both Gram-positive and Gram-negative bacteria. The results show promising potential for metal-loaded capsules as antibacterial delivery vehicles, providing sustained bacterial inhibition over several hours.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Naboneeta Sarkar, Dishary Banerjee, Amit Bandyopadhyay, Susmita Bose
Summary: The study found that surface-modified porous metal and plasma-sprayed HA-coated implants enhanced osteoclast activity, promoting bone repair and regeneration.
JOURNAL OF MATERIALS RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Oleg Mishchenko, Anna Yanovska, Oksana Sulaieva, Roman Moskalenko, Mykola Pernakov, Yevheniia Husak, Viktoriia Korniienko, Volodymyr Deineka, Oleksii Kosinov, Olga Varakuta, Simonas Ramanavicius, Suren Varzhapetjan, Almira Ramanaviciene, Dzanna Krumina, Gundega Knipse, Arunas Ramanavicius, Maksym Pogorielov
Summary: A novel calcium deficient HA/beta-TCP bone grafting nanomaterial was developed for maxillary sinus augmentation. The nanomaterial exhibited high biocompatibility, enhanced cell proliferation, stimulated collagen expression, and promoted blood clot formation, supporting cell aggregation and new bone growth. Clinical trial results showed successful installation of dental implants without early postoperative complications, indicating the potential of this nanomaterial to improve the success rate of maxillary sinus augmentation.
Article
Materials Science, Ceramics
Z. Mollaei, F. Kermani, S. Mollazadeh, S. Kargozar, J. Vahdati Khakhi
Summary: The influence of heat treatment on the properties of silicon-doped calcium phosphates was investigated using density functional theory (DFT) and experimental methods. The results showed that the crystallization rate was affected by the fuel type and the amount of Si4+ ions. Crystal growth and doping of Si4+ ions on the surface of CaPs were found to decrease the activation energy of the oxygen reduction reaction (ORR). The research suggests that the crystallized HAp structure has the potential to reduce oxidative stress in the human body.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Z. Mollaei, F. Kermani, F. Moosavi, S. Kargozar, J. Vahdati Khakhi, S. Mollazadeh
Summary: The innovative OSCS system was proposed to overcome agglomeration of particles during SCS synthesis, resulting in increased surface area, decreased particle size, and band-gap of beta-MnO2 nanoparticles. The structural properties and antioxidant activity of the nanoparticles were investigated, showing high potential against free radicals.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Garmroudi Nezhad, F. Kermani, Z. Mollaei, M. Mashreghi, J. Vahdati Khakhi, S. Mollazadeh
Summary: In this study, the ratio of reducing to oxidizing elements (F/O) was determined as an indicator for oxygen interference during the solution combustion synthesis (SCS) process of ZnO particles. The obtained result, called special point (S.P), was used to interpret the role of S.P in the SCS reactions. ZnO particles were synthesized with different F/O values (0.75, 1, 1.25) in the presence of various substances. The correlations between S.P, physicochemical properties, and density functional theory (DFT) predictions were investigated, showing a direct relation between these parameters.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Simin Nazarnezhad, Farzad Kermani, Vahid Reza Askari, Seyede Atefe Hosseini, Alireza Ebrahimzadeh-Bideskan, Ali Moradi, Reza Kazemi Oskuee, Sahar Mollazadeh, Saeid Kargozar
Summary: Skin defects are a prevalent and serious global issue, and providing appropriate coverage is necessary for reducing mortality risk and promoting wound healing. In this study, the researchers designed nanofibrous scaffolds that mimic the extracellular matrix using natural and synthetic polymers. The fabricated scaffolds demonstrated suitable physicochemical properties, blood compatibility, and potential for avoiding bacterial invasion, making them a promising construct for epidermal wound healing.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Oncology
Farzad Kermani, Arghavan Vojdani-Saghir, Sahar Mollazadeh Beidokhti, Simin Nazarnezhad, Zahra Mollaei, Sepideh Hamzehlou, Ahmed El-Fiqi, Francesco Baino, Saeid Kargozar
Summary: A series of Fe-doped mesoporous bioactive glasses were successfully synthesized via the sol-gel method. The Fe-doped glasses showed good physico-chemical and biological properties. These glasses have the potential to activate Fenton's reaction and generate reactive oxygen species, which can be used in cancer therapy strategies.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Z. Mollaei, F. Kermani, M. Kahani, F. Moosavi, S. Mollazadeh, J. Vahdati Khaki
Summary: The current study proposes new input data for glass science and engineering based on simple calculations of configurational entropy. The configurational entropy of silicate-based glasses with different amounts of alkali or alkaline earth oxide additives was calculated, and the relation between entropy and glass properties was theoretically investigated. The results revealed positive or negative slopes in the entropy-Tg curves for different glass compositions, which could be attributed to changing concentrations of non-bridging oxygens, increasing entropy, and changing melting points.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Materials Science, Ceramics
Amirreza Mansoori-Kermani, Shohreh Mashayekhan, Farzad Kermani, Mohammad J. Abdekhodaie
Summary: Novel biodegradable bioactive bone cements containing calcium sulfate hemihydrate, bioactive glass, and tricalcium silicate were developed. The optimized binary system of calcium sulfate hemihydrate and bioactive glass was used to obtain composite bioactive bone cements by adding different quantities of tricalcium silicate. These cements exhibited desirable handling properties, controlled degradability, and superior mechanical properties. They also showed favorable bioactivity, bone-bonding ability, and biocompatibility, suggesting their potential for clinical applications.
CERAMICS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Farzad Kermani, Simin Nazarnezhad, Zahra Mollaei, Sahar Mollazadeh, Alireza Ebrahimzadeh-Bideskan, Vahid Reza Askari, Reza Kazemi Oskuee, Ali Moradi, Seyede Atefe Hosseini, Zoleikha Azari, Francesco Baino, Saeid Kargozar
Summary: Zn- and Cu-doped 13-93B3 borate mesoporous bioactive glasses (MBGs) were synthesized using nitrate precursors in the presence of Pluronic P123. The mineralization process of hydroxyapatite (HAp) on the glass surface was investigated by studying the changes in dynamic surface tension (SFT) of simulated body fluid (SBF). The doped MBGs showed changes in various properties and the SFT of SBF was found to be an important factor for predicting and confirming the HAp mineralization process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Stefania De Luca, Valentina Verdoliva, Saeid Kargozar, Francesco Baino
Summary: This study investigates the coating of three-dimensional porous glass-derived scaffolds with hyaluronic acid (HA)-fatty acids for the first time. The scaffold's surface and struts were successfully coated with HA-palmitate and HA-oleate conjugates through a dipping procedure. In vitro tests showed that the deposition of the polymeric coating did not inhibit the apatite-forming ability of scaffolds, indicating the potential of these novel bioactive systems to promote bone healing.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Nanoscience & Nanotechnology
Saeid Kargozar, Amirhossein Moghanian, Ali Rashvand, Amir K. Miri, Sepideh Hamzehlou, Francesco Baino, Masoud Mozafari, Andrew Z. Wang
Summary: Bioactive glasses (BGs) have been successfully used in tissue engineering and regenerative medicine, and recent studies have shown their potential applications in oncology. Nanostructured BGs (NBGs) doped with anticancer elements can enhance their toxic effects against tumor cells and participate in tissue regeneration. However, the application of NBGs in oncology is still in its early stages and many questions need to be addressed, such as the impact of NBG composition, degradation, size, and morphology on their anticancer efficacy, as well as their ability to shrink tumors and cure cancer.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Neda Alasvand, Sara Simorgh, Maziar Malekzadeh Kebria, Azam Bozorgi, Salah Moradi, Vahid Hosseinpour Sarmadi, Kaveh Ebrahimzadeh, Naser Amini, Farzad Kermani, Saeid Kargozar, Peiman Brouki Milan
Summary: In this study, strontium BGs derived from 58S glass were synthesized and characterized. The properties of the BGs were improved by substituting calcium ions with copper or cobalt ions. The synthesized BGs were evaluated for their structure, morphology, bioactivity, and cellular compatibility. The results showed that the Co-SrBGs exhibited higher compatibility and promoted bone nodule formation, making them suitable candidates for in vivo bone tissue engineering.
Review
Engineering, Biomedical
Zoleikha Azari, Sara Gorgani, Seyede Atefe Hosseini, Andrew Z. Wang, Hae-Won Kim, Saeid Kargozar
Summary: Immune cells can regulate new blood vessel formation by secreting proangiogenic mediators and modulating endothelial cell and endothelial progenitor cell activities. The properties of biomaterials and scaffolds can influence immune cells' potential for angiogenesis. Loading specific biomolecular cargoes onto 3D scaffolds can further improve immune cell behavior in promoting angiogenesis. Balancing pro- and anti-angiogenic mediators is important in developing biomaterials and scaffolds to modulate immune cell activities. This review emphasizes the role of immune cells in angiogenesis and the significance of their modulation by biomaterials and scaffolds in tissue engineering.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2023)
Review
Engineering, Biomedical
Saeid Kargozar, Sahar Mollazadeh, Farzad Kermani, Thomas J. Webster, Simin Nazarnezhad, Sepideh Hamzehlou, Francesco Baino
Summary: Hydroxyapatite nanoparticles (HAp NPs) have promising applications in cancer therapy. Their chemical structure allows for loading and delivering a wide range of anticancer drugs in a targeted manner, minimizing complications. Incorporating therapeutic elements into the basic composition of HAp NPs enhances their anticancer effects. HAp NPs can be transformed into smart anticancer agents through surface modifications for targeted killing of cancer cells.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Farzad Kermani, Hossein Sadidi, Ali Ahmadabadi, Seyed Javad Hoseini, Seyed Hasan Tavousi, Alireza Rezapanah, Simin Nazarnezhad, Seyede Atefe Hosseini, Sahar Mollazadeh, Saeid Kargozar
Summary: In this study, silver-doped borate-based mesoporous bioactive glass (MBGs) was successfully synthesized using nitrate precursors. The MBGs showed good biocompatibility with fibroblasts and exhibited potent antibacterial activity. This research holds promise for burn management.
BIOENGINEERING-BASEL
(2022)
Article
Chemistry, Physical
Saeid Kargozar, Peiman Brouki Milan, Moein Amoupour, Farzad Kermani, Sara Gorgani, Simin Nazarnezhad, Sara Hooshmand, Francesco Baino
Summary: This study synthesized magnesium-doped bioactive glasses (BGs) for bone reconstruction and fabricated them into 3D scaffolds using the sponge replica approach. The results showed that the Mg-doped BGs were compatible with human osteosarcoma cells and could promote bone nodule formation in vitro and improve the migratory ability of human umbilical vein endothelial cells. In vivo experiments demonstrated the effectiveness of the BG-based scaffolds in promoting bone regeneration.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
