Article
Pharmacology & Pharmacy
Sonyabapu Yadav, Kalyan Ramesh, Obireddy Sreekanth Reddy, Viswanathan Karthika, Parveen Kumar, Sung-Han Jo, Seong Yoo, Sang-Hyug Park, Kwon Taek Lim
Summary: In this study, redox-responsive core-cross-linked (CCL) micelles were synthesized using diselenide (Se-Se) and disulfide (S-S) bonds, and their sensitivity to oxidation and reduction was compared. The micelles showed structural stability under physiological conditions but de-cross-linked in response to GSH and H2O2 treatments. DLS studies demonstrated that the Se-Se micelles were more responsive to changes in the redox environment compared to the S-S micelles. The developed micelles exhibited a pH-dependent drug release and showed cytotoxicity against cancer cells while remaining non-toxic to normal cells.
Article
Nanoscience & Nanotechnology
Jinsong Tao, Zhengjie Wei, Yaxin Cheng, Meng Xu, Qiuxia Li, Simon Ming-Yuen Lee, Wei Ge, Kathy Qian Luo, Xueqing Wang, Ying Zheng
Summary: A transparent zebrafish model offers advantages for preclinical screening and evaluation. In this study, an apoptosis-sensing xenograft zebrafish tumor model was established to evaluate the anti-cancer effects of redox-responsive cross-linked Pluronic polymeric micelles. The model provides a visual, rapid, effective, and noninvasive assessment of anti-cancer effects at the cellular level.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Sonyabapu Yadav, Parveen Kumar, Sung-Han Jo, Sang-Hyug Park, Won-Ki Lee, Seong Ii Yoo, Kwon Taek Lim
Summary: This study reports on a redox-responsive core-cross-linked micelle that can efficiently deliver drugs. The micelle is structurally stable under physiological conditions but can release drugs under acidic and redox environments. The micelle shows no cytotoxicity towards normal cells but exhibits significant cytotoxicity towards cancer cells.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Engineering, Biomedical
Kai Xiao, Qiangqiang Liu, Nell Suby, Wenwu Xiao, Rinki Agrawal, Michael Vu, Hongyong Zhang, Yan Luo, Yuanpei Li, Kit S. Lam
Summary: A nanoparticle system targeted at luteinizing hormone-releasing hormone (LHRH) receptor and responsive to the tumor microenvironment has been developed for selective delivery of chemotherapeutic drugs to triple-negative breast cancer (TNBC) cells. This system shows high drug loading efficiency, receptor-mediated internalization into TNBC cells, and improved cytotoxicity compared to non-targeted counterparts. In vivo studies demonstrate enhanced tumor distribution and penetration of payloads, leading to superior therapeutic efficacy in TNBC models. These results offer new insights into precise drug delivery for TNBC treatment.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Heba F. Abed, Waad H. Abuwatfa, Ghaleb A. Husseini
Summary: This paper explores the physiological and biochemical basis of redox-responsive drug delivery systems as a potential cancer treatment, and reviews recent advances in the chemical composition and design of these systems. It discusses five main redox-responsive chemical entities, focusing on the most commonly used disulfide bonds and their incorporation into liposomes, polymeric micelles, and nanogels.
Article
Nanoscience & Nanotechnology
Parveen Kumar, Seon-Hwa Kim, Sonyabapu Yadav, Sung-Han Jo, Seong Yoo II, Sang-Hyug Park, Kwon Taek Lim
Summary: Cross-linking of nanocarriers allows targeted drug release, addressing issues such as drug leakage and side effects, thereby improving the efficacy of nanomedicines.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Jumpei Kida, Daisuke Aoki, Hideyuki Otsuka
Summary: This study reports the mechanochemical strengthening of cross-linked elastomers using macrocyclic mechanophores containing a dynamic covalent disulfide bond, successfully imparting the polymers with self-strengthening functionality without the need for any additives such as monomers and modifiers.
Article
Polymer Science
Lei Wang, Yuanbo Cai, Haoruo Zhang, Huawei Zou, Yang Chen, Mei Liang, Zhengguang Heng
Summary: This study introduces a reversible cross-linked structure to enhance the mechanical properties and self-healing ability of silicone elastomers at room temperature. The influence of cross-linker content on the elastomer's performance was investigated, and the structure of the self-healing materials was characterized using low-field NMR.
Article
Chemistry, Multidisciplinary
Lixin Zhang, Daowen Zhang, Yongfang Yang, Yue Zhang
Summary: A new method of stimuli-responsive proteinosome fabrication using shell cross-linked micelle as a template was reported in this research. The proteinosomes had a size of about 50 nm and capsule-like structures, were thermoresponsive with a phase transition temperature at 35 degrees C. The proteinosome showed low toxicity to cells and could be internalized. The fabrication had no significant influence on the structure and activity of the protein.
Article
Pharmacology & Pharmacy
Wenqian Yang, Pengwen Chen, Eger Boonstra, Taehun Hong, Horacio Cabral
Summary: Messenger RNA (mRNA) is a promising therapeutic modality, but its fragility and limited intracellular access pose challenges. This study developed pH-responsive cross-linked micelles for stable mRNA delivery and complete release in endosomal pH. The cross-linked micelles increased mRNA delivery efficiency and promoted protein expression.
Article
Chemistry, Multidisciplinary
Yaru Li, Simin Feng, Peipei Dai, Fang Liu, Yaqi Shang, Qian Yang, Juan Qin, Zhiguang Yuchi, Zheng Wang, Yanjun Zhao
Summary: A tailored Trojan horse nanocarrier with pH-labile zeolitic imidazolate framework-8 (ZIF-8) as the core and disulfide-linked amphiphilic polymer-drug conjugate as the steric shell is designed. The nanocarrier exhibits improved drug release and therapeutic efficacy through the collapse of ZIF-8 under low pH conditions, inducing the liberation and further cleavage of the drug.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Polymer Science
Yannik Olszowy, Janick Wesselmann, Shenja Fabienne Over, Florian Paetzold, Ralf Weberskirch
Summary: This study investigated core crosslinked micelles based on poly(2-ethyl-2-oxazoline)-block-poly(n-butyl acrylate-co-d,l-homocysteine thiolactone acrylamide) by employing different di- and triamines and nucleophilic ring-opening reaction. The quantity of crosslinked micelle and free block copolymer was quantified by size exclusion chromatography (SEC), and the crosslinking conditions were optimized. Subsequently, micelles crosslinked with cystamine exhibited degradation times of 1.5 h to 5 h in the presence of dithiothreitol (DTT), depending on the composition of the hydrophobic core.
Article
Pharmacology & Pharmacy
Fen Zhang, Qian Yao, Xiaoqi Chen, Haijun Zhou, Mengmeng Zhou, Yantao Li, Hua Cheng
Summary: The post-encapsulation and release of the anticancer drug doxorubicin hydrochloride (DOX·HCl) through the cell-like transmission functions of polymeric vesicles were investigated. Ethylenediamine-modified cross-linked pH-responsive polymeric vesicles were fabricated for the first time using redox-initiated reversible addition-fragmentation chain transfer dispersion polymerization. The vesicles showed a pH-dependent open and closed state, and exhibited a faster release rate of DOX at pH 5.0 compared to pH 6.5. The DOX-loaded vesicles had low cytotoxicity and higher cellular uptake capability compared to free DOX.
Article
Chemistry, Multidisciplinary
Wei Ji, Xiaodan Li, Mingshu Xiao, Yueyang Sun, Wei Lai, Hongbo Zhang, Hao Pei, Li Li
Summary: This study presents a DNA-scaffolded disulfide redox network for selective cargo release within cancer cells and programmable drug-delivery kinetics. By tuning the density of disulfide bonds, drug-release kinetics can be controlled effectively, enhancing the therapeutic effect on multidrug-resistant cancer.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Lili Ren, Junfang Nie, Jie Wei, Yaning Li, Jun Yin, Xiaolong Yang, Guoguang Chen
Summary: A block copolymer with active targeting and disulfide bond response was designed for simultaneous delivery of chemotherapy and photothermal therapy drugs, showing ideal therapeutic effect in antitumor activity.
Article
Polymer Science
Jing Yang, Xian Jun Loh, Beng Hoon Tan, Zibiao Li
MACROMOLECULAR RAPID COMMUNICATIONS
(2019)
Article
Polymer Science
Xiaoshan Fan, Khin Yin Win, Zhiguo Hu, Xian Jun Loh, Zibiao Li
MACROMOLECULAR RAPID COMMUNICATIONS
(2019)
Article
Polymer Science
Minghuan Liu, Choon Peng Teng, Khin Yin Win, Yisong Chen, Xiaoyan Zhang, Da-Peng Yang, Zibiao Li, Enyi Ye
MACROMOLECULAR RAPID COMMUNICATIONS
(2019)
Article
Chemistry, Applied
Xiaoyan Zhang, Jinfei Zhou, Da-Peng Yang, Shaoyun Chen, Jiale Huang, Zibiao Li
Article
Polymer Science
Xuepeng Wang, Bo Chen, Wenbo Dong, Xiaohu Zhang, Zibiao Li, Yonggang Xiang, Hao Chen
MACROMOLECULAR RAPID COMMUNICATIONS
(2019)
Editorial Material
Polymer Science
Xian Jun Loh, Zibiao Li
MACROMOLECULAR RAPID COMMUNICATIONS
(2019)
Review
Chemistry, Multidisciplinary
Zhi Wei Kenny Low, Zibiao Li, Cally Owh, Pei Lin Chee, Enyi Ye, Dan Kai, Da-Peng Yang, Xian Jun Loh
Article
Polymer Science
Xiuhuan Song, Xiaoxiao Zhang, Tianduo Li, Zibiao Li, Hong Chi
Article
Chemistry, Multidisciplinary
Da-Peng Yang, Zibiao Li, Minghuan Liu, Xiaoyan Zhang, Yisong Chen, Hun Xue, Enyi Ye, Rafael Luque
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2019)
Article
Chemistry, Multidisciplinary
Guijian Guan, Mingliang You, Xuan Liu, Yun-Long Wu, Enyi Ye, Zibiao Li
ADVANCED MATERIALS INTERFACES
(2019)
Article
Engineering, Biomedical
Zengping Liu, Sing Shy Liow, Siew Li Lai, Asfa Alli-Shaik, Graham E. Holder, Bhav Harshad Parikh, Subramanian Krishnakumar, Zibiao Li, Mein Jin Tan, Jayantha Gunaratne, Veluchamy Amutha Barathi, Walter Hunziker, Rajamani Lakshminarayanan, Clement Woon Teck Tan, Caroline K. Chee, Paul Zhao, Gopal Lingam, Xian Jun Loh, Xinyi Su
NATURE BIOMEDICAL ENGINEERING
(2019)
Article
Materials Science, Biomaterials
Wenqiang Li, Chenfang Xu, Shuxian Li, Xiuying Chen, Xiaoshan Fan, Zhiguo Hu, Yun-Long Wu, Zibiao Li
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Nanoscience & Nanotechnology
Lu Jiang, Zheng Luo, Xian Jun Loh, Yun-Long Wu, Zibiao Li
ACS APPLIED BIO MATERIALS
(2019)
Review
Chemistry, Multidisciplinary
Chenfang Xu, Yun-Long Wu, Zibiao Li, Xian Jun Loh
MATERIALS CHEMISTRY FRONTIERS
(2019)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
