Article
Immunology
Jingxuan Zhou, Nanhai Zhang, Adil Aldhahrani, Mohamed Mohamed Soliman, Liebing Zhang, Feng Zhou
Summary: Puerarin improves high-fat and high-fructose diet-induced nonalcoholic fatty liver disease (NAFLD) by modulating liver lipid accumulation, liver function, oxidative stress, and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Jinwang Li, Siyu Xie, Wendi Teng
Summary: Sulforaphane (SFA) has the potential to improve lipid metabolism, inhibit lipid accumulation and apoptosis, making it a potential candidate for preventing and treating nonalcoholic fatty liver disease (NAFLD).
Review
Cell Biology
Ke-Qiong Deng, Xuewei Huang, Fang Lei, Xiao-Jing Zhang, Peng Zhang, Zhi-Gang She, Jingjing Cai, Yan-Xiao Ji, Hongliang Li
Summary: Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide due to the global pandemic of metabolic diseases. This article highlights the links between hepatic lipid species and their mechanisms in mediating the pathogenesis of NAFLD, with a focus on saturated fatty acids, cholesterol, oxidized phospholipids, and their intermediates.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Plant Sciences
Dongqin Xu, Wenhao Zhao, Yiting Feng, Xiao Wen, Hanxiao Liu, Jie Ping
Summary: Pentoxifylline attenuates nonalcoholic fatty liver (NAFL) by inhibiting hepatic macrophage M1 polarization, indicating its potential as a therapeutic candidate for NAFL treatment.
Review
Biochemistry & Molecular Biology
Maria Notarnicola, Alberto Ruben Osella, Maria Gabriella Caruso, Pasqua Letizia Pesole, Antonio Lippolis, Valeria Tutino, Caterina Bonfiglio, Valentina De Nunzio, Maria Principia Scavo, Antonella Mirizzi, Isabella Franco, Tamara Lippolis, Rosalba D'Alessandro, Maria Grazia Refolo, Caterina Messa
Summary: NAFLD is considered as a hepatic manifestation of metabolic syndrome, characterized by excessive lipid accumulation and oxidative stress leading to liver injury. The identification of genetic and epigenetic modifications contributing to NAFLD pathogenesis is crucial, while lifestyle modifications remain the main prevention and treatment approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Huicui Liu, Tao Chen, Xiaoqing Xie, Xinlei Wang, Yiwen Luo, Nan Xu, Zhen Sa, Min Zhang, Zhifei Chen, Xinzhong Hu, Juxiu Li
Summary: The study demonstrates that BG from highland barley can significantly alleviate liver steatosis induced by NAFLD, by altering lipid metabolic patterns and regulating lipid metabolism-related genes. Additionally, the research also identified 13 differentially regulated lipid species that may serve as lipid biomarkers.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Food Science & Technology
Hui Han, Yi Jiang, Mengyu Wang, Mebratu Melaku, Lei Liu, Yong Zhao, Nadia Everaert, Bao Yi, Hongfu Zhang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disorder that is closely related to gut dysfunction. The bidirectional communication between the gut and liver, mediated by metabolites, plays a role in the pathogenesis of NAFLD.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Medicine, Research & Experimental
Qing Zheng, Min Zhu, Xin Zeng, Wen Liu, Fudong Fu, Xiaoyu Li, Guangneng Liao, Yanrong Lu, Younan Chen
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease, and there is no effective treatment for its advanced stage, nonalcoholic steatohepatitis (NASH). This study compared and evaluated five different NAFLD mouse models, analyzing their characteristics and suitability for research and drug development. The high-fat diet (HFD) model showed early insulin resistance and mild liver steatosis, while the high-fat, high-fructose, and high-cholesterol diet (FFC) model exacerbated glucose and lipid metabolism disorders. The FFC combined with streptozotocin (STZ) model accelerated the pathologic process of NASH, and the STAM model showed the fastest formation of fibrosis nodules.
LABORATORY INVESTIGATION
(2023)
Review
Food Science & Technology
Jing-Wen Yang, Hong-Fang Ji
Summary: Phytosterols are bioactive food components found in plant cell membranes, especially in nuts and oilseeds. Many studies have shown their therapeutic potential for nonalcoholic fatty liver disease (NAFLD). They lower total cholesterol and triglyceride levels through various mechanisms and improve NAFLD.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Endocrinology & Metabolism
Hangkai Huang, Jiarong Xie, Yan Zeng, Zhening Liu, Min Miao, Lei Xu, Chengfu Xu
Summary: This study aimed to explore the association between serum remnant cholesterol and the development of nonalcoholic fatty liver disease (NAFLD). The results showed a positive correlation between high serum remnant cholesterol levels and increased risk of NAFLD, which remained significant even among individuals with normal levels of LDL-C, HDL-C, and triglycerides.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Yang Zou, Jianyun Lan, Yanjia Zhong, Shuo Yang, Huimin Zhang, Guobo Xie
Summary: The study found a significant association between elevated RC and the risk of NAFLD, with differences in this association among sex, BMI, and age stratifications. Compared with traditional lipid parameters, RC showed a better predictive ability for NAFLD in men.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Suresh K. Nagumalli, Rose A. Willett, Aline de Conti, Volodymyr P. Tryndyak, Mark I. Avigan, Goncalo Gamboa da Costa, Frederick A. Beland, Ivan Rusyn, Igor P. Pogribny
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease characterized by excessive accumulation of lipids in hepatocytes. Recent studies have shown that changes in lipid composition, particularly in PUFA/MUFA ratios, play a crucial role in the development and severity of NAFLD. This research analyzed the fatty acid composition in various mouse models and demonstrated that alterations in PUFA/MUFA ratios can serve as a diagnostic marker for NAFLD severity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yoon-Kwang Lee, Jung Eun Park, Mikang Lee, Ryan Mifflin, Yang Xu, Robert Novak, Yanqiao Zhang, James P. Hardwick
Summary: This study explores the potential role of Small heterodimer partner (SHP) in the development of nonalcoholic steatohepatitis (NASH). The findings suggest that SHP deletion can protect against NASH progression by inhibiting inflammatory and fibrotic genes, reducing oxidative stress and macrophage infiltration.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Nutrition & Dietetics
Rui Li, Zhongxue Chen
Summary: Anti-inflammatory diet is beneficial for reducing the risk of NAFLD in US adults. The DII is a stronger predictor of hepatic measures than the TAC, and future studies on hepatic health should use the DII to estimate dietary inflammatory potential.
JOURNAL OF NUTRITION
(2022)
Article
Plant Sciences
Rongshuang Huang, Fan Guo, Yanping Li, Yan Liang, Guobo Li, Ping Fu, Liang Ma
Summary: The study shows that low-dose triptolide can alleviate NAFLD-induced hepatic steatosis, inflammation, and fibrosis, while activating AMPK protein to prevent lipogenesis and fibrosis.
Article
Hematology
Seong Jun Park, Jung Yoon, Hong Seog Seo, Chae Seung Lim
Summary: This study evaluated a new platelet function analyzing system, Anysis-200, and compared it with PFA-200. The results showed that Anysis-200 had moderate to fair agreement with PFA-200 and could be potentially useful for screening cardiac patients with abnormal platelet function.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2022)
Article
Pharmacology & Pharmacy
Byoung Geol Choi, Jung Boone Kim, Seung-Woon Rha, Suhng Wook Kim, Min Woo Lee, Michael S. Lee, Se Yeon Choi, Jae Kyeong Byun, Jinah Cha, Jin Oh Na, Cheol Ung Choi, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Sunghoi Hong
Summary: This study found an association between anaemia and the development of diabetes mellitus as well as mortality rates. More research is needed to validate these findings.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu-Ra Lee, Bark-Lynn Lew, Woo-Young Sim, Jongki Hong, Bong-Chul Chung
Summary: Catecholamines and steroids were simultaneously analyzed for the first time in this study using a hydrolysis procedure and chemical derivatization, resulting in increased sensitivity. The validated method identified significantly higher metanephrine content in patients with alopecia areata. This quantitative profiling method has potential applications in the diagnosis and research of various diseases.
Article
Biochemistry & Molecular Biology
Yu Ra Lee, Bark Lynn Lew, Woo Young Sim, Jongki Hong, Bong Chul Chung
Summary: Metabolomics analysis of pattern baldness patients and control subjects revealed differences in steroid biosynthesis pathway in both males and females. This study confirms the metabolic pathway in pattern baldness patients using hair samples for the first time and emphasizes the need to connect pattern baldness with sex-related differences.
Article
Endocrinology & Metabolism
Yong-Jik Lee, Yoo-Na Jang, Hyun-Min Kim, Yoon-Mi Han, Hong Seog Seo, Youngsub Eom, Jong-Suk Song, Ji Hoon Jeong, Tae Woo Jung
Summary: Obesity is associated with cataract development, and it has been found that the alpha 1-adrenergic receptor agonist midodrine has a beneficial effect on cataracts in an obesity rat model. The mechanisms of action include inhibiting the synthesis of sorbitol, reducing oxidative stress and inflammation, and promoting normal aerobic glycolysis.
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Jabar Ali, Seung-Woon Rha, Byoung Geol Choi, Jae Kyeong Byun, Se Yeon Choi, Jin Ah Cha, Soohyung Park, Kyuho Lee, Seungmin Back, Jieun Lee, Dong Oh Kang, Jah Yeon Choi, Seung-Young Roh, Jin Oh Na, Cheol Ung Choi, Jin-Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Mohammad Wasim, Zair Hassan
Summary: This study found that DES-associated coronary artery spasm is associated with a higher incidence of diffuse spasm, ST-T change, and adverse clinical outcomes at 3 years.
INDIAN HEART JOURNAL
(2022)
Article
Multidisciplinary Sciences
Liping Wang, Guang Lin, Zhongyuan Zuo, Yarong Li, Seul Kee Byeon, Akhilesh Pandey, Hugo J. Bellen
Summary: Recessive variants in GBA1 can lead to Gaucher disease, a common lysosome storage disease. Using CRISPR-Cas9, we generated a null allele of the Drosophila ortholog Gba1b and found that it is expressed in glia but not in neurons. GlcCer is synthesized upon neuronal activity and transported from neurons to glia through exosomes. Glial TGF-beta/BMP induces GlcCer transfer from neurons to glia, and the White protein promotes GlcCer trafficking to glial lysosomes for degradation.
Review
Endocrinology & Metabolism
Ewout Muylle, Huafang Jiang, Christin Johnsen, Seul Kee Byeon, Wasantha Ranatunga, Kishore Garapati, Roman M. Zenka, Graeme Preston, Akhilesh Pandey, Tamas Kozicz, Fang Fang, Eva Morava
Summary: TRIT1 defect is a rare disorder of transcription characterized by developmental delay, seizures, and abnormal mitochondrial function. It can be identified as a potentially recognizable syndrome with specific features.
JOURNAL OF INHERITED METABOLIC DISEASE
(2022)
Article
Biology
Guang Lin, Burak Tepe, Geoff McGrane, Regine C. Tipon, Gist Croft, Leena Panwala, Amanda Hope, Agnes J. H. Liang, Zhongyuan Zuo, Seul Kee Byeon, Lily Wang, Akhilesh Pandey, Hugo J. Bellen
Summary: Infantile neuroaxonal dystrophy is a lethal pediatric neurodegenerative disorder caused by recessive variants in PLA2G6 gene. Dysregulation of retromer function, ceramide metabolism, endolysosomal pathway, and mitochondrial morphology was observed in INAD patient-derived neurons. Drugs targeting these pathways, as well as an AAV-based gene therapy approach, showed promising therapeutic effects in INAD models.
Article
Medicine, Research & Experimental
Yong-Jik Lee, Hyun-Min Kim, Yoo-Na Jang, Yoon-Mi Han, Hong Seog Seo, Tae Woo Jung, Ji Hoon Jeong, Hyun Jung Lee, Kyung Oh Jung
Summary: This study investigated the therapeutic mechanism of buspirone against lipid metabolism disturbed by hypertension in early stage. The results showed that buspirone could reduce lipid accumulation and decrease body weight and abdominal fat weight. Additionally, buspirone could lower blood pressure. By activating PPARd-dependent catabolic metabolism to produce energy, buspirone could improve lipid metabolism and normalize high blood pressure.
Article
Biotechnology & Applied Microbiology
Jae Hun Jung, Da-Qing Yang, Hongming Song, Xiangyu Wang, Xinyan Wu, Kwang Pyo Kim, Akhilesh Pandey, Seul Kee Byeon
Summary: Lipids play important roles in health and disease, including cancer. Mutations in the PIK3CA gene, which codes for the PI3K catalytic subunit p110α, are frequently found in cancer cells. We used untargeted lipidomics to analyze changes in lipid profiles in breast cancer cells with these mutations. Our results reveal a potential link between altered lipid profile and carcinogenesis caused by PIK3CA mutations.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2023)
Article
Medical Informatics
Seul Kee Byeon, Anil K. Madugundu, Kishore Garapati, Madan Gopal Ramarajan, Mayank Saraswat, Praveen M. Kumar, Travis Hughes, Rameen Shah, Mrinal M. Patnaik, Nicholas Chia, Susan Ashrafzadeh-Kian, Joseph D. Yao, Bobbi S. Pritt, Roberto Cattaneo, Mohamed E. Salama, Roman M. Zenka, Benjamin R. Kipp, Stefan K. G. Grebe, Ravinder J. Singh, Amir A. Sadighi Akha, Alicia Algeciras-Schimnich, Surendra Dasari, Janet E. Olson, Jesse R. Walsh, A. J. Venkatakrishnan, Garrett Jenkinson, John C. O'Horo, Andrew D. Badley, Akhilesh Pandey
Summary: In this retrospective cohort study, biomarkers that reliably predict severe and clinical outcomes of COVID-19 were discovered by analyzing samples from 455 participants. The study found that multiomic molecular signatures in plasma collected before hospital admission could be used to predict disease severity, demonstrating the potential of machine learning approaches in identifying novel clinical signatures.
LANCET DIGITAL HEALTH
(2022)
Article
Spectroscopy
Chaelin Lee, Min-Jeong Oh, Geum Joon Cho, Dong Jun Byun, Hong Seog Seo, Man Ho Choi
Summary: This study used LC-MS to investigate the steroidogenic roles in preeclampsia and compared two different linear regression models. The results showed altered steroidogenesis in preeclampsia patients.
MASS SPECTROMETRY LETTERS
(2022)
Article
Medicine, General & Internal
Yoo Na Jang, Yong Jik Lee, Yoon Mi Han, Hyun Min Kim, Hong Seog Seo, Ji Hoon Jeong, Seung Yeon Park, Tae Woo Jung
Summary: The study evaluated the anti-diabetic function of the anti-hypertensive drug fimasartan on skeletal muscle and liver cells in a high glucose state. Fimasartan improved glucose metabolism by regulating PPAR delta in cells.
YONSEI MEDICAL JOURNAL
(2022)
Article
Health Care Sciences & Services
Shaopeng Xu, Seung-Woon Rha, Byoung Geol Choi, Hong Seog Seo
Summary: This study investigated the influence of statin on glycemic control in different age groups. The findings suggest that statin treatment is associated with adverse glycemic control in the elderly population.