Journal
MARINE DRUGS
Volume 17, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/md17030156
Keywords
gamma-oryzanol; algae oil; self-emulsifying; alginate; controlled release
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Funding
- Ministry of Science and Technology [NSC 105-2221-E-005-077]
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Self-emulsion improves solubility and bioavailability for -oryzanol/algae oil, and alginate beads can be used as controlled release carriers. In this study, self-emulsified alginate beads (SEABs) were prepared with different weight ratios of self-emulsion treatment (5%, 10%, 15%, 20%, and 30%) with alginate. We found that the microstructure with a surfactant of SEABs had a different appearance with alginate-based beads. The encapsulation of -oryzanol corresponded with the self-emulsion/alginate ratio, which was 98.93 similar to 60.20% with a different formulation of SEABs. During in vitro release, SEABs had the gastric protection of -oryzanol/algae oil, because -oryzanol and emulsion were not released in the simulated stomach fluid. When the SEABs were transferred to a simulation of the small intestine, they quickly began to swell and dissolve, releasing a higher content of the emulsion. We observed that the emulsion that formed had a bimodal distribution in the simulated intestinal fluid as a result of the hydrogel and emulsion droplets, leading to the formation of large aggregates. These results suggested that -oryzanol encapsulation within alginate beads via emulsification combined with gelation can serve as an effective controlled delivery system.
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