Article
Chemistry, Applied
Xiuying Liu, Fei Xia, Shaoen Zhang, Yuanyuan Cheng, Ling Fan, Si Kang, Xue Gao, Xiaofei Sun, Jianrong Li, Xuepeng Li, Lijie Zhu
Summary: A multiplex immunochromatographic assay based on dual-color aggregation-induced emission nanoparticles was developed for the simultaneous detection of nitrofuran metabolites. The method showed higher detection sensitivity and acceptable recoveries compared to commercial test strips.
Article
Chemistry, Analytical
Yaqian Chen, Jing Ren, Xuechi Yin, Yuechun Li, Rui Shu, Jianlong Wang, Daohong Zhang
Summary: In this study, vanadium disulfide nanosheet (VS2NS) was successfully applied as an enzyme label in lateral flow immunoassay (LFIA) for the detection of 17-β-estradiol. Compared to natural horseradish peroxidase, VS2NS exhibited better catalytic performance, stability, and adsorption ability, resulting in lower detection limit and wider linear range in the LFIA.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Artem O. Melekhin, Veronika V. Tolmacheva, Elena G. Shubina, Stanislava G. Dmitrienko, Vladimir V. Apyari, Artyom Grudev
Summary: In this study, 5-nitro-2-furaldehyde (5-NFA) was utilized as a new derivatizing agent for nitrofuran metabolites analysis, with magnetic solid phase extraction (MSPE) enhancing the efficiency of sample clean-up. The method showed high recoveries, good precision, and low limits of detection and quantitation, making it suitable for the analysis of nitrofuran metabolites in honey samples.
Article
Biophysics
Lei Huang, Shulin Tian, Wenhao Zhao, Ke Liu, Xing Ma, Jinhong Guo
Summary: The lateral flow assay (LFA) is a widely used paper-based on-site biosensor for detecting target analytes in minutes. Aptamers, as biorecognition molecules, are being explored as an alternative to antibodies in LFAs, offering advantages over traditional methods. Different formats of aptamer-based LFAs can achieve on-site detection of target analytes efficiently.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemical Research Methods
Fernando G. M. Violante, Wagner Wollinger, Evelyn F. Guimaraes, Bruno C. Garrido, Francisco Radler de Aquino Neto
Summary: The comparability and metrological traceability of measurement results are crucial for reliable decision-making. Using certified reference materials and potential primary reference measurement procedures are necessary in analytical chemistry to ensure traceable measurements. In this work, qNMR was used to determine the purity of nitrofuran metabolites with consistent results compared to those obtained by mass balance approach.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yan Huang, Tailin Xu, Yong Luo, Conghui Liu, Xuan Gao, Zhihao Cheng, Yongqiang Wen, Xueji Zhang
Summary: Integration of ultrasound enrichment as sample preparation with lateral flow biosensor (LFB) enables rapid detection of ultra-trace proteins in blood, reducing false positive readings caused by interference. This microchip shows great potential in clinical diagnosis by detecting ultra-trace biomarkers.
ANALYTICAL CHEMISTRY
(2021)
Article
Food Science & Technology
Pingping Gao, Lihan Wang, Yang He, Yitian Wang, Xinyan Yang, Shiqian Fu, Xue Qin, Qing Chen, Chaoxin Man, Yujun Jiang
Summary: A novel lateral flow assay based on aptamer-magnetic separation and multifold Au nanoparticles was developed for visual detection of Salmonella enterica ser. Typhimurium. The method achieved high sensitivity and specificity without the need for nucleic acid amplification or pre-enrichment, significantly improving the detection limit compared to traditional assays.
Article
Chemistry, Analytical
Na Ying, Yuan Wang, Xuefeng Song, Liguo Yang, Bo Qin, Yanqing Wu, Wenhong Fang
Summary: A new detection assay for Vibrio parahaemolyticus was introduced, utilizing aptamer combined with magnetic nanoparticles, hybridization chain reaction, and lateral flow nucleotide biosensor. It showed high specificity and fast detection time, making it suitable for low-resource laboratories or districts.
Article
Chemistry, Multidisciplinary
Maria Salvador, Jose Luis Marques-Fernandez, Alexander Bunge, Jose Carlos Martinez-Garcia, Rodica Turcu, Davide Peddis, Maria del Mar Garcia-Suarez, Maria Dolores Cima-Cabal, Montserrat Rivas
Summary: Lateral flow immunoassays combined with magnetic nanoclusters and antibodies, along with two strategies to increase sensitivity and accuracy, hold great promise for application in pneumonia diagnosis.
Article
Chemistry, Physical
Shaoyan Hu, Deyong Wang, Xianglong Li, Wei Zhao, Tianpeng Qu, Yun Wang
Summary: This study found that using melting separation process can result in higher alloy yield, iron recovery rate, and chromium content in the alloy when dealing with chromium slag. On the other hand, a lower pre-reduction temperature and magnetic separation process were found to be more beneficial for improving the chromium-iron ratio in the slag.
Article
Chemistry, Analytical
Shuai Liu, Zhizhen Lai, Mo Zhang, Hongtao Tian, Jiang Zhou, Zhili Li
Summary: A simple and efficient enrichment strategy based on Amino-functionalized Polymer-Magnetic MicroParticles (NH2-PMMPs) with coral-like porous structures was developed to detect 320 anionic metabolites, including 102 polar phosphate metabolites. Previously unknown polar phosphate metabolites were identified in serum samples using this enrichment method, demonstrating its advantages for mass spectrometric analysis. The high sensitivity of the method enabled the detection of 36 polar anion metabolites from 10 cell equivalent samples.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Qingcai Yu, Jing Zhang, Wanwei Qiu, Kun Li, Lisheng Qian, Xueji Zhang, Guodong Liu
Summary: A gold nanorod-based lateral flow nucleic acid biosensor was developed for visual detection of DNA with high sensitivity and short test time. By forming a sandwich-type complex on the LFNAB, target DNA could be detected without instrumentation, and quantitative analysis was achieved using a portable strip reader.
Article
Geochemistry & Geophysics
Ahmed M. Elmahdy, Hajime Miki, Keiko Sasaki, Mohsen Farahat
Summary: The effect of microwave pre-treatment on the magnetic properties of tennantite and enargite was investigated. Magnetic susceptibility, XRD, and XPS characterization were conducted to explore the changes in their magnetic properties. Magnetic separation of chalcopyrite binary mixtures with enargite and tennantite was performed, showing significant arsenic rejection rates of 84.2% and 76.3% respectively.
Article
Engineering, Environmental
Weiqiang Li, Xuekun Bai, Fangbin Xiao, Jin Huang, Xianxiang Zeng, Qian Xu, Yang Song, Xiaoyun Xu, Hengyi Xu
Summary: This study introduces a magnetic separation-based electrochemical biosensor for the detection of Methicillin-resistant Staphylococcus aureus (MRSA). The sensor showed good stability and applicability, with a detection limit of 3.8 x 101 CFU/mL. MRSA was successfully detected in cerebrospinal fluid samples with satisfactory recoveries and validation results. Overall, this study presents a promising method for the detection of MRSA, with the potential to be further developed into a universal pathogen detection method.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Analytical
Yang Chen, Min Zhang, Xin Wang, Xin Wang, Zainabu Majid, Kunlun Huang, Wentao Xu, Yunbo Luo, Cheng Nan
Summary: A multifunction and portable 3D-printed magnetic separation device with graded lateral flow assay is presented for semi-automated pretreatment and rapid detection of Staphylo-coccus aureus in food. It allows purification and enrichment of the Pd@Pt NPs-antibody-S. aureus complex, with a recovery rate of 81.7-96.1% in actual food samples. The Pd@Pt NPs-mediated signal amplification immunoassay achieved graded detection of S. aureus, reducing the detection limit and paving the way for cost-effective and sensitive point-of-care testing.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Medicinal
Jianghong Dong, Shengwei Chen, Runfeng Li, Wei Cui, Haiming Jiang, Yixia Ling, Zifeng Yang, Wenhui Hu
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Qinge Ma, Rongrui Wei, Zhipei Sang, Jianghong Dong
BIOORGANIC CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Jianghong Dong, Mengjie Xiao, Qinge Ma, Guicheng Zhang, Weijie Zhao, Mengjie Kong, Yue Zhang, Luyun Qiu, Wenhui Hu
BIOORGANIC CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Jianghong Dong, Fengmei Yang, Shuang Li, Zewen Li, Yuanhang Qin
NATURAL PRODUCT COMMUNICATIONS
(2020)
Article
Chemistry, Medicinal
Qin-Ge Ma, Rong-Rui Wei, Zhi-Pei Sang, Jiang-Hong Dong
Summary: Cucumis bisexualis is a wild fruit with high nutritional and medicinal values. Several previously undescribed compounds isolated from its fruits show moderate hepatoprotective activities.
Article
Chemistry, Multidisciplinary
Jianghong Dong, Qinglan Pei, Panpan Wang, Qinge Ma, Wenhui Hu
Summary: This study presents a regiocontrolled synthesis of 2-amino-1,3,4-thiadiazoles from readily available thiosemicarbazides using POCl3. Additionally, 2-amino-1,3,4-oxadiazole derivatives were prepared via cyclization of thiosemicarbazide intermediates. In vitro assays demonstrated the inhibitory activities of selected compounds against influenza A virus strains.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Physical
Panpan Wang, Fengmei Yan, Jianghong Dong, Shengqiang Wang, Yu Shi, Mengdan Zhu, Yuting Zuo, Hui Ma, Ruirui Xue, Dingjie Zhai, Xiaoyu Song
Summary: Depression has a severe impact on people's health worldwide. Developing novel NDRI antidepressants that do not interfere with cognitive function is urgent. This study aimed to selectively identify new NDRI candidates targeting hNET and hDAT by integrating various strategies. The results yielded 5 high-activity compounds, with 4 of them showing balanced activities on both targets.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Panpan Wang, Xiaonan Gao, Ke Zhang, Qinglan Pei, Xiaobo Xu, Fengmei Yan, Jianghong Dong, Chenxi Jing
Summary: This study explores the binding characteristics of eight PAMs representing five chemical series using multiple computational methods, defining the shared binding modes and indicating specific indicators that regulate PAMs affinity. The findings shed light on the binding mechanism and physicochemical regularity underlying PAMs affinity, providing a potential blueprint for discovering and assessing novel PAMs for hmGlu(2).
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
