Article
Biochemistry & Molecular Biology
Yu-Chen Liu, Katragunta Kumar, Cheng-Hsiu Wu, Kai-Chih Chang, Cheng-Kang Chiang, Yen-Peng Ho
Summary: A nucleic acid aptamer specific to MRSA has been immobilized on magnetic nanoparticles for capturing bacteria before mass spectrometry analysis, which enhances MRSA identification accuracy. Under optimized conditions, the aptamer-modified nanoparticles showed high capture efficiency for MRSA and low capture rates for non-target bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Michela Galgano, Paolo Capozza, Francesco Pellegrini, Marco Cordisco, Alessio Sposato, Sabina Sblano, Michele Camero, Gianvito Lanave, Giuseppe Fracchiolla, Marialaura Corrente, Francesco Cirone, Adriana Trotta, Maria Tempesta, Domenico Buonavoglia, Annamaria Pratelli
Summary: The study found that essential oils such as lemon, pine, fennel, basil, melissa, thyme, and ginger have broad-spectrum antimicrobial activity. The activity of ginger oil against Staphylococcus aureus strains showed a dose-effect correlation, while fennel oil showed low activity. Pine, melissa, and basil oils showed bactericidal effects against S. aureus, and lemon oil had different effects on different strains. Thyme oil showed complete inhibition of growth for both E. coli and S. aureus.
Article
Biochemistry & Molecular Biology
Yeseul Kim, Sanghun Kim, Kiu-Hyung Cho, Jin-Hyung Lee, Jintae Lee
Summary: Bacterial biofilm formation can be effectively inhibited by cinnamaldehyde and its derivatives, especially 4-nitrocinnamaldehyde. These compounds exhibit strong antibiofilm activities against UPEC and S. aureus, making them promising candidates for the treatment of biofilm-associated diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Tianyi Li, Qinghua Zou, Binghua Zhang, Di Xiao
Summary: MALDI-TOF MS technology can accurately identify Escherichia coli and Shigella spp., which is crucial for disease control and prevention. By identifying characteristic peaks of decarboxylation products, we were able to distinguish E. coli from Shigella spp. This technology is advantageous for its high throughput, high quality, and ease of operation, and is of significant value for the diagnosis of E. coli and Shigella-related diseases.
ANALYTICA CHIMICA ACTA
(2023)
Article
Agriculture, Multidisciplinary
Zhang Hui-lin, Zhao Yi-yang, Zhou Zi-chong, Ding Huan-zhong
Summary: In this study, the susceptibility breakpoints of cefquinome against E. coli and S. aureus in pigs were determined, with low resistance rates observed. Pharmacokinetic/pharmacodynamic cut-off values were established, providing guidance for effective treatment of infections caused by these bacteria strains. Adjustment of dosing regimen showed increased effectiveness for S. aureus infections, highlighting the importance of surveillance and dosage guidance for cefquinome in pigs.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Biophysics
Yong Zhao, Yanzhao Li, Pingping Zhang, Ziheng Yan, Yugui Zhou, Yipu Du, Chunyu Qu, Yajun Song, Ding Zhou, Songnan Qu, Ruifu Yang
Summary: The study developed a highly sensitive fluorescent immunosensor using CDs-microspheres for the specific detection of Escherichia coli O157:H7 in milk, showing strong fluorescence intensity, good stability, and high uniformity in fluorescence. The immunosensor had a detection limit of 2.4 x 10(2) CFU/mL and could detect spiked E. coli O157:H7 in milk within 30 minutes with good repeatability. Additionally, the method could detect trace amounts of E. coli O157:H7 in real milk samples with 100% accuracy after bacterial enrichment, demonstrating its potential as a rapid and sensitive tool for pathogen detection in milk and other foods.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Materials Science, Multidisciplinary
C. Guerra, A. Ringuede, M. I. Azocar, M. Walter, C. Galarce, F. Bedioui, M. Cassir, M. Sancy
Summary: AISI 430 stainless steel is an attractive material for use in the healthcare industry, but shows clear signs of corrosion after two weeks of exposure in a sterile medium.
Article
Food Science & Technology
Hong Yan, Yingying Lu, Xin Li, Yanglei Yi, Xin Wang, Yuanyuan Shan, Bianfang Liu, Yuan Zhou, Xin Lu
Summary: Bacteriocin BM1829 has antimicrobial activity against both Gram-positive and Gram-negative bacteria, and exhibits good stability against various environmental factors. It can disrupt membrane integrity, arrest the cell cycle, and reduce bacterial populations during food storage, suggesting its potential as a food preservative or antibacterial agent.
Article
Microbiology
Sunghyun Yoon, Yon Kyoung Park, Tae Sung Jung, Seong Bin Park
Summary: In this study, 95 strains of Staphylococcus aureus isolated from stool samples in Busan, South Korea showed diverse antibiotic resistance patterns and distribution of enterotoxin genes. Molecular typing using MALDI-TOF MS and RAPD revealed different clonal lineages among the S. aureus strains.
Article
Food Science & Technology
Han Du, Tao Ping, Wei Wu, Qingli Yang
Summary: This study prepared a simple and sensitive DNA tetrahedral fluorescence signal amplifier for sandwich detection of Staphylococcus aureus. The amplifier improved the fluorescence detection sensitivity and selectivity of S. aureus, and it may also be applicable to the detection of other food pathogens or environmental microorganisms in the future.
Article
Materials Science, Ceramics
Jose Domingo Trujillo-Casarreal, Jesus Morales-Jimenez, V Rodriguez-Gonzalez
Summary: Metallic nanoparticles (NPs) with size and morphology that enable a large surface-to-volume ratio exhibit antibacterial properties. The surface functionalization of copper sulfide NPs on mesoporous SiO2 spheres (PMSi) was successfully achieved. The antibacterial activity of PMSi loaded with sulfamethoxazole (SMX) against Escherichia coli and Staphylococcus aureus was studied. CuS and Cu functionalized on PMSi exhibited a good spectrum of antimicrobial activity against Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Article
Microbiology
Jiaxin Yu, Ni Tien, Yu-Ching Liu, Der-Yang Cho, Jia-Wen Chen, Yin-Tai Tsai, Yu-Chen Huang, Huei-Jen Chao, Chao-Jung Chen
Summary: This study proposes a machine learning model based on MALDI-TOF MS for rapid MRSA prediction. The model was evaluated and validated on a prospective test and four external clinical sites. It can be easily integrated into current clinical workflows and help support proper antibiotic treatments.
MICROBIOLOGY SPECTRUM
(2022)
Article
Environmental Sciences
Li Lin, Ziying Su, Yi Li, Chi Zhang
Summary: This study investigates the inactivation mechanisms of pathogenic microorganisms in water using metal-free modified g-C3N4 under visible light, focusing on two common bacteria. It reveals distinct inactivation kinetics of E. coli and S. aureus, as well as the different impacts of important water parameters. Additionally, scavenger experiments indicate the role of superoxide radicals in E. coli inactivation and the importance of both superoxide and hydroxyl radicals in S. aureus inactivation.
Article
Engineering, Environmental
Li-Ting Yen, Chih-Huang Weng, Nhu Anh Thi Than, Jing-Hua Tzeng, Astrid R. Jacobson, Kesinee Iamsaard, Van Dien Dang, Yao-Tung Lin
Summary: This study characterized the mode of inactivation of S. aureus and E. coli via biocalcium oxide (BCO) using various microscopy and spectroscopy techniques. The results demonstrated that BCO altered bacterial cell permeability, leading to sustained inactivation. BCO exhibited superior disinfection capacity compared to other shell-derived disinfectants, making it a cost-effective option for pathogen control.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Aiman Batool, Mercy Bore, Jingwen Wu, Chaoyu Li, Hongjuan Zeng
Summary: The combination of silver nanoparticles and cefazolin can enhance the antibacterial effectiveness of cefazolin, exhibiting strong antibacterial activity against Escherichia coli and Staphylococcus aureus.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anas Shamsi, Moyad Shahwan, Mohd Shahnawaz Khan, Fahad A. Alhumaydhi, Suliman A. Alsagaby, Waleed Al Abdulmonem, Bekhzod Abdullaev, Dharmendra Kumar Yadav
Summary: This study investigated the binding of Huperzine A with human serum albumin (HSA) using computational methods. The results of molecular docking and molecular dynamic simulation showed interactions between Huperzine A and HSA, which were further validated by experimental assays. These findings suggest that Huperzine A may be a potential drug for Alzheimer's disease treatment.
Article
Chemistry, Physical
Ali Ounissi, Hafida Merouani, Widad Sobhi, Nadia Ouddai, John Simmie, Mohd Shahnawaz Khan, Muhammad Nadeem Asghar, Yacine Benguerba
Summary: The two different methods of attack by the free radicals HO* and HO2* on the purine/pyrimidine complex were investigated, revealing a nucleophilic/electrical attack mechanism with a high radical fraction and potential impact on DNA integrity. Additionally, the interaction of HO2* with guanine and cytosine was explored, indicating effects on other biological structures beyond DNA.
COMPUTATIONAL AND THEORETICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Bader Saud Alotaibi, Jatin Joshi, Mohammad Raghibul Hasan, Mohd Shahnawaz Khan, Salem Hussain Alharethi, Taj Mohammad, Fahad A. Alhumaydhi, Abdelbaset Mohamed Elasbali, Md Imtaiyaz Hassan
Summary: In this study, potential inhibitors of ROCK1 were identified through structure-based virtual screening of natural compounds. Isoononin and Candidissiol showed appreciable binding affinity and selectivity towards ROCK1, and molecular dynamics simulations confirmed their stability.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Majed S. Alokail, Amal Majed H. Alenad, Nojood Altwaijry, Nouf Omar Alafaleq, Abdulaziz Mohammed Alamri, Mubarak Ali Zawba
Summary: Alpha-amylase plays an important role in the management of diabetes and its complications. This study explored the binding of caffeic acid and coumaric acid with alpha-amylase and their effects on the formation of advanced glycation end-products (AGEs). The results showed that both compounds could bind to alpha-amylase and inhibit the formation of AGEs. Caffeic acid exhibited stronger antiglycative activity compared to p-coumaric acid, which could be attributed to its additional -OH group and high antioxidant activity. The study also highlighted the role of hydrogen bonding in the complex formation. Molecular docking studies suggested that these compounds could be utilized in the design of antidiabetic drugs.
Article
Health Care Sciences & Services
Mohd Adnan, Deeba Shamim Jairajpuri, Muskan Chaddha, Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Taj Mohammad, Abdelbaset Mohamed Elasbali, Waleed Abu Al-Soud, Salem Hussain Alharethi, Md Imtaiyaz Hassan
Summary: This study screened the Indian Medicinal Plants, Phytochemistry and Therapeutics database for potential AKT1 inhibitors. Two compounds, tuberosin and villosol, were identified as promising candidates for the therapeutic targeting of OSCC and other cancers.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Computer Science, Information Systems
Mohamed Hassaoui, Mohamed Hanini, Said El Kafhali
Summary: The use of C2 servers in cyberattacks has increased significantly, with attackers using DGA technique to hide their servers. Existing techniques for binary classification of domain names have issues with real-time detection and sensitivity to data. This paper proposes the DTFS-DGA model, which combines neural networks and traditional machine learning models to detect DGA in real-time without relying on reverse engineering and being insensitive to data size.
JOURNAL OF COMPUTER SECURITY
(2023)
Article
Environmental Sciences
Nojood Altwaijry, Mohd Shahnawaz Khan, Gouse M. Shaik, Mohammad Tarique, Mehjbeen Javed
Summary: In this study, various parameters of oxidative stress, immune response, and abnormalities in the erythrocyte nucleus of Labeo rohita inhabiting the polluted Kshipra River, India, were measured. The heavy metal concentrations in the river water were in the order of Ni > Fe > Cd > Cr > Mn > Zn > Cu. The fish showed increased levels of antioxidant enzymes in gills, liver, and gut compared to the reference fish, but decreased levels of GST and GSH. Heavy metals also caused immunosuppression and histopathological changes in the fish. These findings highlight the potential impact of heavy metal-induced stress on fish inhabiting polluted river water and the importance of pollution control.
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nojood Altwaijry, Ghaliah S. Almutairi, Mohd Shahnawaz Khan, Gouse M. Shaik, Majed S. Alokail
Summary: Amyloid fibrils accumulation can cause lethal conditions, but the use of Chlorothiazide (CTZ) can prevent or treat this disease. In this study, the effects of CTZ on hen egg white lysozyme (HEWL) aggregation were examined using various methods. The results showed that CTZ can reduce the formation of amyloid fibrils and prevent aggregation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Nojood Altwaijry, Moneera Saud Al-Bagmi, Nouf Omar Alafaleq, Majed S. Alokail, Moyad Shahwan, Anas Shamsi
Summary: Proto-oncogene tyrosine-protein kinase ROS (ROS1) is a member of a receptor family that affects epithelial cell differentiation and is highly expressed in various tumors. This study identified two potential inhibitors of ROS1 through virtual screening of phytochemicals. The findings highlight the role of ROS1 in multiple physiological processes and suggest the potential use of phytochemicals for therapeutic development targeting ROS1-associated non-small cell lung cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Ajamaluddin Malik, Javed Masood Khan, Abdullah S. S. Alhomida, Mohammad Shamsul Ola, Majed S. S. Alokail, Mohd Shahnawaz Khan, Amal M. M. Alenad, Nojood Altwaijry, Nouf Omar Alafaleq, Hamza Odeibat
Summary: Several proteins and peptides have the ability to form amyloid fibrils, which can lead to a variety of diseases. The process by which these proteins transition from a folded and soluble state to an amyloid fibril is not well understood.
JOURNAL OF MOLECULAR RECOGNITION
(2023)
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Nojood Altwaijry, Nasimudeen R. Jabir, Abdulaziz Mohammed Alamri, Mohammad Tarique, Azhar U. Khan
Summary: Ovarian cancer treatment is highly challenging due to the lack of clinical symptoms and sensitivity biomarkers leading to late-stage diagnosis. This study evaluated the anticancer potential of biogenic zinc oxide nanoparticles (ZnO NPs) synthesized using pumpkin seed extracts.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Nouf Omar Alafaleq, Torki A. Zughaibi, Nasimudeen R. Jabir, Azhar U. Khan, Mohd Shahnawaz Khan, Shams Tabrez
Summary: This study investigates the anticancer potential of Cu-Mn bimetallic NPs synthesized from pumpkin seed extract against colon adenocarcinoma cancer cell line (HT-29). The results show significant anticancer efficacy of CMBNPs against the studied cancer cell line, with no significant cytotoxicity on normal cells.
Review
Chemistry, Medicinal
Nazia Nazam, Nasimudeen R. Jabir, Iftikhar Ahmad, Saif A. Alharthy, Mohd Shahnawaz Khan, Rashid Ayub, Shams Tabrez
Summary: Cancer is a global health problem that is on the rise, and ovarian cancer is one of the leading causes of mortality worldwide. Current treatments for ovarian cancer have limited effectiveness and come with side effects, recurrence risk, and drug resistance. Therefore, there is a need for alternative, cost-effective, and safer therapeutic strategies.
Article
Multidisciplinary Sciences
Nojood Altwaijry, Ghaliah S. Almutairi, Mohd Shahhnawaz Khan, Majed S. Alokail, Nouf Alafaleq, Rizwan Ali
Summary: Protein misfolding can lead to amyloid fiber aggregation, which is associated with various diseases. This study examines the anti-aggregating effect of Valsartan on HEWL amyloid fibrils through spectroscopy, docking, and microscopic analysis.
Article
Pharmacology & Pharmacy
Mohammad Rashid Khan, Sheikh Fayaz Ahmad, Ahmed Nadeem, Faisal Imam, Naif O. Al-Harbi, Mohd Shahnawaz Khan, Meshal Alsahli, Khaled Alhosaini
Summary: This study explored the therapeutic outcome of Cathepsin B inhibitor (CA-074) against retinopathy and optic neuritis caused by experimental autoimmune encephalomyelitis (EAE). The findings showed that CA-074 could ameliorate optic neuritis and retinopathy by reducing inflammation, as well as reducing demyelination and axonal injuries in EAE mice.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)
