Article
Chemistry, Analytical
Samira Dowlatshah, Maria Ramos-Payan, Mohammad Saraji
Summary: A microchip device integrating liquid-liquid-solid phase microextraction was presented for the first time in this study, showing efficient extraction of permethrin and cypermethrin in water samples. Optimal conditions were established for the rapid extraction and analysis of the two pesticides, leading to successful results with good reproducibility and precision.
Article
Chemistry, Analytical
Li Chen, Jincheng Wang, Tyllis Xu, Xinrui Feng, Chuixiu Huang, Xiantao Shen
Summary: Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment drugs for pregnant and breastfeeding women, and the quantitative analysis of SSRIs in biological samples is crucial in public health and clinical practice. This paper discussed the recent development of sample preparation methods for SSRI analysis, including both traditional and new sample pretreatment techniques.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemical Research Methods
Jae Bem You, Detlef Lohse, Xuehua Zhang
Summary: The article introduces a green, fast one-step method called nanoextraction for extraction and detection of target analytes from dense suspensions, achieving a limit of detection for a fluorescent model analyte obtained from particle suspension samples. Research shows that high particle concentration in suspension samples does not reduce extraction efficiency.
Review
Biochemical Research Methods
Juan Antonio Ocana-Gonzalez, Noemi Aranda-Merino, Juan Luis Perez-Bernal, Maria Ramos-Payan
Summary: Liquid phase microextraction (LPME) and electromembrane microextraction (EME) are two popular techniques in sample treatment, both utilizing membrane-assisted extraction. Solid supports in the form of supported liquid membranes (SLMs) play a critical role in enhancing extraction reproducibility. Various SLMs have been successfully employed in different application fields, allowing the extraction of compounds with diverse natures. The development of environmentally friendly materials and solvents has also been a focus in recent years.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Analytical
Alejandro Martin, Rut Fernandez-Torres, Miguel Angel Bello-Lopez, Maria Ramos-Payan
Summary: This article introduces a new microfluidic device to improve the enrichment factor in miniaturized systems. The device is designed for liquid phase microextractions and can simultaneously extract acidic compounds with a wide range of polarities. The system operates under stagnant acceptor phase conditions and optimal operational parameters were determined. A new highly efficient supported liquid membrane, tributyl phosphate, was found for simultaneous extraction of analytes with different polarities. The method was successfully applied to human urine samples, demonstrating its potential for various applications.
Article
Chemistry, Analytical
Fatemeh Parvizi, Arsalan Parvareh, Rouhollah Heydari
Summary: A microfluidic device-based liquid phase microextraction followed by HPLC-UV analysis was introduced and optimized for the extraction and determination of mesalazine. The effects of main variables on the extraction efficiency were investigated and the optimal conditions were confirmed to achieve 100% extraction efficiency.
MICROCHEMICAL JOURNAL
(2022)
Review
Biochemical Research Methods
Hongyan Wu, Chiranjeevi Kanike, Arnab Atta, Xuehua Zhang
Summary: This article presents a review on nanoextraction based on surface nanodroplets, which can continuously extract and enrich target analytes from a sample solution in a continuous flow system. Nanoextraction is characterized by its simplicity in operation, low consumption of organic solvent, and high enrichment factor. The article also summarizes the formation principle and key features of surface nanodroplets, and discusses the major findings of nanoextraction combined with in-droplet chemistry for sensitive and quantitative detection. Lastly, the future trend of nanoextraction is discussed.
Article
Chemistry, Analytical
Yilin Zou, Liyuan Wang, Huaze Sun, Gang Wang, Long-Yue Meng, Maurizio Quinto, Donghao Li
Summary: The innovative and versatile microextraction technique based on nanoconfined solvent on carbon nanofibers allows easy modulation of extraction capabilities towards polar, medium polar, and nonpolar substances. The nanoconfined liquid phase nanoextraction process shows excellent characteristics in terms of extraction recoveries, extraction time, reliability, and versatility. Additionally, a needle-tip device has been developed for direct and minimally invasive analyte extraction, making this technique a powerful candidate for high-throughput analyses of biological samples.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Mohammed Altahir Suliman, Taofiq Abdulraheem Olarewaju, Chanbasha Basheer, Hian Kee Lee
Summary: Petroleum is a complex material containing a wide range of compounds, and ASTM methods are globally accepted but have limitations in terms of sample preparation. The challenge in petrochemical analysis is to develop rapid and simpler automated sample preparation procedures. Microextraction is considered an excellent complement to current methods.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Review
Chemistry, Analytical
Mahdi Ghorbani, Parisa Mohammadi, Majid Keshavarzi, Aliakbar Ziroohi, Morteza Mohammadi, Mohsen Aghamohammadhasan, Maryam Pakseresht
Summary: Antidepressants are a crucial class of drugs for treating depression, and determining their presence in biological samples is important for controlling adverse effects and studying their pharmacokinetics. However, the low concentration and high matrix effects of these drugs in samples present a challenge for direct measurement. Sample preparation techniques, such as extraction and microextraction, are used to overcome these difficulties. This review investigates various extraction and microextraction methods for antidepressants in biological, water, and wastewater samples, and discusses their advantages, disadvantages, and recent developments.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Malek Hassan, Furkan Uzcan, Usama Alshana, Mustafa Soylak
Summary: A novel method combining switchable-hydrophilicity liquid-liquid microextraction and magnetic nanoparticle-based dispersive solid-phase microextraction was proposed for the determination of erythrosine using UV/Vis spectrophotometry. The method showed excellent analytical performance with high sensitivity, low detection limits, and good reproducibility, making it suitable for the extraction and determination of erythrosine in food and consumer products.
Article
Chemistry, Analytical
Alejandro Martin, Elia Santigosa, Maria Ramos-Payan
Summary: In this study, a novel solvent-free microfluidic method for liquid phase microextraction (LPME) was proposed. The efficiency of biodegradable membranes without organic solvent in microfluidic formats was investigated, and a comparison with electromembrane extraction (EME) was conducted. The results showed that the solvent-free LPME microfluidic format had similar extraction efficiencies to the solvent-free EME format, but the LPME format was preferred due to its simplicity. The proposed green microfluidic device was successfully applied to urine samples, achieving high recoveries for all analytes and low relative standard deviation. Compared with conventional membranes, the solvent-free microfluidic systems based on biodegradable solid support materials offered the same advantages in terms of membrane stability and allowed consecutive extractions.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Alejandro Martin, Elia Santigosa, Maria Ramos-Payan
Summary: Microfluidic devices have made significant advancements in recent years and have become an important tool in pharmaceutical analysis. This study proposes a green microfluidic method for the simultaneous extraction of basic polar and non-polar compounds, offering a more sustainable and environmentally friendly alternative.
MICROCHEMICAL JOURNAL
(2023)
Review
Chemistry, Analytical
Giovanni D'Orazio, Alessandra Gentili, Salvatore Fanali, Chiara Fanali, Chiara Dal Bosco
Summary: Progress in material science has brought about innovative solutions for sample preparation, such as the evolution of solid-phase extraction towards miniaturized techniques and the use of nanomaterials as sorbents. Research in the past five years has shown that only 40% of works in the clinical and pharmaceutical sectors applied innovative or green approaches for sample preparation, with a general trend being the reduction of solvent volumes and sample processing times.
CURRENT ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Mina Alidoust, Yadollah Yamini, Mahroo Baharfar, Shahram Seidi, Fatemeh Rasouli
Summary: This study introduced a versatile combination of electromembrane extraction (EME) with thin film solid phase microextraction (TF-SPME) using a microfluidic chip device, demonstrating its applicability in the determination of synthetic food dyes with low LODs and a wide linear dynamic range under optimized conditions. The system also showed low RSD values and acceptable reusability of the thin film for multiple extractions.
Article
Biochemical Research Methods
Noemi Aranda-Merino, Maria Ramos-Payan, Manuel Callejon-Mochon, Mercedes Villar-Navarro, Rut Fernandez-Torres
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Frederik Andre Hansen, Elia Santigosa-Murillo, Maria Ramos-Payan, Maria Munoz, Elisabeth Leere Oiestad, Stig Pedersen-Bjergaard
Summary: This study investigated hydrophobic deep eutectic solvents as supported liquid membranes for electromembrane extraction, and found that mixtures of coumarin and thymol were efficient in extracting non-polar bases, non-polar acids, and polar bases. The SLMs with aromatic properties exhibited high hydrogen bonding capabilities, providing excellent clean-up efficiency with no matrix effects from plasma.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Analytical
Hadi Tabani, Michal Alexovic, Jan Sabo, Maria Ramos Payan
Summary: The introduction of a variety of chemicals in different industrial fields has made sample preparation inevitable for trace analysis. Traditional extraction techniques face challenges such as tedious procedures and hazards to personnel and the environment, leading to the introduction of microextraction techniques. Agarose, as a natural material, has been utilized in solid phase microextraction, micro-solid phase extraction, and liquid phase microextraction techniques, showing advantages such as easy fabrication, adjustability, inertness, and biodegradability.
Article
Chemistry, Analytical
Elia Santigosa-Murillo, Santiago Maspoch, Maria Munoz, Maria Ramos-Payan
Summary: The microfluidic device described in this work offers an efficient and fast solution for the simultaneous determination of acidic and basic drugs, with extraction efficiencies over 98% for all analytes in human urine samples. The device is stable, reproducible, and compatible with a single battery, making it a robust choice for analytical purposes.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biochemical Research Methods
Elia Santigosa, Stig Pedersen-Bjergaard, Maria Munoz, Maria Ramos-Payan
Summary: This study utilized a green microfluidic device for simultaneous extraction of multiple drugs, with the discovery of a deep eutectic solvent mixture that was highly efficient in extracting both non-polar and polar acidic drugs. The operation was simple, and the use of chemical waste was minimized due to the green and non-hazardous nature of the chemicals involved.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Samira Dowlatshah, Elia Santigosa, Mohammad Saraji, Maria Ramos Payan
Summary: Liquid phase microextraction into a microfluidic device has made significant advances in downscaled and miniaturized extraction of sulfonamides. The proposed method using tributyl phosphate as a supported liquid membrane achieved high extraction efficiencies and low detection limits for sulfadiazine, sulfamerazine, sulfamethazine, and sulfamethoxazole. The developed microfluidic device showed great potential for efficient and rapid determination of sulfonamides in urine samples.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Chemistry, Analytical
Julia Kazakova, Mercedes Villar-Navarro, Juan Luis Perez-Bernal, Maria Ramos-Payan, Miguel Angel Bello-Lopez, Rut Fernandez-Torres
Summary: This study proposed a method for the determination of 2,4-, 2,5-, and 2,6-dinitrophenols and some of their metabolites in human urine and saliva. By using liquid phase microextraction coupled with ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry, low detection and quantitation limits of the target analytes were achieved, allowing the investigation and tentative identification of metabolites.
MICROCHEMICAL JOURNAL
(2021)
Article
Environmental Studies
Phoebe Gittelson, Danielle Diamond, Lynn Henning, Maria Payan, Lynn Utesch, Nancy Utesch
Summary: Community-driven research has revealed the negative health impacts of industrial agriculture on nearby communities, with rural communities in Wisconsin and Delaware exposing pollution issues. Biogas, falsely marketed as a renewable energy solution, actually harms local communities, increases farmer debt, and perpetuates harmful agriculture practices.
ENVIRONMENTAL JUSTICE
(2022)
Article
Biochemical Research Methods
Samira Dowlatshah, Mohammad Saraji, Stig Pedersen-Bjergaard, Maria Ramos-Payan
Summary: This paper developed fully green and biodegradable supported liquid membranes for microextraction, using natural deep eutectic solvents and agarose. A microfluidic device was employed for determination of sulfonamide pharmaceuticals in urine samples, achieving spiking recoveries in the range of 77-100%. The performance of the eco-friendly system was comparable to conventional supported liquid membranes.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Chemistry, Analytical
Elia Santigosa, Stig Pedersen-Bjergaard, Pablo Gimenez-Gomez, Maria Munoz, Maria Ramos-Payan
Summary: In this study, a microfluidic device was used to simultaneously extract model analytes with different polarities using liquid-phase microextraction. A mixture of tributyl phosphate and dihexyl ether was found to be highly efficient for the extraction of non-polar and polar model analytes.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemical Research Methods
Samira Dowlatshah, Mohammad Saraji, Maria Ramos-Payan
Summary: A environmentally friendly microfluidic system based on natural deep eutectic solvents immobilized in agarose membranes was developed for extracting parabens from urine samples. The system showed advantages of nontoxic solvents, miniaturized method and biodegradable materials, and was successfully applied for the determination of parabens in urine samples.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Review
Biochemical Research Methods
Juan Antonio Ocana-Gonzalez, Noemi Aranda-Merino, Juan Luis Perez-Bernal, Maria Ramos-Payan
Summary: Liquid phase microextraction (LPME) and electromembrane microextraction (EME) are two popular techniques in sample treatment, both utilizing membrane-assisted extraction. Solid supports in the form of supported liquid membranes (SLMs) play a critical role in enhancing extraction reproducibility. Various SLMs have been successfully employed in different application fields, allowing the extraction of compounds with diverse natures. The development of environmentally friendly materials and solvents has also been a focus in recent years.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Analytical
Alejandro Martin, Rut Fernandez-Torres, Miguel Angel Bello-Lopez, Maria Ramos-Payan
Summary: This article introduces a new microfluidic device to improve the enrichment factor in miniaturized systems. The device is designed for liquid phase microextractions and can simultaneously extract acidic compounds with a wide range of polarities. The system operates under stagnant acceptor phase conditions and optimal operational parameters were determined. A new highly efficient supported liquid membrane, tributyl phosphate, was found for simultaneous extraction of analytes with different polarities. The method was successfully applied to human urine samples, demonstrating its potential for various applications.
Article
Chemistry, Analytical
Samira Dowlatshah, Frederik Andre Hansen, Chen Zhou, Maria Ramos-Payan, Trine Grongaug Halvorsen, Stig Pedersen-Bjergaard
Summary: Electromembrane extraction (EME) of peptides involves the transfer of positively charged peptides from an aqueous sample through a liquid membrane into an aqueous acceptor solution under an electrical field. However, the use of ionic carriers in the liquid membrane increases the system's conductivity and leads to instability and drifting pH. In this study, a selection of organic solvents without ionic carriers was tested as pure liquid membrane for EME of peptides, and tri(pentyl) phosphate was found to be the most suitable solvent. It extracted peptides with a net charge of +1 and no more than two polar side chains, and was able to extract leu-enkephalin, met-enkephalin, and endomorphin from human blood plasma.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Alejandro Martin, Elia Santigosa, Maria Ramos-Payan
Summary: In this study, a novel solvent-free microfluidic method for liquid phase microextraction (LPME) was proposed. The efficiency of biodegradable membranes without organic solvent in microfluidic formats was investigated, and a comparison with electromembrane extraction (EME) was conducted. The results showed that the solvent-free LPME microfluidic format had similar extraction efficiencies to the solvent-free EME format, but the LPME format was preferred due to its simplicity. The proposed green microfluidic device was successfully applied to urine samples, achieving high recoveries for all analytes and low relative standard deviation. Compared with conventional membranes, the solvent-free microfluidic systems based on biodegradable solid support materials offered the same advantages in terms of membrane stability and allowed consecutive extractions.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)
