Article
Immunology
Helen C. Steel, W. D. Francois Venter, Annette J. Theron, Ronald Anderson, Charles Feldman, Natasha Arulappan, Theresa M. Rossouw
Summary: This study investigated the effects of cART on biomarkers of platelet activation in HIV-infected individuals. The findings suggest that sCD40L may be a potential biomarker of successful cART, while PDGF-BB levels may indicate persistent low-level antigenemia. The study highlighted the importance of monitoring biomarkers of platelet activation in HIV treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Sourima Biswas Shivhare, Qinsheng Lu, Dingqian Sun, Huomei Hou, Judith N. Bulmer, Barbara A. Innes, Dharani K. Hapangama, Gendie E. Lash
Summary: This study investigated the expression pattern of PDGF-BB and its receptors in the endometrium of healthy control women and those with AUB-E across the menstrual cycle. The results showed a reduction in endothelial cell expression of PDGF-BB and PDGFR alpha in the mid and late secretory phases in AUB-E, which may contribute to the reduced vascular maturation observed in these women.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Cell Biology
Pengfei Zhu, Zhengchao Wang, Zhenxing Sun, Bokai Liao, Yu Cai
Summary: The study found that recombinant PDGF-BB alleviated OA by inhibiting chondrocyte apoptosis, reducing cartilage hyperplasia, and regulating collagen metabolism.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Psychiatry
Keita Idemoto, Tamaki Ishima, Tomihisa Niitsu, Tatsuki Hata, Sumiko Yoshida, Kotaro Hattori, Tadasu Horai, Ikuo Otsuka, Hidenaga Yamamori, Shigenobu Toda, Yosuke Kameno, Kiyomitsu Ota, Yasunori Oda, Atsushi Kimura, Tasuku Hashimoto, Norio Mori, Mitsuru Kikuchi, Yoshio Minabe, Ryota Hashimoto, Akitoyo Hishimoto, Kazuyuki Nakagome, Masaomi Iyo, Kenji Hashimoto
Summary: The study suggests that serum platelet-derived growth factor BB (PDGF-BB) may be a potential biomarker to differentiate between bipolar disorder (BD) and major depressive disorder (MDD).
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Aditya Girish, Ketan Jolly, Nijmeh Alsaadi, Maria de la Fuente, Arielle Recchione, Ran An, Dante Disharoon, Zachary Secunda, Shruti Raghunathan, Norman F. Luc, Cian Desai, Elizabeth Knauss, Xu Han, Keren Hu, Hanyang Wang, Ujjal Didar Singh Sekhon, Nathan Rohner, Umut A. Gurkan, Marvin Nieman, Matthew D. Neal, Anirban Sen Gupta
Summary: This study presents the design and evaluation of thrombin-loaded injury-site-targeted lipid nanoparticles (t-TLNPs) that can specifically localize at an injury site and release thrombin for hemostatic action. The nanoparticles were found to restore hemostatic dysfunction and reduce bleeding in both in vitro and in vivo experiments.
Article
Biotechnology & Applied Microbiology
Zhiguo Yuan, Zhuocheng Lyu, Wei Zhang, Jue Zhang, You Wang
Summary: This study presents a new treatment concept for osteoarticular lesions using a porous bioactive prosthesis with regenerative activity. The researchers fabricated chitosan/mesoporous silica nanoparticles composite microspheres as a carrier for the sequential release of growth factors. The results show that the scaffold is biocompatible, promotes cell migration and chondrogenic differentiation, and promotes cartilage regeneration in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Parasitology
Ying Ke, Xiaojuan Bi, Ning Yang, Jin Chu, Xiaohong Li, Wenmei Ma, Hui Liu, Hui Wang, Liang Li, Cheng Li, Yongde Qin, Tuerganaili Aji, Yingmei Shao, Guodong Lu, Renyong Lin
Summary: PDGF-BB can serve as a simple, non-invasive, and quick biomarker to assess the metabolic activity of lesions in AE patients. It is significantly negatively correlated with metabolically active AE and positively correlated with metabolic activity, PNM stage, and lesion size.
Article
Chemistry, Multidisciplinary
Ana L. Graca, Manuel Gomez-Florit, Hugo Osorio, Marcia T. Rodrigues, Rui M. A. Domingues, Rui L. Reis, Manuela E. Gomes
Summary: This study produced and characterized platelet-derived EVs and investigated their effects on different cell types. The EVs were found to regulate stem cell differentiation, promote angiogenesis, and modulate macrophage polarization, suggesting their potential as therapeutic tools in tissue engineering and regenerative medicine.
Article
Biochemistry & Molecular Biology
Susan Y. S. Li, Rebecca Johnson, Leon C. D. Smyth, Mike Dragunow
Summary: This review provides an updated overview of the actions of platelet-derived growth factors on neurovascular function, their role in regulating perivascular cell types, and their clinical relevance and therapeutic potential for neurological diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kaikai Fan, Xinhua Ruan, Leilei Wang, Wanli Lu, Qiangwei Shi, Yawei Xu
Summary: The study showed that circ_0004872 promotes proliferation, migration, and dedifferentiation of HA-VSMCs induced by PDGF-BB by enhancing TXNIP levels, with miR-513a-5p playing a regulatory role in this process.
VASCULAR PHARMACOLOGY
(2021)
Article
Biology
Jin Sun, Xin Jiang, Junnan Luo, Liheng Zhao, Zuhua Xu, Wende Xiao
Summary: Transfecting two growth factors into rat bone marrow mesenchymal stem cells and compounding with platelet-rich plasma can inhibit adipogenic differentiation and promote cell viability.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Engineering, Biomedical
Harsha Kabra, Tanaya Walimbe, Kate Stuart, Camille Indey, Swati Jalgaonkar, Elvis Ikwa, Taylor Skurnac, Julia Chen, Andrew Woolley, Nicholas M. Snead, Nathan Bachtell, Diana J. Leeming, Morten Karsdal, Glenn Prestwich, Alyssa Panitch, John Paderi
Summary: SBR-294, targeting collagen-mediated platelet activation and PDGF activity, showed potential therapeutic benefits in reducing liver fibrosis in the CCl4 mouse model. Further investigation is warranted to explore its potential as a treatment for liver fibrosis.
Article
Materials Science, Biomaterials
Yaxin Li, Ziyang Liu, Chen Zhao, Chenci Xu, Airi Shin, Jiaqing Wu, Dejian Li, Kaili Lin, Jiaqiang Liu
Summary: Regenerating bone tissue in the presence of diabetes mellitus (DM) is a challenge due to impaired stem cell function in a high-glucose environment. The researchers developed an injectable sustained-release PDGF-BB nanocomposite hydrogel, which restored stem cell proliferation and migration and promoted osteogenesis in high glucose conditions. Nano clay LAPONITE (R) was added to provide continuous PDGF-BB release and enhance mechanical strength. This hydrogel successfully healed calvarial lesions in diabetic rats and has potential for treating diabetic patients.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Shintaro Yamaguchi, Ryo Isaka, Yuji Sakahashi, Hirofumi Tsujino, Yuya Haga, Kazuma Higashisaka, Yasuo Tsutsumi
Summary: Research has found that silver nanoparticles with a diameter of 10 nm can inhibit retinoic acid-induced neuronal differentiation. This inhibitory effect may be achieved through the oxidative stress pathway, induction of mitochondrial ROS production, and decreased expression of mitochondrial fusion-related genes.
ACS APPLIED NANO MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Weikang Zhang, Yuhang Gong, Xiaohang Zheng, Jianxin Qiu, Ting Jiang, Lihua Chen, Fangying Lu, Xinhui Wu, Fengmin Cheng, Zhenghua Hong
Summary: PDGF-BB promotes extracellular matrix synthesis of NPCs and inhibits pyroptosis, participating in the inhibition of IDD through regulating the MAPK signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)