Journal
KIDNEY INTERNATIONAL
Volume 96, Issue 2, Pages 342-349Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.kint.2019.02.013
Keywords
nephrotic syndrome; podocyte; proteinuria
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Funding
- rare disease consortium by the Bundesministerium fur Bildung und Forschung [01GM1518D]
- DFG [MU379777/1-1, SCHI 587/11-1]
- National Institute of General Medical Sciences of the National Institutes of Health [P20GM0103423, P20GM104318]
- Else-Kroner-Fresenius Stiftung (EKFS)-Einzelantrag of the Federal Ministry of Education and Research (BMBF) [2016_A162 A, 01GM1518B]
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Proteinuria can be induced by impairment of any component of the glomerular filtration barrier (GFB). To determine the role of circulating permeability factors on glomerular damage, we developed a parabiosis-based zebrafish model to generate a common circulation between zebrafish larvae. A morpholino-mediated knockdown of a podocyte specific gene (nephronectin) was induced in one zebrafish larva which was then fused to an un-manipulated fish. Notably, proteinuria and glomerular damage were present in the manipulated fish and in the parabiotically-fused partner. Thus, circulating permeability factors may be induced by proteinuria even when an induced podocyte gene dysregulation is the initiating cause.
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