Journal
KIDNEY INTERNATIONAL
Volume 95, Issue 5, Pages 1041-1052Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.kint.2018.10.042
Keywords
hypertension; insulin resistance; obesity; (pro)renin receptor
Categories
Funding
- National Kidney Foundation of Utah and Idaho
- National Institutes of Health [DK097007]
- Veterans Affairs Merit Review
Ask authors/readers for more resources
The (pro)renin receptor (PRR) is a multifunctional protein that is expressed in multiple organs. Binding of prorenin/renin to the PRR activates angiotensin II-dependent and angiotensin II-independent pathways. The PRR is also involved in autophagy and Wnt/beta catenin signaling, functions that are not contingent on prorenin binding. Emerging evidence suggests that the PRR plays an important role in blood pressure regulation and glucose and lipid metabolism. Herein, we review PRR function in health and disease, with particular emphasis on hypertension and the metabolic syndrome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available