Article
Chemistry, Physical
Haiyi Chen, Yu Kang, Mojie Duan, Tingjun Hou
Summary: The study revealed that the presence of heparan sulfate is crucial for the binding between the spike protein of SARS-CoV-2 and host ACE2, while the stability of the T470-F490 loop and hydrophobic interactions play key roles in the binding process.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Biotechnology & Applied Microbiology
Fatemah O. F. O. Alshammari, Yousef M. Al-Saraireh, Ahmed M. M. Youssef, Yahya M. Al-Sarayra, Hamzeh Mohammad Alrawashdeh
Summary: The study found intense glypican-1 expression in all breast cancer histopathological subtypes, with a significant difference in expression compared to normal breast tissue. Additionally, a higher expression of glypican-1 was observed in advanced grade and larger tumor size breast cancer patients, but showed no obvious relationship with other biomarkers.
ONCOTARGETS AND THERAPY
(2021)
Review
Virology
Rhonda C. Kines, John T. Schiller
Summary: Human papillomaviruses (HPV) are the primary cause of cervical cancer and attach to heparan sulfate proteoglycans (HSPG). HPV requires exposure of the basement membrane and wounds, where modifications in HSPG's sulfation patterns occur, to efficiently attach and infect. Similar HSPG modifications can be found on tumor cells. In recent years, the use of HPV to target and treat tumors has emerged.
Article
Cell Biology
Olga Ostrovsky, Katia Beider, Hila Magen, Merav Leiba, Ralph D. Sanderson, Israel Vlodavsky, Arnon Nagler
Summary: This study identified significant associations between certain SNPs in the HPSE and HPSE2 genes and primary paraskeletal disease. The HPSE SNPs rs4693608 and rs4693084, as well as the HPSE SNPs rs4364254 and rs4426765, showed a strong association with PS. The HPSE2 SNP rs657442 was found to have a protective association with primary paraskeletal disease and lytic bone lesions.
Review
Biochemistry & Molecular Biology
Anastasia V. Strokotova, Elvira V. Grigorieva
Summary: Glucocorticoids are commonly used to treat various diseases but can cause side effects. Recent studies suggest that the toxic effects of glucocorticoids on key extracellular components in the brain may be an underlying mechanism for these side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Carlo Sorrentino, Stefania Livia Ciummo, Luigi D'Antonio, Cristiano Fieni, Paola Lanuti, Alice Turdo, Matilde Todaro, Emma Di Carlo
Summary: IL30 plays a crucial role in regulating the viability and growth of breast cancer stem cells (BCSC) through juxtacrine signals and mediators such as CXCL10 and IL23. Targeting IL30 could potentially restrain the BCSC compartment and counteract breast cancer progression by disrupting its autocrine loops and immune subversion pathways.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Quentin Klopfenstein, Valentin Derangere, Laurent Arnould, Marion Thibaudin, Emeric Limagne, Francois Ghiringhelli, Caroline Truntzer, Sylvain Ladoire
Summary: The prognosis of early breast cancer is associated with the clinic-pathological stage and the molecular characteristics of tumor cells. In some patients, the presence of tumor-infiltrating immune cells can impact long term outcome. A new gene expression deconvolution algorithm was developed to estimate immune cell populations in tumors and found that myeloid cells were associated with poor outcomes, while lymphoid cells were linked to favorable prognosis. This information, when combined with clinical stage and PAM50, can improve the prediction of relapse or death in early breast cancer patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Chenghui Yang, Zhen Wang, Lili Li, Zhigang Zhang, Xiaoyan Jin, Pin Wu, Shanshan Sun, Jun Pan, Ke Su, Fang Jia, Leyi Zhang, Haijun Wang, Xiuyan Yu, Xuan Shao, Ke Wang, Fuming Qiu, Jun Yan, Jian Huang
Summary: Naged, a subset of neutrophils, plays a crucial role in premetastatic niche formation during breast cancer metastasis. It is characterized by distinct cell markers and morphological features, and is maintained by the key transcription factor SIRT1 for their function in promoting tumor metastasis through mitochondria-dependent NETs formation. Therapeutic interventions targeting the SIRT1-Naged-NETs axis show promise for reducing breast cancer lung metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Arianna Parnigoni, Paola Moretto, Manuela Viola, Evgenia Karousou, Alberto Passi, Davide Vigetti
Summary: Breast cancer is the most common neoplasm in women, and its lethality is mainly due to the ability of tumor cells to invade and seed distant organs. Hormone receptors play a critical role in determining tumor aggressiveness and targeted therapies, but the role of the tumor microenvironment is also evident. This article focuses on the role of the extracellular matrix polysaccharide hyaluronan in relation to hormone receptor expression in breast cancer cells.
Article
Hematology
Linda M. Hiebert
Summary: Diabetes is a complex disease that affects millions of people worldwide, and the role of proteoglycans, particularly heparan sulfate proteoglycans (HSPGs), in its pathogenesis has recently gained attention. HSPGs play crucial roles in various physiological processes, and their modification in diabetes can lead to complications in different tissues and organs. Understanding the role of HSPGs in diabetes may help develop new treatments and preventive measures for this condition.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Oncology
Dandan Sheng, Wei Ma, Rui Zhang, Lei Zhou, Qiaodan Deng, Juchuanli Tu, Weilong Chen, Fuchuang Zhang, Nailong Gao, Mengxue Dong, Dong Wang, Fengkai Li, Yin Liu, Xueyan He, Shengzhong Duan, Lixing Zhang, Tong Liu, Suling Liu
Summary: Our study reveals that DTX-induced CCL3 triggers proinflammatory macrophage polarization and facilitates phagocytosis of cancer cells. CCL3 induction in combination with DTX may provide a promising therapeutic rationale for increasing DTX chemosensitivity in breast cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Engineering, Chemical
Mengling Liu, Qing Liu, Yitao Yuan, Suyao Li, Yu Dong, Li Liang, Zhiguo Zou, Tianshu Liu
Summary: This study identified a potential predictive biomarker for immunotherapy efficacy in pMMR mCRC, showing that high HPSE expression is associated with immune checkpoint molecules, tumor mutation burden, and macrophage infiltration. It suggests that pMMR mCRC patients with high HPSE expression may respond to immune checkpoint inhibitors.
Article
Biochemistry & Molecular Biology
Linh Nguyen, Kelli A. McCord, Duong T. Bui, Kim M. Bouwman, Elena N. Kitova, Mohamed Elaish, Dhanraj Kumawat, Gour C. Daskhan, Ilhan Tomris, Ling Han, Pradeep Chopra, Tzu-Jing Yang, Steven D. Willows, Andrew L. Mason, Lara K. Mahal, Todd L. Lowary, Lori J. West, Shang-Te Danny Hsu, Tom Hobman, Stephen M. Tompkins, Geert-Jan Boons, Robert P. de Vries, Matthew S. Macauley, John S. Klassen
Summary: Evidence suggests that host glycans, specifically glycolipids containing sialic acid, play a role in facilitating the entry of SARS-CoV-2 virus into host cells by binding to the receptor-binding domain (RBD) of the spike protein. Depletion of cell surface sialic acid levels through various methods decreases RBD binding and infection of the virus, indicating the importance of sialylated glycans in viral entry.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Oncology
Josh W. DiGiacomo, Ines Godet, Michael Trautmann-Rodriguez, Daniele M. Gilkes
Summary: Studies have shown that the ECM can play a crucial role in driving ER signaling and resistance to endocrine therapy in breast cancer. By inhibiting FGF2-FGFR1 binding, the sensitivity to ER-targeted therapy can be restored.
MOLECULAR CANCER RESEARCH
(2021)
Article
Cell Biology
Toshihiro Inubushi, Nag Priyanka, Masakatsu Watanabe, Yusuke Takahashi, Shinnosuke Kusano, Hiroshi Kurosaka, Silvana Papagerakis, Petros Papagerakis, Mikako Hayashi, Takashi Yamashiro
Summary: This study demonstrates that the chlorinated oxidant MA-T can enhance dentinogenesis by modifying HSPG and activating Wnt signaling. The treatment decreases sulfation of HSPG, upregulates the expression of dentin-related genes, and promotes dentin formation in developing teeth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Sueli M. P. S. Torres, Helena B. Nader, Ricardo S. Simoes, Edmund C. Baracat, Jose M. Soares-Jr, Manuel de J. Simoes, Regina C. T. Gomes
Summary: The estradiol treatment alone (EG) or associated with progesterone (EPG) affected the concentration of hyaluronan acid, increased cell proliferation, and decreased cell death in mammary tissue.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Enio R. Vasques, Estela R. R. Figueira, Joel A. Rocha-Filho, Cinthia Lanchotte, Jorge L. S. Ximenes, Helena B. Nader, Ivarne L. S. Tersariol, Marcelo A. Lima, Tiago Rodrigues, Jose E. M. Cunha, Eleazar Chaib, Luiz A. C. D'Albuquerque, Flavio H. F. Galvao
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2022)
Article
Biology
A. P. S. Mesquita, M. Matsuoka, S. A. Lopes, P. C. A. Pernambuco Filho, A. S. Cruz, H. B. Nader, C. C. Lopes
Summary: This study evaluates the effect of NO on the adhesiveness, invasiveness, and migration of anoikis-resistant endothelial cells. It is found that inhibition of NO release decreases cell adhesiveness to fibronectin, laminin, and collagen IV, while increasing invasiveness and migration. These changes are associated with MMP-2 up-regulation and ATF3 down-regulation.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Biology
J. Chinoca, D. S. Andrade, A. Mendes, P. De Marchi, T. G. Prieto, C. M. Baldavira, C. Farhat, J. R. M. Martins, H. B. Nader, D. M. Carraro, V. L. Capelozzi, V de Sa
Summary: We evaluated the levels of hyaluronan (HA) in sputum as a noninvasive tool for predicting disease progression and treatment response in non-small cell lung cancer (NSCLC) patients. Higher levels of HA in sputum were associated with tumor stage, phenotype, treatment response, and outcome. In early-stage NSCLC, patients with lower HA levels had better response and progression-free survival after systemic chemotherapy. Patients with low HA levels also showed better response and progression-free survival after combined immunotherapy and chemotherapy in advanced-stage disease.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Otorhinolaryngology
Gilad Horowitz, John R. De Almeida, Ilyes Berania, David P. Goldstein, Hugo Fontan Koehler, Luiz Paulo Kowalski, Leandro Luongo Matos, Adi Brenner-Ullman, Dan M. Fliss, Nidal Muhanna, Daniel Halpern, Narin Nard-Carmel, Omer J. Ungar, Anton Warshavsky
Summary: In patients with oral cavity squamous cell carcinoma (OCSCC), masticator space involvement may result in positive surgical margins in tumors extending above the supra-mandibular notch.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Critical Care Medicine
Anthony Gebran, Apostolos Gaitanidis, Dias Argandykov, Lydia R. Maurer, Ander Dorken Gallastegi, Mary Bokenkamp, Osaid Alser, Dmitri Nepogodiev, Aneel Bhangu, Haytham M. A. Kaafarani
Summary: This study analyzed the mortality and pulmonary complication rates of COVID-19 patients undergoing emergency general surgery, finding significantly higher rates in these patients, especially in those with preoperative respiratory symptoms.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Neurosciences
Danielle de Paula Moreira, Angela May Suzuki, Andre Luiz Teles e Silva, Elisa Varella-Branco, Maria Cecilia Zorel Meneghetti, Gerson Shigeru Kobayashi, Mariana Fogo, Merari de Fatima Ramires Ferrari, Rafaela Regina Cardoso, Naila Cristina Vilaca Lourenco, Karina Griesi-Oliveira, Elaine Cristina Zachi, Debora Romeo Bertola, Karina de Souza Weinmann, Marcelo Andrade de Lima, Helena Bonciani Nader, Andrea Laurato Sertie, Maria Rita Passos-Bueno
Summary: Biallelic pathogenic variants in TBCK lead to IHPRF3, but the molecular mechanisms are not fully understood. This study reported two sisters with IHPRF3 and TBCK variants and provided evidence that TBCK may play a critical role in the early secretory pathway in neuroprogenitor cells. Impairment of TBCK function has been associated with disrupted vesicle transport and autophagosome biogenesis, altered cell cycle progression, and impaired migration capacity.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Oncology
Claudio R. Cernea, Leandro Luongo Matos, Cecilia Eugenio, Giovanna Mattos Ferreira, Yasmin Sa Cerqueira, Ana Kober N. Leite, Felipe A. B. Vanderlei, Dorival de Carlucci, Renato N. Gotoda, Flavio C. Hojaij, Vergilius J. F. Araujo-Filho
Summary: Active surveillance for PTMC has gained increasing interest. Molecular methods can effectively detect aggressive PTMC, enabling timely surgery for those patients, while other patients with indolent PTMC can be actively monitored. Thyroid lobectomy is a acceptable surgical alternative.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Otorhinolaryngology
Lorenzo Fernandes Moca Trevisani, Isabelle Fernandes Kulcsar, Ana Kober Nogueira Leite, Marco Aurelio Vamondes Kulcsar, Graziele Aparecida Simoes Lima, Rogerio Aparecido Dedivitis, Luiz Paulo Kowalski, Leandro Luongo Matos
Summary: This study aimed to analyze the prognostic relationship between weight loss and preoperative hematological indexes in patients with pT4a squamous cell carcinoma of the oral cavity. The results showed that weight loss greater than 10%, red cell distribution width values greater than 14.3%, and extracapsular spread were independent variables associated with the risk of death. Patients with advanced squamous cell carcinoma of the oral cavity exhibited significant weight loss and immunocompromised state, which were risk factors for lower survival.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Leandro Luongo Matos, Renato Castro Capuzzo, Paola Andrea Galbiatti Pedruzzi, Terence Farias, Jose Wilson Mourao de Farias, Carlos Takahiro Chone, Hugo Fontan Kohler, Jose Guilherme Vartanian, Fernando Luiz Dias, Eduardo Vieira Couto, Fabio Roberto Pinto, Andre Lopes Carvalho, Luiz Paulo Kowalski
Summary: In a real-world scenario, sentinel lymph node biopsy is shown to be accurate and safe for patients with early lip and oral cavity squamous cell carcinoma, with similar results to elective neck dissection.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Jaqueline Vaz Vanini, Leonardo Kenji Sakaue Koyama, Leandro Luongo de Matos, Jose Martins Figueredo Junior, Claudio Roberto Cernea, Cibele Pidorodeski Nagano, Claudia Malheiros Coutinho-Camillo, Ricardo Hsieh, Silvia Vanessa Lourenco
Summary: This study investigated the presence of epithelial-mesenchymal markers in oral squamous cell carcinoma with bone invasion and their relationship with clinical-pathological parameters and prognostic factors. The results showed evidence of total or partial epithelial-mesenchymal transition (EMT) in oral squamous cell carcinoma bone invasion, and the transcription factor twist appeared to be involved in bone invasion and disease progression.
JOURNAL OF BONE ONCOLOGY
(2022)
Article
Otorhinolaryngology
Guilherme Arruda Fernandes, Leandro Luongo de Matos, Rogerio Aparecido Dedivitis
Summary: This study aimed to assess the risk factors for malignancy among patients with multinodular goiter submitted to total thyroidectomy. The results showed that the Bethesda index, older age group, shorter clinical history, smaller number of nodules, and smaller size of nodule were related to the diagnosis of papillary carcinoma.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2023)
Article
Genetics & Heredity
Thais Kristini Almendros Barbosa, Rosario Dominguez Crespo Hirata, Glaucio Monteiro Ferreira, Jessica Bassani Borges, Victor Fernandes de Oliveira, Renata Gorjao, Elisangela Rodrigues da Silva Marcal, Rodrigo Marques Goncalves, Andre Arpad Faludi, Renata Caroline Costa de Freitas, Carolina Dagli-Hernandez, Raul Hernandes Bortolin, Gisele Medeiros Bastos, Tania Cristina Pithon-Curi, Helena Bonciani Nader, Mario Hiroyuki Hirata
Summary: Familial hypercholesterolemia (FH) is caused by harmful mutations in the LDLR gene, resulting in significantly increased low-density lipoprotein (LDL) cholesterol and premature atherosclerotic cardiovascular disease. In this study, the functional effects of LDLR variants in Brazilian FH patients were assessed. It was found that LDLR null and defective variants reduce LDL binding and uptake in activated T-lymphocytes, while LDLR missense variants affect LDLR conformational stability and the dissociation of the LDLR-ApoB complex.
Review
Oncology
Leandro Luongo Matos, Yasmin Laryssa Moura Guimaraes, Ana Kober Leite, Claudio Roberto Cernea
Summary: Oral squamous cell carcinoma (OSCC) patients with larger depth of invasion (DOI) and/or width are included in stage III, which is a heterogeneous group. Features such as extranodal extension, positive or close margins, specific tumor and nodal characteristics are associated with adverse prognosis and warrant adjuvant treatment. However, for stage III OSCC without adverse features, there is no strong evidence to recommend or exclude adjuvant treatment. Further studies are needed to determine the appropriate management for these patients.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Otorhinolaryngology
Gustavo Fernandes de Alvarenga, Ana Kober Nogueira Leite, Carlos Neutzling Lehn, Rogerio Aparecido Dedivitis, Marianne Yumi Nakai, Beatriz Godoi Cavalheiro, Gilberto Vaz Teixeira, Rafael De Cicco, Luiz Paulo Kowalski, Leandro Luongo de Matos
Summary: This study evaluated the impact of the COVID-19 pandemic on consultation, follow-up demand, and treatment volume at Brazilian Head and Neck Surgery Centers. The data revealed a significant reduction in consultations, attending patients, diagnostic exams, and surgical procedures between 2019 and 2020. The COVID-19 pandemic had a significant national impact on Brazilian Head and Neck Surgery Centers.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2023)