Journal
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
Volume 47, Issue 4, Pages 540-549Publisher
SPRINGER
DOI: 10.1007/s11239-019-01826-9
Keywords
Fibrin clot; Peripheral arterial disease; Endovascular treatment; In-stent restenosis
Ask authors/readers for more resources
IntroductionHypolysible fibrin clots composed of tightly packed fibers characterize patients with peripheral artery disease (PAD) especially those with critical limb ischemia (CLI). Little is known about the impact of a prothrombotic clot phenotype on restenosis following endovascular revascularization in CLI. The goal of this study was to compare fibrin clot properties and their determinants in CLI patients with restenosis after endovascular treatment (ET) and those free of this complication.Methods85 patients with CLI and restenosis within 1year after ET on optimal pharmacotherapy and 47 PAD control patients without restenosis were included into the study. Plasma fibrin clot permeability (Ks, a measure of the average pore size in the fibrin network) and clot lysis time (CLT) with its potential determinants were determined. During follow-up, the composite endpoint including re-intervention, amputation and death was assessed.ResultsCompared with the control group, patients with restenosis had reduced K-s (-9.5%, p<0.001), prolonged CLT (+12.4%, p=0.003), higher thrombin generation (+7.9%, p<0.001) and elevated von Willebrand factor (vWF) antigen (+14.2%, p<0.001). During a 24months follow-up the composite endpoint occurred in 54 CLI patients with restenosis (63.5%) and nine control patients (19.1%, p<0.001) with no association with baseline K-s and CLT.ConclusionThe increased thrombin formation and unfavorable fibrin clot properties occur in patients with CLI who experienced restenosis despite optimal endovascular and pharmacological therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available